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Infectious Disease: Gastroenteritis
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Total 38826 results found since Jan 2013.
Dissemination of IncI plasmid encoding < em > bla < /em > < sub > CTX-M-1 < /sub > is not hampered by its fitness cost in the pig's gut
Antimicrob Agents Chemother. 2023 Sep 13:e0011123. doi: 10.1128/aac.00111-23. Online ahead of print.ABSTRACTMultiresistance plasmids belonging to the IncI incompatibility group have become one of the most pervasive plasmid types in extended-spectrum beta-lactamase-producing Escherichia coli of animal origin. The extent of the burden imposed on the bacterial cell by these plasmids seems to modulate the emergence of "epidemic" plasmids. However, in vivo data in the natural environment of the strains are scarce. Here, we investigated the cost of a blaCTX-M-1-IncI1 epidemic plasmid in a commensal E. coli animal strain, UB12-RC...
Source: Antimicrobial Agents and Chemotherapy - September 13, 2023 Category: Microbiology Authors: Margaux Allain Anne Claire Mah érault Benoit Gachet Caroline Martinez B énédicte Condamine M élanie Magnan Isabelle Kempf Erick Denamur Luce Landraud Source Type: research
Effectiveness of cefmetazole versus meropenem for invasive urinary tract infections caused by extended-spectrum β-lactamase-producing < em > Escherichia coli < /em >
Antimicrob Agents Chemother. 2023 Sep 13:e0051023. doi: 10.1128/aac.00510-23. Online ahead of print.ABSTRACTCefmetazole is active against extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC) and is a potential candidate for carbapenem-sparing therapy. This multicenter, observational study included patients hospitalized for invasive urinary tract infection due to ESBLEC between March 2020 and November 2021 at 10 facilities in Japan, for whom either cefmetazole or meropenem was initiated as a definitive therapy within 96 h of culture collection and continued for at least 3 d. Outcomes included clinical and micr...
Source: Antimicrobial Agents and Chemotherapy - September 13, 2023 Category: Microbiology Authors: Kayoko Hayakawa Yasufumi Matsumura Kohei Uemura Shinya Tsuzuki Aki Sakurai Ryutaro Tanizaki Koh Shinohara Takehiro Hashimoto Ryota Hase Takashi Matono Hideaki Kato Momoko Mawatari Hiroshi Hara Yukihiro Hamada Sho Saito Norio Ohmagari Yohei Doi Source Type: research
Preparation of silver nanoparticles by Osbeckia stellata aqueous extract via green synthesis approach: Characterization and assessment of their antioxidant, antidiabetic, cytotoxicity, and antibacterial properties
This study showed the spherical shape and crystalline nature of NPs. Zeta potential was used to determine the stability of Ag NPs. Biosynthesized Ag NPs showed significantly potent antioxidant, antidiabetic, and cytotoxicity activity. Ag NPs also showed effectiveness against gram-positive (Escherichia coli) and gram-negative (Staphylococcus aureus) bacteria in the antimicrobial activity study. The result concluded that these Ag NPs might be used in biomedical and pharmacological fields.
Source: Biotechnology and Applied Biochemistry - September 13, 2023 Category: Biochemistry Authors: Tania Baishya,
Priya Das,
Gouhar Jahan Ashraf,
Tarun Kumar Dua,
Paramita Paul,
Gouranga Nandi,
Ankita Dutta,
Divya Limbu,
Anoop Kumar,
Manab Deb Adhikari,
Malay Bhattacharya,
Ranabir Sahu Tags: ORIGINAL ARTICLE Source Type: research
Metronidazole-Loaded Camphor-Based In Situ Forming Matrix for Periodontitis Treatment
AAPS PharmSciTech. 2023 Sep 12;24(7):185. doi: 10.1208/s12249-023-02640-6.ABSTRACTPeriodontitis is a widespread oral health problem caused by bacterial infections that lead to tooth loss and other systemic diseases. The aim of this study was to provide an alternative treatment for periodontitis by developing a metronidazole-loaded in situ forming matrix (ISM) using camphor as its matrix former. Five-percent w/w metronidazole dissolved in N-methyl pyrrolidone (NMP) with varying concentrations of camphor (30-50% w/w) and triacetin (0-25% w/w) were used. The physicochemical properties and antimicrobial activities of formulati...
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Kritamorn Jitrangsri Nutdanai Lertsuphotvanit Ngamsil Kabthong Thawatchai Phaechamud Source Type: research
Phosphatase A1 accessory protein PlaS from Serratia marcescens controls cell membrane permeability, fluidity, hydrophobicity, and fatty acid composition in Escherichia coli BL21
Int J Biol Macromol. 2023 Sep 10:126776. doi: 10.1016/j.ijbiomac.2023.126776. Online ahead of print.ABSTRACTPhospholipase A1 (PlaA) plays a pivotal role in diverse applications within the food and biochemical medical industries. Herein, we investigate the impact of the accessory protein encoded by plaS from Serratia marcescens on PlaA activity in Escherichia coli. Notably, PlaS demonstrates the ability to enhance PlaA activity while concurrently exhibiting inhibitory effects on the growth of E. coli BL21 (DE3). Our study revolves around probing the inhibitory action of PlaS on E. coli BL21 (DE3). PlaS exhibits a propensity...
Source: International Journal of Biological Macromolecules - September 12, 2023 Category: Biochemistry Authors: Xiangfei Li Jie Zhou Rumeng Han Fei Yu Kun Liu Ming Zhao Yan Liu Zhenglian Xue Shiguang Zhao Source Type: research
Longitudinal analysis of differences and similarities in antimicrobial resistance among commensal Escherichia coli isolated from market swine and sows at slaughter in the United States of America, 2013-2019
Int J Food Microbiol. 2023 Sep 7;407:110388. doi: 10.1016/j.ijfoodmicro.2023.110388. Online ahead of print.ABSTRACTThe emergence of antimicrobial resistance in swine enteric bacteria poses a significant public health challenge. Our study evaluated publicly available data collected by the National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS) between 2013 and 2019 at slaughter plants across the United States of America, focusing on commensal E. coli isolated from swine cecal contents originating from two distinct swine production systems: market hogs (n = 2090) and sows (n = 1147). In both producti...
Source: International Journal of Food Microbiology - September 12, 2023 Category: Food Science Authors: Hamid Reza Sodagari Isha Agrawal Setyo Yudhanto Csaba Varga Source Type: research
Metronidazole-Loaded Camphor-Based In Situ Forming Matrix for Periodontitis Treatment
AAPS PharmSciTech. 2023 Sep 12;24(7):185. doi: 10.1208/s12249-023-02640-6.ABSTRACTPeriodontitis is a widespread oral health problem caused by bacterial infections that lead to tooth loss and other systemic diseases. The aim of this study was to provide an alternative treatment for periodontitis by developing a metronidazole-loaded in situ forming matrix (ISM) using camphor as its matrix former. Five-percent w/w metronidazole dissolved in N-methyl pyrrolidone (NMP) with varying concentrations of camphor (30-50% w/w) and triacetin (0-25% w/w) were used. The physicochemical properties and antimicrobial activities of formulati...
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Kritamorn Jitrangsri Nutdanai Lertsuphotvanit Ngamsil Kabthong Thawatchai Phaechamud Source Type: research
Characterization of bifunctional alginate lyase Aly644 and antimicrobial activity of enzymatic hydrolysates
Appl Microbiol Biotechnol. 2023 Sep 12. doi: 10.1007/s00253-023-12745-4. Online ahead of print.ABSTRACTAn alginate lyase gene aly644 encoding a member of polysaccharide lyase family 6 was obtained from a metagenome of Antarctic macroalgae-associated microbes. The gene was expressed heterologously in Escherichia coli, and the recombinant protein was purified using a Ni-NTA His Tag Kit. With sodium alginate as the substrate, recombinant Aly644 exhibited an optimum reaction temperature of 50°C and an optimum reaction pH of 7.0. The Vmax and Km values of Aly644 toward sodium alginate were 112.36 mg/mL·min and 16.75 mg/mL, re...
Source: Applied Microbiology and Biotechnology - September 12, 2023 Category: Microbiology Authors: Ao Zhang Zhe Cao Luying Zhao Qian Zhang Liping Fu Jiang Li Tao Liu Source Type: research
Longitudinal analysis of differences and similarities in antimicrobial resistance among commensal Escherichia coli isolated from market swine and sows at slaughter in the United States of America, 2013-2019
Int J Food Microbiol. 2023 Sep 7;407:110388. doi: 10.1016/j.ijfoodmicro.2023.110388. Online ahead of print.ABSTRACTThe emergence of antimicrobial resistance in swine enteric bacteria poses a significant public health challenge. Our study evaluated publicly available data collected by the National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS) between 2013 and 2019 at slaughter plants across the United States of America, focusing on commensal E. coli isolated from swine cecal contents originating from two distinct swine production systems: market hogs (n = 2090) and sows (n = 1147). In both producti...
Source: International Journal of Food Microbiology - September 12, 2023 Category: Food Science Authors: Hamid Reza Sodagari Isha Agrawal Setyo Yudhanto Csaba Varga Source Type: research
Metronidazole-Loaded Camphor-Based In Situ Forming Matrix for Periodontitis Treatment
AAPS PharmSciTech. 2023 Sep 12;24(7):185. doi: 10.1208/s12249-023-02640-6.ABSTRACTPeriodontitis is a widespread oral health problem caused by bacterial infections that lead to tooth loss and other systemic diseases. The aim of this study was to provide an alternative treatment for periodontitis by developing a metronidazole-loaded in situ forming matrix (ISM) using camphor as its matrix former. Five-percent w/w metronidazole dissolved in N-methyl pyrrolidone (NMP) with varying concentrations of camphor (30-50% w/w) and triacetin (0-25% w/w) were used. The physicochemical properties and antimicrobial activities of formulati...
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Kritamorn Jitrangsri Nutdanai Lertsuphotvanit Ngamsil Kabthong Thawatchai Phaechamud Source Type: research
Evaluation of the Potential Therapeutic Properties of Liquidambar orientalis Oil
In conclusion, the oil from the Sigla tree offers promising therapeutic potential and warrants further exploration.PMID:37699128 | DOI:10.1002/cbdv.202300291
Source: Chemistry and Biodiversity - September 12, 2023 Category: Biochemistry Authors: Mehmet Cengiz Baloglu Lutfiye Yildiz Ozer Buket Pirci Gokhan Zengin Abdullahi Ibrahim Uba Yasemin Celik Altunoglu Source Type: research
Decoding SEC24 Homolog D, COPII coat complex component accuracy as a signature gene in three human cancers
In this study, we conducted an extensive investigation of SEC24D, aiming to elucidate its potential role and underlying mechanisms across multiple human tumors. Our analysis relied on data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. To validate our findings, we employed RNA sequencing (RNA-seq), targeted bisulfite sequencing (bisulfite-seq) molecular techniques. Our findings revealed elevated mRNA (Messenger RNA) and protein levels of SEC24D in different tumor tissues. However, the up-regulation of SEC24D was significantly correlated with shorter overall survival (OS), metastasis, and v...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Weiwei Du Yang Sun Wentao Ji Tian Luo Dandan Zhang Weihong Guo Jianping Liang Yanhua Lv Mengwei Dong Kaixin Li Source Type: research
Mannan oligosaccharides selenium ameliorates intestinal mucosal barrier, and regulate intestinal microbiota to prevent Enterotoxigenic Escherichia coli -induced diarrhea in weaned piglets
In conclusion, our study showed that dietary MOSS supplementation ameliorated intestinal mucosa barrier, and regulated intestinal microbiota to prevent ETEC induced diarrhea in weaned piglets.PMID:37696080 | DOI:10.1016/j.ecoenv.2023.115448
Source: Ecotoxicology and Environmental Safety - September 11, 2023 Category: Environmental Health Authors: Andong Zha Ruiqi Tu Ming Qi Jing Wang Bie Tan Peng Liao Chenchen Wu Yulong Yin Source Type: research
