Filtered By:
Cancer: Leukemia
This page shows you your search results in order of date. This is page number 5.
Order by Relevance | Date
Total 28367 results found since Jan 2013.
Interleukin-37 gene expression is down-regulated in patients with acute myeloid leukemia and shown to be affected by CD14 and HLA-DR immunophenotypes
In conclusion, IL37 mRNA expression was down-regulated in AML patients, especially females, and those with the FAB M4 type and the WHO PML-RARA type. This expression may be affected by the immunophenotypic markers CD14 and HLA-DR.PMID:37716188 | DOI:10.1016/j.cyto.2023.156368
Source: Cytokine - September 16, 2023 Category: Molecular Biology Authors: Mustafa A Bashi Ali H Ad'hiah Source Type: research
Genes, Vol. 14, Pages 1807: Aldehyde Dehydrogenase Genes as Prospective Actionable Targets in Acute Myeloid Leukemia
In conclusion, we identify ALDH1A1 and ALDH2 as prospective actionable targets for the treatment of AML in high-risk patients. Substances that inhibit both enzymatic activities constitute potentially effective pharmaceutics.
Source: Genes - September 16, 2023 Category: Genetics & Stem Cells Authors: Garrett M. Dancik Lokman Varisli Veysel Tolan Spiros Vlahopoulos Tags: Article Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
Targeting SDCBP2 in acute myeloid leukemia
Cell Signal. 2023 Sep 13:110889. doi: 10.1016/j.cellsig.2023.110889. Online ahead of print.ABSTRACTAcute myeloid leukemia (AML) remains a biologically heterogeneous disease with high morbidity and mortality under the existing treatment strategies. Our previous study showed that E2A might be a potential therapeutic target for AML, but the underlying mechanism was unclear. Here, we found that SDCBP2 might be a target gene of E2A through RNA-seq combined ChIP-seq screening. This was also demonstrated by Co-IP experiment. Furthermore, the expression of E2A and SDCBP2 were increased in both AML cell lines and patient samples. D...
Source: Cellular Signalling - September 15, 2023 Category: Cytology Authors: Yan Du Lan-Lan Li Feihu Chen Yan Du Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: International Journal of Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
A novel KMT2A::DCP1B rearrangement in chronic neutrophilic leukemia
Int J Lab Hematol. 2023 Sep 15. doi: 10.1111/ijlh.14173. Online ahead of print.NO ABSTRACTPMID:37712389 | DOI:10.1111/ijlh.14173
Source: International Journal of Laboratory Hematology - September 15, 2023 Category: Hematology Authors: Lei Yang Xiaoshan Yang Yun Zhuang Jue Wang Xiaojun Chen Wentao Hu Dan Shan Rong Rong Xin Zhou Sheng Xiao Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
LC-PDA-QTof-MS characterization of the stress degradation products of Zanubrutinib: A novel BTK inhibitor
This study provides comprehensive information on the inherent stability of ZAN which will be useful in the drug development and manufacturing processes.PMID:37713985 | DOI:10.1016/j.jpba.2023.115714
Source: Biomed Res - September 15, 2023 Category: Research Authors: Murali Mohan Bhandi Debasish Swain Srinivas Ragampeta Mohana Krishna Reddy Mudiam Source Type: research
Synthesis and Anticancer Activity of Phosphinoylated and Phosphonoylated N-Heterocycles Obtained by the Microwave-Assisted Palladium Acetate-Catalyzed Hirao Reaction
Chemistry. 2023 Sep 15:e202302465. doi: 10.1002/chem.202302465. Online ahead of print.ABSTRACTA literature survey showed that different derivatives with the 9-phenyl-9H-carbazole or the dihydroindoline scaffold may be of biological activity including cytotoxic effect. Driven by this experience, we wished to synthesize P-functionalized derivatives of the above mentioned N-heterocycles. Three N-heterocycles, 9-(4-bromophenyl)-9H-carbazole, 3-bromo-9-phenyl-9H-carbazole and 1-(5-bromoindolin-1-yl)ethan-1-one were coupled with dialkyl phosphites and diarylphosphine oxides using Pd(OAc)2 (10%) as the catalyst precursor and trie...
Source: Chemistry - September 15, 2023 Category: Chemistry Authors: Bianka Husz ár Ren áta Szolga Szilvia B ősze Rita Ol áhné Szabó Andr ás Simon Konstantin Karaghiosoff M átyás Czugler L ászló Drahos Gy örgy Keglevich Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: International Journal of Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model
J Immunol. 2023 Sep 15:ji2300111. doi: 10.4049/jimmunol.2300111. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (alloSCT) is, in many clinical settings, the only curative treatment for acute myeloid leukemia (AML). The clinical benefit of alloSCT greatly relies on the graft-versus-leukemia (GVL) effect. However, AML relapse remains the top cause of posttransplant death; this highlights the urgent need to enhance GVL. Studies of human GVL have been hindered by the lack of optimal clinically relevant models. In this article, we report, the successful establishment of a novel (to our knowledg...
Source: Journal of Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Bei Jia Chenchen Zhao Kentaro Minagawa Hiroko Shike David F Claxton W Christopher Ehmann Witold B Rybka Shin Mineishi Ming Wang Todd D Schell K Sandeep Prabhu Robert F Paulson Yi Zhang Leonard D Shultz Hong Zheng Source Type: research
LC-PDA-QTof-MS characterization of the stress degradation products of Zanubrutinib: A novel BTK inhibitor
This study provides comprehensive information on the inherent stability of ZAN which will be useful in the drug development and manufacturing processes.PMID:37713985 | DOI:10.1016/j.jpba.2023.115714
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Murali Mohan Bhandi Debasish Swain Srinivas Ragampeta Mohana Krishna Reddy Mudiam Source Type: research
The JAK3 < sup > Q988P < /sup > mutation reveals oncogenic potential and resistance to ruxolitinib
Mol Carcinog. 2023 Sep 15. doi: 10.1002/mc.23632. Online ahead of print.ABSTRACTT-cell acute lymphoblastic leukemia (T-ALL) arises from the malignant transformation of T-cell progenitors at various differentiation stages. Given that patients who relapse have a dismal prognosis, there is an urgent need to identify the molecular alterations that are present in such patients and promote leukemogenesis to implement personalized therapies with higher efficacy and fewer adverse effects. In the present manuscript, we identified the JAK3Q988P mutation in a T-ALL patient who did not achieve a durable response after the conventional...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Antonio Lahera Laura Vela-Mart ín Pablo Fern ández-Navarro Pilar Llamas Jos é L López-Lorenzo Javier Cornago Javier Santos Jos é Fernández-Piqueras Mar ía Villa-Morales Source Type: research
