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The anterior insula shows heightened interictal intrinsic connectivity in migraine without aura
Conclusions: Patients with migraine display interictal changes in the topology of intrinsic connections, with greater connectivity between primary sensory cortices, the pons, and the anterior insula, a region involved in representing and coordinating responses to emotional salience.
Source: Neurology - March 9, 2015 Category: Neurology Authors: Tso, A. R., Trujillo, A., Guo, C. C., Goadsby, P. J., Seeley, W. W. Tags: Migraine, fMRI ARTICLE Source Type: research

Does the presence of aura inform us regarding migraine severity and response to treatment?
In 1944, Leão1 described cortical spreading depression, the phenomenon now widely believed to underlie what some persons with headache perceive as "aura." Aura is a somewhat misleading term because it can occur before a migraine, during or after a migraine, or occur without any associated headache. It can also occur with many other types of headache, but in clinical practice it is usually in association with migraine that we consider it.2 Less than 30% of migraineurs will experience an aura, and some patients will have some attacks with and other attacks without an associated aura.3 The symptoms due to aura are well...
Source: Neurology - May 4, 2015 Category: Neurology Authors: Ward, T. N. Tags: Migraine, Outcome research, Clinical trials Randomized controlled (CONSORT agreement) EDITORIALS Source Type: research

Visual cortex hyperexcitability in migraine in response to sound-induced flash illusions
Conclusions: Results from this study add novel clues to our understanding of visual cortex hyperexcitability in migraine, especially migraine with aura. Furthermore, these analyses underscore how pathologic changes in cortical excitability affect multisensory interactions. Cross-modal illusions represent a valid tool for exploration of functional connectivity between sensory areas, which likely has an important role in the pathophysiology of migraine.
Source: Neurology - May 18, 2015 Category: Neurology Authors: Brighina, F., Bolognini, N., Cosentino, G., Maccora, S., Paladino, P., Baschi, R., Vallar, G., Fierro, B. Tags: All Headache, Migraine, All Clinical Neurology, All Neuropsychology/Behavior ARTICLE Source Type: research

Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants
Conclusions: Our findings indicate shared genetic susceptibility to migraine and IS, with a particularly strong overlap between MO and both LAS and CE pointing towards shared mechanisms. Our observations on MA are consistent with a limited role of common genetic variants in this subtype.
Source: Neurology - May 25, 2015 Category: Neurology Authors: Malik, R., Freilinger, T., Winsvold, B. S., Anttila, V., Vander Heiden, J., Traylor, M., de Vries, B., Holliday, E. G., Terwindt, G. M., Sturm, J., Bis, J. C., Hopewell, J. C., Ferrari, M. D., Rannikmae, K., Wessman, M., Kallela, M., Kubisch, C., Fornage, Tags: Migraine, All Cerebrovascular disease/Stroke, Case control studies, All Genetics, Association studies in genetics ARTICLE Source Type: research

The management of migraine in primary care
This study aimed to audit the management of adults with migraine in a Newcastle GP practice against NICE guidelines (2012) on the acute and prophylactic treatment of migraine. A search of practice records for patients with a new diagnosis of migraine between December 2013–14 identified 38 patients. Medical records were reviewed to determine if their management was consistent with NICE guidance. Acute treatment was indicated in 35 patients, with 27 (77%) receiving correct treatment. 1 patient (3%) received unrecommended treatment, while 7 (20%) received no treatment. Prophylactic treatment was given to 11/13 (85%) pat...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Ralston, K. Tags: Headache (including migraine) Thur 21, Parallel session 5: Therapeutics Source Type: research

Age-specific association of migraine with cryptogenic TIA and stroke: Population-based study
Conclusions: In this population-based study of stroke etiology stratified by age, migraine was most strongly associated with cryptogenic TIA and ischemic stroke, particularly at older ages, suggesting a causal role or a shared etiology.
Source: Neurology - October 26, 2015 Category: Neurology Authors: Li, L., Schulz, U. G., Kuker, W., Rothwell, P. M., On behalf of the Oxford Vascular Study Tags: Migraine, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Change in brain network connectivity during PACAP38-induced migraine attacks: A resting-state functional MRI study
Conclusions: PACAP38-induced migraine attack is associated with altered connectivity of several large-scale functional networks of the brain.
Source: Neurology - January 11, 2016 Category: Neurology Authors: Amin, F. M., Hougaard, A., Magon, S., Asghar, M. S., Ahmad, N. N., Rostrup, E., Sprenger, T., Ashina, M. Tags: Migraine ARTICLE Source Type: research

Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention
Conclusions Melatonin 3 mg is better than placebo for migraine prevention, more tolerable than amitriptyline and as effective as amitriptyline 25 mg.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 12, 2016 Category: Neurosurgery Authors: Goncalves, A. L., Martini Ferreira, A., Ribeiro, R. T., Zukerman, E., Cipolla-Neto, J., Peres, M. F. P. Tags: Open access, Headache (including migraine), Pain (neurology), Pain (palliative care), Pain (anaesthesia), Drugs: musculoskeletal and joint diseases Source Type: research

Journal Club: Change in brain network connectivity during PACAP38-induced migraine attacks
There is evidence to suggest that migraine attacks involve changes in complex neuronal networks that can be measured using functional MRI (fMRI) methods including resting state functional connectivity (RSFC). Networks that have previously been shown to be involved in the sensory and affective aspects of pain perception include the default mode network (DMN), salience network (SN), and sensorimotor network (SMN) (figure).1 In a recent study, Amin et al.2 examined the RSFC of these 3 networks at baseline and in the early phases of experimentally induced migraine in patients with migraine without aura. In order to capture the...
Source: Neurology - October 16, 2016 Category: Neurology Authors: DeSouza, D. D., O'Hare, M., Woldeamanuel, Y. W., Cowan, R. P. Tags: All Headache, Migraine, fMRI, All Pain, Functional neuroimaging RESIDENT AND FELLOW SECTION Source Type: research

Migraine in kleine-levin syndrome
Conclusions The association with migraine deserves further investigation, not only as a reliable risk marker but for exploration of the pathophysiology of KLS and novel therapeutic avenues. Initial use of triptans in two of our patients has yielded encouraging results. We encourage others to look for signs of migraine in their patients and consider the use of appropriate therapy.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Donnelly, H., Leschziner, G., Marin, J., Nesbitt, A. Tags: Dementia, Drugs: CNS (not psychiatric), Headache (including migraine), Pain (neurology), Sleep disorders (neurology), Ophthalmology, Memory disorders (psychiatry), Sleep disorders ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Characterisation of the premonitory stage of migraine in paediatric migraineurs
The premonitory stage of migraine is an increasingly recognised area of interest within headache research. This phase has not been rigorously studied in children. Cases of children seen within the Specialist Headache Service at Great Ormond Street Hospital for Children between 1999–2015 were randomly selected, if at least one premonitory symptom was recorded in the initial consultation clinic letter. The age at headache onset, family history of headache, headache diagnosis, presence of episodic syndromes which may be associated with headache, gestation at birth, mode of delivery and presence of premonitory symptoms o...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Karsan, N., Prabhakar, P., Goadsby, P. J. Tags: Headache (including migraine), Pain (neurology) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Migraine relief: Nonpainful stimulation for acute attacks
In their article "Nonpainful remote electrical stimulation alleviates episodic migraine pain," Dr. Yarnitsky et al.1 investigated the use of nonpainful electrical stimulation of the skin of the arm in reducing migraine attacks. Therapeutic electrical stimulation has been widely used for pain treatment. It is believed to be effective when applying the stimulation next to the painful location. For example, the Food and Drug Administration has approved the first device for migraine prevention using electrical stimulation to the area above the eyes. A number of other neurostimulators are under investigation for migraine.2...
Source: Neurology - March 27, 2017 Category: Neurology Authors: Monteith, T. S. Tags: All Headache, Migraine, All Health Services Research, Patient safety PATIENT PAGES Source Type: research

Body composition status and the risk of migraine: A meta-analysis
Conclusions: The current body of evidence shows that the risk of migraine is increased in obese and underweight individuals. Studies are needed to confirm whether interventions that modify obesity status decrease the risk of migraine.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Gelaye, B., Sacco, S., Brown, W. J., Nitchie, H. L., Ornello, R., Peterlin, B. L. Tags: All Headache, Migraine ARTICLE Source Type: research

Erenumab (AMG 334) in episodic migraine: Interim analysis of an ongoing open-label study
Conclusions: One-year efficacy, supported by functional improvements and favorable safety and tolerability profiles, supports further investigation of erenumab as a preventive treatment in patients with EM. Clinicaltrials.gov identifier: NCT01952574. Classification of evidence: This study provides Class IV evidence that for patients with episodic migraine, erenumab reduces long-term MMD and improves headache-related disability and migraine-specific quality of life.
Source: Neurology - September 18, 2017 Category: Neurology Authors: Ashina, M., Dodick, D., Goadsby, P. J., Reuter, U., Silberstein, S., Zhang, F., Gage, J. R., Cheng, S., Mikol, D. D., Lenz, R. A. Tags: Migraine, All Clinical trials, Class IV ARTICLE Source Type: research

Health Care Utilization and Costs in Patients With Migraine Who Have Failed Previous Preventive Treatments
Conclusions TF in patients with migraine was associated with a substantial resource and cost burden, which increased with the number of TFs.
Source: Neurology Clinical Practice - June 7, 2021 Category: Neurology Authors: Newman, L., Vo, P., Zhou, L., Lopez Lopez, C., Cheadle, A., Olson, M., Fang, J. Tags: Migraine, Medical care Research Source Type: research