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Infectious Disease: Coronavirus
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Total 74749 results found since Jan 2013.
Quantitative analysis of respiratory viruses based on lab-on-a-chip platform
Anal Bioanal Chem. 2023 Sep 8. doi: 10.1007/s00216-023-04935-w. Online ahead of print.ABSTRACTThe quantitative analysis of respiratory viruses is of great importance for rapid diagnosis, precision medicine, and prognosis. Several current quantitative analysis systems have been proposed and commercialized. Although they have been proven in trials, quantitative analyzes based on real samples are still complex, time-consuming, and expensive. Therefore, they are not able to directly quantify real samples. In this work, we presented a lab-on-a-chip platform combined with an automated control system to achieve quantitative analy...
Source: Analytical and Bioanalytical Chemistry - September 8, 2023 Category: Chemistry Authors: Ning Zhang Chao Yue Xiaobo Zhan Zhi Cheng Chao Li Yaohua Du Feng Tian Source Type: research
Percutaneous cholecystostomy in the management of acute cholecystitis-comparative analysis of before and after the COVID 19 pandemic
CONCLUSION: PC is an effective and safe treatment method that reduced the operating room and intensive care burden during the exacerbation of the COVID 19 pandemic. Therefore, it seems like a logical option to expand the PC indications at times when the number of COVID 19 patients increases.PMID:37681720 | DOI:10.14744/tjtes.2023.22901
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - September 8, 2023 Category: Emergency Medicine Authors: Fatih K ılınç Çağlayan Çakır Ömer Yıldız Alpen Yahya G ümüşoğlu Abd ülcelil Gezmiş Fidan Ayg ün Source Type: research
Quantitative analysis of respiratory viruses based on lab-on-a-chip platform
Anal Bioanal Chem. 2023 Sep 8. doi: 10.1007/s00216-023-04935-w. Online ahead of print.ABSTRACTThe quantitative analysis of respiratory viruses is of great importance for rapid diagnosis, precision medicine, and prognosis. Several current quantitative analysis systems have been proposed and commercialized. Although they have been proven in trials, quantitative analyzes based on real samples are still complex, time-consuming, and expensive. Therefore, they are not able to directly quantify real samples. In this work, we presented a lab-on-a-chip platform combined with an automated control system to achieve quantitative analy...
Source: Analytical and Bioanalytical Chemistry - September 8, 2023 Category: Chemistry Authors: Ning Zhang Chao Yue Xiaobo Zhan Zhi Cheng Chao Li Yaohua Du Feng Tian Source Type: research
USE OF RECOMBINANT S1 PROTEIN WITH hFc FOR ANALYSIS OF SARS-COV-2 ADSORPTION AND EVALUATION OF DRUGS THAT INHIBIT ENTRY INTO VERO E6 CELLS
Immunol Lett. 2023 Sep 6:S0165-2478(23)00145-1. doi: 10.1016/j.imlet.2023.09.002. Online ahead of print.ABSTRACTThe significant number of deaths and cases of infection by the new coronavirus SARS-CoV-2 requires an urgent demand for effective and available drugs for the treatment of COVID-19.However, the need for biosafety level 3 (NB-3) laboratories for experiments with the virus has made it very difficult for such research to meet this demand. It is known that angiotensin-converting enzyme 2 (ACE2), located on the surface of host cells, is the viral receptor for the spike (S) protein of SARS-CoV-2. This protein is a tetra...
Source: Immunology Letters - September 8, 2023 Category: Allergy & Immunology Authors: J éssica Carla Martins Couto Ta Ãs Vidal Eduardo Reichert Decker Janio M Santurio Carlos Fernando de Mello Micheli Mainardi Pillat Source Type: research
Person-centred critical care for a person with learning disability and COVID-19: case study of positive risk taking
Br J Nurs. 2023 Sep 7;32(16):776-784. doi: 10.12968/bjon.2023.32.16.776.ABSTRACTPeople with learning disabilities are known to experience a wide range of health inequalities and have a lower life expectancy than the general population. During the COVID-19 pandemic this extended to higher mortality rates following infection with the novel coronavirus. This case study presents an example of a positive outcome for Jade, a 21-year-old woman with learning disabilities and autism who required a long period in intensive care following COVID-19 infection. It demonstrates the impact of effective multidisciplinary collaboration invo...
Source: British Journal of Nursing - September 8, 2023 Category: Nursing Authors: Penny Clarke Rachel Brannan Scott Taylor Juliet MacArthur Source Type: research
Self-directed learning about normal birth with web-based support for nurse-midwife students in Thailand: A mixed methods study
CONCLUSION: Learning about normal birth on the web-based learning support platform can improve nurse-midwife students' self-discipline and self-directed learning, leading to sustainable knowledge and personal development. This was particularly significant and full of implications for learning and practice during the coronavirus disease 2019 pandemic. Acquired insights about web-based learning processes can be applied in other situations to further develop nursing and midwifery instruction, enhancing the learners' ability to apply theoretical knowledge to practice and provide effective care for women during childbirth.PMID:...
Source: Midwifery - September 8, 2023 Category: Midwifery Authors: Wareerat Jittitaworn Peeranan Wisanskoonwong Source Type: research
The significance of IFITM3 polymorphism in COVID-19 asymptomatic and ICU admission Kurdish patients
CONCLUSION: This study demonstrated that the rs12252 AA genotype is probably associated with asymptomatic COVID-19. In addition, the patients having haplotypes of minor alleles rs12252, rs34481144, and rs7478728 may be associated to COVID-19 ICU admission.PMID:37683443 | DOI:10.1016/j.cyto.2023.156349
Source: Cytokine - September 8, 2023 Category: Molecular Biology Authors: Peshnyar M A Rashid Gaza F Salih Source Type: research
Self-directed learning about normal birth with web-based support for nurse-midwife students in Thailand: A mixed methods study
CONCLUSION: Learning about normal birth on the web-based learning support platform can improve nurse-midwife students' self-discipline and self-directed learning, leading to sustainable knowledge and personal development. This was particularly significant and full of implications for learning and practice during the coronavirus disease 2019 pandemic. Acquired insights about web-based learning processes can be applied in other situations to further develop nursing and midwifery instruction, enhancing the learners' ability to apply theoretical knowledge to practice and provide effective care for women during childbirth.PMID:...
Source: Midwifery - September 8, 2023 Category: Midwifery Authors: Wareerat Jittitaworn Peeranan Wisanskoonwong Source Type: research
A fully integrated duplex RT-LAMP device for the detection of viral infections
In this study, we showed and evaluated a prototype of a microfluidic system, and showed that duplex RT-LAMP can detect and distinguish between the two viruses, with LoDs of 2,000 copies/ml for bovine coronavirus and 200 copies/ml for influenza A/X-31 virus.PMID:37682413 | DOI:10.1007/s10544-023-00676-w
Source: Biomedical Microdevices - September 8, 2023 Category: Biomedical Engineering Authors: Nicolas Mytzka Skaiste Arbaciauskaite Natalia Sandetskaya Kai Mattern Dirk Kuhlmeier Source Type: research
The significance of IFITM3 polymorphism in COVID-19 asymptomatic and ICU admission Kurdish patients
CONCLUSION: This study demonstrated that the rs12252 AA genotype is probably associated with asymptomatic COVID-19. In addition, the patients having haplotypes of minor alleles rs12252, rs34481144, and rs7478728 may be associated to COVID-19 ICU admission.PMID:37683443 | DOI:10.1016/j.cyto.2023.156349
Source: Cytokine - September 8, 2023 Category: Molecular Biology Authors: Peshnyar M A Rashid Gaza F Salih Source Type: research
Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses
Conclusions: It was demonstrated that CBD inhibits structurally dissimilar viruses, suggesting that this phytochemical has broad-spectrum antiviral effect, representing a valuable alternative in emergency situations during viral outbreaks, like the one caused by severe acute respiratory syndrome coronavirus 2 in 2020.PMID:37682578 | DOI:10.1089/can.2023.0103
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Agostina B Marquez Josefina Vicente Eliana Castro Daiana Vota Mar Ãa S RodrÃguez-Varela Priscila A Lanza Castronuovo Giselle M Fuentes Alejandro R Parise Leonardo Romorini Diego E Alvarez Carlos A Bueno Cristina L Ramirez Agustina Alaimo Cybele C Garc à Source Type: research
Person-centred critical care for a person with learning disability and COVID-19: case study of positive risk taking
Br J Nurs. 2023 Sep 7;32(16):776-784. doi: 10.12968/bjon.2023.32.16.776.ABSTRACTPeople with learning disabilities are known to experience a wide range of health inequalities and have a lower life expectancy than the general population. During the COVID-19 pandemic this extended to higher mortality rates following infection with the novel coronavirus. This case study presents an example of a positive outcome for Jade, a 21-year-old woman with learning disabilities and autism who required a long period in intensive care following COVID-19 infection. It demonstrates the impact of effective multidisciplinary collaboration invo...
Source: British Journal of Nursing - September 8, 2023 Category: Nursing Authors: Penny Clarke Rachel Brannan Scott Taylor Juliet MacArthur Source Type: research
Discovery of new non-covalent and covalent inhibitors targeting SARS-CoV-2 papain-like protease and main protease
In this report, we identified [1,2]selenazolo[5,4-c]pyridin-3(2H)-one and benzo[d]isothiazol-3(2H)-one as attractive scaffolds of PLpro and Mpro inhibitors. The representative compounds 6c and 7e exhibited excellent PLpro inhibition with percent inhibition of 42.9% and 44.9% at 50 nM, respectively. The preliminary enzyme kinetics experiment and fluorescent labelling experiment results determined that 6c was identified as a covalent PLpro inhibitor, while 7e was a non-covalent inhibitor. Molecular docking and dynamics simulations revealed that 6c and 7e bound to Zn-finger domain of PLpro. Compounds 6c and 7e were also ident...
Source: Bioorganic Chemistry - September 8, 2023 Category: Chemistry Authors: Wandong Liu Juan Wang Suyun Wang Kairui Yue Yu Hu Xiaochun Liu Lihao Wang Shengbiao Wan Ximing Xu Source Type: research
Percutaneous cholecystostomy in the management of acute cholecystitis-comparative analysis of before and after the COVID 19 pandemic
CONCLUSION: PC is an effective and safe treatment method that reduced the operating room and intensive care burden during the exacerbation of the COVID 19 pandemic. Therefore, it seems like a logical option to expand the PC indications at times when the number of COVID 19 patients increases.PMID:37681720 | DOI:10.14744/tjtes.2023.22901
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - September 8, 2023 Category: Emergency Medicine Authors: Fatih K ılınç Çağlayan Çakır Ömer Yıldız Alpen Yahya G ümüşoğlu Abd ülcelil Gezmiş Fidan Ayg ün Source Type: research
