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CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis
CONCLUSION: CD14 and CSF1R are highly expressed in osteoarthritis and may be therapeutic targets for osteoarthritis.PMID:37693684 | PMC:PMC10492034
Source: International Journal of Clinical and Experimental Pathology - September 11, 2023 Category: Pathology Authors: Meiliang Zheng Zheng Li Yingfa Feng Xiaoyu Zhang Source Type: research
Azacitidine (Vidaza < sup > ® < /sup > ) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)
CONCLUSIONS: Azacitidine 75 mg/m2 prior to a second hematopoietic stem cell transplantation is safe in children with relapsed MDS/JMML. Although the long-term advantage remains to be assessed, this study suggests that azacitidine is an efficacious option for relapsed JMML.CLINICAL TRIAL REGISTRATION: EudraCT 2010-022235-10.PMID:37695474 | DOI:10.1007/s40272-023-00588-5
Source: Paediatric Drugs - September 11, 2023 Category: Pediatrics Authors: Alba Rubio-San-Sim ón Natasha K A van Eijkelenburg Raoull Hoogendijk Henrik Hasle Charlotte M Niemeyer Michael N Dworzak Marco Zecca Marta Lopez-Yurda Julie M Janssen Alwin D R Huitema Marry M van den Heuvel-Eibrink Eric J Laille Harm van Tinteren Christ Source Type: research
CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis
CONCLUSION: CD14 and CSF1R are highly expressed in osteoarthritis and may be therapeutic targets for osteoarthritis.PMID:37693684 | PMC:PMC10492034
Source: International Journal of Clinical and Experimental Pathology - September 11, 2023 Category: Pathology Authors: Meiliang Zheng Zheng Li Yingfa Feng Xiaoyu Zhang Source Type: research
IgG and insulin enhance endocytosis in THP-1 cells via activation of phosphatidylinositol 3-kinase (PI3K)
In this study, we investigated the regulatory mechanism of endocytosis in THP-1 cells, a monocytic leukemia cell line. We analyzed the effect of IgG and insulin, which are abundant in the serum and play important roles in immunity and metabolism, respectively, on the endocytic activity in THP-1 cells. The results indicated that IgG and insulin enhance pinocytosis and phagocytosis via activation of phosphatidylinositol 3-kinase (PI3K). Our results suggest that IgG and insulin contribute to the maintenance of endocytic activity and are important for antigen presentation and nutrient uptake.PMID:37696069 | DOI:10.1016/j.bbrc.2023.09.008
Source: Biochemical and Biophysical Research communications - September 11, 2023 Category: Biochemistry Authors: Karin Egusa Shusaku Shibutani Hiroyuki Iwata Source Type: research
CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis
CONCLUSION: CD14 and CSF1R are highly expressed in osteoarthritis and may be therapeutic targets for osteoarthritis.PMID:37693684 | PMC:PMC10492034
Source: International Journal of Clinical and Experimental Pathology - September 11, 2023 Category: Pathology Authors: Meiliang Zheng Zheng Li Yingfa Feng Xiaoyu Zhang Source Type: research
Azacitidine (Vidaza < sup > ® < /sup > ) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)
CONCLUSIONS: Azacitidine 75 mg/m2 prior to a second hematopoietic stem cell transplantation is safe in children with relapsed MDS/JMML. Although the long-term advantage remains to be assessed, this study suggests that azacitidine is an efficacious option for relapsed JMML.CLINICAL TRIAL REGISTRATION: EudraCT 2010-022235-10.PMID:37695474 | DOI:10.1007/s40272-023-00588-5
Source: Paediatric Drugs - September 11, 2023 Category: Pediatrics Authors: Alba Rubio-San-Sim ón Natasha K A van Eijkelenburg Raoull Hoogendijk Henrik Hasle Charlotte M Niemeyer Michael N Dworzak Marco Zecca Marta Lopez-Yurda Julie M Janssen Alwin D R Huitema Marry M van den Heuvel-Eibrink Eric J Laille Harm van Tinteren Christ Source Type: research
CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis
CONCLUSION: CD14 and CSF1R are highly expressed in osteoarthritis and may be therapeutic targets for osteoarthritis.PMID:37693684 | PMC:PMC10492034
Source: International Journal of Clinical and Experimental Pathology - September 11, 2023 Category: Pathology Authors: Meiliang Zheng Zheng Li Yingfa Feng Xiaoyu Zhang Source Type: research
New indole alkaloid Morucolletotricin from endophytic fungus < em > Colletotrichum queenslandicum < /em > associated with < em > Morus australis < /em > Poir. Leaf
Nat Prod Res. 2023 Sep 10:1-6. doi: 10.1080/14786419.2023.2250520. Online ahead of print.ABSTRACTSix compounds were isolated from the ethyl acetate extract of endophytic fungus Colletotrichum queenslandicum derived from Morus australis Poir. leaf. Based on NMR and MS data led to characterised of these compounds including one new indole alkaloid Morucolletotricin (1) along with two other indole alkaloids; tryptopol (2) and indole-3-acetic acid (3), phomopyronol (4), 2-(3-aminophenyl)acetic acid (5) and ergosterol (6). phomopyronol (4) and 2-(3-aminophenyl)acetic acid (5) were first reported from Colletotrichum fungi. The cy...
Source: Natural Product Research - September 10, 2023 Category: Biochemistry Authors: Kurnia Nastira Ningsih Euis Holisotan Hakim Source Type: research
Geographic Disparity of Outcome in Patients With Cancer Over Decades: The Surveillance, Epidemiology, and End Results
CONCLUSIONS: Significant disparities in cancer care exist among geographic locations. Geographic differences in survival appear more prominent when highly effective therapies are available.PMID:37690903 | DOI:10.1016/j.clml.2023.08.001
Source: Clinical Lymphoma and Myeloma - September 10, 2023 Category: Cancer & Oncology Authors: Koji Sasaki Kiyomi Morita Hagop Kantarjian Guillermo Garcia-Manero Elias Jabbour Farhad Ravandi Marina Konopleva Gautam Borthakur William Wierda Naval Daver Koichi Takahashi Courtney DiNardo Guillermo Montalban Bravo Ghayas C Issa Sherry A Pierce Kelly A Source Type: research
A C < sub > H < /sub > 2C < sub > H < /sub > 3 hinge region enhances the cytotoxicity of anti-CD5 CAR-T cells targeting T cell acute lymphoblastic leukemia
Int Immunopharmacol. 2023 Sep 8;124(Pt A):110904. doi: 10.1016/j.intimp.2023.110904. Online ahead of print.ABSTRACTChimeric antigen receptor T cell (CAR-T) therapies show considerable clinical efficacy in patients with B cell malignancies, but their efficacy is limited in patients with T cell acute lymphoblastic leukemia (T-ALL). CD5 is expressed on ∼85 % of malignant T cells, and CD5-targeting CAR-T cells can exhibit potent antitumor activity against T-ALL. However, optimization of CAR costimulatory endo-, hinge, and transmembrane domains could further increase their expansion and persistence, thereby enhancing their ef...
Source: International Immunopharmacology - September 10, 2023 Category: Allergy & Immunology Authors: Huantong Wu Yajie Yu Yu Zhao Weihua Liu Zhongfeng Liu Guangji Zhang Zhiguo Chen Source Type: research
Geographic Disparity of Outcome in Patients With Cancer Over Decades: The Surveillance, Epidemiology, and End Results
CONCLUSIONS: Significant disparities in cancer care exist among geographic locations. Geographic differences in survival appear more prominent when highly effective therapies are available.PMID:37690903 | DOI:10.1016/j.clml.2023.08.001
Source: Clinical Lung Cancer - September 10, 2023 Category: Cancer & Oncology Authors: Koji Sasaki Kiyomi Morita Hagop Kantarjian Guillermo Garcia-Manero Elias Jabbour Farhad Ravandi Marina Konopleva Gautam Borthakur William Wierda Naval Daver Koichi Takahashi Courtney DiNardo Guillermo Montalban Bravo Ghayas C Issa Sherry A Pierce Kelly A Source Type: research
A C < sub > H < /sub > 2C < sub > H < /sub > 3 hinge region enhances the cytotoxicity of anti-CD5 CAR-T cells targeting T cell acute lymphoblastic leukemia
Int Immunopharmacol. 2023 Sep 8;124(Pt A):110904. doi: 10.1016/j.intimp.2023.110904. Online ahead of print.ABSTRACTChimeric antigen receptor T cell (CAR-T) therapies show considerable clinical efficacy in patients with B cell malignancies, but their efficacy is limited in patients with T cell acute lymphoblastic leukemia (T-ALL). CD5 is expressed on ∼85 % of malignant T cells, and CD5-targeting CAR-T cells can exhibit potent antitumor activity against T-ALL. However, optimization of CAR costimulatory endo-, hinge, and transmembrane domains could further increase their expansion and persistence, thereby enhancing their ef...
Source: International Immunopharmacology - September 10, 2023 Category: Allergy & Immunology Authors: Huantong Wu Yajie Yu Yu Zhao Weihua Liu Zhongfeng Liu Guangji Zhang Zhiguo Chen Source Type: research
New indole alkaloid Morucolletotricin from endophytic fungus < em > Colletotrichum queenslandicum < /em > associated with < em > Morus australis < /em > Poir. Leaf
Nat Prod Res. 2023 Sep 10:1-6. doi: 10.1080/14786419.2023.2250520. Online ahead of print.ABSTRACTSix compounds were isolated from the ethyl acetate extract of endophytic fungus Colletotrichum queenslandicum derived from Morus australis Poir. leaf. Based on NMR and MS data led to characterised of these compounds including one new indole alkaloid Morucolletotricin (1) along with two other indole alkaloids; tryptopol (2) and indole-3-acetic acid (3), phomopyronol (4), 2-(3-aminophenyl)acetic acid (5) and ergosterol (6). phomopyronol (4) and 2-(3-aminophenyl)acetic acid (5) were first reported from Colletotrichum fungi. The cy...
Source: Natural Product Research - September 10, 2023 Category: Biochemistry Authors: Kurnia Nastira Ningsih Euis Holisotan Hakim Source Type: research
