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Vaccination: Cancer Vaccines
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Total 8118 results found since Jan 2013.
Creation and characterization of a recombinant mammalian orthoreovirus expressing σ1 fusion proteins encoding human epidermal growth factor receptor 2 peptides
Virology. 2023 Aug 19;587:109871. doi: 10.1016/j.virol.2023.109871. Online ahead of print.ABSTRACTMammalian orthoreovirus (MRV) is an oncolytic virus that has been tested in over 30 clinical trials. Increased clinical success has been achieved when MRV is used in combination with other onco-immunotherapies. This has led the field to explore the creation of recombinant MRVs which incorporate immunotherapeutic sequences into the virus genome. This work focuses on creation and characterization of a recombinant MRV, S1/HER2nhd, which encodes a truncated σ1 protein fused in frame with three human epidermal growth factor recept...
Source: Virology - August 27, 2023 Category: Virology Authors: Nicole A Jandick Cathy L Miller Source Type: research
Plant Viruses as Adjuvants for Next-Generation Vaccines and Immunotherapy
Vaccines (Basel). 2023 Aug 16;11(8):1372. doi: 10.3390/vaccines11081372.ABSTRACTVaccines are the cornerstone of infectious disease control and prevention. The outbreak of SARS-CoV-2 has confirmed the urgent need for a new approach to the design of novel vaccines. Plant viruses and their derivatives are being used increasingly for the development of new medical and biotechnological applications, and this is reflected in a number of preclinical and clinical studies. Plant viruses have a unique combination of features (biosafety, low reactogenicity, inexpensiveness and ease of production, etc.), which determine their potentia...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Nikolai Nikitin Yuri Vasiliev Angelina Kovalenko Ekaterina Ryabchevskaya Olga Kondakova Ekaterina Evtushenko Olga Karpova Source Type: research
COVID-19 Vaccination Effectiveness in the General Population of an Italian Province: Two Years of Follow-Up
Vaccines (Basel). 2023 Aug 4;11(8):1325. doi: 10.3390/vaccines11081325.ABSTRACTWe carried out a cohort study on the overall population of the province of Pescara, Italy, to assess the real-world effectiveness of SARS-CoV-2 vaccination against infection, severe, or lethal COVID-19, two years after the start of the vaccination campaign. We included all the resident or domiciled subjects, and extracted the official demographic, vaccination, COVID-19, hospital and co-pay exemption datasets from 1 January 2021, up to 15 February 2023. Cox proportional hazards analyses were adjusted for gender, age, diabetes, hypertension, COPD,...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Annalisa Rosso Maria Elena Flacco Graziella Soldato Giuseppe Di Martino Cecilia Acuti Martellucci Roberto Carota Marco De Benedictis Graziano Di Marco Rossano Di Luzio Matteo Fiore Antonio Caponetti Lamberto Manzoli Source Type: research
Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy
Pharmaceutics. 2023 Aug 1;15(8):2068. doi: 10.3390/pharmaceutics15082068.ABSTRACTLipid nanoparticles (LNPs) have gained great attention as carriers for mRNA-based therapeutics, finding applications in various indications, extending beyond their recent use in vaccines for infectious diseases. However, many aspects of LNP structure and their effects on efficacy are not well characterized. To further exploit the potential of mRNA therapeutics, better control of the relationship between LNP formulation composition with internal structure and transfection efficiency in vitro is necessary. We compared two well-established ioniza...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Christoph Wilhelmy Isabell Sofia Keil Lukas Uebbing Martin A Schroer Daniel Franke Thomas Nawroth Matthias Barz Ugur Sahin Heinrich Haas Mustafa Diken Peter Langguth Source Type: research
Enhancement of Neutralization Responses through Sequential Immunization of Stable Env Trimers Based on Consensus Sequences from Select Time Points by Mimicking Natural Infection
Int J Mol Sci. 2023 Aug 10;24(16):12642. doi: 10.3390/ijms241612642.ABSTRACTHIV-1 vaccines have been challenging to develop, partly due to the high level of genetic variation in its genome. Thus, a vaccine that can induce cross-reactive neutralization activities will be needed. Studies on the co-evolution of antibodies and viruses indicate that mimicking the natural infection is likely to induce broadly neutralizing antibodies (bnAbs). We generated the consensus Env sequence for each time point in subject CH505, who developed broad neutralization activities, and selected five critical time points before broad neutralizatio...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Mingming Wan Xiao Yang Jie Sun Elena E Giorgi Xue Ding Yan Zhou Yong Zhang Weiheng Su Chunlai Jiang Yaming Shan Feng Gao Source Type: research
GV1001 Inhibits the Severity of the Ligature-Induced Periodontitis and the Vascular Lipid Deposition Associated with the Periodontitis in Mice
In conclusion, our study suggests that GV1001 prevents the exacerbation of periodontitis and atherosclerosis associated with periodontitis partly by inhibiting local, systemic, and vascular inflammation and phenotypic changes of vascular endothelial cells.PMID:37628753 | DOI:10.3390/ijms241612566
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Sharon Y Kim Yun-Jeong Kim Suyang Kim Mersedeh Momeni Alicia Lee Alexandra Treanor Sangjae Kim Reuben H Kim No-Hee Park Source Type: research
mRNA vaccine in cancer therapy: Current advance and future outlook
Clin Transl Med. 2023 Aug;13(8):e1384. doi: 10.1002/ctm2.1384.ABSTRACTMessenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer. In the past 2 years, SARS-CoV-2 mRNA vaccines have contributed tremendously against SARS-CoV2, which has prompted the arrival of the mRNA vaccine research boom, especially in the research of cancer vaccines. Compared with conventional cancer vaccines, mRNA vaccines have significant advantages, including efficient production of protective immune responses, relatively low s...
Source: Clinical Breast Cancer - August 24, 2023 Category: Cancer & Oncology Authors: Youhuai Li Mina Wang Xueqiang Peng Yingying Yang Qishuang Chen Jiaxing Liu Qing She Jichao Tan Chuyuan Lou Zehuan Liao Xuexin Li Source Type: research
Facile preparation of PEGylated polyethylenimine polymers as vaccine carriers with reduced cytotoxicity and enhanced Interleukin-2 (IL-2) production
In this study, through facile modification of mPEG5k-4-toluenesulfonate (mPEG5k-OTs) on PEI25k under mild conditions, a series of "stealth" mPEG5k-PEI25k polymers (PP1, PP2 and PP3) were prepared, their structures and physicochemical properties were characterized and theoretically analyzed. The polymers could bind/load ovalbumin (OVA) to form mPEG5k-PEI25k/OVA complexes as negatively charged nanoparticles with small hydrodynamic particle size (80-210 nm) and narrow size distribution. Compared to PEI25k/OVA, lower cytotoxicity could be achieved on mPEG5k-PEI25k/OVA complexes in dendritic cells (DCs). In DCs-RF 33.70 T-cells...
Source: Colloids and Surfaces - August 24, 2023 Category: Biotechnology Authors: Jian Chen Hui Wang Li Zhang Wanying Yan Ruilong Sheng Source Type: research
Vaccination Coverage Among Adolescents Aged 13-17 Years - National Immunization Survey-Teen, United States, 2022
MMWR Morb Mortal Wkly Rep. 2023 Aug 25;72(34):912-919. doi: 10.15585/mmwr.mm7234a3.ABSTRACTThree vaccines are routinely recommended for adolescents to prevent pertussis, meningococcal disease, and cancers caused by human papillomavirus (HPV). CDC analyzed data from the 2022 National Immunization Survey-Teen for 16,043 adolescents aged 13-17 years to assess vaccination coverage. Birth cohort analyses were conducted to assess trends in vaccination coverage by age 13 years (i.e., before the 13th birthday) and by age 14 years (i.e., before the 14th birthday) among adolescents who were due for routine vaccination before and dur...
Source: MMWR Morb Mortal Wkl... - August 24, 2023 Category: Epidemiology Authors: Cassandra Pingali David Yankey Laurie D Elam-Evans Lauri E Markowitz Madeleine R Valier Benjamin Fredua Samuel J Crowe Carla L DeSisto Shannon Stokley James A Singleton Source Type: research
Facile preparation of PEGylated polyethylenimine polymers as vaccine carriers with reduced cytotoxicity and enhanced Interleukin-2 (IL-2) production
In this study, through facile modification of mPEG5k-4-toluenesulfonate (mPEG5k-OTs) on PEI25k under mild conditions, a series of "stealth" mPEG5k-PEI25k polymers (PP1, PP2 and PP3) were prepared, their structures and physicochemical properties were characterized and theoretically analyzed. The polymers could bind/load ovalbumin (OVA) to form mPEG5k-PEI25k/OVA complexes as negatively charged nanoparticles with small hydrodynamic particle size (80-210 nm) and narrow size distribution. Compared to PEI25k/OVA, lower cytotoxicity could be achieved on mPEG5k-PEI25k/OVA complexes in dendritic cells (DCs). In DCs-RF 33.70 T-cells...
Source: Colloids and Surfaces - August 24, 2023 Category: Biotechnology Authors: Jian Chen Hui Wang Li Zhang Wanying Yan Ruilong Sheng Source Type: research
Vaccination Coverage Among Adolescents Aged 13-17 Years - National Immunization Survey-Teen, United States, 2022
MMWR Morb Mortal Wkly Rep. 2023 Aug 25;72(34):912-919. doi: 10.15585/mmwr.mm7234a3.ABSTRACTThree vaccines are routinely recommended for adolescents to prevent pertussis, meningococcal disease, and cancers caused by human papillomavirus (HPV). CDC analyzed data from the 2022 National Immunization Survey-Teen for 16,043 adolescents aged 13-17 years to assess vaccination coverage. Birth cohort analyses were conducted to assess trends in vaccination coverage by age 13 years (i.e., before the 13th birthday) and by age 14 years (i.e., before the 14th birthday) among adolescents who were due for routine vaccination before and dur...
Source: MMWR Morb Mortal Wkl... - August 24, 2023 Category: Epidemiology Authors: Cassandra Pingali David Yankey Laurie D Elam-Evans Lauri E Markowitz Madeleine R Valier Benjamin Fredua Samuel J Crowe Carla L DeSisto Shannon Stokley James A Singleton Source Type: research
mRNA vaccine in cancer therapy: Current advance and future outlook
Clin Transl Med. 2023 Aug;13(8):e1384. doi: 10.1002/ctm2.1384.ABSTRACTMessenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer. In the past 2 years, SARS-CoV-2 mRNA vaccines have contributed tremendously against SARS-CoV2, which has prompted the arrival of the mRNA vaccine research boom, especially in the research of cancer vaccines. Compared with conventional cancer vaccines, mRNA vaccines have significant advantages, including efficient production of protective immune responses, relatively low s...
Source: Clinical Genitourinary Cancer - August 24, 2023 Category: Cancer & Oncology Authors: Youhuai Li Mina Wang Xueqiang Peng Yingying Yang Qishuang Chen Jiaxing Liu Qing She Jichao Tan Chuyuan Lou Zehuan Liao Xuexin Li Source Type: research
Vaccination Coverage Among Adolescents Aged 13-17 Years - National Immunization Survey-Teen, United States, 2022
MMWR Morb Mortal Wkly Rep. 2023 Aug 25;72(34):912-919. doi: 10.15585/mmwr.mm7234a3.ABSTRACTThree vaccines are routinely recommended for adolescents to prevent pertussis, meningococcal disease, and cancers caused by human papillomavirus (HPV). CDC analyzed data from the 2022 National Immunization Survey-Teen for 16,043 adolescents aged 13-17 years to assess vaccination coverage. Birth cohort analyses were conducted to assess trends in vaccination coverage by age 13 years (i.e., before the 13th birthday) and by age 14 years (i.e., before the 14th birthday) among adolescents who were due for routine vaccination before and dur...
Source: MMWR Morb Mortal Wkl... - August 24, 2023 Category: Epidemiology Authors: Cassandra Pingali David Yankey Laurie D Elam-Evans Lauri E Markowitz Madeleine R Valier Benjamin Fredua Samuel J Crowe Carla L DeSisto Shannon Stokley James A Singleton Source Type: research
