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Allosteric switch for electrochemical aptasensor toward heavy metals pollution of Lentinus edodes sensitized with porphyrinic metal-organic frameworks
We present an appropriate electrochemical aptasensor for Ag + assay based on biomimetic catalysis of porphyrin-encapsulated MOF (PorMOF) and allosteric switch of C-rich DNA. Thanks to the excellent biocompatibility, PorMOFs as nanozyme are used to design signal probes by loading duplex-like DNA scaffold. Owing to the specific recognition of Ag+ toward cytosine (C) base-rich DNA, PorMOF at the distal end was close to the underlying electrode via C-Ag+-C formation, leading to an enhanced current of catalytic hydroxylamine oxidation for signal generation. Using the positive correlation between current response and Ag+ level, ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Xiaowei Huang Chenyong Huang Lili Zhou Guangyue Hou Jinyuan Sun Xinai Zhang Xiaobo Zou Source Type: research
pH ‐responsive resveratrol‐loaded ZIF‐8 nanoparticles modified with tannic acid for promoting colon cancer cell apoptosis
In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy . By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 14, 2023 Category: Materials Science Authors: Xueqiang Sun,
Fuxin Li,
Lingyan Yuan,
Zhitong Bing,
Xun Li,
Kehu Yang Tags: RESEARCH ARTICLE Source Type: research
Mitigation of Anti ‐Drug Antibody Production for Augmenting Anticancer Efficacy of Therapeutic Protein via Co‐Injection of Nano‐Rapamycin
Co-injection of the PEGylated rapamycin nanoparticles and a protein toxin (trichosanthin) can mitigate the formation of anti-drug antibody via inducing durable antigen-specific tolerance. The combination of trichosanthin and the rapamycin nanoparticles yields an enhanced effect to inhibit the growth of breast tumor. AbstractThe induction of anti-drug antibody (ADA) is a formidable challenge for protein-based therapy. Trichosanthin (TCS) as a class of ribosome-inactivating proteins is widely studied in tumor treatment. However, the immunogenicity can induce the formation of ADA, which can cause hypersensitivity reactions an...
Source: Small - September 14, 2023 Category: Nanotechnology Authors: Ya Chang,
Wei Xiong,
Chenming Zou,
Ping Zeng,
Jiazhen Hou,
Bahtiyor Muhitdinov,
Yuanyuan Shen,
Yongzhuo Huang,
Shengrong Guo Tags: Research Article Source Type: research
Expanding the ubiquitin code in pancreatic cancer
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 11:166884. doi: 10.1016/j.bbadis.2023.166884. Online ahead of print.ABSTRACTThe ubiquitin-proteasome system (UPS) is a fundamental regulatory mechanism in cells, vital for maintaining cellular homeostasis, compiling signaling transduction, and determining cell fates. These biological processes require the coordinated signal cascades of UPS members, including ubiquitin ligases, ubiquitin-conjugating enzymes, deubiquitinases, and proteasomes, to ubiquitination and de-ubiquitination on substrates. Recent studies indicate that ubiquitination code rewriting is particularly prominent ...
Source: Biochimica et Biophysica Acta - September 13, 2023 Category: Biochemistry Authors: Wenyan Yang Shiqun Wang Shengqiang Tong Wei-Dong Zhang Jiang-Jiang Qin Source Type: research
Alkaloids as Additional Weapons in the Fight against Breast Cancer: A review
This study also includes an overview of synthesized analogues and pharmacological characteristics that will be beneficial to scientists working on alkaloids for medicinal purposes. In a recent survey of the literature, alkaloids are an important component of plant-derived antitumor medicines that hold great potential for the future development of cancer therapy and preventive therapies. We have also discussed structural analysis relationship (SAR) studies. Moreover, it covers clinical trial medications and FDA-approved medicines from the last five years that will be useful in further research.PMID:37702171 | DOI:10.2174/09...
Source: Current Medicinal Chemistry - September 13, 2023 Category: Chemistry Authors: None Chahat Keshav Taruneshwar Jha Rohit Bhatia Pooja A Chawla Source Type: research
Peroxisome proliferator-activated receptors as therapeutic target for cancer
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17931. Online ahead of print.ABSTRACTPeroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the nuclear receptor family. There are three subtypes of PPARs, including PPAR-α, PPAR-β/δ and PPAR-γ. They are expressed in different tissues and act by regulating the expression of target genes in the form of binding to ligands. Various subtypes of PPAR have been shown to have significant roles in a wide range of biological processes including lipid metabolism, body energy homeostasis, cell proliferation and differentiation, bone formation, tiss...
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Yuqing Wang Feifei Lei Yiyun Lin Yuru Han Lei Yang Huabing Tan Source Type: research
pH-responsive resveratrol-loaded ZIF-8 nanoparticles modified with tannic acid for promoting colon cancer cell apoptosis
In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy. By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.PMID:37702969 | DOI:10.1002/jbm.b.35320
Source: Biomed Res - September 13, 2023 Category: Research Authors: Xueqiang Sun Fuxin Li Lingyan Yuan Zhitong Bing Xun Li Kehu Yang Source Type: research
Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance
Adv Cancer Res. 2023;160:133-203. doi: 10.1016/bs.acr.2023.03.002. Epub 2023 Apr 7.ABSTRACTLong noncoding RNAs (lncRNAs) comprise a diverse class of RNA molecules that regulate various physiological processes and have been reported to be involved in several human pathologies ranging from neurodegenerative disease to cancer. Therapeutic resistance is a major hurdle for cancer treatment. Over the past decade, several studies has emerged on the role of lncRNAs in cancer drug resistance and many trials have been conducted employing them. LncRNAs also regulate different cell death pathways thereby maintaining a fine balance of ...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Sandhik Nandi Atanu Mondal Aritra Ghosh Shravanti Mukherjee Chandrima Das Source Type: research
PFKP: More than phosphofructokinase
Adv Cancer Res. 2023;160:1-15. doi: 10.1016/bs.acr.2023.03.001. Epub 2023 Mar 30.ABSTRACTPhosphofructokinase (PFK) is one of the key enzymes that functions in glycolysis. Studies show that PFKP regulates cell proliferation, apoptosis, autophagy, cell migration/metastasis, and stemness through glycolysis and glycolysis-independent functions. PFKP performs its function not only in the cytoplasm, but also at the cell membrane, on the mitochondria, at the lysosomal membrane, and in the nucleus. The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, th...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Haizhen Wang Tiffany Penaloza Amanda J Manea Xueliang Gao Source Type: research
pH-responsive resveratrol-loaded ZIF-8 nanoparticles modified with tannic acid for promoting colon cancer cell apoptosis
In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy. By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.PMID:37702969 | DOI:10.1002/jbm.b.35320
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Xueqiang Sun Fuxin Li Lingyan Yuan Zhitong Bing Xun Li Kehu Yang Source Type: research
Alkaloids as Additional Weapons in the Fight against Breast Cancer: A review
This study also includes an overview of synthesized analogues and pharmacological characteristics that will be beneficial to scientists working on alkaloids for medicinal purposes. In a recent survey of the literature, alkaloids are an important component of plant-derived antitumor medicines that hold great potential for the future development of cancer therapy and preventive therapies. We have also discussed structural analysis relationship (SAR) studies. Moreover, it covers clinical trial medications and FDA-approved medicines from the last five years that will be useful in further research.PMID:37702171 | DOI:10.2174/09...
Source: Current Medicinal Chemistry - September 13, 2023 Category: Chemistry Authors: None Chahat Keshav Taruneshwar Jha Rohit Bhatia Pooja A Chawla Source Type: research
Peroxisome proliferator-activated receptors as therapeutic target for cancer
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17931. Online ahead of print.ABSTRACTPeroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the nuclear receptor family. There are three subtypes of PPARs, including PPAR-α, PPAR-β/δ and PPAR-γ. They are expressed in different tissues and act by regulating the expression of target genes in the form of binding to ligands. Various subtypes of PPAR have been shown to have significant roles in a wide range of biological processes including lipid metabolism, body energy homeostasis, cell proliferation and differentiation, bone formation, tiss...
Source: J Cell Mol Med - September 13, 2023 Category: Molecular Biology Authors: Yuqing Wang Feifei Lei Yiyun Lin Yuru Han Lei Yang Huabing Tan Source Type: research
Lnc-ing epigenetic mechanisms with autophagy and cancer drug resistance
Adv Cancer Res. 2023;160:133-203. doi: 10.1016/bs.acr.2023.03.002. Epub 2023 Apr 7.ABSTRACTLong noncoding RNAs (lncRNAs) comprise a diverse class of RNA molecules that regulate various physiological processes and have been reported to be involved in several human pathologies ranging from neurodegenerative disease to cancer. Therapeutic resistance is a major hurdle for cancer treatment. Over the past decade, several studies has emerged on the role of lncRNAs in cancer drug resistance and many trials have been conducted employing them. LncRNAs also regulate different cell death pathways thereby maintaining a fine balance of ...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Sandhik Nandi Atanu Mondal Aritra Ghosh Shravanti Mukherjee Chandrima Das Source Type: research
PFKP: More than phosphofructokinase
Adv Cancer Res. 2023;160:1-15. doi: 10.1016/bs.acr.2023.03.001. Epub 2023 Mar 30.ABSTRACTPhosphofructokinase (PFK) is one of the key enzymes that functions in glycolysis. Studies show that PFKP regulates cell proliferation, apoptosis, autophagy, cell migration/metastasis, and stemness through glycolysis and glycolysis-independent functions. PFKP performs its function not only in the cytoplasm, but also at the cell membrane, on the mitochondria, at the lysosomal membrane, and in the nucleus. The functions of PFKP are extensively studied in cancer cells. PFKP is also highly expressed in certain immune cells; nevertheless, th...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Haizhen Wang Tiffany Penaloza Amanda J Manea Xueliang Gao Source Type: research
