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Drug: Tetracycline
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Total 6239 results found since Jan 2013.
Clinical Effectiveness of Tetracycline-Class Agents Based Regimens in Patients With Carbapenem-Resistant < em > Acinetobacter baumannii < /em > Bacteremia: A Single-Center Retrospective Cohort Study
This study evaluated the clinical outcome of carbapenem-resistant Acinetobacter baumannii (CRAB) bacteremia and the clinical effectiveness of tetracyclines-based therapy. In a retrospective cohort study over 5 years period, 108 patients were included in the study. The overall 30-day mortality rate was 71.4%. Pitt's bacteremia score (PBS) (adjusted hazard ratio [aHR], 1.32; 95% confidence interval [CI], 1.22-1.42 per 1-point), colistin-single regimens (aHR, 0.34; 95% CI, 0.17-0.69), and tetracyclines single/tetracyclines-colistin combination regimens (aHR, 0.18; 95% CI, 0.07-0.48) were independently associated with 30-day m...
Source: J Korean Med Sci - August 30, 2023 Category: General Medicine Authors: Si-Ho Kim Yu Mi Wi Kyong Ran Peck Source Type: research
Preparation of sludge-based biochar loaded with ferromanganese and its removal mechanism of tetracycline hydrochloride
Environ Sci Pollut Res Int. 2023 Aug 30. doi: 10.1007/s11356-023-29558-7. Online ahead of print.ABSTRACTTo remove the serious contamination caused by tetracycline hydrochloride, this paper uses the method of impregnation followed by pyrolysis to prepare ferromanganese-loaded sludge-based biochar and investigate its effectiveness in removing tetracycline hydrochloride. The material was characterized by field emission SEM, FTIR, and X-ray diffraction analysis. The possible reaction mechanisms involved in the removal of tetracycline were deduced based on the determination of Mn2+ during the reaction process and XPS characteri...
Source: Environmental Science and Pollution Research International - August 30, 2023 Category: Environmental Health Authors: Li Hua Lumengfei Yu Fanglin Dang Hui Zhao Ting Wei Source Type: research
Clinical Effectiveness of Tetracycline-Class Agents Based Regimens in Patients With Carbapenem-Resistant < em > Acinetobacter baumannii < /em > Bacteremia: A Single-Center Retrospective Cohort Study
This study evaluated the clinical outcome of carbapenem-resistant Acinetobacter baumannii (CRAB) bacteremia and the clinical effectiveness of tetracyclines-based therapy. In a retrospective cohort study over 5 years period, 108 patients were included in the study. The overall 30-day mortality rate was 71.4%. Pitt's bacteremia score (PBS) (adjusted hazard ratio [aHR], 1.32; 95% confidence interval [CI], 1.22-1.42 per 1-point), colistin-single regimens (aHR, 0.34; 95% CI, 0.17-0.69), and tetracyclines single/tetracyclines-colistin combination regimens (aHR, 0.18; 95% CI, 0.07-0.48) were independently associated with 30-day m...
Source: J Korean Med Sci - August 30, 2023 Category: General Medicine Authors: Si-Ho Kim Yu Mi Wi Kyong Ran Peck Source Type: research
The molecular epidemiology and antimicrobial resistance of < i > Staphylococcus pseudintermedius < /i > canine clinical isolates submitted to a veterinary diagnostic laboratory in South Africa
by Lufuno Phophi, Mohamed Abouelkhair, Rebekah Jones, Maryke Henton, Daniel N. Qekwana, Stephen A. KaniaStaphylococcus pseudintermedius is an important cause of clinical infections in small-animal-veterinary medicine. Evolutionary changes of strains using multilocus sequence typing (MLST) have been observed amongS.pseudintermedius in European countries and the United States. However, there are limited or no studies on the detection of methicillin resistantStaphylococcus pseudintermedius (MRSP) and predominating MLST strains in South Africa. Therefore, this study aimed to determine the molecular epidemiology ofS.pseudinterm...
Source: PLoS One - August 30, 2023 Category: Biomedical Science Authors: Lufuno Phophi Source Type: research
Clinical and histological features and treatment outcomes of patients with Morbihan disease: a systematic review
AbstractMorbihan disease (MD) is considered a rare complication of rosacea, which is difficult to diagnose and challenging to treat. Here, we performed a systematic review of available case reports and case series to summarize key clinical and pathologic features of and successful treatment regimens for MD. We conducted a search of the PubMed/MEDLINE, EMBASE, and Cochrane electronic databases from their inception to the date of search on March 6, 2023. We found that MD affects patients in the fifth decade of life on average, more commonly reported in male than female (69% vs 31%). Clinically, MD affects the eyelids, cheeks...
Source: Archives of Dermatological Research - August 28, 2023 Category: Dermatology Source Type: research
TET-Yeasate: An engineered yeast whole-cell lysate-based approach for high performance tetracycline degradation
Environ Int. 2023 Aug 17;179:108158. doi: 10.1016/j.envint.2023.108158. Online ahead of print.ABSTRACTThe widespread of tetracycline (TC) residues in anthropogenic and natural environments pose an immediate threat to public health. Herein, we established the TET-Yeasate, an approach based on whole-cell lysate of engineered yeast, to mitigate the TC contamination in environment. The TET-Yeasate is defined as the biological matrix of whole cell lysate from engineered yeast that containing TC-degradative components (Tet(X), NADPH, Mg2+) and protective macromolecules. The TET-Yeasate was able to efficiently eliminate TC residu...
Source: Environment International - August 27, 2023 Category: Environmental Health Authors: Qian He Zhuoyu Lin Meilin Qin Yu Huang Zhaoxiang Lu Mei Zheng Chaoyue Cui Cang Li Xiaojing Zhang Xiaoping Liao Yahong Liu Hao Ren Jian Sun Source Type: research
Identification of Drug Targets and Their Inhibitors in < em > Yersinia pestis < /em > Strain 91001 through Subtractive Genomics, Machine Learning, and MD Simulation Approaches
In this study, k-nearest neighbor (kNN) and support vector machine (SVM) were used to predict the active hits against the beta-ketoacyl-ACP synthase III drug target predicted by the subtractive genomics approach. Among the 1012 compounds of the South African Natural Products database, 11 hits were predicted as active. Further, the active hits were docked against the active site of beta-ketoacyl-ACP synthase III. Out of the total 11 active hits, the 3 lowest docking score hits that showed strong interaction with the drug target were shortlisted along with the standard drug and were simulated for 100 ns. The MD simulation re...
Source: Genomics Proteomics ... - August 26, 2023 Category: Genetics & Stem Cells Authors: Hamid Ali Abdus Samad Amar Ajmal Amjad Ali Ijaz Ali Muhammad Danial Masroor Kamal Midrar Ullah Riaz Ullah Muhammad Kalim Source Type: research
The Impact of Rapid Drug Susceptibility Tests on Gonorrhea Burden and Lifespan of Antibiotic Treatments: A Modeling Study Among Men Who Have Sex With Men in the United States
Am J Epidemiol. 2023 Aug 24:kwad175. doi: 10.1093/aje/kwad175. Online ahead of print.ABSTRACTRapid point-of-care tests that diagnose gonococcal infections and identify susceptibility to antibiotics enable individualized treatment. This could improve patient outcomes and slow the emergence and spread of resistance. However, little is known about the long-term impact of such diagnostics on the burden of gonorrhea and the effective lifespan of antibiotics. We used a mathematical model of gonorrhea transmission among men who have sex with men in the US to project the annual rate of reported gonorrhea cases and the effective li...
Source: Am J Epidemiol - August 25, 2023 Category: Epidemiology Authors: Reza Yaesoubi Qin Xi Katherine Hsu Thomas L Gift Sancta B St Cyr Minttu M R önn Joshua A Salomon Yonatan H Grad Source Type: research
