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Geographic Disparity of Outcome in Patients With Cancer Over Decades: The Surveillance, Epidemiology, and End Results
CONCLUSIONS: Significant disparities in cancer care exist among geographic locations. Geographic differences in survival appear more prominent when highly effective therapies are available.PMID:37690903 | DOI:10.1016/j.clml.2023.08.001
Source: Clinical Lymphoma and Myeloma - September 10, 2023 Category: Cancer & Oncology Authors: Koji Sasaki Kiyomi Morita Hagop Kantarjian Guillermo Garcia-Manero Elias Jabbour Farhad Ravandi Marina Konopleva Gautam Borthakur William Wierda Naval Daver Koichi Takahashi Courtney DiNardo Guillermo Montalban Bravo Ghayas C Issa Sherry A Pierce Kelly A Source Type: research
Detection of red cell alloantibody prior to overflow phenomenon in a case of warm AIHA secondary to Chronic Lymphocytic Leukemia and Myasthenia Gravis: A Case Report
CONCLUSION: This case emphasizes the significance of understanding the overflow phenomenon in AIHA as it can guide a transfusion medicine specialist in early detection and identification of underlying alloantibodies which is crucial for appropriate transfusion management in AIHA. However, early presentation and timely workup along with high level of suspicion is crucial to identify this phenomenon.PMID:37689387 | DOI:10.1016/j.tracli.2023.09.001
Source: Transfusion Clinique et Biologique - September 9, 2023 Category: Hematology Authors: Davood Bava Vasanth Asirvatham Saptarshi Mandal Amit Kumar Rohilla Siddharth Mittal Source Type: research
Second primary malignancies in patients with lymphoma in Denmark after high-dose chemotherapy and autologous haematopoietic stem-cell transplantation: a population-based, retrospective cohort study
Lancet Haematol. 2023 Sep 6:S2352-3026(23)00212-0. doi: 10.1016/S2352-3026(23)00212-0. Online ahead of print.ABSTRACTBACKGROUND: Second primary malignancies (SPMs) are known complications after chemotherapy, but the risk is not well characterised for patients with lymphoma treated with high-dose chemotherapy and autologous haematopoietic stem-cell transplantation (HSCT). We aimed to investigate the rate of SPMs in this population relative to matched control individuals from the general population.METHODS: In this retrospective, population-based cohort study, patients aged 18 years or older with an aggressive lymphoma who r...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Trine Trab Joachim Baech Lasse Hjort Jakobsen Simon Husby Marianne Tang Severinsen Sandra Eloranta Jette S G ørløv Judit M J ørgensen Sif Gudbrandsdottir Thomas Stauffer Larsen Peter Brown Kirsten Gr ønbæk Karin E Smedby Tarec C El-Galaly Source Type: research
Detection of red cell alloantibody prior to overflow phenomenon in a case of warm AIHA secondary to Chronic Lymphocytic Leukemia and Myasthenia Gravis: A Case Report
CONCLUSION: This case emphasizes the significance of understanding the overflow phenomenon in AIHA as it can guide a transfusion medicine specialist in early detection and identification of underlying alloantibodies which is crucial for appropriate transfusion management in AIHA. However, early presentation and timely workup along with high level of suspicion is crucial to identify this phenomenon.PMID:37689387 | DOI:10.1016/j.tracli.2023.09.001
Source: Transfusion Clinique et Biologique - September 9, 2023 Category: Hematology Authors: Davood Bava Vasanth Asirvatham Saptarshi Mandal Amit Kumar Rohilla Siddharth Mittal Source Type: research
Prospective analysis to determine barriers to allogeneic hematopoietic cell transplantation in patients with acute leukemia
Am J Hematol. 2023 Sep 9. doi: 10.1002/ajh.27084. Online ahead of print.ABSTRACTAllogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment for patients with acute leukemia. Despite this, studies have shown that only a minority of patients ultimately proceed to allo-HCT. The primary objective of this prospective, observational study was to identify the rate of allo-HCT in patients for whom it was recommended, and reasons why patients deemed appropriate and eligible for HCT did not subsequently undergo transplant. Between April 2016 and April 2021, adult patients with newly diagnosed or rela...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Karthik Nath Jasme Lee Theresa A Elko Lauren Levy Elaina Preston Sean M Devlin Doris M Ponce Richard J Lin Brian C Shaffer Christina Cho Ioannis Politikos Ann A Jakubowski Jae H Park Raajit Rampal Miguel-Angel Perales Martin S Tallman Juliet N Barker Elli Source Type: research
Early Life Nutrition Factors and Risk of Acute Leukemia in Children: Systematic Review and Meta-Analysis
Nutrients. 2023 Aug 29;15(17):3775. doi: 10.3390/nu15173775.ABSTRACTAcute leukemia commonly occurs in young children with peak incidence at the age of 2-5 years. However, the etiology is still unclear and many preventable risk factors still deserve to be reviewed. The focus of this systematic review and meta-analysis is to summarize the evidence concerning early life nourishment (breastfeeding, early life diet), neonatal vitamin K administration and the risk of acute leukemia. All epidemiological studies published up to June 2023 and assessing diet-related risk factors for childhood acute leukemia were identified in two el...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Ambroise Kouame Kintossou Jessica Blanco-Lopez Isabel Iguacel Silvia Pisanu Claudia Choma Bettega Almeida Eva Steliarova-Foucher Ciska Sierens Marc J Gunter Elena J Ladas Ronald D Barr Koen Van Herck Zisis Kozlakidis Inge Huybrechts Source Type: research
Detection of red cell alloantibody prior to overflow phenomenon in a case of warm AIHA secondary to Chronic Lymphocytic Leukemia and Myasthenia Gravis: A Case Report
CONCLUSION: This case emphasizes the significance of understanding the overflow phenomenon in AIHA as it can guide a transfusion medicine specialist in early detection and identification of underlying alloantibodies which is crucial for appropriate transfusion management in AIHA. However, early presentation and timely workup along with high level of suspicion is crucial to identify this phenomenon.PMID:37689387 | DOI:10.1016/j.tracli.2023.09.001
Source: Transfusion Clinique et Biologique - September 9, 2023 Category: Hematology Authors: Davood Bava Vasanth Asirvatham Saptarshi Mandal Amit Kumar Rohilla Siddharth Mittal Source Type: research
Conferone, a coumarin from < em > Ferula flabelliloba < /em > , induced toxic effects on adult T-cell leukemia/lymphoma cells
CONCLUSION: Obtained findings indicated that conferone induced considerable cytotoxic effects on MT-2 cells in a time- and dose-dependent manner. In addition, accumulation of cells in the sub-G1 phase of the cell cycle was detected upon conferone administration. Moreover, conferone reduced the expression of CDK6, c-MYC, CFLIPL, and NF-κB (Rel-A) in MT-2 cells. Accordingly, conferone could be considered as a potent agent against ATL, although complementary investigations are required to define more precisely its mechanism of action.PMID:37688389 | DOI:10.1177/03946320231197592
Source: International Journal of Immunopathology and Pharmacology - September 9, 2023 Category: Allergy & Immunology Authors: Houshang Rafatpanah Marziyeh Golizadeh Maryam Mahdifar Shakiba Mahdavi Mehrdad Iranshahi Fatemeh B Rassouli Source Type: research
Frequency and prognostic influence of ASXL1 mutations and its potential association with BCR-ABL1 transcript type and smoke in chronic myeloid leukemia patients
CONCLUSION: Our findings suggest that ASXL1 mutations may be favorable predictive biomarkers to determine the best TKI for each patient, and to prevent CML progression.PMID:37689224 | DOI:10.1016/j.gene.2023.147776
Source: Gene - September 9, 2023 Category: Genetics & Stem Cells Authors: Aras Rafiq Mohammed Dlnya Assad Golale Rostami Mohammad Hamid Source Type: research
Detection of red cell alloantibody prior to overflow phenomenon in a case of warm AIHA secondary to Chronic Lymphocytic Leukemia and Myasthenia Gravis: A Case Report
CONCLUSION: This case emphasizes the significance of understanding the overflow phenomenon in AIHA as it can guide a transfusion medicine specialist in early detection and identification of underlying alloantibodies which is crucial for appropriate transfusion management in AIHA. However, early presentation and timely workup along with high level of suspicion is crucial to identify this phenomenon.PMID:37689387 | DOI:10.1016/j.tracli.2023.09.001
Source: Transfusion Clinique et Biologique - September 9, 2023 Category: Hematology Authors: Davood Bava Vasanth Asirvatham Saptarshi Mandal Amit Kumar Rohilla Siddharth Mittal Source Type: research
Conferone, a coumarin from < em > Ferula flabelliloba < /em > , induced toxic effects on adult T-cell leukemia/lymphoma cells
CONCLUSION: Obtained findings indicated that conferone induced considerable cytotoxic effects on MT-2 cells in a time- and dose-dependent manner. In addition, accumulation of cells in the sub-G1 phase of the cell cycle was detected upon conferone administration. Moreover, conferone reduced the expression of CDK6, c-MYC, CFLIPL, and NF-κB (Rel-A) in MT-2 cells. Accordingly, conferone could be considered as a potent agent against ATL, although complementary investigations are required to define more precisely its mechanism of action.PMID:37688389 | PMC:PMC10493046 | DOI:10.1177/03946320231197592
Source: International Journal of Immunopathology and Pharmacology - September 9, 2023 Category: Allergy & Immunology Authors: Houshang Rafatpanah Marziyeh Golizadeh Maryam Mahdifar Shakiba Mahdavi Mehrdad Iranshahi Fatemeh B Rassouli Source Type: research
Frequency and prognostic influence of ASXL1 mutations and its potential association with BCR-ABL1 transcript type and smoke in chronic myeloid leukemia patients
CONCLUSION: Our findings suggest that ASXL1 mutations may be favorable predictive biomarkers to determine the best TKI for each patient, and to prevent CML progression.PMID:37689224 | DOI:10.1016/j.gene.2023.147776
Source: Gene - September 9, 2023 Category: Genetics & Stem Cells Authors: Aras Rafiq Mohammed Dlnya Assad Golale Rostami Mohammad Hamid Source Type: research
Detection of red cell alloantibody prior to overflow phenomenon in a case of warm AIHA secondary to Chronic Lymphocytic Leukemia and Myasthenia Gravis: A Case Report
CONCLUSION: This case emphasizes the significance of understanding the overflow phenomenon in AIHA as it can guide a transfusion medicine specialist in early detection and identification of underlying alloantibodies which is crucial for appropriate transfusion management in AIHA. However, early presentation and timely workup along with high level of suspicion is crucial to identify this phenomenon.PMID:37689387 | DOI:10.1016/j.tracli.2023.09.001
Source: Transfusion Clinique et Biologique - September 9, 2023 Category: Hematology Authors: Davood Bava Vasanth Asirvatham Saptarshi Mandal Amit Kumar Rohilla Siddharth Mittal Source Type: research
