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CRISPR based therapeutic targeting of signaling pathways in breast cancer
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 2:166872. doi: 10.1016/j.bbadis.2023.166872. Online ahead of print.ABSTRACTBreast cancer represents the prevailing malignancy in females and contributing towards mortality on a global scale. There are innumerable anomalous genes that are responsible in the multi factorial carcinogenesis pathway. Although several disease-causing mutations have been detected, therapy frequently focuses on attenuating the manifestation of the disease rather than harmonizing the mutation in the target area. However, the emergence of the CRISPR-Cas system as a DNA modifying tool has proved to be a pr...
Source: Biochimica et Biophysica Acta - September 4, 2023 Category: Biochemistry Authors: Gauri Misra Sidra Qaisar Priyanshi Singh Source Type: research
Intratumoral heterogeneity after targeted therapy in murine cancer models with differing degrees of malignancy
In conclusion, mp MRI enables to assess dedicated therapy-related intratumoral changes and may serve as a biomarker for treatment response assessment.PMID:37666208 | DOI:10.1016/j.tranon.2023.101773
Source: Translational Oncology - September 4, 2023 Category: Cancer & Oncology Authors: M Gerwing E Hoffmann C Geyer A Helfen B Maus R Schinner L Wachsmuth W Heindel M Eisenblaetter C Faber M Wildgruber Source Type: research
Flexibility in the bridge of chalcone derivatives is important for the inhibition of cellular growth
Bioorg Med Chem Lett. 2023 Sep 2:129467. doi: 10.1016/j.bmcl.2023.129467. Online ahead of print.ABSTRACTChalcones and their derivatives are a privileged scaffold in medicinal chemistry, demonstrating numerous biological activities. These molecules have shown significant potential toward the development of novel cancer therapies. While much is known about modification to the chalcone aryl rings, little is known about conformations of the bridge between the aryl rings. Here we report the synthesis and biological evaluation of a series of molecules with flexible and rigid bridge conformations. Crystal structures of a select g...
Source: Bioorganic and Medicinal Chemistry Letters - September 4, 2023 Category: Chemistry Authors: Trevor M Stantliff Amber Hill Mary Elaine Kuo Hadley E Neal Tighe C Harrod Katy Goens Mark Mashuta Anna M Christianson Amanda J Krzysiak Source Type: research
CRISPR based therapeutic targeting of signaling pathways in breast cancer
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 2:166872. doi: 10.1016/j.bbadis.2023.166872. Online ahead of print.ABSTRACTBreast cancer represents the prevailing malignancy in females and contributing towards mortality on a global scale. There are innumerable anomalous genes that are responsible in the multi factorial carcinogenesis pathway. Although several disease-causing mutations have been detected, therapy frequently focuses on attenuating the manifestation of the disease rather than harmonizing the mutation in the target area. However, the emergence of the CRISPR-Cas system as a DNA modifying tool has proved to be a pr...
Source: Biochimica et Biophysica Acta - September 4, 2023 Category: Biochemistry Authors: Gauri Misra Sidra Qaisar Priyanshi Singh Source Type: research
NaYF4:Yb/Er@Mn3O4@GOX Nanocomposite for Upconversion Fluorescence Imaging and Synergistic Cascade Cancer Therapy by Apoptosis and Ferroptosis
A versatile self-cascading nanocomposite is synthesized by encapsulating glucose oxidase (GOX) within NaYF4:Yb/Er@Mn3O4 (UCMn@GOX) nanoparticles. This ingeniously designed nanocomposite holds immense promise for seamlessly integrating tumor diagnosis and treatment through synergistic cascade reactions. AbstractThe cell elimination strategy based on reactive oxygen species (ROS) is a promising method for tumor therapy. However, its efficacy is significantly limited by ROS deficiency caused by H2O2 substrate deficiency and up-regulation of cellular antioxidant defense induced by high glutathione (GSH) content in tumor cells....
Source: Small - September 4, 2023 Category: Nanotechnology Authors: Yinyin Chen,
Haoran Li,
Baoshan Hou,
Aimin Wu,
Wei Wu,
Chunxia Li,
Hao Wang,
Daiwen Chen,
Xianxiang Wang Tags: Research Article Source Type: research
Molecules, Vol. 28, Pages 6431: Exploring the Biomedical Applications of Biosynthesized Silver Nanoparticles Using Perilla frutescens Flavonoid Extract: Antibacterial, Antioxidant, and Cell Toxicity Properties against Colon Cancer Cells
In this study, we also explained the plausible mechanisms of the biosynthesis, anticancer, and antibacterial effects of PFFE-AgNPs. Overall, these findings suggest that PFFE-AgNPs have potential as a multi-functional nanomaterial for biomedical applications, particularly in cancer therapy and infection control. However, it is important to note that further research is needed to determine the safety and efficacy of these nanoparticles in vivo, as well as to explore their potential in other areas of medicine.
Source: Molecules - September 4, 2023 Category: Chemistry Authors: Tianyu Hou Yurong Guo Wanyu Han Yang Zhou Vasudeva Reddy Netala Huizhen Li He Li Zhijun Zhang Tags: Article Source Type: research
Current progress, strategy, and prospects of PD-1/PDL-1 immune checkpoint biosensing platforms for cancer diagnostics, therapy monitoring, and drug screening
Biosens Bioelectron. 2023 Aug 28;240:115644. doi: 10.1016/j.bios.2023.115644. Online ahead of print.ABSTRACTRecent technological advancements in testing and monitoring instrumentation have greatly contributed to the progress in cancer treatment by surgical, chemotherapeutic and radiotherapeutic interventions. However, the mortality rate still remains high, calling for the development of new treatment strategies with higher efficacy. Extensive efforts driven in this direction have included broadening of early cancer screening and applying innovative theranostic nanotechnologies. They have been supported by platforms introdu...
Source: Biosensors and Bioelectronics - September 3, 2023 Category: Biotechnology Authors: Katarzyna Ratajczak Hubert Grel Piotr Olejnik Slawomir Jakiela Magdalena Stobiecka Source Type: research
Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors
In this study, based on rational drug design strategy, we designed and synthesized a series of pyrimidine derivatives with hydroxamic acid as novel dual JMJD3 and HDAC inhibitors for synergistic cancer treatment. Compound A5b exhibited inhibitory potency against JMJD3 and HDAC1/6 simultaneously and favorable cytotoxicity against human cancer cells such as A549 and U937. Furthermore, mechanistic studies showed that A5b treatment in A549 cells increased the hypermethylation of histone H3K27 and hyperacetylation of H3K9, suppressed clonogenicity, migration and invasion of cancer cells. Besides, A5b induced apoptosis via the c...
Source: Bioorganic and Medicinal Chemistry Letters - September 3, 2023 Category: Chemistry Authors: Anqi Li Wenwen Zheng Boren Xiao Wenjun Huang Lulu Li Minglang Luo Zijian Liu Bizhu Chu Yuyang Jiang Source Type: research
A practical approach to the ESC 2022 cardio-oncology guidelines. Comments by a team of experts: cardiologists and oncologists
Kardiol Pol. 2023 Sep 3. doi: 10.33963/v.kp.96840. Online ahead of print.ABSTRACTThe 2022 European Society of Cardiology (ESC) guidelines [1] are a comprehensive document, prepared jointly by experts in cardiology and oncology. In the case of an oncological patient, it is necessary to individualize care in relation to the cardiological condition, the stage of the cancer and the type of potential anti-cancer therapy. Cardiac care optimisation should be undertaken before the start of oncological therapy, and continued during oncological therapy, as well as long-term after its completion [2]. The published ESC Guidelines were...
Source: Polish Heart Journal - September 3, 2023 Category: Cardiology Authors: Przemys ław Leszek Aneta Klotzka Stanis ław Bartuś Pawe ł Burchardt Anna M Czarnecka Monika D ługosz-Danecka Marek Gierlotka Hanna Kose ła-Paterczyk Agata Krawczyk-O żóg Tomasz Kubiatowski Marcin Kurzyna Adam Maciejczyk Przemys ław Mitkowski Alek Source Type: research
Subverted macrophages in the triple-negative breast cancer ecosystem
Biomed Pharmacother. 2023 Sep 1;166:115414. doi: 10.1016/j.biopha.2023.115414. Online ahead of print.ABSTRACTTumor-associated macrophages (TAMs) are the most critical effector cells of innate immunity and the most abundant tumor-infiltrating immune cells. They play a key role in the clearance of apoptotic bodies, regulation of inflammation, and tissue repair to maintain homeostasis in vivo. With the progression of triple-negative breast cancer（TNBC）, TAMs are "subverted" from tumor-promoting immune cells to tumor-promoting immune suppressor cells, which play a significant role in tumor development and are considered po...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 3, 2023 Category: Drugs & Pharmacology Authors: Linxiao Shang Yuting Zhong Yan Yao Cun Liu Lu Wang Wenfeng Zhang Jingyang Liu Xue Wang Changgang Sun Source Type: research
A practical approach to the ESC 2022 cardio-oncology guidelines. Comments by a team of experts: cardiologists and oncologists
Kardiol Pol. 2023 Sep 3. doi: 10.33963/v.kp.96840. Online ahead of print.ABSTRACTThe 2022 European Society of Cardiology (ESC) guidelines [1] are a comprehensive document, prepared jointly by experts in cardiology and oncology. In the case of an oncological patient, it is necessary to individualize care in relation to the cardiological condition, the stage of the cancer and the type of potential anti-cancer therapy. Cardiac care optimisation should be undertaken before the start of oncological therapy, and continued during oncological therapy, as well as long-term after its completion [2]. The published ESC Guidelines were...
Source: Kardiologia Polska - September 3, 2023 Category: Cardiology Authors: Przemys ław Leszek Aneta Klotzka Stanis ław Bartuś Pawe ł Burchardt Anna M Czarnecka Monika D ługosz-Danecka Marek Gierlotka Hanna Kose ła-Paterczyk Agata Krawczyk-O żóg Tomasz Kubiatowski Marcin Kurzyna Adam Maciejczyk Przemys ław Mitkowski Alek Source Type: research
Collagen code in tumor microenvironment: Functions, molecular mechanisms, and therapeutic implications
Biomed Pharmacother. 2023 Sep 1;166:115390. doi: 10.1016/j.biopha.2023.115390. Online ahead of print.ABSTRACTThe tumor microenvironment (TME) is crucial in cancer progression, and the extracellular matrix (ECM) is an important TME component. Collagen is a major ECM component that contributes to tumor cell infiltration, expansion, and distant metastasis during cancer progression. Recent studies reported that collagen is deposited in the TME to form a collagen wall along which tumor cells can infiltrate and prevent drugs from working on the tumor cells. Collagen-tumor cell interaction is complex and requires the activation o...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 3, 2023 Category: Drugs & Pharmacology Authors: Qian Zhang Zi-Yi An Wen Jiang Wei-Lin Jin Xin-Yang He Source Type: research
Current progress, strategy, and prospects of PD-1/PDL-1 immune checkpoint biosensing platforms for cancer diagnostics, therapy monitoring, and drug screening
Biosens Bioelectron. 2023 Aug 28;240:115644. doi: 10.1016/j.bios.2023.115644. Online ahead of print.ABSTRACTRecent technological advancements in testing and monitoring instrumentation have greatly contributed to the progress in cancer treatment by surgical, chemotherapeutic and radiotherapeutic interventions. However, the mortality rate still remains high, calling for the development of new treatment strategies with higher efficacy. Extensive efforts driven in this direction have included broadening of early cancer screening and applying innovative theranostic nanotechnologies. They have been supported by platforms introdu...
Source: Biosensors and Bioelectronics - September 3, 2023 Category: Biotechnology Authors: Katarzyna Ratajczak Hubert Grel Piotr Olejnik Slawomir Jakiela Magdalena Stobiecka Source Type: research
Role of cancer-educated mesenchymal stromal cells on tumor progression
Biomed Pharmacother. 2023 Sep 1;166:115405. doi: 10.1016/j.biopha.2023.115405. Online ahead of print.ABSTRACTThe malignant tumor is the main cause of human deaths worldwide. Current therapies focusing on the tumor itself have achieved unprecedented benefits. Various pro-tumorigenic factors in the tumor microenvironment (TME) could abolish the effect of cancer therapy. Mesenchymal stromal cells (MSCs) are one of the substantial components in the tumor microenvironment, contributing to tumor progression. However, MSCs are not inherently tumor-promoting. Indeed, they acquire pro-tumorigenic properties under the education of t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 3, 2023 Category: Drugs & Pharmacology Authors: Ting Liu Shuwei Guo Yong Ji Wei Zhu Source Type: research
A practical approach to the ESC 2022 cardio-oncology guidelines. Comments by a team of experts: cardiologists and oncologists
Kardiol Pol. 2023 Sep 3. doi: 10.33963/v.kp.96840. Online ahead of print.ABSTRACTThe 2022 European Society of Cardiology (ESC) guidelines [1] are a comprehensive document, prepared jointly by experts in cardiology and oncology. In the case of an oncological patient, it is necessary to individualize care in relation to the cardiological condition, the stage of the cancer and the type of potential anti-cancer therapy. Cardiac care optimisation should be undertaken before the start of oncological therapy, and continued during oncological therapy, as well as long-term after its completion [2]. The published ESC Guidelines were...
Source: Polish Heart Journal - September 3, 2023 Category: Cardiology Authors: Przemys ław Leszek Aneta Klotzka Stanis ław Bartuś Pawe ł Burchardt Anna M Czarnecka Monika D ługosz-Danecka Marek Gierlotka Hanna Kose ła-Paterczyk Agata Krawczyk-O żóg Tomasz Kubiatowski Marcin Kurzyna Adam Maciejczyk Przemys ław Mitkowski Alek Source Type: research
