Filtered By:
Condition: Disability
This page shows you your search results in order of date. This is page number 3.
Order by Relevance | Date
Total 66181 results found since Jan 2013.
Should realignment goals vary based on patient frailty status in adult spinal deformity?
CONCLUSIONS: Consideration of physiological age, in addition to chronological age, may be beneficial in the management of operative goals to maximize clinical outcomes while minimizing junctional failure. This combination enables the spine surgeon to fortify a surgical plan for even the most challenging patients undergoing ASD corrective surgery.PMID:37728390 | DOI:10.3171/2023.5.SPINE23456
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Peter G Passias Jamshaid M Mir Tyler K Williamson Peter S Tretiakov Pooja Dave Virginie Lafage Renaud Lafage Andrew J Schoenfeld Source Type: research
Selective thoracolumbar fusion in adult spinal deformity double curves with circumferential minimally invasive surgery: 2-year minimum follow-up
CONCLUSIONS: Selective thoracolumbar fusion with CMIS for ASD double curves can provide significant clinical improvements. Despite limiting fusion constructs to within the lower thoracic and/or lumbar spine, significant correction can be observed in the uninstrumented thoracic curve. The rate of mechanical complications was low, and the 2-year follow-up results suggested that limited fusion constructs are viable options for ASD double curve patients.PMID:37728379 | DOI:10.3171/2023.6.SPINE23360
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Neel Anand Jerry Robinson Andrew Chung David Gendelberg Jos é H Jiménez-Almonte Sheila Kahwaty Babak Khandehroo Corey Walker Source Type: research
Cervical laminoplasty versus laminectomy and posterior cervical fusion for cervical myelopathy: propensity-matched analysis of 24-month outcomes from the Quality Outcomes Database
CONCLUSIONS: Compared with PCF, laminoplasty was associated with decreased blood loss, decreased length of hospitalization, and higher rates of home discharge. At 3 months, laminoplasty was associated with a higher rate of return to baseline activities. At 24 months, laminoplasty was associated with greater improvements in neck disability. Otherwise, laminoplasty and PCF shared similar outcomes for functional status, pain, quality of life, and satisfaction. Laminoplasty and PCF achieved similar neck pain scores, suggesting that moderate preoperative neck pain may not necessarily be a contraindication for laminoplasty.PMID:...
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Eunice Yang Praveen V Mummaneni Dean Chou Mohamad Bydon Erica F Bisson Christopher I Shaffrey Oren N Gottfried Anthony L Asher Domagoj Coric Eric A Potts Kevin T Foley Michael Y Wang Kai-Ming Fu Michael S Virk John J Knightly Scott Meyer Paul Park Cheerag Source Type: research
Adverse effects of frailty on the outcomes of surgery for degenerative cervical myelopathy: results from a prospective multicenter international data set of 757 patients
CONCLUSIONS: Increasing frailty is associated with worse baseline functional and quality of life measures in patients undergoing surgery for DCM. Frailty does not affect the magnitude of improvement in outcome measures after surgery, but reduces the chance of achieving the MCID for functional impairment significantly. Preoperative frailty assessment can therefore help guide clinicians in managing expectations after surgery for DCM. Potentially modifiable factors should be optimized in frail patients preoperatively to enhance functional outcomes.PMID:37728372 | DOI:10.3171/2023.6.SPINE23461
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Jamie R F Wilson Jetan H Badhiwala Ali Moghaddamjou Alexander R Vaccaro Paul M Arnold Ronald H M A Bartels Giuseppe Barbagallo Michael G Fehlings Source Type: research
Economic burden of nonoperative treatment of adult spinal deformity
CONCLUSIONS: Patients with ASD undergoing operative treatment at baseline had greater sagittal deformity and greater improvement in health-related quality of life postoperatively compared to patients treated nonoperatively. Additionally, patients in the nonoperative cohort overall had an increase in ODI and did not show improvement in utility gained. Patients in the nonoperative cohort who had low disability and sagittal deformity underwent successful maintenance and cost-effective treatment.PMID:37728175 | DOI:10.3171/2023.7.SPINE23195
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Peter G Passias Waleed Ahmad Pooja Dave Renaud Lafage Virginie Lafage Jamshaid Mir Eric O Klineberg Khaled M Kabeish Jeffrey L Gum Breton G Line Robert Hart Douglas Burton Justin S Smith Christopher P Ames Christopher I Shaffrey Frank Schwab Richard Hosti Source Type: research
Coronary atherosclerotic plaque phenotype and physiopathologic mechanisms: Is there an influence of sex? Insights from intracoronary imaging
Atherosclerosis. 2023 Sep 18:117273. doi: 10.1016/j.atherosclerosis.2023.117273. Online ahead of print.ABSTRACTCoronary artery disease (CAD) is the leading cause of disability and death in both women and men; considerable differences in clinical presentation, natural history and prognosis are reported between sexes. Different pathophysiological mechanisms play a major role, including sex-related and gender-related features or a combination of both. Reports from intracoronary imaging studies pointed towards morphological plaque features, which seemed to differ between men and women, albeit results reported so far were not c...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Filippo Luca Gurgoglione Emilia Solinas Bettina Pfleiderer Antonella Vezzani Giampaolo Niccoli Source Type: research
Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke
In this study, we found that PKD2 expression and activity were significantly upregulated in the ipsilateral side of the brain after transient focal cerebral ischemia, which coincides with the upregulation of PKD2 in primary neurons in response to in vitro ischemia, implying a potential role of PKD2 in neuronal survival in ischemic stroke. Using kinase-dead PKD2 knock-in (PKD2-KI) mice, we examined whether loss of PKD2 activity affected stroke outcomes in mice subjected to 1 h of transient middle cerebral artery occlusion (tMCAO) and 24 h of reperfusion. Our data demonstrated that PKD2-KI mice exhibited larger infarction vo...
Source: Neurobiology of Disease - September 20, 2023 Category: Neurology Authors: Jaclyn A Connelly Xuejing Zhang Yuzhou Chen Yapeng Chao Yejie Shi Tija C Jacob Q Jane Wang Source Type: research
Transport use limitations and its association with social participation among patients with stroke living in rural India
CONCLUSIONS: Independent use of different modes of transport, particularly public transportation, reduced among rural Indian stroke survivors. These transport limitations are significantly associated with reduced social participation, highlighting the need for interventions to improve accessibility and fostering greater community engagement for stroke survivors in this population.IMPLICATIONS FOR REHABILITATIONLimited transportation access limits social participation for stroke survivors in rural India.Study results show a significant decrease in independent transport use among stroke survivors, affecting their social part...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: Kajal Chavda V Prakash Source Type: research
Learning to drive with neurological conditions: profile of users of an adapted driver training program and cognitive factors associated with success
CONCLUSION: These results suggest that approximately half of the persons enrolled in a driver training program designed for learners with neurological conditions, obtain a driver's license; and that attention, and to a lesser extent executive functioning and working memory, are related to driving program success.IMPLICATIONS FOR REHABILITATIONIn individual with neurological conditions, learning how to drive can be challenging.An adapted driver training program, involving collaboration between driving instructors and healthcare professionals, simplification of theoretical learning, and increasing driving practice opportunit...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: Adam Fahmi Mathieu Garon Alexandra Ribon-Demars Laurie Dubois Martin Caouette Marie- Ève Lamontagne Simon Beaulieu-Bonneau Source Type: research
Standardized circuit class group training versus individualized goal-directed group training to improve upper limb function in stroke survivors during in-patient rehabilitation: a pragmatic trial
CONCLUSIONS: A standardized training could reduce the mental workload for therapists, but patients seemed less engaged. A combination of both might be most beneficial.Trial registration: Dutch Trial Register: NL8844 and NL9471IMPLICATIONS FOR REHABILITATIONProviding a standardized training program after stroke reduces therapists' mental workload.Individualized goal-directed group training results in the best achievement of rehabilitation goals.A combination of standardized and individual training would use best of both intervention modalities.Patients should be involved in the co-creation developing process of training pro...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: S G Rozevink C M Beerepoot C K van der Sluis J M Hijmans Source Type: research
Adverse effects of frailty on the outcomes of surgery for degenerative cervical myelopathy: results from a prospective multicenter international data set of 757 patients
CONCLUSIONS: Increasing frailty is associated with worse baseline functional and quality of life measures in patients undergoing surgery for DCM. Frailty does not affect the magnitude of improvement in outcome measures after surgery, but reduces the chance of achieving the MCID for functional impairment significantly. Preoperative frailty assessment can therefore help guide clinicians in managing expectations after surgery for DCM. Potentially modifiable factors should be optimized in frail patients preoperatively to enhance functional outcomes.PMID:37728372 | DOI:10.3171/2023.6.SPINE23461
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Jamie R F Wilson Jetan H Badhiwala Ali Moghaddamjou Alexander R Vaccaro Paul M Arnold Ronald H M A Bartels Giuseppe Barbagallo Michael G Fehlings Source Type: research
Economic burden of nonoperative treatment of adult spinal deformity
CONCLUSIONS: Patients with ASD undergoing operative treatment at baseline had greater sagittal deformity and greater improvement in health-related quality of life postoperatively compared to patients treated nonoperatively. Additionally, patients in the nonoperative cohort overall had an increase in ODI and did not show improvement in utility gained. Patients in the nonoperative cohort who had low disability and sagittal deformity underwent successful maintenance and cost-effective treatment.PMID:37728175 | DOI:10.3171/2023.7.SPINE23195
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Peter G Passias Waleed Ahmad Pooja Dave Renaud Lafage Virginie Lafage Jamshaid Mir Eric O Klineberg Khaled M Kabeish Jeffrey L Gum Breton G Line Robert Hart Douglas Burton Justin S Smith Christopher P Ames Christopher I Shaffrey Frank Schwab Richard Hosti Source Type: research
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
CONCLUSION: The intellectual disability of moderate type (MID) was associated with abnormal changes in the levels of essential mineral elements and adipokines and increased levels of cellular oxidative stress. Thus, evaluating plasma mineral elements and adipokines levels could be a potential diagnostic parameter for diagnosing MID.PMID:37730529 | PMC:PMC10512604 | DOI:10.1186/s12860-023-00490-5
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Ahmad H Alghadir Sami A Gabr Amir Iqbal Source Type: research
Relationship between 4-month functional brain network topology and 24-month neurodevelopmental outcome in children with congenital heart disease
Eur J Paediatr Neurol. 2023 Sep 11;47:47-59. doi: 10.1016/j.ejpn.2023.09.005. Online ahead of print.ABSTRACTSurvivors of complex forms of congenital heart disease (CHD)∗ are at high risk of neurodevelopmental disabilities. Neuroimaging studies have pointed to brain anomalies and immature networks in infants with CHD, yet less is known about their functional network topology and associations with neurodevelopment. To characterize the functional network topology in 4-month-old infants with repaired CHD, we compared graph theory metrics measured using resting-state functional near-infrared spectroscopy (rs-fNIRS) between in...
Source: European Journal of Paediatric Neurology - September 20, 2023 Category: Neurology Authors: Sarah Provost Sol ène Fourdain Phetsamone Vannasing Julie Tremblay Kassandra Roger Yalina Garc ía-Puente Am élie Doussau Marie-Claude Vinay Zorina Von Siebenthal Natacha Paquette Nancy Poirier Anne Gallagher Source Type: research
Functional and clinical outcomes in the Krukenberg amputation
J Hand Surg Eur Vol. 2023 Sep 20:17531934231202010. doi: 10.1177/17531934231202010. Online ahead of print.ABSTRACTWe evaluated the outcomes of the Krukenberg procedure conducted for the loss of a hand secondary to an electrical burn injury in six patients (10 hands). Patient demographics, indications for surgery, surgical strategy, complications, clinical measurements and Disabilities of the Arm, Shoulder and Hand (DASH) score were recorded, in addition to subjective outcome measures, including self-perception of social acceptance and employment status. The median DASH score at follow-up was 22 (range 4-50, interquartile r...
Source: Hand Surgery - September 20, 2023 Category: Surgery Authors: Weisang Luo Yongjune Kim Vichet Tan Picheata Ek Sophie Hunt Harriet Howells Source Type: research
