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Sympathetic Neural Overdrive and Diminished Exercise Capacity in Reduced Ejection Fraction Heart Failure Related to Anthracycline- Based Chemotherapy
Am J Physiol Heart Circ Physiol. 2023 Sep 8. doi: 10.1152/ajpheart.00476.2023. Online ahead of print.ABSTRACTCardiotoxicity is the most worrying cardiovascular alteration in patients treated with chemotherapy. To improve the understanding regarding the cardiotoxicity, we studied whether: 1) patients with cardiac dysfunction related to anthracycline-based chemotherapy have augmented sympathetic nerve activity and decreased exercise capacity and 2) these responses are similar to those observed in patients with heart failure caused by other etiologies. Sixteen patients with heart failure with reduced ejection fraction related...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 8, 2023 Category: Physiology Authors: Amanda G Rodrigues Allan R K Sales Diego Faria Silvia M R Fonseca Marina M K Bond Camila P Jordao Francis R de Souza Cristina S Bittar Marilia H H Dos Santos Adriana O Sarmento Marcelo V Negrao Ludhmila A Hajjar Carlos E Negr ão Roberto Kalil Filho Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine Reports - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
Novel design of dual-action Pt(IV) anticancer pro-drugs based on cisplatin and derivatives of the Tyrosine Kinase Inhibitors imatinib and nilotinib
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Darren Fergal Beirne, Barbara Farkas, Chiara Donati, Valentina Gandin, Isabel Rozas, Trinidad Velasco-Torrijos, Diego Montagner Tyrosine Kinases (TKs) are emerging as important targets in cancer therapy and some of their inhibitors TKi (i.e. Imatinib and Nilotinib) are FDA approved drugs that are used as selective... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - September 7, 2023 Category: Chemistry Authors: Darren Fergal Beirne Source Type: research
The Relationship Between Taste and Smell Alterations and Quality of Life Among Women With Breast Cancer Receiving Chemotherapy
Oncol Nurs Forum. 2023 Jun 15;50(4):499-508. doi: 10.1188/23.ONF.499-508.ABSTRACTOBJECTIVES: To understand taste and smell alterations (TSAs) and their relationship with quality of life among women with breast cancer receiving chemotherapy.SAMPLE & SETTING: A descriptive correlational study was conducted with 121 women with breast cancer receiving chemotherapy, and data were collected through an online survey.METHODS & VARIABLES: The Taste and Smell Survey was used to measure TSAs, and the Functional Assessment of Cancer Therapy-Breast was used to measure quality of life.RESULTS: More than half of the participants ...
Source: Oncology Nursing Forum - September 7, 2023 Category: Nursing Authors: Hae Jeong An Sook Jung Kang Source Type: research
Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics
We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplas...
Source: Angewandte Chemie - September 7, 2023 Category: Chemistry Authors: Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Chunhai Fan Yaakov Nahmias Itamar Willner Source Type: research
GLUT5: structure, functions, diseases and potential applications
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023158. Online ahead of print.ABSTRACTGlucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has been well understood to play a significant role in the pathogenesis of human digestive diseases. Recently, the role of GL...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aqian Song Yuanpeng Mao Hongshan Wei Source Type: research
The Relationship Between Taste and Smell Alterations and Quality of Life Among Women With Breast Cancer Receiving Chemotherapy
Oncol Nurs Forum. 2023 Jun 15;50(4):499-508. doi: 10.1188/23.ONF.499-508.ABSTRACTOBJECTIVES: To understand taste and smell alterations (TSAs) and their relationship with quality of life among women with breast cancer receiving chemotherapy.SAMPLE & SETTING: A descriptive correlational study was conducted with 121 women with breast cancer receiving chemotherapy, and data were collected through an online survey.METHODS & VARIABLES: The Taste and Smell Survey was used to measure TSAs, and the Functional Assessment of Cancer Therapy-Breast was used to measure quality of life.RESULTS: More than half of the participants ...
Source: Oncology Nursing Forum - September 7, 2023 Category: Nursing Authors: Hae Jeong An Sook Jung Kang Source Type: research
GLUT5: structure, functions, diseases and potential applications
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023158. Online ahead of print.ABSTRACTGlucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has been well understood to play a significant role in the pathogenesis of human digestive diseases. Recently, the role of GL...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aqian Song Yuanpeng Mao Hongshan Wei Source Type: research
The Relationship Between Taste and Smell Alterations and Quality of Life Among Women With Breast Cancer Receiving Chemotherapy
Oncol Nurs Forum. 2023 Jun 15;50(4):499-508. doi: 10.1188/23.ONF.499-508.ABSTRACTOBJECTIVES: To understand taste and smell alterations (TSAs) and their relationship with quality of life among women with breast cancer receiving chemotherapy.SAMPLE & SETTING: A descriptive correlational study was conducted with 121 women with breast cancer receiving chemotherapy, and data were collected through an online survey.METHODS & VARIABLES: The Taste and Smell Survey was used to measure TSAs, and the Functional Assessment of Cancer Therapy-Breast was used to measure quality of life.RESULTS: More than half of the participants ...
Source: Oncology Nursing Forum - September 7, 2023 Category: Nursing Authors: Hae Jeong An Sook Jung Kang Source Type: research
GLUT5: structure, functions, diseases and potential applications
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023158. Online ahead of print.ABSTRACTGlucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has been well understood to play a significant role in the pathogenesis of human digestive diseases. Recently, the role of GL...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aqian Song Yuanpeng Mao Hongshan Wei Source Type: research
The Relationship Between Taste and Smell Alterations and Quality of Life Among Women With Breast Cancer Receiving Chemotherapy
Oncol Nurs Forum. 2023 Jun 15;50(4):499-508. doi: 10.1188/23.ONF.499-508.ABSTRACTOBJECTIVES: To understand taste and smell alterations (TSAs) and their relationship with quality of life among women with breast cancer receiving chemotherapy.SAMPLE & SETTING: A descriptive correlational study was conducted with 121 women with breast cancer receiving chemotherapy, and data were collected through an online survey.METHODS & VARIABLES: The Taste and Smell Survey was used to measure TSAs, and the Functional Assessment of Cancer Therapy-Breast was used to measure quality of life.RESULTS: More than half of the participants ...
Source: Oncology Nursing Forum - September 7, 2023 Category: Nursing Authors: Hae Jeong An Sook Jung Kang Source Type: research
