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Hepatocellular carcinoma risk, cirrhosis and hepatitis C
High profile public health strategy needed Related items fromOnMedica Overweight teens more likely to have severe liver disease later Scotland reveals target of halving child obesity by 2030 JCVI recommends universal HPV vaccination Lower cancer risk in people with higher vitamin D levels Public drastically underestimates cannabis risks
Source: OnMedica Blogs - December 3, 2018 Category: General Medicine Source Type: blogs
Fight Aging! Newsletter, November 26th 2018
This study is the culmination of a decade of research that has repeatedly demonstrated that this vaccine can effectively and safely target in animal models what we think may cause Alzheimer's disease. I believe we're getting close to testing this therapy in people."
Although earlier research established that antibodies significantly reduce amyloid buildup in the brain, researchers needed to find a safe way to introduce them into the body. A vaccine developed elsewhere showed promise in the early 2000s, but when tested in humans, it caused brain swelling in some patients. The new idea was to start with DNA coding for...
Source: Fight Aging! - November 25, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, November 19th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - November 18, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Obama, Prince Harry, Angelina: Celebrities As Health Influencers
Beloved Hollywood celebrities, famous politicians or members of the British royal family: no better advertisement for fitness tracker producers and health tech companies. As models, actors and actresses are highly influential people, their early adoption of digital solutions could also push the masses towards living more healthily with technologies. On the other hand, celebrities are inclined to follow questionable health trends, too, which go against decades of medical evidence. Those examples, everyone should rather reject.
Wearables conquered Hollywood, the White House, and the British royal family
Celebrities are all a...
Source: The Medical Futurist - November 15, 2018 Category: Information Technology Authors: nora Tags: Social media in Healthcare celebrities digital health digital technologies digital technology famous fitness future health influencer health influencers Hollywood trackers trends wearables wellness Source Type: blogs
A Popular Science View of Checkpoint Inhibitor Cancer Immunotherapies
Checkpoint inhibitor therapies are a demonstrably successful approach to cancer immunotherapy. They suppress a mechanism that normally restrains immune cells from attacking other cells. This mechanism is abused by cancers, alongside a variety of other ways in which the immune system can be subverted or quieted. Any advanced tumor tends to have evolved into a state in which it is ignored or even helped by the immune system. Checkpoint inhibitor therapies are an improvement on chemotherapy when it comes to the trade-off between harming the cancer and harming the patient, as well as in the odds of success, but still present r...
Source: Fight Aging! - November 13, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Conference on Drug Pricing Injects New Statistics Into Debate, Few New Insights (Part 1 of 2)
The price of medications has become a leading social issue, distorting economies around the world and providing easy talking points to politicians of all parties (not that they know how to solve the problem). Last week I attended a conference on the topic at the Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics at Harvard Law School.
On one level, the increasing role that drugs play in health care is salutary. Wouldn’t you rather swallow a pill than go in for surgery, with the attendant risks of anesthesia, postoperative pain opiates, and exposure to the increasingly scary bacteria that lurk in h...
Source: EMR and HIPAA - November 8, 2018 Category: Information Technology Authors: Andy Oram Tags: Healthcare Reform Medical Economics Personalized Medicine Precision Medicine Drug Pricing Healthcare Costs Medication Pricing Source Type: blogs
Nonsense-Based Health Care - in the Service of Political Ideology and Sectarian Beliefs
ConclusionSince 2016, we have seen increasing attempts to distort or ignore medical science, clinical and epidemiological research findings to support the political ideology of the ruling party and the religious beliefs of their extreme fundamentalist supporters. As we have discussed, most recentlyhere, the Trump regime has seen fit to put ill-informed people in positions of power in health care and public health agencies. Some of these people have put their political and/or religious agendas ahead of the public ' s health. Our examples above show a continuing inclination by the administration, its sympat...
Source: Health Care Renewal - November 2, 2018 Category: Health Management Tags: DHHS disinformation Donald Trump ill-informed management mission-hostile management propaganda Source Type: blogs
Fight Aging! Newsletter, October 22nd 2018
In this report, we propose that the molecular mechanisms of beneficial actions of CR should be classified and discussed according to whether they operate under rich or insufficient energy resource conditions. Future studies of the molecular mechanisms of the beneficial actions of CR should also consider the extent to which the signals/factors involved contribute to the anti-oxidative, anti-inflammatory, anti-tumor and other CR actions in each tissue or organ, and thereby lead to anti-aging and prolongevity.
RNA Interference of ATP Synthase Subunits Slows Aging in Nematodes
https://www.fightaging.org/archives/...
Source: Fight Aging! - October 21, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Infection as the Link Between Cellular Senescence, Autophagy, and Immunosenescence
This open access paper reviews the interactions between cellular senescence, autophagy, and immunosenescence, with chronic infection as a mediating mechanism. Given the present state of knowledge and biotechnology, it is challenging enough to look at any two aspects of the aging body and consider how they might interact in isolation, but this can only ever be a thin slice of the bigger picture. All systems and states in our biochemistry interact with one another in some way, directly or indirectly, and examining ever larger sets of relationships between greater numbers of systems and states is the path to greater understan...
Source: Fight Aging! - October 17, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
10 things a pediatric oncologist wants you to know
1. Cancer is not rare. Technically, childhood cancer is rare compared to adult cancer, but it’s not as rare as you think. Outside of my work, I can think of 3 people who I know personally that had a childhood cancer. A teammate on my high school basketball team, my sister-in-law, and a high school debate teammate. My guess is that you also know someone from church, a coworker’s kid, or one of your kids’ classmates who has been affected by this disease.
2. Curing cancer and preventing cancer is not the same thing. We do have a cure for the majority of childhood cancers. Nearly 90 percent of children dia...
Source: Kevin, M.D. - Medical Weblog - September 17, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/wendy-a-rhoades" rel="tag" > Wendy A. Rhoades, MD < /a > Tags: Conditions Oncology/Hematology Pediatrics Source Type: blogs
Fight Aging! Newsletter, September 17th 2018
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - September 16, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, September 10th 2018
In conclusion, HSC ageing is characterised by reduced self-renewal, myeloid and platelet HSC skewing, and expanded clonal haematopoiesis that is considered a preleukaemic state. The underlying molecular mechanisms seem to be related to increased oxidative stress due to ROS accumulation and DNA damage, which are influenced by both cell- and cell non-autonomous mechanisms such as prolonged exposure to infections, inflammageing, immunosenescence, and age-related changes in the HSC niche. Thus, HSC ageing seems to be multifactorial and we are only beginning to connect all the dots.
The Price of Progress or the Waste...
Source: Fight Aging! - September 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mechanisms Involved in the Aging of Hematopoietic Stem Cells
In conclusion, HSC ageing is characterised by reduced self-renewal, myeloid and platelet HSC skewing, and expanded clonal haematopoiesis that is considered a preleukaemic state. The underlying molecular mechanisms seem to be related to increased oxidative stress due to ROS accumulation and DNA damage, which are influenced by both cell- and cell non-autonomous mechanisms such as prolonged exposure to infections, inflammageing, immunosenescence, and age-related changes in the HSC niche. Thus, HSC ageing seems to be multifactorial and we are only beginning to connect all the dots.
Source: Fight Aging! - September 6, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Abscopal Effect
In the waning years of my career as a Nuclear Radiologist, I have become somewhat more jaded than I was as a younger doc. When you see cancer and other diseases fifty times a day, sometimes getting better, sometimes getting worse, that ' s bound to happen. Of course, I ' m far prefer reporting improvement, but relapses are also part of this job. The oncologists wander into the reading room every few minutes, or so it seems, anyway, to look at their patients ' scans (the gantry is generally still warm). If the news is bad, I will tell them in all honesty that I admire the strength it will take to deliver the bad news. On th...
Source: Dalai's PACS Blog - August 19, 2018 Category: Radiology Source Type: blogs
Fight Aging! Newsletter, August 6th 2018
In this study, we analyzed FGF21 levels and alterations in the expression of genes encoding components of the FGF21-responsive molecular machinery in adipose tissue from aged individuals so as to ascertain whether altered FGF21 responsiveness that develops with aging jeopardizes human health and/or accelerates metabolic disturbances associated with aging.
We studied a cohort of 28 healthy elderly individuals (≥70 years) with no overt signs of metabolic or other pathologies and compared them with a cohort of 35 young healthy controls (≤40 years). Serum FGF21 levels were significantly increased in elderly individ...
Source: Fight Aging! - August 5, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
