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Cancer: Leukemia
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Total 28367 results found since Jan 2013.
Is Treosulfan-Based Conditioning Attractive as a Reduced-Intensity Conditioning Regimen in Korea?
CONCLUSION: This study suggests that Treo/Flu conditioning may be an alternative to Bu/Flu regimen in elderly patients with high-risk who are not suitable for standard conditioning.PMID:37698206 | PMC:PMC10497350 | DOI:10.3346/jkms.2023.38.e281
Source: J Korean Med Sci - September 12, 2023 Category: General Medicine Authors: Se Hyung Kim Young Sok Ji Jina Yun Seong Hyeok Choi Sung Hee Lim Chan Kyu Kim Seong Kyu Park Source Type: research
Glycan node profiling of soluble and membrane glycoproteins in whole cell lysates
Anal Biochem. 2023 Sep 10;680:115317. doi: 10.1016/j.ab.2023.115317. Online ahead of print.ABSTRACTGlycan node analysis (GNA) is a molecularly bottom-up glycomics technique based on the relative quantification of glycan linkage-specific monosaccharide units ("glycan nodes"). It was originally applied to blood plasma/serum, where it detected and predicted progression, reoccurrence, and survival in different types of cancer. Here, we have adapted this technology to previously inaccessible membrane glycoproteins from cultured cells. The approach is facilitated by methanol/chloroform precipitation of cell lysates and a "liquid...
Source: Analytical Biochemistry - September 12, 2023 Category: Biochemistry Authors: Jes ús S Aguilar Díaz de León Jorvani Cruz Villarreal Erandi P Kapuruge Chad R Borges Source Type: research
Is Treosulfan-Based Conditioning Attractive as a Reduced-Intensity Conditioning Regimen in Korea?
CONCLUSION: This study suggests that Treo/Flu conditioning may be an alternative to Bu/Flu regimen in elderly patients with high-risk who are not suitable for standard conditioning.PMID:37698206 | PMC:PMC10497350 | DOI:10.3346/jkms.2023.38.e281
Source: J Korean Med Sci - September 12, 2023 Category: General Medicine Authors: Se Hyung Kim Young Sok Ji Jina Yun Seong Hyeok Choi Sung Hee Lim Chan Kyu Kim Seong Kyu Park Source Type: research
Glycan node profiling of soluble and membrane glycoproteins in whole cell lysates
Anal Biochem. 2023 Nov 1;680:115317. doi: 10.1016/j.ab.2023.115317. Epub 2023 Sep 10.ABSTRACTGlycan node analysis (GNA) is a molecularly bottom-up glycomics technique based on the relative quantification of glycan linkage-specific monosaccharide units ("glycan nodes"). It was originally applied to blood plasma/serum, where it detected and predicted progression, reoccurrence, and survival in different types of cancer. Here, we have adapted this technology to previously inaccessible membrane glycoproteins from cultured cells. The approach is facilitated by methanol/chloroform precipitation of cell lysates and a "liquid phase...
Source: Analytical Biochemistry - September 12, 2023 Category: Biochemistry Authors: Jes ús S Aguilar Díaz de León Jorvani Cruz Villarreal Erandi P Kapuruge Chad R Borges Source Type: research
A Deeply Quiescent Subset of CML LSC Depend on FAO Yet Avoid Deleterious ROS by Suppressing Mitochondrial Complex I
CONCLUSION: We investigated the biological aspects related to LSC heterogeneity in CML patients and demonstrated the ability of specific small molecule CBP/β-catenin antagonists to safely eliminate deeply quiescent therapy resistant CSC. These observations may represent an attractive generalizable therapeutic strategy that could help develop better protocols to eradicate the quiescent LSC population.PMID:37691195 | DOI:10.2174/1874467217666230906092236
Source: Genomics Proteomics ... - September 11, 2023 Category: Genetics & Stem Cells Authors: Nyam-Osor Chimge Min-Hsuan Chen Cu Nguyen Yuqi Zhao Xiwei Wu Paulina Garcia Gonzalez Heather Ogana Samantha Hurwitz Jia-Ling Teo Xiaolong Chen Juan Du Victor Jin Yong-Mi Kim Masaya Ono Rafael J Arg üello Michael Kahn Source Type: research
PCSK9 inhibitors suppress oxidative stress and inflammation in atherosclerotic development by promoting macrophage autophagy
CONCLUSIONS: This study reveals a novel protective mechanism by which PCSK9 inhibition enhances autophagy and thereby reduces oxidative stress and inflammation in atherosclerosis.PMID:37692938 | PMC:PMC10492065
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Jinjing Yang Xiurui Ma Dan Niu Yu Sun Xiaohong Chai Yongzhi Deng Jingping Wang Jin Dong Source Type: research
Signaling pathways governing the behaviors of leukemia stem cells
Genes Dis. 2023 Mar 23;11(2):830-846. doi: 10.1016/j.gendis.2023.01.008. eCollection 2024 Mar.ABSTRACTLeukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia, understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies showed that leukemia stem cells (LSCs) play essential roles in the pathogenesis of leukemia by targeting several signaling pathways, including Notch, Wnt, Hedgehog, and STAT3. LSCs are highly proliferative cells that stimulate t...
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Shirin Azizidoost Ava Nasrolahi Mohadeseh Sheykhi-Sabzehpoush Amir Anbiyaiee Seyed Esmaeil Khoshnam Maryam Farzaneh Shahab Uddin Source Type: research
CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis
CONCLUSION: CD14 and CSF1R are highly expressed in osteoarthritis and may be therapeutic targets for osteoarthritis.PMID:37693684 | PMC:PMC10492034
Source: International Journal of Clinical and Experimental Pathology - September 11, 2023 Category: Pathology Authors: Meiliang Zheng Zheng Li Yingfa Feng Xiaoyu Zhang Source Type: research
Azacitidine (Vidaza < sup > ® < /sup > ) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)
CONCLUSIONS: Azacitidine 75 mg/m2 prior to a second hematopoietic stem cell transplantation is safe in children with relapsed MDS/JMML. Although the long-term advantage remains to be assessed, this study suggests that azacitidine is an efficacious option for relapsed JMML.CLINICAL TRIAL REGISTRATION: EudraCT 2010-022235-10.PMID:37695474 | DOI:10.1007/s40272-023-00588-5
Source: Paediatric Drugs - September 11, 2023 Category: Pediatrics Authors: Alba Rubio-San-Sim ón Natasha K A van Eijkelenburg Raoull Hoogendijk Henrik Hasle Charlotte M Niemeyer Michael N Dworzak Marco Zecca Marta Lopez-Yurda Julie M Janssen Alwin D R Huitema Marry M van den Heuvel-Eibrink Eric J Laille Harm van Tinteren Christ Source Type: research
CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis
CONCLUSION: CD14 and CSF1R are highly expressed in osteoarthritis and may be therapeutic targets for osteoarthritis.PMID:37693684 | PMC:PMC10492034
Source: International Journal of Clinical and Experimental Pathology - September 11, 2023 Category: Pathology Authors: Meiliang Zheng Zheng Li Yingfa Feng Xiaoyu Zhang Source Type: research
A Deeply Quiescent Subset of CML LSC Depend on FAO Yet Avoid Deleterious ROS by Suppressing Mitochondrial Complex I
CONCLUSION: We investigated the biological aspects related to LSC heterogeneity in CML patients and demonstrated the ability of specific small molecule CBP/β-catenin antagonists to safely eliminate deeply quiescent therapy resistant CSC. These observations may represent an attractive generalizable therapeutic strategy that could help develop better protocols to eradicate the quiescent LSC population.PMID:37691195 | DOI:10.2174/1874467217666230906092236
Source: Genomics Proteomics ... - September 11, 2023 Category: Genetics & Stem Cells Authors: Nyam-Osor Chimge Min-Hsuan Chen Cu Nguyen Yuqi Zhao Xiwei Wu Paulina Garcia Gonzalez Heather Ogana Samantha Hurwitz Jia-Ling Teo Xiaolong Chen Juan Du Victor Jin Yong-Mi Kim Masaya Ono Rafael J Arg üello Michael Kahn Source Type: research
IgG and insulin enhance endocytosis in THP-1 cells via activation of phosphatidylinositol 3-kinase (PI3K)
In this study, we investigated the regulatory mechanism of endocytosis in THP-1 cells, a monocytic leukemia cell line. We analyzed the effect of IgG and insulin, which are abundant in the serum and play important roles in immunity and metabolism, respectively, on the endocytic activity in THP-1 cells. The results indicated that IgG and insulin enhance pinocytosis and phagocytosis via activation of phosphatidylinositol 3-kinase (PI3K). Our results suggest that IgG and insulin contribute to the maintenance of endocytic activity and are important for antigen presentation and nutrient uptake.PMID:37696069 | DOI:10.1016/j.bbrc.2023.09.008
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Karin Egusa Shusaku Shibutani Hiroyuki Iwata Source Type: research
