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Drug: Methotrexate
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Total 4930 results found since Jan 2013.
A high-throughput UPLC-MS/MS method for the determination of eight anti-tumor drugs in plasma
CONCLUSION: This validated approach was shown to be reliable and effective in clinical management, being a valuable support in therapeutic drug monitoring and subsequent individualized dosing optimization.PMID:37429484 | DOI:10.1016/j.ab.2023.115230
Source: Analytical Biochemistry - July 10, 2023 Category: Biochemistry Authors: Yao Liu Zhichao He Heng Liang Minzhen Han Jinxingyi Wang Qian Liu Yanping Guan Source Type: research
Leveraging decagonal in-silico strategies for uncovering IL-6 inhibitors with precision
Comput Biol Med. 2023 Jul 3;163:107231. doi: 10.1016/j.compbiomed.2023.107231. Online ahead of print.ABSTRACTInterleukin-6 upregulation leads to various acute phase reactions such as local inflammation and systemic inflammation in many diseases like cancer, multiple sclerosis, rheumatoid arthritis, anemia, and Alzheimer's disease stimulating JAK/STAT3, Ras/MAPK, PI3K-PKB/Akt pathogenic pathways. Since no small molecules are available in the market against IL-6 till now, we have designed a class of small bioactive 1,3 - indanedione (IDC) molecules for inhibiting IL-6 using a decagonal approach computational studies. The IL-...
Source: Molecular Medicine - July 8, 2023 Category: Molecular Biology Authors: Akey Krishna Swaroop P K Krishnan Namboori M Esakkimuthukumar T K Praveen Palathoti Nagarjuna Sunil Kumar Patnaik Jubie Selvaraj Source Type: research
Determination of methotrexate in plasma and environmental samples using an electrochemical sensor modified by UiO66-NH < sub > 2 < /sub > /mesoporous carbon nitride composite and synergistic signal amplification with decorated AuNPs
In this study, UiO66-NH2/mesoporous carbon nitride (M - C3N4) composite provides a porous structure for decorated Au nanoparticles (AuNPs) to prepare a potent modifier for carbon paste electrode (CPE). Due to environmental toxicity of methotrexate, its sensitive, fast and, low-cost determination in workplace environments is of great interest. So, the modified CPE was applied as a sensitivity analysis approach for methotrexate in plasma samples. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used as techniques to optimize the analysis and measurement of methotrexate. To measure this drug, several effe...
Source: Chemosphere - July 7, 2023 Category: Chemistry Authors: Amirabbas Mir Mehdi Shabani-Nooshabadi Neda Ziaie Source Type: research
Compared efficacy of rituximab, abatacept, and tocilizumab in patients with rheumatoid arthritis refractory to methotrexate or TNF inhibitors agents: a systematic review and network meta-analysis
CONCLUSION: We found high heterogeneity among studies comparing rituximab, abatacept, and tocilizumab. On multivariate metaregressions, if the conditions of the RCTs were similar, we estimate that abatacept could increase the chance of reaching an ACR70 response by 2.2-fold compared to tocilizumab.PMID:37415193 | DOI:10.1186/s42358-023-00298-z
Source: Adv Data - July 6, 2023 Category: Epidemiology Authors: Alisson Pugliesi Amanda Borges de Oliveira Ana Beatrice Oliveira Ricardo Xavier Licia Maria Henrique da Mota Manoel Barros Bertolo Miguel Angel Gonzalez-Gay Gustavo Citera Luiz Sergio Fernandes de Carvalho Source Type: research
ASAP Synthesis of Methotrexate-Loaded Dumbbell-Shaped Titanium Dioxide/Gold Nanorods Coated with Mesoporous Silica and Decorated with Upconversion Nanoparticles for Near-Infrared-Driven Trimodal Cancer Treatment
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.3c04300
Source: ACS Applied Materials and Interfaces - July 5, 2023 Category: Materials Science Authors: Pranjyan Dash, Senthilkumar Thirumurugan, Ching-Li Tseng, Yu-Chien Lin, Sung-Lung Chen, Udesh Dhawan, and Ren-Jei Chung Source Type: research
Takayasu Arteritis: A Difficult Diagnosis in a Patient With an Extensive Cardiovascular History
We present a case of a 57-year-old male with a history of extensive cardiovascular disease, initially attributed to atherosclerosis, resulting in several interventions, such as catheterization and major cardiac surgery, which didn't help improve his symptoms. Further evaluation revealed diffuse wall thickening of the aorta and its roots, as well as labs that suggested elevated inflammatory markers, comprehensive review of his chart and previous admissions, revealed that he had a well-documented aortitis for which he underwent a biopsy, which at the time was unrevealing. Furthermore, as he had significant aortic aneurysmal ...
Source: Atherosclerosis - July 3, 2023 Category: Cardiology Authors: Carlos Pe ña Niketa Kalara Pallavi Vellagapudi Fernando Poli Source Type: research
Methotrexate degradation in artificial wastewater using non-thermal pencil plasma jet
Environ Sci Pollut Res Int. 2023 Jul 3. doi: 10.1007/s11356-023-28502-z. Online ahead of print.ABSTRACTThe rising global cancer rate is driving up the consumption of anticancer drugs. This causing a noticeable increase in the levels of these drugs in wastewater. The drugs are not metabolized effectively by the human body, leading to their presence in human waste, as well as in the effluent from hospitals and drug manufacturing industries. Methotrexate is a commonly used drug for treating various types of cancer. Its complex organic structure makes it difficult to degrade using conventional methods. The present work propose...
Source: Environmental Science and Pollution Research International - July 3, 2023 Category: Environmental Health Authors: Vikas Rathore Shruti Patel Akanksha Pandey Jignasa Savjani Shital Butani Heman Dave Sudhir Kumar Nema Source Type: research
Immunosuppressive nanoparticles containing recombinant PD-L1 and methotrexate alleviate multi-organ inflammation
In this study, recombinant murine PD-L1 (rmPD-L1) was used for controlling T cell immunity to treat multi-organ inflammation. To enhance the immunosuppressive effect, we incorporated methotrexate, an anti-inflammatory drug, into hybrid nanoparticles (HNPs) and decorated the surface of HNPs with rmPD-L1 to produce immunosuppressive HNPs (IsHNPs). IsHNP treatment effectively targeted PD-1-expressing CD4 and CD8 T cells in the splenocytes; additionally, it promoted the production of Foxp3-expressing regulatory T cells, which suppressed the differentiation of helper T cells. IsHNP treatment also inhibited anti-CD3 antibody-med...
Source: Biomaterials - July 2, 2023 Category: Materials Science Authors: Eun-Koung An Wei Zhang Hae-Bin Park So-Jung Kim Hee-Yun Eom Juyoung Hwang Minseok Kwak Ji Yeon Lee Peter Chang-Whan Lee Jun-O Jin Source Type: research
