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< em > Salvia dumetorum < /em > essential oil: GC-MS analysis, antibacterial activity and effect on the formation of < em > Streptococcus mutans < /em > biofilms
In this study SDEO was screened for its antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Candida albicans and the amount of biofilm formed by Streptococcus mutans bacteria. For the first time the chemical composition of SDEO growing in Central Kazakhstan was established. The results obtained from GC-MS showed the predominance of sesquiterpenoids (54.15%). The antibacterial study results showed that SDEO exhibited strong antibacterial activity against B. subtilis and S. aureus in vitro and also demonstrated an inhibitory effect on S. mutans biofilm formation on 1% sucrose medium...
Source: Natural Product Research - September 11, 2023 Category: Biochemistry Authors: Yana К Levaya Gayane А Atazhanova Тomas Kacergius Svetlana А Ivasenko Alexandr B Marchenko Margarita Yu Ishmuratova Мarlen К Smagulov Source Type: research

Prevalence and Antimicrobial-Resistant Features of < em > Shigella < /em > Species in East Africa from 2015-2022: A Systematic Review and Meta-Analysis
CONCLUSION: The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.PMID:37692062 | PMC:PMC10492654 | DOI:10.1155/2023/8277976
Source: Interdisciplinary Perspectives on Infectious Diseases - September 11, 2023 Category: Infectious Diseases Authors: Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Source Type: research

Oral administration of a 2-aminopyrimidine robenidine analogue (NCL195) significantly reduces < em > Staphylococcus aureus < /em > infection and reduces < em > Escherichia coli < /em > infection in combination with sub-inhibitory colistin concentrations in a bioluminescent mouse model
In this study, we examined the efficacy of oral treatment with NCL195 (± low-dose colistin) in comparison to oral moxifloxacin in bioluminescent Staphylococcus aureus and Escherichia coli peritonitis-sepsis models. Four oral doses of 50 mg/kg NCL195, commencing immediately post-infection, were administered at 4 h intervals in the S. aureus peritonitis-sepsis model. We used a combination of four oral doses of 50 mg/kg NCL195 and four intraperitoneal doses of colistin at 0.125 mg/kg, 0.25 mg/kg, or 0.5 mg/kg in the E. coli peritonitis-sepsis model. Subsequently, the dose rates of four intraperitoneal doses of colistin were ...
Source: Antimicrobial Agents and Chemotherapy - September 11, 2023 Category: Microbiology Authors: Hang Thi Nguyen Henrietta Venter Lucy Woolford Kelly A Young Adam McCluskey Sanjay Garg Sylvia S Sapula Stephen W Page Abiodun David Ogunniyi Darren J Trott Source Type: research

Prevalence and Antimicrobial-Resistant Features of < em > Shigella < /em > Species in East Africa from 2015-2022: A Systematic Review and Meta-Analysis
CONCLUSION: The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.PMID:37692062 | PMC:PMC10492654 | DOI:10.1155/2023/8277976
Source: Interdisciplinary Perspectives on Infectious Diseases - September 11, 2023 Category: Infectious Diseases Authors: Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Source Type: research

Improving the Durability of Chitosan Films through Incorporation of Magnesium, Tungsten, and Graphene Oxides for Biomedical Applications
In this study, loaded with tungsten oxide (WO3), Magnesium oxide (MgO), and graphene oxide (GO) on chitosan (CS) membrane, an inexpensive polymer casting method was successfully prepared for wound healing applications. All fabricated composites were characterized by X-ray powder diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). A scanning electron microscope (SEM) was used to study the synthesized film samples' morphology as well as their microstructure. The formed WO3/MgO@CS shows a great enhancement in the UV-Vis analysis with a highly intense peak at 401 nm and a n...
Source: Chemistry and Biodiversity - September 11, 2023 Category: Biochemistry Authors: Fatimah Alaithan Mai M Khalaf Mohamed M Gouda T A Yousef Sayed H Kenawy Mortaga M Abou-Krisha Manal F Abou Taleb Saad Shaaban Abdullah M M Alkars Hany Abd El-Lateef Source Type: research

Green synthesis of silver nanoparticles from discarded shells of velvet tamarind (Dialium cochinchinense) and their antimicrobial synergistic potentials and biofilm inhibition properties
In this study, discarded shell of velvet tamarind fruit is explored as a potent reducing agent for biogenic synthesis of silver nanoparticles (VeV-AgNPs). Silver nanoparticles were formed in minutes under sunlight exposure, which was considerably fast compared to under ambient conditions. The optical, structural and morphological studies revealed that the nanoparticle colloidal solution consisted of particles with quasi-spherical and rodlike morphologies. To investigate antimicrobial properties, eight microorganisms were exposed to the VeV-AgNPs. The results indicated that VeV-AgNPs had enhanced antimicrobial activity, wit...
Source: Biometals - September 11, 2023 Category: Biochemistry Authors: Bright Ankudze David Neglo Francis Nsiah Source Type: research

Mannan oligosaccharides selenium ameliorates intestinal mucosal barrier, and regulate intestinal microbiota to prevent Enterotoxigenic Escherichia coli -induced diarrhea in weaned piglets
In conclusion, our study showed that dietary MOSS supplementation ameliorated intestinal mucosa barrier, and regulated intestinal microbiota to prevent ETEC induced diarrhea in weaned piglets.PMID:37696080 | DOI:10.1016/j.ecoenv.2023.115448
Source: Ecotoxicology and Environmental Safety - September 11, 2023 Category: Environmental Health Authors: Andong Zha Ruiqi Tu Ming Qi Jing Wang Bie Tan Peng Liao Chenchen Wu Yulong Yin Source Type: research

Oral administration of a 2-aminopyrimidine robenidine analogue (NCL195) significantly reduces < em > Staphylococcus aureus < /em > infection and reduces < em > Escherichia coli < /em > infection in combination with sub-inhibitory colistin concentrations in a bioluminescent mouse model
In this study, we examined the efficacy of oral treatment with NCL195 (± low-dose colistin) in comparison to oral moxifloxacin in bioluminescent Staphylococcus aureus and Escherichia coli peritonitis-sepsis models. Four oral doses of 50 mg/kg NCL195, commencing immediately post-infection, were administered at 4 h intervals in the S. aureus peritonitis-sepsis model. We used a combination of four oral doses of 50 mg/kg NCL195 and four intraperitoneal doses of colistin at 0.125 mg/kg, 0.25 mg/kg, or 0.5 mg/kg in the E. coli peritonitis-sepsis model. Subsequently, the dose rates of four intraperitoneal doses of colistin were ...
Source: Antimicrobial Agents and Chemotherapy - September 11, 2023 Category: Microbiology Authors: Hang Thi Nguyen Henrietta Venter Lucy Woolford Kelly A Young Adam McCluskey Sanjay Garg Sylvia S Sapula Stephen W Page Abiodun David Ogunniyi Darren J Trott Source Type: research

Prevalence and Antimicrobial-Resistant Features of < em > Shigella < /em > Species in East Africa from 2015-2022: A Systematic Review and Meta-Analysis
CONCLUSION: The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.PMID:37692062 | PMC:PMC10492654 | DOI:10.1155/2023/8277976
Source: Interdisciplinary Perspectives on Infectious Diseases - September 11, 2023 Category: Infectious Diseases Authors: Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Source Type: research

< em > Salvia dumetorum < /em > essential oil: GC-MS analysis, antibacterial activity and effect on the formation of < em > Streptococcus mutans < /em > biofilms
In this study SDEO was screened for its antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Candida albicans and the amount of biofilm formed by Streptococcus mutans bacteria. For the first time the chemical composition of SDEO growing in Central Kazakhstan was established. The results obtained from GC-MS showed the predominance of sesquiterpenoids (54.15%). The antibacterial study results showed that SDEO exhibited strong antibacterial activity against B. subtilis and S. aureus in vitro and also demonstrated an inhibitory effect on S. mutans biofilm formation on 1% sucrose medium...
Source: Natural Product Research - September 11, 2023 Category: Biochemistry Authors: Yana К Levaya Gayane А Atazhanova Тomas Kacergius Svetlana А Ivasenko Alexandr B Marchenko Margarita Yu Ishmuratova Мarlen К Smagulov Source Type: research

Green synthesis of silver nanoparticles from discarded shells of velvet tamarind (Dialium cochinchinense) and their antimicrobial synergistic potentials and biofilm inhibition properties
In this study, discarded shell of velvet tamarind fruit is explored as a potent reducing agent for biogenic synthesis of silver nanoparticles (VeV-AgNPs). Silver nanoparticles were formed in minutes under sunlight exposure, which was considerably fast compared to under ambient conditions. The optical, structural and morphological studies revealed that the nanoparticle colloidal solution consisted of particles with quasi-spherical and rodlike morphologies. To investigate antimicrobial properties, eight microorganisms were exposed to the VeV-AgNPs. The results indicated that VeV-AgNPs had enhanced antimicrobial activity, wit...
Source: Biometals - September 11, 2023 Category: Biochemistry Authors: Bright Ankudze David Neglo Francis Nsiah Source Type: research

Prevalence and Antimicrobial-Resistant Features of < em > Shigella < /em > Species in East Africa from 2015-2022: A Systematic Review and Meta-Analysis
CONCLUSION: The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.PMID:37692062 | PMC:PMC10492654 | DOI:10.1155/2023/8277976
Source: Interdisciplinary Perspectives on Infectious Diseases - September 11, 2023 Category: Infectious Diseases Authors: Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Source Type: research