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Sympathetic Neural Overdrive and Diminished Exercise Capacity in Reduced Ejection Fraction Heart Failure Related to Anthracycline- Based Chemotherapy
Am J Physiol Heart Circ Physiol. 2023 Sep 8. doi: 10.1152/ajpheart.00476.2023. Online ahead of print.ABSTRACTCardiotoxicity is the most worrying cardiovascular alteration in patients treated with chemotherapy. To improve the understanding regarding the cardiotoxicity, we studied whether: 1) patients with cardiac dysfunction related to anthracycline-based chemotherapy have augmented sympathetic nerve activity and decreased exercise capacity and 2) these responses are similar to those observed in patients with heart failure caused by other etiologies. Sixteen patients with heart failure with reduced ejection fraction related...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 8, 2023 Category: Physiology Authors: Amanda G Rodrigues Allan R K Sales Diego Faria Silvia M R Fonseca Marina M K Bond Camila P Jordao Francis R de Souza Cristina S Bittar Marilia H H Dos Santos Adriana O Sarmento Marcelo V Negrao Ludhmila A Hajjar Carlos E Negr ão Roberto Kalil Filho Source Type: research
Integrative analysis identifies AKAP8L as an immunological and prognostic biomarker of pan-cancer
Aging (Albany NY). 2023 Sep 7;15. doi: 10.18632/aging.205003. Online ahead of print.ABSTRACTA-kinase anchoring protein 8L (AKAP8L) belong to the A-kinase anchoring protein (AKAP) family. Recent studies have proved that AKAP8L is associated with the progression of various tumors. To establish a more complete understanding of the significance of AKAP8L across various types of cancers, we conducted a detailed analysis of multiple histological datasets, including the level of gene expression in pancancer, biological function, molecular characteristics, as well as the diagnostic and prognostic value of AKAP8L in pancancer. Furt...
Source: Aging - September 8, 2023 Category: Biomedical Science Authors: Libo Zhou Jinhong Mei Runfu Cao Xiaoqiang Liu Bin Fu Ming Ma Binbin Gong Lianmin Luo Yifu Liu Qiqi Zhu Xuan Meng Source Type: research
Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells
In this study, we sought a new way to target phosphoinositides metabolism. Using a high-throughput phosphatidylinositol 5-phosphate 4-kinase-alpha (PI5P4Kα) assay, we have identified that the immunosuppressor KRP203/Mocravimod induces a significant perturbation in phosphoinositide metabolism in U87MG glioblastoma cells. Despite high sequence similarity of PI5P4K and PI4K isozymes, in vitro kinase assays showed that KRP203 activates some (e.g., PI5P4Kα, PI4KIIβ) while inhibiting other phosphoinositide kinases (e.g., PI5P4Kβ, γ, PI4KIIα, class I PI3K-p110α, δ, γ). Furthermore, KRP203 enhances PI3P5K/PIKFYVE's substr...
Source: Biochemical and Biophysical Research communications - September 8, 2023 Category: Biochemistry Authors: Yoshiki Ikeda Mindy I Davis Kazutaka Sumita Yuxiang Zheng Satoshi Kofuji Mika Sasaki Yoshihisa Hirota Rajan Pragani Min Shen Matthew B Boxer Koh Takeuchi Toshiya Senda Anton Simeonov Atsuo T Sasaki Source Type: research
A cocktail therapeutic strategy based on clofarabine-containing aptamer-PROTAC for enhanced cancer therapy
Chem Commun (Camb). 2023 Sep 8. doi: 10.1039/d3cc02904b. Online ahead of print.ABSTRACTBy introducing a therapeutic nucleoside analogue tail to the parent Aptamer-PROTACs, a PROTAC-cocktail system (ApTCs-3X) was designed and evaluated. ApTCs-3X exhibited improved nuclease resistance and efficiently degraded target protein with subcellular localization preference. This cocktail therapy results in enhanced therapeutic outcomes, making it suitable for advancing PROTAC in combination therapy.PMID:37681438 | DOI:10.1039/d3cc02904b
Source: Chemical Communications - September 8, 2023 Category: Chemistry Authors: Zhenzhen Chen Mohan Chen Ran Liu Huanhuan Fan Jingjing Zhang Source Type: research
Sympathetic Neural Overdrive and Diminished Exercise Capacity in Reduced Ejection Fraction Heart Failure Related to Anthracycline- Based Chemotherapy
Am J Physiol Heart Circ Physiol. 2023 Sep 8. doi: 10.1152/ajpheart.00476.2023. Online ahead of print.ABSTRACTCardiotoxicity is the most worrying cardiovascular alteration in patients treated with chemotherapy. To improve the understanding regarding the cardiotoxicity, we studied whether: 1) patients with cardiac dysfunction related to anthracycline-based chemotherapy have augmented sympathetic nerve activity and decreased exercise capacity and 2) these responses are similar to those observed in patients with heart failure caused by other etiologies. Sixteen patients with heart failure with reduced ejection fraction related...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 8, 2023 Category: Physiology Authors: Amanda G Rodrigues Allan R K Sales Diego Faria Silvia M R Fonseca Marina M K Bond Camila P Jordao Francis R de Souza Cristina S Bittar Marilia H H Dos Santos Adriana O Sarmento Marcelo V Negrao Ludhmila A Hajjar Carlos E Negr ão Roberto Kalil Filho Source Type: research
Impact of a mental training program for pediatric cancer patients after allogeneic hematopoietic stem cell transplantation or high-dose chemotherapy - Results of a randomized controlled trial
Palliat Support Care. 2023 Sep 8:1-8. doi: 10.1017/S1478951523000986. Online ahead of print.ABSTRACTOBJECTIVES: Hematopoietic stem cell transplantation (HSCT) or intensive chemotherapy for the treatment of malignant diseases is a highly distressing experience. The affected person's resilience is crucial to coping with this challenging experience. Experience with resilience-enhancing interventions in children and young adults during cancer therapy is scarce. The major objective of this work was developing and evaluating an effective psycho-oncological mental training that complements the standard psychosocial care.METHODS: ...
Source: Palliative and Supportive Care - September 8, 2023 Category: Palliative Care Authors: Michaela D öring Johanna Xemaire Dustin Werle Stefanie Thiel Veronika Schneider Sebastian Michaelis Manuel Schl össer Peter Lang Jennifer Svaldi Karin Melanie Cabanillas Stanchi Source Type: research
Sympathetic Neural Overdrive and Diminished Exercise Capacity in Reduced Ejection Fraction Heart Failure Related to Anthracycline- Based Chemotherapy
Am J Physiol Heart Circ Physiol. 2023 Sep 8. doi: 10.1152/ajpheart.00476.2023. Online ahead of print.ABSTRACTCardiotoxicity is the most worrying cardiovascular alteration in patients treated with chemotherapy. To improve the understanding regarding the cardiotoxicity, we studied whether: 1) patients with cardiac dysfunction related to anthracycline-based chemotherapy have augmented sympathetic nerve activity and decreased exercise capacity and 2) these responses are similar to those observed in patients with heart failure caused by other etiologies. Sixteen patients with heart failure with reduced ejection fraction related...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 8, 2023 Category: Physiology Authors: Amanda G Rodrigues Allan R K Sales Diego Faria Silvia M R Fonseca Marina M K Bond Camila P Jordao Francis R de Souza Cristina S Bittar Marilia H H Dos Santos Adriana O Sarmento Marcelo V Negrao Ludhmila A Hajjar Carlos E Negr ão Roberto Kalil Filho Source Type: research
Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells
In this study, we sought a new way to target phosphoinositides metabolism. Using a high-throughput phosphatidylinositol 5-phosphate 4-kinase-alpha (PI5P4Kα) assay, we have identified that the immunosuppressor KRP203/Mocravimod induces a significant perturbation in phosphoinositide metabolism in U87MG glioblastoma cells. Despite high sequence similarity of PI5P4K and PI4K isozymes, in vitro kinase assays showed that KRP203 activates some (e.g., PI5P4Kα, PI4KIIβ) while inhibiting other phosphoinositide kinases (e.g., PI5P4Kβ, γ, PI4KIIα, class I PI3K-p110α, δ, γ). Furthermore, KRP203 enhances PI3P5K/PIKFYVE's substr...
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Yoshiki Ikeda Mindy I Davis Kazutaka Sumita Yuxiang Zheng Satoshi Kofuji Mika Sasaki Yoshihisa Hirota Rajan Pragani Min Shen Matthew B Boxer Koh Takeuchi Toshiya Senda Anton Simeonov Atsuo T Sasaki Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine Reports - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
Impact of a mental training program for pediatric cancer patients after allogeneic hematopoietic stem cell transplantation or high-dose chemotherapy - Results of a randomized controlled trial
Palliat Support Care. 2023 Sep 8:1-8. doi: 10.1017/S1478951523000986. Online ahead of print.ABSTRACTOBJECTIVES: Hematopoietic stem cell transplantation (HSCT) or intensive chemotherapy for the treatment of malignant diseases is a highly distressing experience. The affected person's resilience is crucial to coping with this challenging experience. Experience with resilience-enhancing interventions in children and young adults during cancer therapy is scarce. The major objective of this work was developing and evaluating an effective psycho-oncological mental training that complements the standard psychosocial care.METHODS: ...
Source: Palliative and Supportive Care - September 8, 2023 Category: Palliative Care Authors: Michaela D öring Johanna Xemaire Dustin Werle Stefanie Thiel Veronika Schneider Sebastian Michaelis Manuel Schl össer Peter Lang Jennifer Svaldi Karin Melanie Cabanillas Stanchi Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine Reports - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
Selective degradation of BRD4 suppresses lung cancer cell proliferation using GSH-responsive PROTAC precursors
Bioorg Chem. 2023 Sep 3;140:106793. doi: 10.1016/j.bioorg.2023.106793. Online ahead of print.ABSTRACTBRD4,as a transcriptional and epigenetic regulator to mediate cellular functions, plays an important role in cancer development.Targeting BRD4 with conventional inhibitors in cancer therapy requires high doses, which often leads to off-target and adverse effects. BRD4-targeted proteolysis-targeting chimeras (PROTACs) can catalytically degrade BRD4 utilizing the endogenous proteasome system, and exhibit promising anti-tumor activity. However, most of the developed PROTACs are non-cancer specific and relatively toxic towards ...
Source: Bioorganic Chemistry - September 8, 2023 Category: Chemistry Authors: Heli Fan Zhili Zhou Dehao Yu Jing Sun Luo Wang Yuanyuan Jia Junyu Tian Wenyi Mi Huabing Sun Source Type: research
Structure and function of extreme TLS DNA polymerase TTEDbh from Thermoanaerobacter tengcongensis
Int J Biol Macromol. 2023 Sep 6:126770. doi: 10.1016/j.ijbiomac.2023.126770. Online ahead of print.ABSTRACTTranslesion synthesis (TLS) is a kind of DNA repair that maintains the stability of the genome and ensures the normal growth of life in cells under emergencies. Y-family DNA polymerases, as a kind of error-prone DNA polymerase, mainly perform TLS. Previous studies have suggested that the occurrence of tumors is associated with the overexpression of human DNA polymerase of the Y family. And the combination of Y-family DNA polymerase inhibitors is promising for cancer therapy. Here we report the functional and structura...
Source: International Journal of Biological Macromolecules - September 8, 2023 Category: Biochemistry Authors: Li-Fei Tian Hongwei Gao Shuyu Yang Yan-Ping Liu Mingzhou Li Wenqing Xu Xiao-Xue Yan Source Type: research
