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An Interview with Lewis Gruber of SIWA Therapeutics
SIWA Therapeutics is one of the few senolytics biotech companies founded prior to the past few years, invigorated with new funding now that the clearance of senescent cells as a basis for rejuvenation is an area of intense interest for the research and development community. The company is also, I believe, running the only senolytics program based the use of monoclonal antibodies. This is a way to encourage the immune system to destroy cells bearing specific surface markers, in this case a form of advanced glycation endproduct that is found on cancerous, senescent, and otherwise dysfunctional cells. Many of our re...
Source: Fight Aging! - February 19, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, February 17th 2020
Discussion of the Evolutionary Genetics of Aging Thymic Involution Contributes to Immunosenescence and Inflammaging The Potential for Exosome Therapies to Treat Sarcopenia Correlations of Mitochondrial DNA Copy Number and Epigenetic Age Measures Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice The Aging Retina, a Mirror of the Aging Brain Evidence for Loss of Capillary Density to be Important in Heart Disease Aspects of Immune System Aging Proceed More Rapidly in Men Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation Transplantation of Senescent Cells is an ...
Source: Fight Aging! - February 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Podcast: Managing Coronavirus Outbreak Anxiety
Does the new coronavirus from China make you a little anxious? How concerned should we be? Is it a real threat or mostly hype? In today’s podcast, Dr. John Grohol, founder and editor-in-chief of PsychCentral.com, explains what the coronavirus is, how it compares to the flu and why it seems to have hit the panic button in a lot of people. He offers tips to avoid getting sick in general, and importantly, gives advice on how to keep our anxiety levels in check when it comes to new disease outbreaks, especially in how we seek information from the media. If you’d like to learn more about the coronavirus and how to deal wi...
Source: World of Psychology - February 13, 2020 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: Anxiety and Panic Disorders General Health-related Interview Podcast The Psych Central Show Source Type: blogs

Aspects of Immune System Aging Proceed More Rapidly in Men
Men do not live as long as women. This is a consistent effect across populations and eras, and there are any number of theories as to why this is the case. This might lead us to expect measurable aspects of aging to be more pronounced in older males than in older females, and researchers here show that this is the case for the age-related dysfunction of the immune system. As we age, the immune system becomes both overactive and less capable, leading to chronic inflammation alongside decreased resistance to infection and cancer. This is an important contribution to age-related frailty, disease, and mortality. Human...
Source: Fight Aging! - February 13, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Newer skin cancer treatments improve prognosis for those with cutaneous melanoma
Cutaneous melanoma, also called malignant melanoma, is the type of skin cancer that is most likely to spread to other parts of the body. Though melanoma accounts for only about 1% of skin cancers, it is responsible for more than 90% of skin cancer-related deaths. But thanks to developments in skin cancer treatment (mostly in the last decade), patients with melanoma have much better chances of living longer. What is a melanoma? Melanoma involves the uncontrolled growth of a type of cell known as a melanocyte. One of the most important functions of a normal melanocyte is to protect your skin from the sun’s damaging ultravi...
Source: Harvard Health Blog - February 3, 2020 Category: Consumer Health News Authors: Dominic Wu, MD Tags: Cancer Skin and Hair Care Source Type: blogs

A Neurologist Shares Her Thoughts on the Individuality of Each Person Living with Dementia
"For years, the push to do something about Alzheimer’s disease-focused almost entirely on drug development. Find a cure. Develop a vaccine to prevent the disease. Develop a drug to “manage” people who live with Alzheimer’s and other types of dementia. What many people weren’t noticing, however, was that in tandem with this effort was a quiet revolution doggedly moving forward...Developing dementia doesn’t take away your individuality or humanity any more than developing cancer or diabetes. Therefore, rather than concentrate only on drugs, we need to help caregivers – and yes professionals – better understan...
Source: Minding Our Elders - January 29, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Coronavirus FAQ
What is a coronavirus? Coronaviruses are a group of viruses that cause diseases in mammals, including humans, and birds. Why are they called coronaviruses? The name derives from the fact that the viral capsule has a “halo” or “crown” surrounding it. What do coronaviruses do? In humans, the virus infects the airways giving rise to flu-like symptoms, a runny nose, cough, sore throat and fever, these are usually mild, but in rare cases can be lethal. Is there a vaccine against coronaviruses? No. Are there any drugs to block or treat infection? No. When were coronaviruses first discovered? In the 1960s ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - January 24, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

Fight Aging! Newsletter, January 20th 2020
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role is t...
Source: Fight Aging! - January 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Vaccines for women: Before conception, during pregnancy, and after a birth
The rise of vaccine-preventable illnesses, such as measles and hepatitis, in the United States and around the globe has been alarming in recent years. For women — especially those hoping to become pregnant, as well as women who are pregnant or have recently had a baby — vaccines can be a worrisome topic. There are many misconceptions about vaccine safety in and around pregnancy that can lead to confusion and unnecessary fear of a lifesaving medical tool. As a practicing ob/gyn, I often discuss vaccines with my patients and help them sort out fears versus facts. Which vaccines should you consider before conception? The ...
Source: Harvard Health Blog - January 10, 2020 Category: Consumer Health News Authors: Ilona T. Goldfarb, MD, MPH Tags: Health Parenting Pregnancy Vaccines Women's Health Source Type: blogs

Fight Aging! Newsletter, December 23rd 2019
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons. Epige...
Source: Fight Aging! - December 22, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, December 9th 2019
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - December 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 25th 2019
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis. Against Senolytics https://www.fightaging.org/archives/2019/11/against-senolytics/ There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a ...
Source: Fight Aging! - November 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Vaccination and Antiviral Therapies Targeting CMV as an Approach to Reducing Immunosenescence
Today's open access paper discusses possible approaches to the treatment of immunosenescence, the age-related decline in effectiveness of the immune system. Unfortunately it is largely a tour of compensatory treatments, ways to force the cells of the immune system into greater or more useful activity without addressing any of the underlying causes of immunosenescence. Many of these methodologies have serious side-effects, are disruptive of normal immune function and overall health, and cannot be applied for the long term. Checkpoint inhibition, or the delivery of recombinant IL-7, for example, both of which are used as sho...
Source: Fight Aging! - November 20, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

HPV and cancer: The underappreciated connection
Did you know that a viral infection can lead to a number of different types of cancer? If that comes as a surprise to you, you’re not alone. In fact, according to a new study, many people have no idea that a common viral infection called human papilloma virus (HPV) can cause cancer of the genitals, anus, mouth, and throat, as well as cervical cancer. Viral infections and cancer The connection between certain viral infections and cancer has been recognized for many years. Some of the most well-established examples include hepatitis C, human immunodeficiency virus (HIV), and human papillomavirus (HPV). One thing these viru...
Source: Harvard Health Blog - November 8, 2019 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Adolescent health Cancer Infectious diseases Men's Health Sexual Conditions Vaccines Women's Health Source Type: blogs