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Assuring the Groundwork for Success: Mentorship, Sponsorship, and Allyship for Practicing Anesthesiologists
Anesth Analg. 2023 Oct 1;137(4):754-762. doi: 10.1213/ANE.0000000000006646. Epub 2023 Sep 5.ABSTRACTThe challenges facing the health care industry in the post-coronavirus disease 2019 (COVID-19) pandemic world are numerous, jeopardizing wellness, and performance. Maintaining engagement and fulfillment of anesthesiologists in their work is now a critical issue in various practice settings: academic, private practice, and corporate medicine. In this article, we offer insights on how mentorship, sponsorship, and allyship are important in the advancement of the anesthesiology workforce including women and underrepresented mino...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Mofya S Diallo Crystal C Wright Alice A Tolbert Coombs Thomas R Vetter Source Type: research
The efficacy of Facebook's vaccine misinformation policies and architecture during the COVID-19 pandemic
Sci Adv. 2023 Sep 15;9(37):eadh2132. doi: 10.1126/sciadv.adh2132. Epub 2023 Sep 15.ABSTRACTOnline misinformation promotes distrust in science, undermines public health, and may drive civil unrest. During the coronavirus disease 2019 pandemic, Facebook-the world's largest social media company-began to remove vaccine misinformation as a matter of policy. We evaluated the efficacy of these policies using a comparative interrupted time-series design. We found that Facebook removed some antivaccine content, but we did not observe decreases in overall engagement with antivaccine content. Provaccine content was also removed, and ...
Source: Adv Data - September 15, 2023 Category: Epidemiology Authors: David A Broniatowski Joseph R Simons Jiayan Gu Amelia M Jamison Lorien C Abroms Source Type: research
Assuring the Groundwork for Success: Mentorship, Sponsorship, and Allyship for Practicing Anesthesiologists
Anesth Analg. 2023 Oct 1;137(4):754-762. doi: 10.1213/ANE.0000000000006646. Epub 2023 Sep 5.ABSTRACTThe challenges facing the health care industry in the post-coronavirus disease 2019 (COVID-19) pandemic world are numerous, jeopardizing wellness, and performance. Maintaining engagement and fulfillment of anesthesiologists in their work is now a critical issue in various practice settings: academic, private practice, and corporate medicine. In this article, we offer insights on how mentorship, sponsorship, and allyship are important in the advancement of the anesthesiology workforce including women and underrepresented mino...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Mofya S Diallo Crystal C Wright Alice A Tolbert Coombs Thomas R Vetter Source Type: research
Achieving COVID-19 zero without lockdown, January 2020 to March 2022: The Taiwan model explained
J Formos Med Assoc. 2023 Sep 13:S0929-6646(23)00345-5. doi: 10.1016/j.jfma.2023.09.001. Online ahead of print.ABSTRACTDespite never imposing a lockdown, Taiwan achieved COVID-19 zero, with reporting only 56 local coronavirus disease 2019 (COVID-19) cases after testing 126,987 individuals in 2020, and further contained a large outbreak rapidly and successfully in 2021. At the onset of the COVID-19 pandemic, our infectious disease modeling results indicated that testing and contact tracing alone would fail to contain the pandemic. However, by supplementing this approach with general public surgical mask-wearing, the reproduc...
Source: J Formos Med Assoc - September 15, 2023 Category: General Medicine Authors: Yi-Hsuan Chen Chi-Tai Fang Source Type: research
RNA nanotechnology: A new chapter in targeted therapy
Colloids Surf B Biointerfaces. 2023 Sep 6;230:113533. doi: 10.1016/j.colsurfb.2023.113533. Online ahead of print.ABSTRACTNanoparticles have been widely studied in the fields of biotechnology, pharmacy, optics and medicine and have broad application prospects. Numerous studies have shown significant interest in utilizing nanoparticles for chemically coating or coupling drugs, aiming to address the challenges of drug delivery, including degradability and uncertainty. Furthermore, the utilization of lipid nanoparticles loaded with novel coronavirus antigen mRNA to control the COVID-19 pandemic has led to a notable surge in re...
Source: Colloids and Surfaces - September 15, 2023 Category: Biotechnology Authors: Tongtong Lv Yingying Meng Yifan Liu Yukun Han Hongwu Xin Xiaochun Peng Jinbai Huang Source Type: research
Adjuvant activities of immunostimulating natural products: Astragalus membranaceus (Fisch.) Bge and Coriolus versicolor in BNT162b2 vaccination against COVID-19 infection
In conclusion, combining AM and CV was effective in acting as an oral adjuvant with the mRNA vaccine BNT162b2 to improve the antigen binding activities against SARS-CoV-2 ancestral and variant SARS-CoV-2 spike proteins, probably via trained immunity of macrophages and dendritic cells.PMID:37713617 | DOI:10.1093/jleuko/qiad106
Source: Journal of Leukocyte Biology - September 15, 2023 Category: Hematology Authors: Ben Chung-Lap Chan Peiting Li Miranda Sin-Man Tsang Johnny Chun-Chau Sung Keith Wai-Yeung Kwong Tao Zheng Sharon Sze-Man Hon Ching-Po Lau Ronald Chi-Yan Ho Fang Chen Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Source Type: research
Investigation of the relationship between monocyte chemoattractant protein 1 rs1024611 variant and severity of COVID-19
CONCLUSION: The MCP-1 gene polymorphism had no impact on COVID-19 severity. However, to confirm these results, a large-scale study needs to be conducted.PMID:37713941 | DOI:10.1016/j.cyto.2023.156367
Source: Cytokine - September 15, 2023 Category: Molecular Biology Authors: Fatemeh Azarfar Bahareh Abbasi Amir Jalali Mohammad Hadi Abbasian Source Type: research
Achieving COVID-19 zero without lockdown, January 2020 to March 2022: The Taiwan model explained
J Formos Med Assoc. 2023 Sep 13:S0929-6646(23)00345-5. doi: 10.1016/j.jfma.2023.09.001. Online ahead of print.ABSTRACTDespite never imposing a lockdown, Taiwan achieved COVID-19 zero, with reporting only 56 local coronavirus disease 2019 (COVID-19) cases after testing 126,987 individuals in 2020, and further contained a large outbreak rapidly and successfully in 2021. At the onset of the COVID-19 pandemic, our infectious disease modeling results indicated that testing and contact tracing alone would fail to contain the pandemic. However, by supplementing this approach with general public surgical mask-wearing, the reproduc...
Source: J Formos Med Assoc - September 15, 2023 Category: General Medicine Authors: Yi-Hsuan Chen Chi-Tai Fang Source Type: research
Assuring the Groundwork for Success: Mentorship, Sponsorship, and Allyship for Practicing Anesthesiologists
Anesth Analg. 2023 Oct 1;137(4):754-762. doi: 10.1213/ANE.0000000000006646. Epub 2023 Sep 5.ABSTRACTThe challenges facing the health care industry in the post-coronavirus disease 2019 (COVID-19) pandemic world are numerous, jeopardizing wellness, and performance. Maintaining engagement and fulfillment of anesthesiologists in their work is now a critical issue in various practice settings: academic, private practice, and corporate medicine. In this article, we offer insights on how mentorship, sponsorship, and allyship are important in the advancement of the anesthesiology workforce including women and underrepresented mino...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Mofya S Diallo Crystal C Wright Alice A Tolbert Coombs Thomas R Vetter Source Type: research
Adjuvant activities of immunostimulating natural products: Astragalus membranaceus (Fisch.) Bge and Coriolus versicolor in BNT162b2 vaccination against COVID-19 infection
In conclusion, combining AM and CV was effective in acting as an oral adjuvant with the mRNA vaccine BNT162b2 to improve the antigen binding activities against SARS-CoV-2 ancestral and variant SARS-CoV-2 spike proteins, probably via trained immunity of macrophages and dendritic cells.PMID:37713617 | DOI:10.1093/jleuko/qiad106
Source: Journal of Leukocyte Biology - September 15, 2023 Category: Hematology Authors: Ben Chung-Lap Chan Peiting Li Miranda Sin-Man Tsang Johnny Chun-Chau Sung Keith Wai-Yeung Kwong Tao Zheng Sharon Sze-Man Hon Ching-Po Lau Ronald Chi-Yan Ho Fang Chen Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Source Type: research
Assuring the Groundwork for Success: Mentorship, Sponsorship, and Allyship for Practicing Anesthesiologists
Anesth Analg. 2023 Oct 1;137(4):754-762. doi: 10.1213/ANE.0000000000006646. Epub 2023 Sep 5.ABSTRACTThe challenges facing the health care industry in the post-coronavirus disease 2019 (COVID-19) pandemic world are numerous, jeopardizing wellness, and performance. Maintaining engagement and fulfillment of anesthesiologists in their work is now a critical issue in various practice settings: academic, private practice, and corporate medicine. In this article, we offer insights on how mentorship, sponsorship, and allyship are important in the advancement of the anesthesiology workforce including women and underrepresented mino...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Mofya S Diallo Crystal C Wright Alice A Tolbert Coombs Thomas R Vetter Source Type: research
Fortifying immunity: PLSCR1 picks battle against SARS-CoV-2
Cell Host Microbe. 2023 Sep 13;31(9):1417-1419. doi: 10.1016/j.chom.2023.08.014.ABSTRACTInterferons (IFNs) and interferon-stimulated genes (ISGs) are the major players in the host innate immunity against viral infection. In a recent Nature paper, Xu et al. identified phospholipid scramblase 1 (PLSCR1) as a novel ISG that restricts severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by blocking virus-cell fusion.PMID:37708846 | DOI:10.1016/j.chom.2023.08.014
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Minghua Li Source Type: research
Signaling pathways in macrophages: molecular mechanisms and therapeutic targets
MedComm (2020). 2023 Sep 11;4(5):e349. doi: 10.1002/mco2.349. eCollection 2023 Oct.ABSTRACTMacrophages play diverse roles in development, homeostasis, and immunity. Accordingly, the dysfunction of macrophages is involved in the occurrence and progression of various diseases, such as coronavirus disease 2019 and atherosclerosis. The protective or pathogenic effect that macrophages exert in different conditions largely depends on their functional plasticity, which is regulated via signal transduction such as Janus kinase-signal transducer and activator of transcription, Wnt and Notch pathways, stimulated by environmental cue...
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Ming Li Mengjie Wang Yuanjia Wen Hongfei Zhang Guang-Nian Zhao Qinglei Gao Source Type: research
Nucleic Acid Detection through RNA-Guided Protease Activity in Type III-E CRISPR-Cas Systems
Chembiochem. 2023 Sep 14:e202300401. doi: 10.1002/cbic.202300401. Online ahead of print.ABSTRACTRNA-guided protease activity was recently discovered in the type III-E CRISPR-Cas systems (Craspase), providing a novel platform for engineering a protein probe instead of the commonly used nucleic acid probe in the nucleic acid detection assays. Here, by adapting a fluorescence readout technique using the affinity- and fluorescent protein dual-tagged Csx30 protein substrate, we established an assay monitoring Csx30 cleavage by target ssRNA-activated Craspase. Four Craspase-based nucleic acid detection systems for genes from sev...
Source: Chembiochem - September 14, 2023 Category: Biochemistry Authors: Qiuqiu He Xinlong Lei Yuanjun Liu Xiaoshen Wang Nan Ji Hang Yin Huiping Wang Heng Zhang Guimei Yu Source Type: research
