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Condition: Disability
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Total 66181 results found since Jan 2013.
Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis
Braz J Med Biol Res. 2023 Sep 8;56:e12776. doi: 10.1590/1414-431X2023e12776. eCollection 2023.ABSTRACTMultiple sclerosis (MS), a neuroinflammation that results in neurodegeneration, is the most prevalent central nervous system inflammatory disease in young people. A diet rich in antioxidants is known to decrease the production/activity of pro-inflammatory cytokines and have a positive impact on the prognosis of MS. The purpose of this study was to assess if dietary antioxidant capacity is related to Expanded Disability Status Scale (EDSS) scores in patients with MS. Patients with MS (n=220; 137 women and 83 men) were asked...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: S Mungan I Guzel B C Demirdogen Source Type: research
"We got there in the end …. somehow, we got there": a qualitative study of healthcare professionals providing care in the community to people with chronic aphasia, and how technology could assist
CONCLUSIONS: HCPs with more aphasia knowledge reported having more positive experiences. Unsuccessful interactions were believed to lead to negative emotional responses in people with aphasia and HCPs, and that miscommunications could lead to compromised care. HCPs reported that interactions and relationships with people with aphasia grew easier over time. HCPs need system level support to acquire the knowledge and skills needed to engage people with aphasia in effective healthcare conversations. Technology has potential to improve interactions.PMID:37702476 | DOI:10.1080/09638288.2023.2256666
Source: Disability and Rehabilitation - September 13, 2023 Category: Rehabilitation Authors: Kylie Casey Robyn O'Halloran Maayken E L van den Berg Miranda L Rose Source Type: research
Development of an ontology to characterize mental functioning
CONCLUSIONS: Challenges emerged in the extent to which we could directly align components in the ICF into an applied ontology of mental functioning. These conceptual challenges required rearrangement of ICF components to adequately support our use case within the social security disability determination process. Findings also have implications to support future NLP efforts for behavioral health outcomes and policy research.PMID:37702040 | DOI:10.1080/09638288.2023.2252337
Source: Disability and Rehabilitation - September 13, 2023 Category: Rehabilitation Authors: Maryanne J Sacco Guy Divita Elizabeth Rasch Source Type: research
Electrical dry needling versus a non-invasive multicomponent intervention in the treatment of myofascial trigger points in patients with chronic low back pain: A randomised clinical trial
CONCLUSIONS: In comparison to a non-invasive multicomponent intervention, electrical dry needling has more positive effects on disability, pain intensity, kinesiophobia, and reducing patients' sensitivity to myofascial trigger points pressure, at post-treatment and at 2 months.CLINICAL TRIAL REGISTRATION NUMBER: NCT04804228. Registered on May 28th, 2021. Available at https://clinicaltrials.gov/ct2/show/NCT04804228.PMID:37700695 | DOI:10.1177/02692155231201589
Source: Clinical Rehabilitation - September 13, 2023 Category: Rehabilitation Authors: Inmaculada Carmen Lara-Palomo Eduardo Antequera-Soler Manuel Fern ández-Sánchez Adelaida Mar ía Castro-Sánchez H éctor García-López Source Type: research
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome
EMBO Mol Med. 2023 Sep 13:e17833. doi: 10.15252/emmm.202317833. Online ahead of print.ABSTRACTSnyder-Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis, hypotonia, and seizures. Symptom management is the only treatment. Reduced SMS activity causes spermidine accumulation while spermine levels are reduced. The resulting exaggerated spermidine:spermine ratio is a biochemical hallmark of SRS that tends to correlate with symptom severity. Our studie...
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Tracy Murray Stewart Jackson R Foley Cassandra E Holbert Maxim Khomutov Noushin Rastkari Xianzun Tao Alex R Khomutov R Grace Zhai Robert A Casero Source Type: research
Targeting biophysical microenvironment for improved treatment of chronic obstructive pulmonary disease
We present the first comprehensive review of four distinct biophysical hallmarks [i.e., extracellular matrix (ECM) microarchitecture, stiffness, fluid shear stress, and mechanical stretch] in COPD, the possible involvement of pathological changes, possible effects, and correlated in vitro models and sum up the emerging COPD treatments targeting these biophysical hallmarks.PMID:37704492 | DOI:10.1016/j.molmed.2023.08.007
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Han Liu Pengbei Fan Fanli Jin Hui Ren Feng Xu Jiansheng Li Source Type: research
Turn-taking and communication modes of students and staff in group activities at non-inclusive schools for students with intellectual disability
Augment Altern Commun. 2023 Sep 13:1-12. doi: 10.1080/07434618.2023.2243517. Online ahead of print.ABSTRACTMost students with intellectual and communicative disability who rely on augmentative and alternative communication (AAC) attend non-inclusive school settings. Little is known about turn-taking and the use of various communication modes in groups of students and staff in this context. Previous studies on single students with intellectual disability in various school settings have found that staff tend to dominate interactions and augmented communication modes are used more during structured than unstructured activitie...
Source: Augmentative and Alternative Communication - September 13, 2023 Category: Speech-Language Pathology Authors: Sofia Wallin Helena Hemmingsson Gunilla Thunberg Jenny Wilder Source Type: research
Lamb-Shaffer syndrome: 20 Spanish patients and literature review expands the view of neurodevelopmental disorders caused by SOX5 haploinsufficiency
In conclusion, LLS is a rare genetic disorder mostly characterized by a wide range of developmental and neurological symptoms. Early diagnosis would allow to start of care programs, clinical follow up, prospective studies and appropriate genetic counseling, to promote clinical and social improvement to have profound lifelong benefits for patients and their families. Further research is needed to better understand the underlying mechanisms of the syndrome related to SOX5 haploinsufficiency.PMID:37702321 | DOI:10.1111/cge.14423
Source: Clinical Genetics - September 13, 2023 Category: Genetics & Stem Cells Authors: Jair Tenorio-Castano Ángela Sánchez-Algaba Gómez M ónica Coronado Pilar Rodr íguez-Martín Alejandro Parra Patricia Pascual Mario Cazalla Natalia Gallego Pedro Arias Aixa V Morales Juli án Nevado Pablo Lapunzina Source Type: research
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome
EMBO Mol Med. 2023 Sep 13:e17833. doi: 10.15252/emmm.202317833. Online ahead of print.ABSTRACTSnyder-Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis, hypotonia, and seizures. Symptom management is the only treatment. Reduced SMS activity causes spermidine accumulation while spermine levels are reduced. The resulting exaggerated spermidine:spermine ratio is a biochemical hallmark of SRS that tends to correlate with symptom severity. Our studie...
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Tracy Murray Stewart Jackson R Foley Cassandra E Holbert Maxim Khomutov Noushin Rastkari Xianzun Tao Alex R Khomutov R Grace Zhai Robert A Casero Source Type: research
Targeting biophysical microenvironment for improved treatment of chronic obstructive pulmonary disease
We present the first comprehensive review of four distinct biophysical hallmarks [i.e., extracellular matrix (ECM) microarchitecture, stiffness, fluid shear stress, and mechanical stretch] in COPD, the possible involvement of pathological changes, possible effects, and correlated in vitro models and sum up the emerging COPD treatments targeting these biophysical hallmarks.PMID:37704492 | DOI:10.1016/j.molmed.2023.08.007
Source: Trends in Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Han Liu Pengbei Fan Fanli Jin Hui Ren Feng Xu Jiansheng Li Source Type: research
Astrocytes in functional recovery following central nervous system injuries
J Physiol. 2023 Sep 13. doi: 10.1113/JP284197. Online ahead of print.ABSTRACTAstrocytes are increasingly recognised as partaking in complex homeostatic mechanisms critical for regulating neuronal plasticity following central nervous system (CNS) insults. Ischaemic stroke and traumatic brain injury are associated with high rates of disability and mortality. Depending on the context and type of injury, reactive astrocytes respond with diverse morphological, proliferative and functional changes collectively known as astrogliosis, which results in both pathogenic and protective effects. There is a large body of research on the...
Source: The Journal of Physiology - September 13, 2023 Category: Physiology Authors: Qasim M Alhadidi Ghaith A Bahader Oiva Arvola Philip Kitchen Zahoor A Shah Mootaz M Salman Source Type: research
CK1 δ/CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma
Cancer Res. 2023 Sep 13. doi: 10.1158/0008-5472.CAN-22-2350. Online ahead of print.ABSTRACTMultiple myeloma (MM) remains an incurable malignancy due to acquisition of intrinsic programs that drive therapy resistance. Here we report that casein kinase-1δ (CK1δ) and CK1ε are therapeutic targets in MM that are necessary to sustain mitochondrial metabolism. Specifically, the dual CK1δ/CK1ε inhibitor SR-3029 had potent in vivo and ex vivo anti-MM activity, including against primary MM patient specimens. RNA sequencing (RNA-seq) and metabolic analyses revealed inhibiting CK1δ/CK1ε disables MM metabolism by suppressing gen...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Karen L Burger Mario R Fernandez Mark B Meads Praneeth Reddy Sudalagunta Paula S Oliveira Rafael Renatino Canevarolo Raghunandan Reddy Alugubelli Alexandre Tungsevik Gabe De Avila Maria Silva Allison I Graeter Hongyue Dai Nicole D Vincelette Antony Prabhu Source Type: research
Repair of a finger pulp or fingertip defect using a palmar rotatory flap pedicled with the perforating branch of the proper palmar digital artery: a retrospective study
CONCLUSION: VRPF-PPDA surgery is a simple, effective, minimally invasive, and reliable method for repairing soft tissue defects in the distal finger pulp or fingertips. Optimal esthetic reconstruction and anatomical and functional repair can be achieved in fingers repaired using the VRPF-PPDA surgical approach.PMID:37705011 | DOI:10.1186/s13018-023-04156-y
Source: Hand Surgery - September 13, 2023 Category: Surgery Authors: Yongjun Du Zhongfeng Cui Shaoquan Pu Zhi Peng Sheng Lu Source Type: research
Self-management Experience of Nurses Living with Migraine: A Qualitative Study
CONCLUSION: The implications of these findings support the incorporation of a critical approach to relational engagement that is person-centred including nonjudgemental, strength-based care as a practice approach when caring for persons living with migraines and the need to include experiential learning in educational curriculums as a strategy to reduce stigma against migraines.PMID:37700606 | DOI:10.1177/08445621231199652
Source: The Canadian Journal of Nursing Research - September 13, 2023 Category: Nursing Authors: Marionette Ngole Dione Lorie Donelle Victoria Smye Deanna Befus Source Type: research
Postbiotic as Novel Alternative Agent or Adjuvant for the Common Antibiotic Utilized in the Food Industry
CONCLUSION: Postbiotic constituents may be a new approach for utilization in the pharmaceutical and food sectors for developing therapeutic treatments. Further metabolomics investigations are required to describe novel postbiotics and clinical trials are also required to define the sufficient dose and optimum administration frequency of postbiotics.PMID:37702234 | DOI:10.2174/1389201025666230912123849
Source: Current Pharmaceutical Biotechnology - September 13, 2023 Category: Biotechnology Authors: Sama Sepordeh Amir Mohammad Jafari Sara Bazzaz Amin Abbasi Ramin Aslani Sousan Houshmandi Aziz Homayouni Rad Source Type: research
