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Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies
Bioorg Med Chem Lett. 2023 Sep 3:129465. doi: 10.1016/j.bmcl.2023.129465. Online ahead of print.ABSTRACTMitoxantrone (MX) is a robust chemotherapeutic with well-characterized applications in treating certain leukemias and advanced breast and prostate cancers. The canonical mechanism of action associated with MX is its ability to intercalate DNA and inhibit topoisomerase II, giving it the designation of a topoisomerase II poison. Years after FDA approval, investigations have unveiled novel protein-binding partners, such as methyl-CpG-binding domain protein (MBD2), PIM1 serine/threonine kinase, RAD52, and others that may con...
Source: Bioorganic and Medicinal Chemistry Letters - September 5, 2023 Category: Chemistry Authors: Savanna Wallin Sarbjit Singh Gloria E O Borgstahl Amarnath Natarajan Source Type: research
HLA Fully-Mismatched Sibling-Derived CD7 CAR-T Therapy Bridging to Haploidentical Hematopoietic Stem Cell Transplantation for Hepatosplenic γδ T-cell Lymphoma
Cell Transplant. 2023 Jan-Dec;32:9636897231194265. doi: 10.1177/09636897231194265.ABSTRACTWhile chimeric antigen receptor (CAR)-T-cell therapy has demonstrated remarkable effectiveness in the treatment of B-cell lymphomas and leukemias, research on T-cell malignancies is still limited. Here, we reported a patient with hepatosplenic γδ T-cell lymphoma refractory to multiple lines of chemotherapy, who eventually achieved first complete remission with flow cytometry-confirmed minimal residual disease negativity after human leukocyte antigen (HLA) fully-mismatched sibling-derived CD7 CAR-T therapy. However, given the allogen...
Source: Cell Transplantation - September 5, 2023 Category: Cytology Authors: Xueer Xu Cheng Zu Mingming Zhang Pingnan Xiao Ruimin Hong Jingjing Feng Huijun Xu Jiazhen Cui Jian Yu Jimin Shi Guoqing Wei Alex H Chang He Huang Yongxian Hu Source Type: research
Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies
Bioorg Med Chem Lett. 2023 Sep 3;94:129465. doi: 10.1016/j.bmcl.2023.129465. Online ahead of print.ABSTRACTMitoxantrone (MX) is a robust chemotherapeutic with well-characterized applications in treating certain leukemias and advanced breast and prostate cancers. The canonical mechanism of action associated with MX is its ability to intercalate DNA and inhibit topoisomerase II, giving it the designation of a topoisomerase II poison. Years after FDA approval, investigations have unveiled novel protein-binding partners, such as methyl-CpG-binding domain protein (MBD2), PIM1 serine/threonine kinase, RAD52, and others that may ...
Source: Bioorganic and Medicinal Chemistry Letters - September 5, 2023 Category: Chemistry Authors: Savanna Wallin Sarbjit Singh Gloria E O Borgstahl Amarnath Natarajan Source Type: research
Design and preclinical testing of an anti-CD41 CAR T cell for the treatment of acute megakaryoblastic leukaemia
J Cell Mol Med. 2023 Sep 4. doi: 10.1111/jcmm.17810. Online ahead of print.ABSTRACTAcute megakaryoblastic leukaemia (AMkL) is a rare subtype of acute myeloid leukaemia (AML) representing 5% of all reported cases, and frequently diagnosed in children with Down syndrome. Patients diagnosed with AMkL have low overall survival and have poor outcome to treatment, thus novel therapies such as CAR T cell therapy could represent an alternative in treating AMkL. We investigated the effect of a new CAR T cell which targets CD41, a specific surface antigen for M7-AMkL, against an in vitro model for AMkL, DAMI Luc2 cell line. The perf...
Source: J Cell Mol Med - September 5, 2023 Category: Molecular Biology Authors: Adrian Bogdan Tigu Catalin Sorin Constantinescu Patric Teodorescu David Kegyes Raluca Munteanu Richard Feder Mareike Peters Ioana Pralea Cristina Iuga Diana Cenariu Andra Marcu Alina Tanase Anca Colita Rares Drula Jon Thor Bergthorsson Victor Greiff Delia Source Type: research
HLA Fully-Mismatched Sibling-Derived CD7 CAR-T Therapy Bridging to Haploidentical Hematopoietic Stem Cell Transplantation for Hepatosplenic γδ T-cell Lymphoma
Cell Transplant. 2023 Jan-Dec;32:9636897231194265. doi: 10.1177/09636897231194265.ABSTRACTWhile chimeric antigen receptor (CAR)-T-cell therapy has demonstrated remarkable effectiveness in the treatment of B-cell lymphomas and leukemias, research on T-cell malignancies is still limited. Here, we reported a patient with hepatosplenic γδ T-cell lymphoma refractory to multiple lines of chemotherapy, who eventually achieved first complete remission with flow cytometry-confirmed minimal residual disease negativity after human leukocyte antigen (HLA) fully-mismatched sibling-derived CD7 CAR-T therapy. However, given the allogen...
Source: Cell Transplantation - September 5, 2023 Category: Cytology Authors: Xueer Xu Cheng Zu Mingming Zhang Pingnan Xiao Ruimin Hong Jingjing Feng Huijun Xu Jiazhen Cui Jian Yu Jimin Shi Guoqing Wei Alex H Chang He Huang Yongxian Hu Source Type: research
Retrospective Case-Control Study of REGEN-COV (casirivimab and imdevimab) Therapy for Patients with COVID-19 and Cancer Using the United States MarketScan ® Database
Conclusion Patients with cancer treated with REGEN-COV experienced a decreased risk for hospitalization, hospitalization duration, and total COVID-19-related costs. Patients with cancer were at a higher risk of being hospitalized for COVID-19 than were those without cancer. The use of neutralizing antibody therapy may reduce the risk of severe COVID-19 infection for patients with cancer with an otherwise high risk. Future replication studies should be conducted using other databases that include Medicaid users and other insured persons for comparison and validation.PMID:37666220 | DOI:10.1159/000533614
Source: Oncology - September 4, 2023 Category: Cancer & Oncology Authors: Kazue Takemoto Source Type: research
Pneumatosis cystoides intestinalis mimicking free intraabdominal air following chemotherapy for relapsed acute myeloblastic leukemia in a transplanted neutropenic child: a case report
CONCLUSIONS: PI is an uncommon complication, and direct radiography/computed tomography scans are very helpful in making the diagnosis in suspicious cases. PI, should be kept in mind, especially in transplanted or relapsed leukemia patients receiving intensive chemotherapy.PMID:37661686 | DOI:10.24953/turkjped.2023.116
Source: The Turkish Journal of Pediatrics - September 4, 2023 Category: Pediatrics Authors: Utku Ayg üneş Barbaros Şahin Karagün İlgen Şaşmaz Kamuran Tutu ş Önder Özden B ülent Antmen Source Type: research
CDK9 Inhibitor Induces Apoptosis, Autophagy, and Suppression of Tumor Growth in Adult T-Cell Leukemia/Lymphoma
Biol Pharm Bull. 2023;46(9):1269-1276. doi: 10.1248/bpb.b23-00228.ABSTRACTAdult T-cell leukemia/lymphoma (ATL) is a hematopoietic malignancy with a poor prognosis that develops in approximately 5% of human T-cell leukemia virus type 1 (HTLV-1) carriers. Cyclin-dependent kinase 9 (CDK9), together with Cyclin T, forms a transcription elongation factor, positive transcription elongation factor b (P-TEFb). P-TEFb promotes transcriptional elongation by phosphorylating the second serine (Ser2) of the seven amino acid repeat sequence in the C-terminal domain of RNA polymerase II (RNAP II). CDK9 inhibitors suppress cell proliferat...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Naho Kato Tomohiro Kozako Takeo Ohsugi Yuichiro Uchida Makoto Yoshimitsu Kenji Ishitsuka Akiyoshi Aikawa Shin-Ichiro Honda Source Type: research
Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
Leukemia. 2023 Sep 4. doi: 10.1038/s41375-023-01978-x. Online ahead of print.NO ABSTRACTPMID:37666943 | DOI:10.1038/s41375-023-01978-x
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Sonja I Berndt Joseph Vijai Yolanda Benavente Nicola J Camp Alexandra Nieters Zhaoming Wang Karin E Smedby Geffen Kleinstern Henrik Hjalgrim Caroline Besson Christine F Skibola Lindsay M Morton Angela R Brooks-Wilson Lauren R Teras Charles Breeze Joshua A Source Type: research
Retrospective Case-Control Study of REGEN-COV (casirivimab and imdevimab) Therapy for Patients with COVID-19 and Cancer Using the United States MarketScan ® Database
Conclusion Patients with cancer treated with REGEN-COV experienced a decreased risk for hospitalization, hospitalization duration, and total COVID-19-related costs. Patients with cancer were at a higher risk of being hospitalized for COVID-19 than were those without cancer. The use of neutralizing antibody therapy may reduce the risk of severe COVID-19 infection for patients with cancer with an otherwise high risk. Future replication studies should be conducted using other databases that include Medicaid users and other insured persons for comparison and validation.PMID:37666220 | DOI:10.1159/000533614
Source: Oncology - September 4, 2023 Category: Cancer & Oncology Authors: Kazue Takemoto Source Type: research
Accelerated Chronic Lymphocytic Leukemia and Richter Transformation in the Era of Novel Agents
Acta Haematol. 2023 Sep 4. doi: 10.1159/000533664. Online ahead of print.ABSTRACTBACKGROUND: Tremendous developments in the field of Chronic Lymphocytic leukemia (CLL) in recent years has led to a revolutionary change in the treatment approach, which today is based on targeted treatments with a good response and optimal prognosis. Nevertheless, CLL can present or progress to "accelerated CLL" (A-CLL) or to "Richter transformation" (RT) and these two entities have a more aggressive course and are still characterized by challenges in the fields of diagnosis, and therapy. In the current review we summarized the latest knowled...
Source: Acta Haematologica - September 4, 2023 Category: Hematology Authors: Ilana Levy Yurkovski Tamar Tadmor Source Type: research
Pneumatosis cystoides intestinalis mimicking free intraabdominal air following chemotherapy for relapsed acute myeloblastic leukemia in a transplanted neutropenic child: a case report
CONCLUSIONS: PI is an uncommon complication, and direct radiography/computed tomography scans are very helpful in making the diagnosis in suspicious cases. PI, should be kept in mind, especially in transplanted or relapsed leukemia patients receiving intensive chemotherapy.PMID:37661686 | DOI:10.24953/turkjped.2023.116
Source: The Turkish Journal of Pediatrics - September 4, 2023 Category: Pediatrics Authors: Utku Ayg üneş Barbaros Şahin Karagün İlgen Şaşmaz Kamuran Tutu ş Önder Özden B ülent Antmen Source Type: research
Accelerated Chronic Lymphocytic Leukemia and Richter Transformation in the Era of Novel Agents
Acta Haematol. 2023 Sep 4. doi: 10.1159/000533664. Online ahead of print.ABSTRACTBACKGROUND: Tremendous developments in the field of Chronic Lymphocytic leukemia (CLL) in recent years has led to a revolutionary change in the treatment approach, which today is based on targeted treatments with a good response and optimal prognosis. Nevertheless, CLL can present or progress to "accelerated CLL" (A-CLL) or to "Richter transformation" (RT) and these two entities have a more aggressive course and are still characterized by challenges in the fields of diagnosis, and therapy. In the current review we summarized the latest knowled...
Source: Acta Haematologica - September 4, 2023 Category: Hematology Authors: Ilana Levy Yurkovski Tamar Tadmor Source Type: research
CDK9 Inhibitor Induces Apoptosis, Autophagy, and Suppression of Tumor Growth in Adult T-Cell Leukemia/Lymphoma
Biol Pharm Bull. 2023;46(9):1269-1276. doi: 10.1248/bpb.b23-00228.ABSTRACTAdult T-cell leukemia/lymphoma (ATL) is a hematopoietic malignancy with a poor prognosis that develops in approximately 5% of human T-cell leukemia virus type 1 (HTLV-1) carriers. Cyclin-dependent kinase 9 (CDK9), together with Cyclin T, forms a transcription elongation factor, positive transcription elongation factor b (P-TEFb). P-TEFb promotes transcriptional elongation by phosphorylating the second serine (Ser2) of the seven amino acid repeat sequence in the C-terminal domain of RNA polymerase II (RNAP II). CDK9 inhibitors suppress cell proliferat...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Naho Kato Tomohiro Kozako Takeo Ohsugi Yuichiro Uchida Makoto Yoshimitsu Kenji Ishitsuka Akiyoshi Aikawa Shin-Ichiro Honda Source Type: research
