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Total 4677907 results found since Jan 2013.

Derivation and External Validation of a Case Mix Model for the Standardized Reporting of 30-Day Stroke Mortality Rates Clinical Sciences
Conclusions— We have derived and externally validated 2 models to predict mortality in unselected patients with acute stroke using commonly collected clinical variables. In settings where the ability to record the full NIHSS on admission is limited, the level of consciousness component of the NIHSS provides a good approximation of the full NIHSS for mortality prediction.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Bray, B. D., Campbell, J., Cloud, G. C., Hoffman, A., James, M., Tyrrell, P. J., Wolfe, C. D. A., Rudd, A. G., on behalf of the Intercollegiate Stroke Working Party Group Tags: Epidemiology Clinical Sciences Source Type: research

Long-Term Costs of Stroke Using 10-Year Longitudinal Data From the North East Melbourne Stroke Incidence Study Clinical Sciences
Conclusions— Costs to 10 years after stroke have not previously been reported. Our findings demonstrate the importance of estimating resource use over longer periods for forecasting lifetime estimates.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Gloede, T. D., Halbach, S. M., Thrift, A. G., Dewey, H. M., Pfaff, H., Cadilhac, D. A. Tags: Health policy and outcome research, Other Stroke Treatment - Medical, Epidemiology Clinical Sciences Source Type: research

Transient Receptor Potential Melastatin Subfamily Member 2 Cation Channel Regulates Detrimental Immune Cell Invasion in Ischemic Stroke Basic Sciences
Conclusions— Although a neuroprotective effect of TRPM2 in vitro is well known, we can show for the first time that the detrimental role of TRPM2 in stroke primarily depends on its role in activating peripheral immune cells. Targeting TRPM2 systemically represents a promising therapeutic approach for ischemic stroke.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Gelderblom, M., Melzer, N., Schattling, B., Gob, E., Hicking, G., Arunachalam, P., Bittner, S., Ufer, F., Herrmann, A. M., Bernreuther, C., Glatzel, M., Gerloff, C., Kleinschnitz, C., Meuth, S. G., Friese, M. A., Magnus, T. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Acute Cerebral Infarction, Brain Circulation and Metabolism, Pathology of Stroke Basic Sciences Source Type: research

Socioeconomic Position and Survival After Stroke in Denmark 2003 to 2012: Nationwide Hospital-Based Study Clinical Sciences
Conclusions— The survival of patients with low income was reduced by 30% as compared with those with high income. Education had only a modest effect and only in patients aged <65 years. The impact of socioeconomic position was on late but not on early poststroke death.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Andersen, K. K., Dalton, S. O., Steding-Jessen, M., Olsen, T. S. Tags: Cerebrovascular disease/stroke, Primary and Secondary Stroke Prevention, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Validity of Acute Stroke Lesion Volume Estimation by Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomographic Score Depends on Lesion Location in 496 Patients With Middle Cerebral Artery Stroke Clinical Sciences
Conclusions— ASPECTS has limitations when lesion location is not considered. Identification of patients with malignant profile by DWI-ASPECTS may be unreliable. ASPECTS may be a useful tool for the evaluation of noncontrast computed tomography. However, if MRI is used, ASPECTS seems dispensable because lesion volume can easily be quantified on DWI maps.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Schroder, J., Cheng, B., Ebinger, M., Kohrmann, M., Wu, O., Kang, D.-W., Liebeskind, D. S., Tourdias, T., Singer, O. C., Christensen, S., Campbell, B., Luby, M., Warach, S., Fiehler, J., Fiebach, J. B., Gerloff, C., Thomalla, G., on behalf of the STIR and Tags: Acute Cerebral Infarction, Acute Stroke Syndromes, Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Arteriopathy Diagnosis in Childhood Arterial Ischemic Stroke: Results of the Vascular Effects of Infection in Pediatric Stroke Study Clinical Sciences
Conclusions— Clinical data and follow-up imaging help, yet uncertainty in the diagnosis of childhood arteriopathy remains. This presents a challenge to better understanding the mechanisms underlying these arteriopathies and designing strategies for prevention of childhood arterial ischemic stroke.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Wintermark, M., Hills, N. K., deVeber, G. A., Barkovich, A. J., Elkind, M. S. V., Sear, K., Zhu, G., Leiva-Salinas, C., Hou, Q., Dowling, M. M., Bernard, T. J., Friedman, N. R., Ichord, R. N., Fullerton, H. J., and the VIPS Investigators, Benedict, Fox, L Tags: Stroke in Children and the Young Clinical Sciences Source Type: research

Catabolic Signaling and Muscle Wasting After Acute Ischemic Stroke in Mice: Indication for a Stroke-Specific Sarcopenia Basic Sciences
Conclusions— Catabolic pathways of muscle tissue are activated after stroke. Impaired feeding, sympathetic overactivation, or infection cannot fully explain this catabolic activation. Wasting of the target muscle of the disrupted innervation correlated to severity of brain injury. Our data indicate the presence of a stroke-specific sarcopenia.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Springer, J., Schust, S., Peske, K., Tschirner, A., Rex, A., Engel, O., Scherbakov, N., Meisel, A., von Haehling, S., Boschmann, M., Anker, S. D., Dirnagl, U., Doehner, W. Tags: Animal models of human disease, Other Stroke Treatment - Medical Basic Sciences Source Type: research

The role of prestroke glycemic control on severity and outcome of acute ischemic stroke.
Conclusions. Our study suggests that poor glycemic control (baseline HbA1c) prior to IS is an independent risk factor for poor survival and a marker for increased stroke severity and unfavorable long-term functional outcome. PMID: 25295219 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Autologous bone marrow mononuclear cells intrathecal transplantation in chronic stroke.
This study demonstrates the potential of autologous BMMNCs intrathecal transplantation in improving the prognosis of functional recovery in chronic stage of stroke. Further clinical trials are recommended. This trial is registered with NCT02065778. PMID: 25126443 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Changes in predicted muscle coordination with subject-specific muscle parameters for individuals after stroke.
The objective of this study was to examine the effect of subject-specific muscle force and activation deficits on predicted muscle coordination when using musculoskeletal models for individuals after stroke. Maximum force generating ability and central activation ratio of the paretic plantar flexors, dorsiflexors, and quadriceps muscle groups were obtained using burst superimposition for four individuals after stroke with a range of walking speeds. Two models were created per subject: one with generic and one with subject-specific activation and maximum isometric force parameters. The inclusion of subject-specific muscle d...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Co-Occurrence of Arthritis and Stroke amongst Middle-Aged and Older Adults in Canada.
Authors: Matveev R, Ardern CI Abstract Arthritis is a chronic inflammatory condition commonly associated with mobility restriction and reduced activity. To date, the extent to which arthritis is an independent risk factor for stroke is unclear, and important, in light of an aging population. The purpose of this study was to (i) quantify the cross-sectional association between stroke and arthritis and (ii) to determine whether the relationship differed in physically active and inactivemiddle-aged and older adults. Data was derived from the 2010 Canadian Community Health Survey (N = 47 188; ≥30 y). Multivariabl...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Factors Affecting the Ability of the Stroke Survivor to Drive Their Own Recovery outside of Therapy during Inpatient Stroke Rehabilitation.
Discussion. To enable the stroke survivor to drive their own recovery outside of therapy, there is a need to increase opportunities for practice and promote active engagement. Suggested strategies include building the stroke survivor's motivation and knowledge, creating an enriched environment, and developing daily routines to provide structure outside of therapy time. PMID: 24800104 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Sedentary behaviour and physical activity of people with stroke in rehabilitation hospitals.
Conclusions. The time stroke survivors spend in stroke rehabilitation units may not be used in the most efficient way to promote maximal recovery. Interventions to promote reduced sedentary time could help improve outcome and these should be tested in clinical trials. PMID: 24772368 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Stroke Survivors Scoring Zero on the NIH Stroke Scale Score Still Exhibit Significant Motor Impairment and Functional Limitation.
Conclusion. While being used in stroke trials, the NIHSS may have limited ability to discriminate between treatment responses, even when only a relatively narrow array of impairment levels exists among patients. Given these findings, NIHSS use should be restricted to acute stroke studies and clinical settings with the goal of reporting stroke severity. PMID: 24772367 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Five Years of Acute Stroke Unit Care: Comparing ASU and Non-ASU Admissions and Allied Health Involvement.
Conclusion. This is the first study to report 5 years of ASU admissions. Acute Stroke Units may benefit from a review of the healthcare provided to all stroke patients. The trends over time with respect to the utilisation of the John Hunter Hospitall's ASU have resulted in a review of the hospitall's Stroke Unit and allied healthcare. PMID: 24729911 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research