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Leukemic-phase mucosa-associated lymphoid tissue lymphoma
Int J Hematol. 2023 Sep 12. doi: 10.1007/s12185-023-03654-3. Online ahead of print.ABSTRACTA 78-year-old man presenting with leukocytosis was admitted to our hospital. The patient was asymptomatic and showed no lymphadenopathy. Peripheral blood flow cytometry revealed a leukemic-phase B-cell lymphoma with medium-to-large abnormal cells with reticulum. Positron emission tomography/computed tomography revealed abnormal uptake in the right orbit, bone marrow, and spleen. We performed immunological staining and fluorescence in situ hybridization on tissues extracted from the right orbit and bone marrow, which led to the diagno...
Source: International Journal of Hematology - September 12, 2023 Category: Hematology Authors: Takayuki Yotsuyanagi Naoto Tomita Yusuke Saiki Akiko Uchida Yu Uemura Yoshinori Suzuki Tsuneaki Hirakawa Masayuki Kato Naoya Nakamura Ayako Arai Source Type: research
Early mortality in German patients with lung cancer: risk factors associated with 30-and 60-day mortality
In this study, we aimed to assess risk factors for 30- and 60-day mortality in German lung cancer patients. In this retrospective cross-sectional analysis, we used data of lung cancer patients treated at LMU Hospital Munich between 2015 and 2019. We categorized patients into 30-day mortality, 60 day-mortality, and longer survival. We used Student's t-test and ANOVA to compare means and Chi2-test to compare frequencies. We used logistic regression analysis to identify factors associated with a risk for early mortality. Of the 2454 lung cancer patients, 2.0% (n = 50) died within 30 and 1.7% (n = 41) within 30 to 60 days of d...
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Amanda Tufman Sophie Schneiderbauer Julia Walter Blerina Resuli Diego Kauffmann-Guerrero Carlo M ümmler Pontus Mertsch Jeremias G ötschke Julia Kov ács Farkhad Manapov Christian Schneider Laura Sellmer Paola Arnold Volker Heinemann J ürgen Behr Daniel Source Type: research
“The Greatest Scientist of All Time” says Scientific American. Who is it?
BY MIKE MAGEE
When it comes to our earthly survival as a human species, words are often under-powered and off-the-mark. Clearer concepts, definitions and terms are required for clarity. Here are five terms that are useful and worth remembering:
Planetary Boundaries
Earth Systems
Human Perturbations
Planetary Scale Destabilization
Holocene Epoch vs. Anthropogenic Epoch
These terms all tie back to a single source – a child of World War II, only seven when his home in Amsterdam was overrun by Nazis. His father was a waiter, his mother a cook in a local hospital. He’d later recall with a sh...
Source: The Health Care Blog - September 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Chemistry Mike Magee Ozone Paul Crutzen Scientific American Source Type: blogs
Improving mycetoma case detection through the training of community health workers in Northern Uganda: protocol for a stepped-wedge cluster-randomized trial
Ther Adv Infect Dis. 2023 Sep 8;10:20499361231198332. doi: 10.1177/20499361231198332. eCollection 2023 Jan-Dec.ABSTRACTINTRODUCTION: The World Health Organization acknowledges the need for countries to incorporate neglected tropical disease care into their routine health care system. However, low detection rates and late presentation of mycetoma to health facilities have been observed in endemic countries, including Uganda.OBJECTIVE: To empower community health workers (CHWs) in Northern Uganda to recognize and refer suspects of mycetoma to health facilities.DESIGN: This will be a stepped-wedge cluster-randomized trial bas...
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Winnie Kibone Andrew Weil Semulimi Richard Kwizera Felix Bongomin Source Type: research
Prostate health index can stratify patients with Prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies
Asian J Androl. 2023 Aug 22. doi: 10.4103/aja202332. Online ahead of print.ABSTRACTWe aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance imaging. Men with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers (Queen Mary Hospital and Princess Margaret Hospital, Hong Kong, China) between January 2017 and June 2022 were included. Ultrasound-magnetic resonance imaging fusion biopsies were performed a...
Source: Asian Journal of Andrology - September 11, 2023 Category: Urology & Nephrology Authors: John Shung-Lai Leung Wai-Kit Ma Brian Sze-Ho Ho Stacia Tsun-Tsun Chun Rong Na Yongle Zhan Chi-Yuen Ng Chi-Ho Ip Ada Tsui-Lin Ng Yiu-Chung Lam Source Type: research
The impact of the COVID-19 pandemic on erectile function in Chinese CP/CPPS patients
This study aimed to investigate the impact of the coronavirus disease 2019 (COVID-19) pandemic on erectile function in Chinese patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). A retrospective study was conducted on 657 CP/CPPS patients who visited The Third Xiangya Hospital of Central South University (Changsha, China) from November 2018 to November 2022. Patients were divided into two groups based on the timeline before and after the COVID-19 outbreak in China. The severity of CP/CPPS, penile erection status, anxiety, and depression was evaluated using the National Institutes of Health-Chronic Pro...
Source: Asian Journal of Andrology - September 11, 2023 Category: Urology & Nephrology Authors: Wei-Jie Song Ji-Wei Huang Yuan Liu Wei Ding Zhi Long Le-Ye He Source Type: research
Sperm acrosin activity may be a useful factor in choosing between ICSI and IVF for infertile male patients
Asian J Androl. 2023 Aug 22. doi: 10.4103/aja202337. Online ahead of print.ABSTRACTThe clinical applications of acrosin activity are limited. We analyzed 61 578 male partners in infertile couples who visited the outpatient department of the Reproductive and Genetic Hospital of CITIC-Xiangya (Changsha, China) between August 2014 and December 2019 to determine the reference ranges and thresholds for acrosin activity in infertile Chinese men; to determine whether correlations exist between acrosin activity and age, sperm concentration, sperm morphology, or sperm motility; and to evaluate whether acrosin activity could serve a...
Source: Asian Journal of Andrology - September 11, 2023 Category: Urology & Nephrology Authors: Ye-Na Hu Liang Hu Xin-Yu Yin Huan Zhang Yang-Qin Peng Gang Liu Ge Lin Wei-Na Li Source Type: research
Assessing the impacts of L-carnitine and modafinil on fatigue in Iraqi multiple sclerosis patients
J Adv Pharm Technol Res. 2023 Jul-Sep;14(3):226-228. doi: 10.4103/JAPTR.JAPTR_225_23. Epub 2023 Jul 28.ABSTRACTFatigue is a prevalent symptom experienced by individuals diagnosed with multiple sclerosis (MS), which greatly affects their daily activities and causes frustration and depression, thus affecting their lives and society. This can be prevented through the use of medicines such as L-carnitine and modafinil. The study aimed to examine the effect of L-carnitine and modafinil on fatigue and which one is better for MS patients. This was a clinical trial. This clinical trial was conducted in cooperation between Al-Kut U...
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Ahmed Hamza Al-Shammari Zainab A Abbood Hayder F Lateef Source Type: research
Amlodipine downregulates gene expression that involved in the signaling pathways of coagulation process in COVID-19 patients: An observational clinical study
This study was carried out in the Department of Pharmacy at Al-Kut University College in Wasit, Iraq, in conjunction with Al Zahraa Hospital from June 2021 to March 2022. A total of 45 COVID-19 patients participated in this study who were grouped into as follows: Group I (n = 23) who had no previous history of hypertension and Group II (n = 22) who had previous hypertension and were treated with amlodipine. Expression of the calcium-sensing receptor (CaSR), coagulation factor V (F5), and methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 Like (MTHFD1L) genes was determined. P values were calculated by Chi-square t...
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Zainab A Abbood Zainab H Ajeel Marwah S Joudah Marwan Salih M Al-Nimer Ahmed Hamza Al-Shammari Source Type: research
Quality Improvement Initiative to Increase Modality Education in a Nephrology Clinic During the COVID-19 Pandemic
Nephrol Nurs J. 2023 Jul-Aug;50(4):313-320.ABSTRACTLow attendance by patients with advanced chronic kidney disease (CKD stage 4 and 5) to the kidney replacement therapy (KRT) education sessions was noted by our nurse practitioners at a safety net hospital. The main outcome measure was the weekly percentage of patients with advanced CKD seen by the nephrology division weekly that completed KRT education. Process measures were weekly KRT session attendance by scheduled patients and the weekly referral of patients to KRT education sessions. The weekly education class attendance by scheduled patients reached the target level. ...
Source: Nephrology Nursing Journal - September 11, 2023 Category: Nursing Authors: Suma Prakash Colleen Rabbitt Iryna Danylyuk Diane Woodford Rui Song Wayne Satz Jan Schriefer Source Type: research
Waldenstrom's macroglobulinemia-like B cell lymphoma with MYD88 L265P mutation and t(14;18)(q32;q21) involving IGH < em > - < /em > MALT1
Leuk Res Rep. 2023 Aug 28;20:100389. doi: 10.1016/j.lrr.2023.100389. eCollection 2023.ABSTRACTA 65-year-old woman was referred to the hospital for further investigation of weight loss, hyperproteinemia, and anemia. Serum immunofixation electrophoresis revealed IgM-κ M protein. Bone marrow examination revealed an increase in the number of B -cells with immunoglobulin kappa light-chain restriction. Although the MYD88 L265P mutation was identified in bone marrow mononuclear cells, which suggested the diagnosis of Waldenstrom's macroglobulinemia (WM), a fusion signal of IgH-MALT1, which is commonly observed in extranodal marg...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Rie Furuta Hiro Tatetsu Jun-Ichirou Yasunaga Mitsunori Ueno Kento Oshiro Satoshi Kumanomido Yawara Kawano Yusuke Higuchi Yumi Honda Yoshiki Mikami Kisato Nosaka Masao Matsuoka Source Type: research
Antiretroviral treatment is less effective at reducing gut microbiome-associated inflammation and T cell activation in people living with HIV in rural versus urban Zimbabwe
Res Sq. 2023 Aug 31:rs.3.rs-3300723. doi: 10.21203/rs.3.rs-3300723/v1. Preprint.ABSTRACTThe widespread availability of antiretroviral therapy (ART) for people living with HIV (PLWH) has dramatically reduced mortality and improved life expectancy. However, even with suppression of HIV-1 replication, chronic immune activation and elevated inflammation persist. Chronic immune activation has been linked to a pro-inflammatory gut microbiome composition, exacerbated by compromised intestinal barrier integrity that occurs after HIV infection. Individuals living in urban versus rural areas of sub-Saharan Africa have differences in...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Alessandro Lazzaro Angela Sofia Burkhart Colorado Charles Preston Neff Nichole Nusbacher Kathryn Boyd Suzanne Fiorillo Casey Martin Janet Siebert Thomas Campbell Margaret Borok Brent Palmer Catherine Lozupone Source Type: research
Maintenance anlotinib improves the survival prognosis of extensive-stage small cell lung cancer: a single-arm, prospective, phase II study
Am J Cancer Res. 2023 Aug 15;13(8):3679-3685. eCollection 2023.ABSTRACTThe extent to which anlotinib provides survival benefits in the maintenance therapy of extensive-stage small cell lung cancer (ES-SCLC) remains unclear. Thus, this study aimed to assess the efficacy and safety of anlotinib monotherapy as maintenance therapy following induction chemotherapy in ES-SCLC patients. 27 ES-SCLC patients registered at the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine were screened from February 2022 to October 2022, of which 3 were not eligible. Eligible patients in stable status after first-line...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Fanming Kong Ziwei Wang Na Wang Dou Zhang Dongying Liao Jing Zhang Yidan Sun Haojian Zhang Yingjie Jia Source Type: research
Clinical outcome analysis of non-small cell lung cancer patients with brain metastasis receiving metastatic brain tumor resection surgery: a multicenter observational study
Am J Cancer Res. 2023 Aug 15;13(8):3607-3617. eCollection 2023.ABSTRACTBrain metastasis is most common in primary non-small cell lung cancer (NSCLC), and some patients require neurosurgical resection for intracranial disease control. Because advances in systemic therapies for metastatic NSCLC have been developed in the past decade, we aimed to analyze and determine clinical factors associated with the postresection survival of NSCLC patients with brain metastasis who underwent neurosurgery followed by systemic therapy. Between January 2017 and December 2021, data for 93 NSCLC patients with brain metastasis treated with neu...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Ping-Chih Hsu Li-Chung Chiu Ko-Ting Chen Chun-Chieh Wang Chen-Te Wu Chiao-En Wu Ho-Wen Ko Scott Chih-Hsi Kuo Yu-Ching Lin Chin-Chou Wang Cheng-Ta Yang Source Type: research
