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Vaccination: Cancer Vaccines
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Total 8118 results found since Jan 2013.
Recent Advances in Messenger Ribonucleic Acid (mRNA) Vaccines and Their Delivery Systems: A Review
Clin Pharmacol. 2023 Aug 3;15:77-98. doi: 10.2147/CPAA.S418314. eCollection 2023.ABSTRACTMessenger ribonucleic acid (mRNA) was found as the intermediary that transfers genetic information from DNA to ribosomes for protein synthesis in 1961. The emergency use authorization of the two covid-19 mRNA vaccines, BNT162b2 and mRNA-1273, is a significant achievement in the history of vaccine development. Because they are generated in a cell-free environment using the in vitro transcription (IVT) process, mRNA vaccines are risk-free. Moreover, chemical modifications to the mRNA molecule, such as cap structures and changed nucleosid...
Source: Clinical Pharmacology: Advances and Applications - August 9, 2023 Category: Allergy & Immunology Authors: Wubetu Yihunie Getinet Nibret Yibeltal Aschale Source Type: research
Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma
This study offers a prospective strategy to develop personalized neoantigen vaccines for augmenting cancer immunotherapy efficiency in immune "cold" HCC.PMID:37552209 | DOI:10.15252/emmm.202216836
Source: Molecular Medicine - August 8, 2023 Category: Molecular Biology Authors: Ming Wu Zijin Luo Zhixiong Cai Qianqian Mao Zhenli Li Hao Li Cao Zhang Yuting Zhang Aoxue Zhong Liming Wu Xiaolong Liu Source Type: research
What does the historic settlement won by Henrietta Lacks ’s family mean for others?
Last week, the family of Henrietta Lacks settled its lawsuit against the huge biotechnology company Thermo Fisher Scientific over its claim that
the company had been “unjustly enriched”
by its use of her cells. Lacks was a Black woman who died of cervical cancer in 1951, soon after a doctor took a sample from her tumor without her knowledge or consent and created an immortal cell line, HeLa.
No financial payments or other terms of the settlement were disclosed, and no judge ruled on the fundamentals of the unusual claim. But some have nevertheless hailed it as precedent setting. And the family
’
s la...
Source: Science of Aging Knowledge Environment - August 7, 2023 Category: Geriatrics Source Type: research
Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression
Elife. 2023 Aug 7;12:e85263. doi: 10.7554/eLife.85263. Online ahead of print.ABSTRACTCancer immunotherapies, in particular checkpoint blockade immunotherapy (CBT), can induce control of cancer growth, with a fraction of patients experiencing durable responses. However, the majority of patients currently do not respond to CBT and the molecular determinants of resistance have not been fully elucidated. Mounting clinical evidence suggests that the clonal status of neoantigens (NeoAg) impacts the anti-tumor T cell response. High intratumor heterogeneity (ITH), where the majority of NeoAgs are expressed subclonally, is correlat...
Source: Cancer Control - August 7, 2023 Category: Cancer & Oncology Authors: Kim Bich Nguyen Malte Roerden Christopher J Copeland Coralie M Backlund Nory G Klop-Packel Tanaka Remba Byungji Kim Nishant K Singh Michael E Birnbaum Darrell J Irvine Stefani Spranger Source Type: research
The most common gastrointestinal alterations in patients with post-COVID syndrome
CONCLUSION: We identified female gender, obesity, cardiovascular diseases, cancer, hypertension and diabetes as major risk factors of post-COVID syndrome. Vaccinated status may prevent post-COVID gastrointestinal symptoms. Orv Hetil. 2023; 164(31): 1206-1212.PMID:37543972 | DOI:10.1556/650.2023.32839
Source: Orvosi Hetilap - August 6, 2023 Category: General Medicine Authors: Kata Angyal Anna Mandula Tajthy B álint Drácz P ál Miheller Mikl ós Horváth Hajnal Sz ékely Veronika Papp Di ána Czompa Attila Szij ártó Kl ára Werling Source Type: research
