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Vaccination: Cancer Vaccines
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Total 733 results found since Jan 2013.
Science Snippet: Lipids in the Limelight
This study could inform the advancement of new antibiotics.Developing new imaging technologies to track lipid droplet formation and breakdown in cancer cells. Understanding this phenomenon could shed light on why lipid droplets accumulate in these cells, which could aid in creating new therapies.
Learn about other scientific terms with the NIGMS glossary.
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 27, 2022 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Cellular Processes COVID-19 Medicines Science-snippet Source Type: blogs
Weekly Australian Health IT Links – 25 July, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----Quite a lot going on this week and we have had a pretty busy comment flow on the blog. Interesting how comment streams evolve!The telehealth debate continues and the Government is yet to notice what a ‘steaming pile of poo’the #myHR is!-----https://www.healthcareitnews.com/news/anz/australia-launches-digital-cancer-hub-childre...
Source: Australian Health Information Technology - July 25, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
mRNA Vaccines: From Tackling Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.
What is mRNA?
In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs
mRNA Vaccines: From Tackling A Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.
What is mRNA?
In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs
Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Innate Immune Activation as a Contributing Cause of Inflammaging, Reduced by Calorie Restriction
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 4th 2022
This study showed that centenarians had very specific changes in CD4+ T cell populations, which were manifested by an elevated Th17/Treg ratio in vivo, as well as a changed secretory phenotype. Although the T cells of centenarians cannot resist the aging-related expression of proinflammatory genes, their secretory phenotype was altered, explaining the relatively low level of inflammation in centenarians. These results suggested the presence of a mechanism to ameliorate inflammaging in centenarians. This may be achieved by reversing the imbalance of Th17/Treg cells and reducing pro-inflammatory cytokines.
Longevit...
Source: Fight Aging! - July 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Voting Republican is bad for your health
Literally. A study byWarraich HJ, Kumar P, Nasir K, Joynt Maddox KE, and Wadhera RK in BMJfinds this: There has actually been lots of previous research on this general question. As the authors note, " Previous studies have shown that counties that elect Republican candidates tend to experience worse health outcomes, such as fewer gains in life expectancy and increased rates of opioid prescription.56789, " so this is just further confirmation. As they summarize their fndings, " the mortality gap between white residents in Democratic versus Republican counties increased fourfold. Rural Republican count...
Source: Stayin' Alive - June 24, 2022 Category: American Health Source Type: blogs
Mirage of Health
My personal update is that I ' m recovering day by day, but it ' s taking a while. I get a little stronger, a little more stamina each day and I expect to get back to my previous full strength in time to put in a solid week of work starting Monday. Meanwhile a little down time isn ' t the worse thing that could have happened.I ' ve gotten some very odd comments which show that some people harbor very basic misunderstandings about heath, illness and medicine. As I have noted here many times, medical intervention was largely ineffective until the 20th Century. It has grown more effective over the past 100+ years, but you nee...
Source: Stayin' Alive - June 17, 2022 Category: American Health Source Type: blogs
The immune system
It occurs to me that right now, a great deal of trouble results from public misunderstanding of the immune system. It would actually be impossible for most of the public to understand very much about the immune system because it is extremely complicated. It depends on elaborate correlation of literally dozens of different kinds of cells, along with complicated features of all other human cells and of pathogens. Understanding how all of this works further depends on fairly deep understanding of basic biology, which believe me very few people have.Into this immense gulf of ignorance wade opportunistic charlatans who want to ...
Source: Stayin' Alive - June 2, 2022 Category: American Health Source Type: blogs
From MARC Student to MacArthur Fellow
Dr. Víctor J. Torres. Credit: Keenan Lacey, Ph.D.
“I study the dance between a bacterium and its host. If we can decode the secrets of that dance—how the pathogen causes disease, and how the host fights back—we might be able to take advantage of vulnerabilities to improve our ability to combat infections,” says Víctor J. Torres, Ph.D., the C. V. Starr Professor of Microbiology at the New York University (NYU) Grossman School of Medicine in New York City.
Discovering and Pursuing a Passion for Science
Growing up, Dr. Torres never would have imagined his highly successful scientific career, especially sinc...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 25, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Injury and Illness Bacteria Infectious Diseases Profiles Source Type: blogs
Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan.
Naked Mole-Rat Skin Shows Fewer Signs of Aging
https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem c...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Science Snippet: RNA ’s Remarkable Roles
RNA, though less well known than its cousin DNA, is equally integral to our bodies. RNA molecules are long, usually single-stranded chains of nucleotides. (DNA molecules are also made up of nucleotides but are typically double-stranded.) There are three major types of RNA, which are all involved in protein synthesis:
Messenger RNA (mRNA) is complementary to one of the DNA strands of a gene and carries genetic information for protein synthesis to the ribosome—the molecular complex in which proteins are made.Transfer RNA (tRNA) works with mRNA to make sure the right amin...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 18, 2022 Category: Research Authors: Matt Mills Tags: Cells Injury and Illness Cellular Processes RNA Science Snippet Source Type: blogs
Fight Aging! Newsletter, May 9th 2022
In conclusion, although several favorable effects are obtained in our heterochronic non-myeloablative transplantation model, additional optimization is needed for better rejuvenation effects.
More on GPNMB as a Target for Senolytic Therapies to Clear Senescent Cells
https://www.fightaging.org/archives/2022/05/more-on-gpnmb-as-a-target-for-senolytic-therapies-to-clear-senescent-cells/
You might recall that researchers recently demonstrated that vaccination against GPNMB is a senolytic strategy, reducing the harmful burden of senescent cells in aged tissues by directing the immune system to destroy these c...
Source: Fight Aging! - May 8, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More on GPNMB as a Target for Senolytic Therapies to Clear Senescent Cells
In conclusion, our results taken together with the above considerations demonstrated that GPNMB was upregulated by lysosomal stress associated with cellular senescence and acted as a protective factor for senescent cells, and suggest that targeting cell/tissue-specific seno-antigens like GPNMB could be a reasonable strategy for next-generation senolytic therapy with higher selectivity and fewer off-target effects.
Link: https://doi.org/10.1038/s41598-022-10522-3
Source: Fight Aging! - May 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
