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Migraine in Young People Linked to Anxiety, Depressive Disorders, Study Shows
Children and adolescents with migraine have approximately twice the risk of anxiety or depression compared with youth without migraine, according to areport in the DecemberJAMA Pediatrics.“One in 10 children and adolescents experience migraine and, across the life span, it is the second most prevalent and disabling disease worldwide,” wrote Katherine Falla, M.D., of the University of Calgary and colleagues. “These results have critical implications for clinical practice, unders coring the need to screen all children and adolescents with migraine for anxiety and depression.”The researchers searched the medical liter...
Source: Psychiatr News - December 7, 2022 Category: Psychiatry Tags: adolescents anxiety children depression JAMA Pediatrics meta-analysis migraine review youth Source Type: research

Provocation of migraine with aura using natural trigger factors
Conclusion: Experimental provocation using self-reported natural trigger factors causes MA only in a small subgroup of patients with MA. Prospective confirmation is important for future studies of migraine trigger factors and in the clinical management of patients with migraine.
Source: Neurology - January 28, 2013 Category: Neurology Authors: Hougaard, A., Amin, F., Hauge, A. W., Ashina, M., Olesen, J. Tags: Migraine, Clinical trials Observational study (Cohort, Case control) ARTICLE Source Type: research

Stroke risk after a first late-onset migraine-like transient neurological attack (tna): oxford vascular study tna cohort
Conclusions The short and long–term risks of stroke in patients with a first migraine–like TNA are significantly lower than after a definite TIA. The trend towards a higher stroke risk than the underlying population rate is similar to that seen in studies of individuals with clinically–definite migraine with aura.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Tuna, M. A., Mehta, Z., Rothwell, P. M. Tags: Headache (including migraine), Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Randomized controlled trial of the CGRP receptor antagonist telcagepant for migraine prevention
Conclusions: These data suggest a potential role for CGRP receptor antagonism in migraine prophylaxis. However, the observed aminotransferase elevations do not support the use of telcagepant for daily administration. Classification of evidence: This study provides Class II evidence that in patients with migraine, telcagepant taken daily reduces headache days by 1.4 days per month compared to placebo and causes 2.5% of patients to have elevations of serum ALT levels.
Source: Neurology - September 8, 2014 Category: Neurology Authors: Ho, T. W., Connor, K. M., Zhang, Y., Pearlman, E., Koppenhaver, J., Fan, X., Lines, C., Edvinsson, L., Goadsby, P. J., Michelson, D. Tags: Migraine, Clinical trials Randomized controlled (CONSORT agreement), Class II ARTICLE Source Type: research

How transparent are migraine clinical trials?: Repository of Registered Migraine Trials (RReMiT)
Transparency in research requires public access to unbiased information prior to trial initiation and openly available results upon study completion. The Repository of Registered Migraine Trials is a global snapshot of registered migraine clinical trials and scorecard of results availability via the peer-reviewed literature, registry databases, and gray literature. The 295 unique clinical trials identified employed 447 investigational agents, with 30% of 154 acute migraine trials and 11% of 141 migraine prophylaxis trials testing combinations of agents. The most frequently studied categories in acute migraine trials were t...
Source: Neurology - October 6, 2014 Category: Neurology Authors: Dufka, F. L., Dworkin, R. H., Rowbotham, M. C. Tags: Migraine, All Clinical trials VIEWS & amp;amp; REVIEWS Source Type: research

Migraine and its psychiatric comorbidities
In conclusion, a review of the literature demonstrates the wide variety of psychiatric comorbidities with migraine. However, more research is needed to elucidate the neurocircuitry underlying the association between migraine and the comorbid psychiatric conditions and to determine the most effective treatment for migraine with psychiatric comorbidity.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 13, 2016 Category: Neurosurgery Authors: Minen, M. T., Begasse De Dhaem, O., Kroon Van Diest, A., Powers, S., Schwedt, T. J., Lipton, R., Silbersweig, D. Tags: JNNP Patients' choice, Headache (including migraine), Stroke, Anxiety disorders (including OCD and PTSD) Source Type: research

What's New in the Treatment of Migraine?
Conclusion: Many new and exciting therapies exist for the treatment of migraine. Keeping up with this rapidly evolving field is important in reducing disability from the common disease of migraine.
Source: Journal of Neuro-Ophthalmology - August 30, 2019 Category: Opthalmology Tags: Disease of the Year: Migraine Source Type: research

Biochemical Modulation and Pathophysiology of Migraine
Conclusions: Migraine is a complex neural disorder and is important to understand when seeing patients who present to neuro-ophthalmology, especially with the successful translation from preclinical and clinical research leading to successful advances in migraine management.
Source: Journal of Neuro-Ophthalmology - December 1, 2019 Category: Opthalmology Tags: Disease of the Year: Migraine Source Type: research

Acupuncture prophylaxis of migraine no better than sham acupuncture for decreasing frequency of headaches
Commentary on: Li Y, Zheng H, Witt CM, et al. Acupuncture for migraine prophylaxis: a randomized controlled trial. Can Med AJ 2012;184:401–10. Context Migraine is a frequent and often disabling condition, in particular when migraine attacks occur frequently. Preventive therapy is recommended for patients with frequent attacks and related disability. Migraine prophylaxis can be performed with medications such as beta-blockers, flunarizine, amitriptyline and anti-epileptics such as valproic acid or topiramate.1 Non-drug treatment includes education, behavioural therapy and exercise. Acupuncture is popular in many Weste...
Source: Evidence-Based Medicine - January 17, 2013 Category: Internal Medicine Authors: Diener, H.-C. Tags: Clinical trials (epidemiology), Headache (including migraine), Pain (neurology), Drugs: psychiatry, Complementary medicine, Ethics Therapeutics Source Type: research

Migraine prevention with a supraorbital transcutaneous stimulator: A randomized controlled trial
Conclusions: Supraorbital transcutaneous stimulation with the device used in this trial is effective and safe as a preventive therapy for migraine. The therapeutic gain (26%) is within the range of those reported for other preventive drug and nondrug antimigraine treatments. Classification of evidence: This study provides Class III evidence that treatment with a supraorbital transcutaneous stimulator is effective and safe as a preventive therapy for migraine.
Source: Neurology - February 18, 2013 Category: Neurology Authors: Schoenen, J., Vandersmissen, B., Jeangette, S., Herroelen, L., Vandenheede, M., Gerard, P., Magis, D. Tags: All Headache, Migraine, Clinical trials Randomized controlled (CONSORT agreement), Class III ARTICLE Source Type: research

Cranial autonomic symptoms in pediatric migraine are the rule, not the exception
Conclusions: In pediatric/adolescent migraine, the presence of cranial autonomic symptoms appears to be the rule rather than the exception. Clinicians should be careful to consider migraine when evaluating a child with headache and associated ocular or nasal symptoms so as to avoid giving a misdiagnosis of sinus headache.
Source: Neurology - July 29, 2013 Category: Neurology Authors: Gelfand, A. A., Reider, A. C., Goadsby, P. J. Tags: All Headache, Migraine, Pediatric headache, All Pain, All Pediatric ARTICLE Source Type: research

Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine
Conclusion: Increased CGRP level measured in peripheral blood outside migraine attacks and in the absence of symptomatic medication could be a biomarker helping in the diagnosis of CM.
Source: Neurology - September 30, 2013 Category: Neurology Authors: Cernuda-Morollon, E., Larrosa, D., Ramon, C., Vega, J., Martinez-Camblor, P., Pascual, J. Tags: Migraine, Cluster headache ARTICLE Source Type: research

Migraine and white matter hyperintensities: The ARIC MRI study
Conclusion: Migraine is associated with WMH volume cross-sectionally but not with WMH progression over time. This suggests that the association between migraine and WMH is stable in older age and may be primarily attributable to changes occurring earlier in life, although further work is needed to confirm these findings.
Source: Neurology - October 7, 2013 Category: Neurology Authors: Hamedani, A. G., Rose, K. M., Peterlin, B. L., Mosley, T. H., Coker, L. H., Jack, C. R., Knopman, D. S., Alonso, A., Gottesman, R. F. Tags: Migraine, MRI, Other cerebrovascular disease/ Stroke, Cognitive aging, Cohort studies ARTICLE Source Type: research

Prevalence of white matter lesions and stroke in children with migraine
Conclusion: WMLs in pediatric patients with migraine and aura are no more prevalent than in controls. They appear to be benign and are not associated with stroke.
Source: Neurology - October 14, 2013 Category: Neurology Authors: Mar, S., Kelly, J. E., Isbell, S., Aung, W. Y., Lenox, J., Prensky, A. Tags: Migraine, Pediatric headache, MRI, All Pediatric, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke ARTICLE Source Type: research

Increased risk of Bell palsy in patients with migraine: A nationwide cohort study
Conclusion: Migraine is a previously unidentified risk factor for Bell palsy. The association between these 2 conditions suggests a linked disease mechanism, which is worthy of further exploration.
Source: Neurology - January 12, 2015 Category: Neurology Authors: Peng, K.-P., Chen, Y.-T., Fuh, J.-L., Tang, C.-H., Wang, S.-J. Tags: All Headache, Migraine, Cranial neuropathy ARTICLE Source Type: research