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Total 66181 results found since Jan 2013.
Motivation-related influences on fNIRS signals during walking exercise: a permutation entropy approach
This study provides early evidence to suggest that while different motivational environments during walking activity influence the magnitude of fNIRS signals, they may not influence the regularity of cortical signals. However, the magnitude of PE difference between motivational conditions was related to self-determined motivation in the aPFC, and this is an area warranting further investigation.PMID:37733031 | DOI:10.1007/s00221-023-06707-5
Source: Experimental Brain Research - September 21, 2023 Category: Neuroscience Authors: Sarah M Schwab Dalton Cooper Nicole S Carver Sarah Doren Pierce Boyne Source Type: research
Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico
Conclusions: Data suggest combined ibogaine and 5-MeO-DMT assisted therapy has potential to provide rapid and robust changes in mental health functioning with a signal of durable therapeutic effects up to 6-months. Future research in controlled settings is warranted.PMID:37734158 | DOI:10.1080/00952990.2023.2220874
Source: The American Journal of Drug and Alcohol Abuse - September 21, 2023 Category: Addiction Authors: Alan Kooi Davis Yitong Xin Nathan Sepeda Lynnette A Averill Source Type: research
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration
Cell Metab. 2023 Sep 15:S1550-4131(23)00331-5. doi: 10.1016/j.cmet.2023.08.010. Online ahead of print.ABSTRACTMuscle-residing regulatory T cells (Tregs) control local tissue integrity and function. However, the molecular interface connecting Treg-based regulation with muscle function and regeneration remains largely unexplored. Here, we show that exercise fosters a stable induction of highly functional muscle-residing Tregs with increased expression of amphiregulin (Areg), EGFR, and ST2. Mechanistically, we find that mice lacking IL6Rα on T cells (TKO) harbor significant reductions in muscle Treg functionality and satelli...
Source: Cell Metabolism - September 21, 2023 Category: Cytology Authors: Maike Becker Sini S Joseph Francisco Garcia-Carrizo Robby Z Tom Daria Opaleva Isabelle Serr Matthias H Tsch öp Tim J Schulz Susanna M Hofmann Carolin Daniel Source Type: research
The Efficacy of Physical Therapy and Rehabilitation Approaches in Chronic Migraine: A Systematic Review and Meta-Analysis
CONCLUSIONS: A limited number of RCTs investigating the efficacy of physical therapy and rehabilitation approaches show promise in improving headache symptoms, reducing disability, and enhancing QoL in CM. Meta-analysis of the data also supported favorable outcomes for both intensity and headache days per month. Further research is needed to better understand the efficacy, optimal duration, and safety of physical therapy and rehabilitation approaches for CM, and to explore alternative interventions.PMID:37735140 | DOI:10.31083/j.jin2205126
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Dilara Onan Esme Ekizo ğlu Halime Ar ıkan Bahar Ta şdelen Aynur Özge Paolo Martelletti Source Type: research
Pain in Parkinson's Disease: Pathophysiology, Classification and Treatment
J Integr Neurosci. 2023 Sep 8;22(5):132. doi: 10.31083/j.jin2205132.ABSTRACTContinuous medical progress is significantly improving the quality of health care. As a result, people are living longer than during the past century, but this has also caused an increase of the prevalence of many neurological disorders. Parkinson's disease (PD) is the fastest growing neurological condition, with a doubling of cases reported between 1995 and 2015 and a further doubling projected by 2030. Parkinson's disease is generally associated with characteristic motor symptoms (resting tremor, rigidity, bradykinesia and postural instability). ...
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Carlo Cattaneo Wolfgang H Jost Source Type: research
Histone Variants and Their Chaperones: An Emerging Epigenetic Mechanism in Neurodevelopment and Neurodevelopmental Disorders
J Integr Neurosci. 2023 Aug 4;22(5):108. doi: 10.31083/j.jin2205108.ABSTRACTNeurodevelopment is a highly regulated process that relies on the precise regulation of gene expression. Numerous epigenetic mechanisms contribute and cooperate to ensure the proper execution of developmental gene expression programs. Indeed, disruption of the molecular machinery regulating the deposition or removal of epigenetics markers is associated with numerous neurodevelopmental disorders, including autism spectrum disorder and intellectual disabilities. Among the various epigenetic marks that are fundamental for brain development, research h...
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Karanveer S Johal Manjinder S Cheema Gilda Stefanelli Source Type: research
Regulation of "Right Ankle Dorsiflexion" Motor Imagery on Brain Function of Spinal Cord Injury: A FOCA-Based Prospective Study
CONCLUSIONS: After SCI, a series of changes in the structure and function of the brain occur. Research on brain plasticity after SCI might help explore the central mechanisms underlying functional recovery after treatments, providing more therapeutic strategies for SCI.PMID:37735119 | DOI:10.31083/j.jin2205127
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Yue Jiang Qian Wang Yan Chen Cheng Luo Wenchun Wang Rizhao Pang Shanshan Zhang An-Ren Zhang Source Type: research
Transport use limitations and its association with social participation among patients with stroke living in rural India
CONCLUSIONS: Independent use of different modes of transport, particularly public transportation, reduced among rural Indian stroke survivors. These transport limitations are significantly associated with reduced social participation, highlighting the need for interventions to improve accessibility and fostering greater community engagement for stroke survivors in this population.IMPLICATIONS FOR REHABILITATIONLimited transportation access limits social participation for stroke survivors in rural India.Study results show a significant decrease in independent transport use among stroke survivors, affecting their social part...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: Kajal Chavda V Prakash Source Type: research
Learning to drive with neurological conditions: profile of users of an adapted driver training program and cognitive factors associated with success
CONCLUSION: These results suggest that approximately half of the persons enrolled in a driver training program designed for learners with neurological conditions, obtain a driver's license; and that attention, and to a lesser extent executive functioning and working memory, are related to driving program success.IMPLICATIONS FOR REHABILITATIONIn individual with neurological conditions, learning how to drive can be challenging.An adapted driver training program, involving collaboration between driving instructors and healthcare professionals, simplification of theoretical learning, and increasing driving practice opportunit...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: Adam Fahmi Mathieu Garon Alexandra Ribon-Demars Laurie Dubois Martin Caouette Marie- Ève Lamontagne Simon Beaulieu-Bonneau Source Type: research
Standardized circuit class group training versus individualized goal-directed group training to improve upper limb function in stroke survivors during in-patient rehabilitation: a pragmatic trial
CONCLUSIONS: A standardized training could reduce the mental workload for therapists, but patients seemed less engaged. A combination of both might be most beneficial.Trial registration: Dutch Trial Register: NL8844 and NL9471IMPLICATIONS FOR REHABILITATIONProviding a standardized training program after stroke reduces therapists' mental workload.Individualized goal-directed group training results in the best achievement of rehabilitation goals.A combination of standardized and individual training would use best of both intervention modalities.Patients should be involved in the co-creation developing process of training pro...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: S G Rozevink C M Beerepoot C K van der Sluis J M Hijmans Source Type: research
Should realignment goals vary based on patient frailty status in adult spinal deformity?
CONCLUSIONS: Consideration of physiological age, in addition to chronological age, may be beneficial in the management of operative goals to maximize clinical outcomes while minimizing junctional failure. This combination enables the spine surgeon to fortify a surgical plan for even the most challenging patients undergoing ASD corrective surgery.PMID:37728390 | DOI:10.3171/2023.5.SPINE23456
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Peter G Passias Jamshaid M Mir Tyler K Williamson Peter S Tretiakov Pooja Dave Virginie Lafage Renaud Lafage Andrew J Schoenfeld Source Type: research
Selective thoracolumbar fusion in adult spinal deformity double curves with circumferential minimally invasive surgery: 2-year minimum follow-up
CONCLUSIONS: Selective thoracolumbar fusion with CMIS for ASD double curves can provide significant clinical improvements. Despite limiting fusion constructs to within the lower thoracic and/or lumbar spine, significant correction can be observed in the uninstrumented thoracic curve. The rate of mechanical complications was low, and the 2-year follow-up results suggested that limited fusion constructs are viable options for ASD double curve patients.PMID:37728379 | DOI:10.3171/2023.6.SPINE23360
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Neel Anand Jerry Robinson Andrew Chung David Gendelberg Jos é H Jiménez-Almonte Sheila Kahwaty Babak Khandehroo Corey Walker Source Type: research
Cervical laminoplasty versus laminectomy and posterior cervical fusion for cervical myelopathy: propensity-matched analysis of 24-month outcomes from the Quality Outcomes Database
CONCLUSIONS: Compared with PCF, laminoplasty was associated with decreased blood loss, decreased length of hospitalization, and higher rates of home discharge. At 3 months, laminoplasty was associated with a higher rate of return to baseline activities. At 24 months, laminoplasty was associated with greater improvements in neck disability. Otherwise, laminoplasty and PCF shared similar outcomes for functional status, pain, quality of life, and satisfaction. Laminoplasty and PCF achieved similar neck pain scores, suggesting that moderate preoperative neck pain may not necessarily be a contraindication for laminoplasty.PMID:...
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Eunice Yang Praveen V Mummaneni Dean Chou Mohamad Bydon Erica F Bisson Christopher I Shaffrey Oren N Gottfried Anthony L Asher Domagoj Coric Eric A Potts Kevin T Foley Michael Y Wang Kai-Ming Fu Michael S Virk John J Knightly Scott Meyer Paul Park Cheerag Source Type: research
Functional and clinical outcomes in the Krukenberg amputation
J Hand Surg Eur Vol. 2023 Sep 20:17531934231202010. doi: 10.1177/17531934231202010. Online ahead of print.ABSTRACTWe evaluated the outcomes of the Krukenberg procedure conducted for the loss of a hand secondary to an electrical burn injury in six patients (10 hands). Patient demographics, indications for surgery, surgical strategy, complications, clinical measurements and Disabilities of the Arm, Shoulder and Hand (DASH) score were recorded, in addition to subjective outcome measures, including self-perception of social acceptance and employment status. The median DASH score at follow-up was 22 (range 4-50, interquartile r...
Source: Hand Surgery - September 20, 2023 Category: Surgery Authors: Weisang Luo Yongjune Kim Vichet Tan Picheata Ek Sophie Hunt Harriet Howells Source Type: research
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
CONCLUSION: The intellectual disability of moderate type (MID) was associated with abnormal changes in the levels of essential mineral elements and adipokines and increased levels of cellular oxidative stress. Thus, evaluating plasma mineral elements and adipokines levels could be a potential diagnostic parameter for diagnosing MID.PMID:37730529 | DOI:10.1186/s12860-023-00490-5
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Ahmad H Alghadir Sami A Gabr Amir Iqbal Source Type: research
