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Vaccination: Cancer Vaccines
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Total 8118 results found since Jan 2013.
Novel competitive enzyme-linked immunosorbent assay for the detection of the high-risk Human Papillomavirus 18 E6 oncoprotein
PLoS One. 2023 Aug 15;18(8):e0290088. doi: 10.1371/journal.pone.0290088. eCollection 2023.ABSTRACTCervical cancer represents a global concern with 604,000 new cases and 342,000 deaths reported annually, with the vast majority diagnosed in low income countries. Despite high-risk Human Papillomavirus (HR HPV)-induced cervical cancer has become highly preventable through prophylactic vaccines, screening programs are critical in the control of cervical carcinogenesis in populations with limited access to vaccination and in older generations of women who have already been exposed to HR HPV infection. The surge of HPV molecular ...
Source: Cancer Control - August 15, 2023 Category: Cancer & Oncology Authors: Natalia E Contreras Julieta S Rold án Daniela S Castillo Source Type: research
Recent advances and applications of peptide-agent conjugates for targeting tumor cells
CONCLUSIONS: This review highlights the potential of ACPs as a promising therapeutic option for cancer treatment, particularly through the use of peptide vaccines and peptide-drug conjugates. Despite the limitations of peptides, such as poor metabolic stability and low bioavailability, modified peptides show promise in addressing these challenges. Various mechanism of action of anticancer peptides. Modes of action against cancer cells including: inducing apoptosis by cytochrome c release, direct cell membrane lysis (necrosis), inhibiting angiogenesis, inducing autophagy-mediated cell death and immune cell regulation.PMID:3...
Source: Cell Research - August 15, 2023 Category: Cytology Authors: Vahab Alamdari-Palangi Khojaste Rahimi Jaberi Mahshid Shahverdi Yasaman Naeimzadeh Amir Tajbakhsh Sahar Khajeh Vahid Razban Jafar Fallahi Source Type: research
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't n...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Albumin pre-opsonized membrane-active iPep nanomedicine potentiates chemo to immunotherapy of cancer
Biomaterials. 2023 Aug 8;301:122269. doi: 10.1016/j.biomaterials.2023.122269. Online ahead of print.ABSTRACTChemotherapy-conjugated immunotherapy in clinical oncology conceptually resembles the combined effects of cytoreduction and immunostimulation in membrane targeted cell killings mediated by pore-forming proteins or host defense peptides. Of the similar concept, targeting cancer cell membrane using membrane active peptides is a hopeful therapeutic modality but had long been hindered from in vivo application. Here we report an enabling strategy of pre-opsonizing a membrane penetrating Ir-complexed octa-arginine peptide ...
Source: Biomaterials - August 13, 2023 Category: Materials Science Authors: Shuangshuang Ji Liu Huang Shiwei Chang Xingwei Sun Hanjie Liu Ang Li Yong Jin Hao Fei Source Type: research
Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria
Expert Rev Vaccines. 2023 Aug 11. doi: 10.1080/14760584.2023.2245890. Online ahead of print.ABSTRACTINTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite.AREAS COVERED: Sporozoites (SPZ), the parasite stage transmitted by Anopheles mosquitoes to humans, are the only vaccine immunogen achieving > 90% efficacy against Pf infection. This review describes &g...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Thomas L Richie L W Preston Church Tooba Murshedkar Peter F Billingsley Eric R James Mei-Chun Chen Yonas Abebe None Natasha Kc Sumana Chakravarty David Dolberg Sara A Healy Halimatou Diawara Mahamadou S Sissoko Issaka Sagara David M Cook Judith E Epstein Source Type: research
Vaccination against Extracellular Vimentin for Treatment of Urothelial Cancer of the Bladder in Client-Owned Dogs
Cancers (Basel). 2023 Aug 3;15(15):3958. doi: 10.3390/cancers15153958.ABSTRACTIt was recently shown that targeting extracellular vimentin (eVim) is safe and effective in preclinical models. Here, we report the safety and efficacy in client-owned dogs with spontaneous bladder cancer of CVx1, an iBoost technology-based vaccine targeting eVim in combination with COX-2 inhibition. This was a single-arm prospective phase 1/2 study with CVx1 in 20 client-owned dogs with spontaneous UC which involved four subcutaneous vaccinations with CVx1 at 2-week intervals for induction of antibody titers, followed by maintenance vaccinations...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Diederik J M Engbersen Judy R van Beijnum Arno Roos Marit van Beelen Jan David de Haan Guy C M Grinwis Jack A Schalken J Alfred Witjes Arjan W Griffioen Elisabeth J M Huijbers Source Type: research
Age-dependent modulation of gut microbiome in response to tumor immunomodulation
In this study, we sequentially treated young mice (~8 weeks) and old mice (>18 months) with bilateral melanoma using FUS and calreticulin nanoparticles (CRT-NP) to enhance immunogenic cell death. The combination of CRT-NP and FUS (CFUS) demonstrated greater efficacy in inducing regression of treated and untreated tumors in young mice compared to old mice. The diminished effectiveness in older mice was associated with significant differences in gut microbiome composition, characterized by alterations in bacterial species and splenic immune cells. Specifically, young mice exposed to CFUS exhibited higher abundance of Bact...
Source: Experimental Gerontology - August 12, 2023 Category: Geriatrics Authors: Akansha Singh Harshini Ashar Ashish Ranjan Source Type: research
Viral nanoparticles: Current advances in design and development
Biochimie. 2023 Aug 10:S0300-9084(23)00197-9. doi: 10.1016/j.biochi.2023.08.006. Online ahead of print.ABSTRACTViral nanoparticles (VNPs) are self-assembling, adaptable delivery systems for vaccines and other therapeutic agents used in a variety of biomedical applications. The potential of viruses to invade and infect various hosts and cells renders them suitable as potential nanocarriers, possessing distinct functional characteristics, immunogenic properties, and improved biocompatibility and biodegradability. VPNs are frequently produced through precise genetic or chemical engineering, which involves adding diverse seque...
Source: Biochimie - August 12, 2023 Category: Biochemistry Authors: Siva Santhiya Arul Brinda Balakrishnan Savithri S Handanahal Sangita Venkataraman Source Type: research
Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria
Expert Rev Vaccines. 2023 Aug 11. doi: 10.1080/14760584.2023.2245890. Online ahead of print.ABSTRACTINTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially for Plasmodium falciparum (Pf), the deadliest human malaria parasite.AREAS COVERED: Sporozoites (SPZ), the parasite stage transmitted by Anopheles mosquitoes to humans, are the only vaccine immunogen achieving > 90% efficacy against Pf infection. This review describes &g...
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Thomas L Richie L W Preston Church Tooba Murshedkar Peter F Billingsley Eric R James Mei-Chun Chen Yonas Abebe None Natasha Kc Sumana Chakravarty David Dolberg Sara A Healy Halimatou Diawara Mahamadou S Sissoko Issaka Sagara David M Cook Judith E Epstein Source Type: research
Age-dependent modulation of gut microbiome in response to tumor immunomodulation
In this study, we sequentially treated young mice (~8 weeks) and old mice (>18 months) with bilateral melanoma using FUS and calreticulin nanoparticles (CRT-NP) to enhance immunogenic cell death. The combination of CRT-NP and FUS (CFUS) demonstrated greater efficacy in inducing regression of treated and untreated tumors in young mice compared to old mice. The diminished effectiveness in older mice was associated with significant differences in gut microbiome composition, characterized by alterations in bacterial species and splenic immune cells. Specifically, young mice exposed to CFUS exhibited higher abundance of Bact...
Source: Experimental Gerontology - August 12, 2023 Category: Geriatrics Authors: Akansha Singh Harshini Ashar Ashish Ranjan Source Type: research
Viral nanoparticles: Current advances in design and development
Biochimie. 2023 Aug 10:S0300-9084(23)00197-9. doi: 10.1016/j.biochi.2023.08.006. Online ahead of print.ABSTRACTViral nanoparticles (VNPs) are self-assembling, adaptable delivery systems for vaccines and other therapeutic agents used in a variety of biomedical applications. The potential of viruses to invade and infect various hosts and cells renders them suitable as potential nanocarriers, possessing distinct functional characteristics, immunogenic properties, and improved biocompatibility and biodegradability. VPNs are frequently produced through precise genetic or chemical engineering, which involves adding diverse seque...
Source: Biochimie - August 12, 2023 Category: Biochemistry Authors: Siva Santhiya Arul Brinda Balakrishnan Savithri S Handanahal Sangita Venkataraman Source Type: research
