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Polymyalgia rheumatica-A challenge in geriatrics : Interdisciplinary presentation of diagnostics and treatment
Z Gerontol Geriatr. 2023 Jul 31. doi: 10.1007/s00391-023-02211-1. Online ahead of print.ABSTRACTPolymyalgia rheumatica is the second most frequent inflammatory rheumatic disease in people aged over 50 years, after rheumatoid arthritis. It is characterized by pain and morning stiffness in the region of the shoulders, hip girdle and neck. It can be associated with giant cell arteritis (CGA). Treatment with glucocorticoids is indispensable. The duration of treatment varies and often exceeds 1 year. The additive administration of methotrexate is an option for saving glucocorticoids. The biologicals tocilizumab or secukinumab a...
Source: Zeitschrift fur Gerontologie und Geriatrie - July 31, 2023 Category: Geriatrics Authors: W Hofmann I K ötter S Winterhalter S Krupp Source Type: research
Nail Psoriasis: An Updated Review of Currently Available Systemic Treatments
CONCLUSION: Several therapies have demonstrated efficacy and safety in the treatment of NP; however, the choice of treatment depends not only on the severity of the nail involvement, but also on whether PsA is present, the patient's comorbidities other than PsA, previous treatment history, and the patient's drug preferences.PMID:37519941 | PMC:PMC10378542 | DOI:10.2147/CCID.S417679
Source: Clinical, Cosmetic and Investigational Dermatology - July 31, 2023 Category: Dermatology Authors: Teresa Battista Massimiliano Scalvenzi Fabrizio Martora Luca Potestio Matteo Megna Source Type: research
Polymyalgia rheumatica-A challenge in geriatrics : Interdisciplinary presentation of diagnostics and treatment
Z Gerontol Geriatr. 2023 Jul 31. doi: 10.1007/s00391-023-02211-1. Online ahead of print.ABSTRACTPolymyalgia rheumatica is the second most frequent inflammatory rheumatic disease in people aged over 50 years, after rheumatoid arthritis. It is characterized by pain and morning stiffness in the region of the shoulders, hip girdle and neck. It can be associated with giant cell arteritis (CGA). Treatment with glucocorticoids is indispensable. The duration of treatment varies and often exceeds 1 year. The additive administration of methotrexate is an option for saving glucocorticoids. The biologicals tocilizumab or secukinumab a...
Source: Zeitschrift fur Gerontologie und Geriatrie - July 31, 2023 Category: Geriatrics Authors: W Hofmann I K ötter S Winterhalter S Krupp Source Type: research
Nail Psoriasis: An Updated Review of Currently Available Systemic Treatments
CONCLUSION: Several therapies have demonstrated efficacy and safety in the treatment of NP; however, the choice of treatment depends not only on the severity of the nail involvement, but also on whether PsA is present, the patient's comorbidities other than PsA, previous treatment history, and the patient's drug preferences.PMID:37519941 | PMC:PMC10378542 | DOI:10.2147/CCID.S417679
Source: Clinical, Cosmetic and Investigational Dermatology - July 31, 2023 Category: Dermatology Authors: Teresa Battista Massimiliano Scalvenzi Fabrizio Martora Luca Potestio Matteo Megna Source Type: research
Polymyalgia rheumatica-A challenge in geriatrics : Interdisciplinary presentation of diagnostics and treatment
Z Gerontol Geriatr. 2023 Jul 31. doi: 10.1007/s00391-023-02211-1. Online ahead of print.ABSTRACTPolymyalgia rheumatica is the second most frequent inflammatory rheumatic disease in people aged over 50 years, after rheumatoid arthritis. It is characterized by pain and morning stiffness in the region of the shoulders, hip girdle and neck. It can be associated with giant cell arteritis (CGA). Treatment with glucocorticoids is indispensable. The duration of treatment varies and often exceeds 1 year. The additive administration of methotrexate is an option for saving glucocorticoids. The biologicals tocilizumab or secukinumab a...
Source: Zeitschrift fur Gerontologie und Geriatrie - July 31, 2023 Category: Geriatrics Authors: W Hofmann I K ötter S Winterhalter S Krupp Source Type: research
Inflammation and immunomodulatory therapies influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid arthritis
CONCLUSION: ABCA1-CEC associated with decreased atherosclerosis in patients with below-median baseline and time-averaged CRP and bDMARD use. Conversely, ABCA1-CEC associated with increased plaque in those with higher CRP, corticosteroid users, methotrexate nonusers, and bDMARD nonusers. While in well-treated and controlled disease ABCA1-CEC appears atheroprotective, in uncontrolled RA its action may be masked or fail to counteract the inflammation-driven proatherogenic state.PMID:37520890 | PMC:PMC10371792 | DOI:10.1016/j.jtauto.2023.100209
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: George A Karpouzas Bianca Papotti Sarah R Ormseth Marcella Palumbo Elizabeth Hernandez Maria Pia Adorni Francesca Zimetti Matthew J Budoff Nicoletta Ronda Source Type: research
Polymyalgia rheumatica-A challenge in geriatrics : Interdisciplinary presentation of diagnostics and treatment
Z Gerontol Geriatr. 2023 Aug;56(5):415-425. doi: 10.1007/s00391-023-02211-1. Epub 2023 Jul 31.ABSTRACTPolymyalgia rheumatica is the second most frequent inflammatory rheumatic disease in people aged over 50 years, after rheumatoid arthritis. It is characterized by pain and morning stiffness in the region of the shoulders, hip girdle and neck. It can be associated with giant cell arteritis (CGA). Treatment with glucocorticoids is indispensable. The duration of treatment varies and often exceeds 1 year. The additive administration of methotrexate is an option for saving glucocorticoids. The biologicals tocilizumab or secukin...
Source: Zeitschrift fur Gerontologie und Geriatrie - July 31, 2023 Category: Geriatrics Authors: W Hofmann I K ötter S Winterhalter S Krupp Source Type: research
Comparison of preventive and therapeutic effects of continuous exercise on acute lung injury induced with methotrexate
Exp Physiol. 2023 Jul 27. doi: 10.1113/EP091162. Online ahead of print.ABSTRACTMethotrexate (Mtx) is used to treat various diseases, including cancer, arthritis and other rheumatic diseases. However, it induces oxidative stress and pulmonary inflammation by stimulating production of reactive oxygen species and cytokines. Considering the positive effects of physical activity, our goal was to investigate the preventive and therapeutic role of continuous training (CT) on Mtx-induced lung injury in rats. The rats were divided into five groups of 14 animals: a control group (C); a continuous exercise training group (CT; healthy...
Source: Cancer Control - July 27, 2023 Category: Cancer & Oncology Authors: Mohammad-Amin Rajizadeh Mahdiyeh Haj Hosseini Mina Bahrami Najmeh Sadat Hosseini Fahimeh Rostamabadi Fatemeh Bagheri Kayvan Khoramipour Hamid Najafipour Mohammad-Abbas Bejeshk Source Type: research
Sinomenine ameliorates collagen-induced arthritis in mice by targeting GBP5 and regulating the P2X7 receptor to suppress NLRP3-related signaling pathways
This study illustrates a novel anti-inflammatory mechanism of SIN; SIN suppresses the activity of NLRP3-related pathways by competitively binding GBP5 and downregulating P2X7R protein expression, which ultimately contributes to the reduction of IL-1β and IL-18 production. The binding specificity of SIN to GBP5 and its inhibitory effect on GBP5 activity suggest that SIN has great potential as a specific GBP5 antagonist.PMID:37482570 | DOI:10.1038/s41401-023-01124-4
Source: Acta Pharmacologica Sinica - July 23, 2023 Category: Drugs & Pharmacology Authors: Juan-Min Li Hai-Shan Deng Yun-da Yao Wei-Ting Wang Jia-Qin Hu Yan Dong Pei-Xun Wang Liang Liu Zhong-Qiu Liu Ying Xie Lin-Lin Lu Hua Zhou Source Type: research
Substitution of calcineurin inhibitors with corticosteroids after allogeneic hematopoietic cell transplantation
In conclusion, CIs were switched to corticosteroids in patients with severe clinical conditions. The incidence of acute GVHD was acceptable. Although the short-term mortality rate was high, improvement of renal function or fluid overload was observed in a certain proportion of the patients.PMID:37480446 | DOI:10.1007/s12185-023-03645-4
Source: International Journal of Hematology - July 22, 2023 Category: Hematology Authors: Shimpei Matsumi Shun-Ichi Kimura Yuhei Nakamura Masakatsu Kawamura Junko Takeshita Shunto Kawamura Nozomu Yoshino Yukiko Misaki Kazuki Yoshimura Ayumi Gomyo Yosuke Okada Yu Akahoshi Masaharu Tamaki Machiko Kusuda Kazuaki Kameda Hidenori Wada Aki Tanihara Source Type: research
Diagnostic and therapeutic practices in adult chronic nonbacterial osteomyelitis (CNO)
CONCLUSIONS: Following from our survey data, adult CNO is a broad and insufficiently characterized disease spectrum, including extra-osseous features. MRI is the favoured imaging diagnostic, and management strategies vary significantly. Overall, pamidronate and anti-TNFα are regarded most successful. The results lay out current practices for adult CNO, which may serve as backbone for a future consensus clinical guideline.PMID:37480122 | PMC:PMC10362746 | DOI:10.1186/s13023-023-02831-1
Source: Pain Physician - July 21, 2023 Category: Anesthesiology Authors: A T Leerling G Clunie E Koutrouba O M Dekkers N M Appelman-Dijkstra E M Winter Source Type: research
Preclinical Demonstration of a Novel Treatment with High Efficacy and No Detectable Toxicity for Inflammatory Skin Conditions including Psoriasis
Biomed Res Int. 2023 Jul 11;2023:4878774. doi: 10.1155/2023/4878774. eCollection 2023.ABSTRACTAlthough the management options for psoriasis have progressed with the use of systemic agents, there are few efficacious nonsteroidal topical therapies for patients with limited or lower grade disease. The effects of allopurinol (Allo) and glutathione (GSH) were examined in two different in vitro models for psoriasis. In the first model, human immortalized keratinocytes (HaCaT) were treated with M5 cocktail (IL-17A, IL-22, oncostatin M, IL-1α, and TNF-α) in four interventional groups (control, Allo, oxypurinol (Oxy), and methotr...
Source: Cell Research - July 20, 2023 Category: Cytology Authors: John P Vanden Heuvel Shuling Zhou Anisha B Patel Harry N Kamerow Peter Baran John P Ford Source Type: research
