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Drug: Methotrexate
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Total 4930 results found since Jan 2013.
Preclinical Demonstration of a Novel Treatment with High Efficacy and No Detectable Toxicity for Inflammatory Skin Conditions including Psoriasis
Biomed Res Int. 2023 Jul 11;2023:4878774. doi: 10.1155/2023/4878774. eCollection 2023.ABSTRACTAlthough the management options for psoriasis have progressed with the use of systemic agents, there are few efficacious nonsteroidal topical therapies for patients with limited or lower grade disease. The effects of allopurinol (Allo) and glutathione (GSH) were examined in two different in vitro models for psoriasis. In the first model, human immortalized keratinocytes (HaCaT) were treated with M5 cocktail (IL-17A, IL-22, oncostatin M, IL-1α, and TNF-α) in four interventional groups (control, Allo, oxypurinol (Oxy), and methotr...
Source: Cancer Control - July 20, 2023 Category: Cancer & Oncology Authors: John P Vanden Heuvel Shuling Zhou Anisha B Patel Harry N Kamerow Peter Baran John P Ford Source Type: research
Early life cancer and chemotherapy lead to cognitive deficits related to alterations in microglial-associated gene expression in prefrontal cortex
Brain Behav Immun. 2023 Jul 17:S0889-1591(23)00182-4. doi: 10.1016/j.bbi.2023.07.009. Online ahead of print.ABSTRACTChildren that survive leukemia are at an increased risk for cognitive difficulties. A better understanding of the neurobiological changes in response to early life chemotherapy will help develop therapeutic strategies to improve quality of life for leukemia survivors. To that end, we used a translationally-relevant mouse model consisting of leukemic cell line (L1210) injection into postnatal day (P)19 mice followed by methotrexate, vincristine, and leucovorin chemotherapy. Beginning one week after the end of ...
Source: Brain, Behavior, and Immunity - July 19, 2023 Category: Neurology Authors: Collin Laaker Claire Cantelon Alyshia Davis Kelsey R Lloyd Nana Agyeman Adam Hiltz Brittany L Smith Jan Pieter Konsman Teresa M Reyes Source Type: research
Genome-scale CRISPR-Cas9 screening stratifies pancreatic cancer with distinct outcomes and immunotherapeutic efficacy
In this study, using the 105 prognostic cancer essential genes identified by genome-scale CRISPR-Cas9 screening and univariate Cox analysis, we established and verified three heterogeneous subtypes via non-negative matrix factorization (NMF) and nearest template prediction (NTP) algorithms in the TCGA-PAAD cohort (176 samples) and four multi-center cohorts (233 samples), respectively. Among them, C1 with the worst prognosis was enriched in immune-related pathways, possessed superior infiltration abundance of immune cells and immune checkpoint molecules expression, and might be most sensitive to immunotherapy. C3, owing a m...
Source: Cellular Signalling - July 19, 2023 Category: Cytology Authors: Libo Wang Deshuang Fu Siyuan Weng Hui Xu Long Liu Chunguang Guo Yuqing Ren Zaoqu Liu Xinwei Han Source Type: research
18FFDG PET-MRI provides survival biomarkers in primary central nervous system lymphoma in the elderly: an ancillary study from the BLOCAGE trial of the LOC network
CONCLUSION: Baseline cerebellar metabolism and sumMTV may predict response to end of chemotherapy in PCNSL. Tumor volume and MILAS at baseline are strong prognostic factors.PMID:37462774 | DOI:10.1007/s00259-023-06334-w
Source: Molecular Medicine - July 18, 2023 Category: Molecular Biology Authors: Laura Rozenblum Damien Galanaud Caroline Houillier Carole Soussain Amandine Baptiste Lisa Belin V éronique Edeline Philippe Naggara Marine Soret Val érie Causse-Lemercier Lise Willems Sylvain Choquet Renata Ursu Kh ê Hoang-Xuan Aur élie Kas Source Type: research
Pharmacologic Treatment Strategies in Psoriatic Arthritis
Clin Ther. 2023 Jul 14:S0149-2918(23)00198-4. doi: 10.1016/j.clinthera.2023.05.010. Online ahead of print.ABSTRACTPURPOSE: The goal of this narrative review was to provide current data on psoriatic arthritis (PsA) therapeutic strategies, supporting treatment decisions with a domain-based approach.METHODS: This narrative review of treatment strategies for PsA focused on several disease domains (ie, peripheral arthritis, enthesitis, axial disease, dactylitis, skin and nail disease), as well as the so-called "related conditions" of uveitis, Crohn's disease, and ulcerative colitis. We searched PubMed, EMBASE, international gui...
Source: Clinical Therapeutics - July 16, 2023 Category: Drugs & Pharmacology Authors: G Ayan A Ribeiro Betul Macit Fabian Proft Source Type: research
Abatacept as Monotherapy and in Combination with Methotrexate in Patients with Juvenile Idiopathic Arthritis: Analysis of 2 Phase III Trials
CONCLUSION: Abatacept monotherapy (SC and IV) was effective and well tolerated in children with pcJIA when prior MTX use was ineffective or not tolerated. Treatment effects of abatacept appear to be independent of MTX co-administration. Consequently, abatacept monotherapy can be considered for those with prior biologic therapy if MTX use is inappropriate.PMID:37453737 | DOI:10.3899/jrheum.2022-1320
Source: J Rheumatol - July 15, 2023 Category: Rheumatology Authors: Nicolino Ruperto Daniel J Lovell Alberto Berman Jordi Anton Diego Oscar Viola Bernard Lauwerys Maria Elena Rama John Bohnsack Johannes Breedt Michel Fischbach Thomas Lutz Kirsten Minden Mahmood Ally Nadina Rubio-P érez Elisabeth Gervais Riana Van Zyl Rob Source Type: research
