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Drug: Methotrexate
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Total 4930 results found since Jan 2013.
Is Methotrexate Ototoxic? Investigating the Ototoxic Late Effects of Pediatric Cancer Treatment
CONCLUSIONS: The results from this study suggest that children who receive therapies not clinically established as ototoxic (i.e., methotrexate) may still be at a high risk of developing long-term hearing loss as a late effect. Due to the high incidence rate of hearing loss among patients with pediatric cancer, we recommend that audiologists be part of the late-effects care team. This study also demonstrates that patients with pediatric cancer treated with methotrexate should receive routine long-term auditory monitoring as part of their standard of care to detect and manage hearing loss early, minimizing adverse outcomes....
Source: American Journal of Audiology - August 2, 2023 Category: Audiology Authors: Brittney Moore Gabrielle Sheets Jordan Doss Ayesha Umrigar Michael Norman Zhide Fang Pinki Prasad Amanda Musso Sloane Clay Fern Tsien Source Type: research
What to Expect When Systemic Treatment in Juvenile Idiopathic Arthritis Is Withdrawn?
CONCLUSION: Flares are frequent when systemic treatment is withdrawn, and uveitis or joint injections could be related risk factors. In MTX and biologic-naïve patients, the frequency of flares occurred in more than half of patients, although they were less frequent when clinical remission lasted for > 1 year.PMID:37527855 | DOI:10.3899/jrheum.2022-1305
Source: J Rheumatol - August 1, 2023 Category: Rheumatology Authors: Juan Carlos Nieto-Gonz ález Daniel Clemente Garulo Alina Boteanu Laura Trives-Folguera Ant ía García-Fernández Pablo Gonz ález Navarro Juan Carlos L ópez Robledillo Indalecio Monteagudo-Sa éz Source Type: research
COVID-19 vaccine-associated myositis: a comprehensive review of the literature driven by a case report
AbstractSeveral cases of vaccine-associated manifestations have been published including cases of inflammatory myositis. Herein, we comprehensively review the literature on the occasion of case of a woman with inflammatory myositis following COVID-19 vaccination. A 67-year-old woman presented with left arm edema, rash, and weakness after the 2nd dose of the BTN162b2 vaccine. Raised muscle enzymes and inflammatory markers with muscle edema on MRI and myositis findings on the electromyogram established the diagnosis. She was successfully treated with methylprednisolone pulses, intravenous immunoglobulin, methotrexate, and hy...
Source: Immunologic Research - August 1, 2023 Category: Allergy & Immunology Source Type: research
Rhein methotrexate-decorated solid lipid nanoparticles altering adjuvant arthritis progression through endoplasmic reticulum stress-mediated apoptosis
In conclusion, RH-MTX-SLNs can represent a promising therapeutic approach for RA showing significant anti-arthritic activity.Graphical abstract
Source: Inflammopharmacology - August 1, 2023 Category: Drugs & Pharmacology Source Type: research
