Filtered By:
Therapy: Cancer Therapy
This page shows you your search results in order of date. This is page number 5.
Order by Relevance | Date
Total 15962 results found since Jan 2013.
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Int J Oncol. 2023 Nov;63(5):126. doi: 10.3892/ijo.2023.5574. Epub 2023 Sep 15.ABSTRACTCancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been ...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Weiqiong Zhang Ruiping Zhou Xin Liu Lin You Chang Chen Xiaoling Ye Jie Liu Youde Liang Source Type: research
Synthesis of Ag nanoparticles for selective dual detection of glutathione and dopamine using N, N-dimethyl-p-phenylenediamine mediated colorimetric probe
We report a simple and easy method to synthesize Ag nanoparticles (Ag NPs) and demonstrate its potential for the detection of glutathione (GSH) and dopamine (DA) via colorimetric assay. The Ag NPs were found to be monodispersed and spherical with a size of 5 ± 2 nm. The X-ray diffraction (XRD) and high resolution transmission electron microscopy (HR-TEM) investigations revealed the formation of crystalline Ag NPs. The colour of N, N-dimethyl-p-phenylenediamine colorimetric assay changed from dark pink to colourless when the concentration of GSH was increased from 1 to 40 μM. Notably, the suspension colour changed from da...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Akash Kumar Sharmiladevi Ramamoorthy Anandhakumar Sundaramurthy Source Type: research
Allosteric switch for electrochemical aptasensor toward heavy metals pollution of Lentinus edodes sensitized with porphyrinic metal-organic frameworks
We present an appropriate electrochemical aptasensor for Ag + assay based on biomimetic catalysis of porphyrin-encapsulated MOF (PorMOF) and allosteric switch of C-rich DNA. Thanks to the excellent biocompatibility, PorMOFs as nanozyme are used to design signal probes by loading duplex-like DNA scaffold. Owing to the specific recognition of Ag+ toward cytosine (C) base-rich DNA, PorMOF at the distal end was close to the underlying electrode via C-Ag+-C formation, leading to an enhanced current of catalytic hydroxylamine oxidation for signal generation. Using the positive correlation between current response and Ag+ level, ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Xiaowei Huang Chenyong Huang Lili Zhou Guangyue Hou Jinyuan Sun Xinai Zhang Xiaobo Zou Source Type: research
Synthesis of Ag nanoparticles for selective dual detection of glutathione and dopamine using N, N-dimethyl-p-phenylenediamine mediated colorimetric probe
We report a simple and easy method to synthesize Ag nanoparticles (Ag NPs) and demonstrate its potential for the detection of glutathione (GSH) and dopamine (DA) via colorimetric assay. The Ag NPs were found to be monodispersed and spherical with a size of 5 ± 2 nm. The X-ray diffraction (XRD) and high resolution transmission electron microscopy (HR-TEM) investigations revealed the formation of crystalline Ag NPs. The colour of N, N-dimethyl-p-phenylenediamine colorimetric assay changed from dark pink to colourless when the concentration of GSH was increased from 1 to 40 μM. Notably, the suspension colour changed from da...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Akash Kumar Sharmiladevi Ramamoorthy Anandhakumar Sundaramurthy Source Type: research
Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects
Eur J Med Res. 2023 Sep 14;28(1):345. doi: 10.1186/s40001-023-01275-4.ABSTRACTCancer poses a significant global health challenge, with predictions of increasing prevalence in the coming years due to limited prevention, late diagnosis, and inadequate success with current therapies. In addition, the high cost of new anti-cancer drugs creates barriers in meeting the medical needs of cancer patients, especially in developing countries. The lengthy and costly process of developing novel drugs further hinders drug discovery and clinical implementation. Therefore, there has been a growing interest in repurposing approved drugs fo...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Roohi Mohi-Ud-Din Apporva Chawla Pooja Sharma Prince Ahad Mir Faheem Hyder Potoo Željko Reiner Ivan Reiner Dilek Arslan Ate şşahin Javad Sharifi-Rad Reyaz Hassan Mir Daniela Calina Source Type: research
Synthesis of Ag nanoparticles for selective dual detection of glutathione and dopamine using N, N-dimethyl-p-phenylenediamine mediated colorimetric probe
We report a simple and easy method to synthesize Ag nanoparticles (Ag NPs) and demonstrate its potential for the detection of glutathione (GSH) and dopamine (DA) via colorimetric assay. The Ag NPs were found to be monodispersed and spherical with a size of 5 ± 2 nm. The X-ray diffraction (XRD) and high resolution transmission electron microscopy (HR-TEM) investigations revealed the formation of crystalline Ag NPs. The colour of N, N-dimethyl-p-phenylenediamine colorimetric assay changed from dark pink to colourless when the concentration of GSH was increased from 1 to 40 μM. Notably, the suspension colour changed from da...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Akash Kumar Sharmiladevi Ramamoorthy Anandhakumar Sundaramurthy Source Type: research
In situ formation of alginic acid-gold nanohybrids for application in cancer photothermal therapy
This article is protected by copyright. All rights reserved.PMID:37706621 | DOI:10.1002/biot.202300019
Source: Biotechnology Journal - September 14, 2023 Category: Biotechnology Authors: Andr é Q Figueiredo Carolina F Rodrigues Natanael Fernandes Il ídio J Correia Andr é F Moreira Source Type: research
The emerging role of the gut microbiome in cancer cell plasticity and therapeutic resistance
Cancer Metastasis Rev. 2023 Sep 14. doi: 10.1007/s10555-023-10138-7. Online ahead of print.ABSTRACTResistance to therapeutic agents is one of the major challenges in cancer therapy. Generally, the focus is given to the genetic driver, especially the genetic mutation behind the therapeutic resistance. However, non-mutational mechanisms, such as epigenetic modifications, and TME alteration, which is mainly driven by cancer cell plasticity, are also involved in therapeutic resistance. The concept of plasticity mainly relies on the conversion of non-cancer stem cells (CSCs) to CSCs or epithelial-to-mesenchymal transition via d...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Priya Mondal Syed Musthapa Meeran Source Type: research
Combined targeting of NAD biosynthesis and the NAD-dependent transcription factor C-terminal Binding Protein as a promising novel therapy for pancreatic cancer
Cancer Res Commun. 2023 Sep 13. doi: 10.1158/2767-9764.CRC-22-0521. Online ahead of print.ABSTRACTCancer therapies targeting metabolic derangements unique to cancer cells are emerging as a key strategy to address refractory solid tumors such as pancreatic ductal adenocarcinomas (PDAC) that exhibit resistance to extreme nutrient deprivation in the tumor microenvironment. Nicotinamide adenine dinucleotide (NAD) participates in multiple metabolic pathways and Nicotinamide phosphoribosyl transferase (NAMPT) is one of the key intracellular enzymes that facilitate the synthesis of NAD. C-terminal Binding Proteins 1 and 2 (CtBP) ...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: M Michael Dcona Kranthi Kumar Chougoni Diana T Dcona Jacqueline L West Sahib J Singh Keith C Ellis Steven R Grossman Source Type: research
Allosteric switch for electrochemical aptasensor toward heavy metals pollution of Lentinus edodes sensitized with porphyrinic metal-organic frameworks
We present an appropriate electrochemical aptasensor for Ag + assay based on biomimetic catalysis of porphyrin-encapsulated MOF (PorMOF) and allosteric switch of C-rich DNA. Thanks to the excellent biocompatibility, PorMOFs as nanozyme are used to design signal probes by loading duplex-like DNA scaffold. Owing to the specific recognition of Ag+ toward cytosine (C) base-rich DNA, PorMOF at the distal end was close to the underlying electrode via C-Ag+-C formation, leading to an enhanced current of catalytic hydroxylamine oxidation for signal generation. Using the positive correlation between current response and Ag+ level, ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Xiaowei Huang Chenyong Huang Lili Zhou Guangyue Hou Jinyuan Sun Xinai Zhang Xiaobo Zou Source Type: research
In situ formation of alginic acid-gold nanohybrids for application in cancer photothermal therapy
This article is protected by copyright. All rights reserved.PMID:37706621 | DOI:10.1002/biot.202300019
Source: Biotechnology Journal - September 14, 2023 Category: Biotechnology Authors: Andr é Q Figueiredo Carolina F Rodrigues Natanael Fernandes Il ídio J Correia Andr é F Moreira Source Type: research
Allosteric switch for electrochemical aptasensor toward heavy metals pollution of Lentinus edodes sensitized with porphyrinic metal-organic frameworks
We present an appropriate electrochemical aptasensor for Ag + assay based on biomimetic catalysis of porphyrin-encapsulated MOF (PorMOF) and allosteric switch of C-rich DNA. Thanks to the excellent biocompatibility, PorMOFs as nanozyme are used to design signal probes by loading duplex-like DNA scaffold. Owing to the specific recognition of Ag+ toward cytosine (C) base-rich DNA, PorMOF at the distal end was close to the underlying electrode via C-Ag+-C formation, leading to an enhanced current of catalytic hydroxylamine oxidation for signal generation. Using the positive correlation between current response and Ag+ level, ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Xiaowei Huang Chenyong Huang Lili Zhou Guangyue Hou Jinyuan Sun Xinai Zhang Xiaobo Zou Source Type: research
Synthesis of Ag nanoparticles for selective dual detection of glutathione and dopamine using N, N-dimethyl-p-phenylenediamine mediated colorimetric probe
We report a simple and easy method to synthesize Ag nanoparticles (Ag NPs) and demonstrate its potential for the detection of glutathione (GSH) and dopamine (DA) via colorimetric assay. The Ag NPs were found to be monodispersed and spherical with a size of 5 ± 2 nm. The X-ray diffraction (XRD) and high resolution transmission electron microscopy (HR-TEM) investigations revealed the formation of crystalline Ag NPs. The colour of N, N-dimethyl-p-phenylenediamine colorimetric assay changed from dark pink to colourless when the concentration of GSH was increased from 1 to 40 μM. Notably, the suspension colour changed from da...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Akash Kumar Sharmiladevi Ramamoorthy Anandhakumar Sundaramurthy Source Type: research
In situ formation of alginic acid-gold nanohybrids for application in cancer photothermal therapy
This article is protected by copyright. All rights reserved.PMID:37706621 | DOI:10.1002/biot.202300019
Source: Biotechnology Journal - September 14, 2023 Category: Biotechnology Authors: Andr é Q Figueiredo Carolina F Rodrigues Natanael Fernandes Il ídio J Correia Andr é F Moreira Source Type: research
