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Drug: Methotrexate
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Total 4930 results found since Jan 2013.
Immunosuppressive nanoparticles containing recombinant PD-L1 and methotrexate alleviate multi-organ inflammation
In this study, recombinant murine PD-L1 (rmPD-L1) was used for controlling T cell immunity to treat multi-organ inflammation. To enhance the immunosuppressive effect, we incorporated methotrexate, an anti-inflammatory drug, into hybrid nanoparticles (HNPs) and decorated the surface of HNPs with rmPD-L1 to produce immunosuppressive HNPs (IsHNPs). IsHNP treatment effectively targeted PD-1-expressing CD4 and CD8 T cells in the splenocytes; additionally, it promoted the production of Foxp3-expressing regulatory T cells, which suppressed the differentiation of helper T cells. IsHNP treatment also inhibited anti-CD3 antibody-med...
Source: Biomaterials - July 2, 2023 Category: Materials Science Authors: Eun-Koung An Wei Zhang Hae-Bin Park So-Jung Kim Hee-Yun Eom Juyoung Hwang Minseok Kwak Ji Yeon Lee Peter Chang-Whan Lee Jun-O Jin Source Type: research
Treatment of new-onset primary central nervous system lymphoma in elderly patients using RMPV chemotherapy: a single-institution experience
Int J Hematol. 2023 Jul 1. doi: 10.1007/s12185-023-03632-9. Online ahead of print.ABSTRACTThe prognosis of primary central nervous system lymphoma (PCNSL) in the elderly remains poor. We aimed to evaluate the outcome of rituximab, methotrexate, procarbazine, and vincristine (RMPV) chemotherapy in elderly patients with new-onset PCNSL. Twenty-eight patients aged ≥ 70 years treated for PCNSL between 2010 and 2020 were examined retrospectively. Nineteen patients received RMPV and nine did not qualify. Patients received five to seven cycles of RMPV plus response-adapted whole-brain radiotherapy (WBRT) and cytarabine. Ten of ...
Source: International Journal of Hematology - July 1, 2023 Category: Hematology Authors: Michiharu Yoshida Takeharu Kato Takeshi Hiu Yoshitaka Imaizumi Simpei Morimoto Daisuke Niino Susumu Yamaguchi Shiro Baba Kenta Ujifuku Koichi Yoshida Ayaka Matsuo Yoichi Morofuji Tsuyoshi Izumo Shinji Okano Yasushi Miyazaki Takayuki Matsuo Source Type: research
Juvenile Dermatomyositis and Infantile Cerebral Palsy: Aicardi-Gouteres Syndrome, Type 5, with a Novel Mutation in SAMHD1-A Case Report
CONCLUSIONS: Early diagnosis of AGS is highly important as it allows starting treatment in a timely manner. Timely treatment, in return, can help avoid the development/progression of end-organ damage, including severe neurological complications and early death. It is necessary to spread information about AGS among neurologists, neonatologists, infectious disease specialists, and pediatricians. A multidisciplinary team approach is required.PMID:37371788 | DOI:10.3390/biomedicines11061693
Source: Herpes - June 28, 2023 Category: Infectious Diseases Authors: Lubov S Sorokina Rinat K Raupov Mikhail M Kostik Source Type: research
Humoral SARS-CoV-2 vaccine responses in patients with giant cell arteritis and polymyalgia rheumatica: decay after primary vaccination and effects of the booster
CONCLUSION: These results indicate that the decay of humoral immunity after primary vaccination is associated with prednisolone treatment, whereas the subsequent increase after booster vaccination, was not. Patients with low antibody concentrations following primary vaccination remained at an immunogenic disadvantage after a single booster vaccination. This longitudinal study in GCA/PMR patients stresses the importance of repeated booster vaccination for patients with poor responses to primary vaccination. This article is protected by copyright. All rights reserved.PMID:37332051 | DOI:10.1002/acr.25173
Source: Cell Research - June 18, 2023 Category: Cytology Authors: Yannick van Sleen Kornelis Sm van der Geest Anne-Marie Buisman Maria Sandovici Debbie van Baarle Elisabeth Brouwer Source Type: research
Aceclofenac and methotrexate combination therapy could influence Th1/Th17 axis to modulate rheumatoid-arthritis-induced inflammation
In conclusion, we propose the study of the immunological signaling pathways in experimental humanized RA mice.PMID:37330038 | DOI:10.1016/j.drudis.2023.103671
Source: Drug Discovery Today - June 17, 2023 Category: Drugs & Pharmacology Authors: Sushmita Negi Nikunj Tandel Prakriti Sharma Rajinder Kumar Rajeev K Tyagi Source Type: research
Efficacy analysis of single-agent carboplatin AUC4 2-weekly as second-line therapy for methotrexate-resistant (MTX-R) low risk gestational trophoblastic neoplasia (GTN)
CONCLUSION: Carboplatin is not sufficiently active in the second-line treatment of low-risk MTX-resistant GTN. New strategies are required to increase hCG CR and spare more toxic CC regimens.PMID:37327541 | DOI:10.1016/j.ygyno.2023.05.072
Source: Gynecologic Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Matthew C Winter John A Tidy Kam Singh Naveed Sarwar Xianne Aguiar Michael J Seckl Source Type: research
Cigarette smoking is associated with decreased long-term treatment cessation of mycophenolate mofetil and methotrexate in cutaneous lupus erythematosus
Lupus. 2023 Jun 16:9612033231183500. doi: 10.1177/09612033231183500. Online ahead of print.NO ABSTRACTPMID:37328162 | DOI:10.1177/09612033231183500
Source: Lupus - June 16, 2023 Category: Rheumatology Authors: Henry W Chen Grant Sprow Rui Feng Victoria P Werth Benjamin F Chong Source Type: research
