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Interplay Between Anatomic and Molecular Factors in the Current Management of Endometrial Cancer
The case presented here offers various dilemmas, for which answers are unclear and are being answered by ongoing studies.1 For stage IA, grade 1 with substantial lymphovascular space invasion (LVSI), American Society for Radiation Oncology guidelines favor brachytherapy while European guidelines place this patient in at least the high-intermediate-risk group, favoring external beam radiation therapy. The revised quantification of PORTEC-1 and -2 data found that patients with ≥4 involved vessels (substantial LVSI) had a 26.3% rate of pelvic lymph node recurrence compared with 6.7% for 1 to 3 foci (focal LVSI) and 3.3% with no LVSI.
Source: International Journal of Radiation Oncology * Biology * Physics - August 29, 2023 Category: Radiology Authors: Hirsch Matani, Sushil Beriwal Tags: Gray Zone Source Type: research
A new way to visualize prostate brachytherapy needles using ultrasound color Doppler and needle surface modifications
Suboptimal ultrasound conspicuity of the brachytherapy applicator can lead to inaccurate image reconstructions of the applicator resulting in decreased tumor control or increased normal tissue dose. This feasibility study aims to improve ultrasound conspicuity of high-dose rate (HDR) brachytherapy needles by modifying the surface of the needles to produce a color Doppler twinkling signature.
Source: Brachytherapy - August 29, 2023 Category: Cancer & Oncology Authors: Justine M. Dupere, Eric E. Brost, Susheil Uthamaraj, Christine U. Lee, Matthew W. Urban, Bradley J. Stish, Christopher L. Deufel Source Type: research
Locally advanced cervical cancer: how the improvement in techniques in external beam radiotherapy and brachytherapy impacts on survival outcomes and long-term toxicities
ConclusionIn this series, the group of patients receiving optimized ICBT had an advantage in terms of OS and CSS suggesting that the use of new Treatment Planning Systems associated with 3D imaging, improves the long-term survival. Additionally, a significant reduction in late rectal and urinary toxicity has been observed.
Source: La Radiologia Medica - August 28, 2023 Category: Radiology Source Type: research
Cs-131 prostate brachytherapy boost and effect of hydrogel rectal spacer on long-term patient-reported rectal bleeding and bowel quality of life
This study evaluates long-term patient-reported bowel quality of life (QOL), rectal bleeding, and bleeding bother in patients with prostate cancer treated with external beam radiation therapy (EBRT) and Cesium-131 LDR brachytherapy (LDR-BT) boost with and without hydrogel rectal spacer.
Source: Brachytherapy - August 28, 2023 Category: Cancer & Oncology Authors: Mohamed K. Abdelhakiem, Andrew Keller, Rajesh R. Bajpai, Ryan P. Smith, Sushil Beriwal, Ronald Benoit Source Type: research
Outcome comparison of radical prostatectomy versus seed brachytherapy for clinically localized prostate cancer using two biochemical recurrence definitions
We compared the outcome of radical prostatectomy (RP) with seed brachytherapy (BT) in clinically localized prostate cancer (LPCa) using two different biochemical recurrence (BCR) definitions.
Source: BMC Surgery - August 27, 2023 Category: Surgery Authors: Xue-hua Zhu, Fan Zhang, Ze-nan Liu, Ji-de He, Zi-ang Li, Lu-lin Ma, Yi Huang and Jian Lu Tags: Research Source Type: research
Pain in High-Dose-Rate Brachytherapy for Cervical Cancer: A Retrospective Cohort Study
J Pers Med. 2023 Jul 26;13(8):1187. doi: 10.3390/jpm13081187.ABSTRACTHigh-dose-rate brachytherapy (HDR) is part of the main treatment for locally advanced uterine cervical cancer. Our aim was to evaluate the incidence and intensity of pain and patients' satisfaction during HDR. Risk factors for suffering pain were also analyzed. A retrospective study was carried out by extracting data from patients who had received HDR treatment for five years. Postoperative analgesia had been administered using pre-established analgesic protocols for 48 h. Pain assessment was collected according to a protocol by the acute pain unit. Analg...
Source: Cancer Control - August 25, 2023 Category: Cancer & Oncology Authors: Ángel Becerra-Bolaños Miriam Jim énez-Gil Mario Federico Yurena Dom ínguez-Díaz Luc ía Valencia Aurelio Rodr íguez-Pérez Source Type: research
Dosimetric Investigation of Six Ru-106 Eye Plaques by EBT3 Radiochromic Films and Monte Carlo Simulation
CONCLUSION: The measured dose distributions and lateral dose profiles may be utilized in the treatment planning system to cover clinical volumes such as the clinical target volume and the gross tumor volume.PMID:37609514 | PMC:PMC10440413 | DOI:10.31661/jbpe.v0i0.2010-1206
Source: Health Physics - August 23, 2023 Category: Physics Authors: Mojtaba Arjmand Fariba Ghassemi Payman Rafiepour Reyhaneh Zeinali Hamid Riazi-Esfahani Akbar Beiki-Ardakani Source Type: research
In vivo dosimetry in cancer patients undergoing intraoperative radiation therapy
Phys Med Biol. 2023 Aug 22. doi: 10.1088/1361-6560/acf2e4. Online ahead of print.ABSTRACTIn vivo dosimetry (IVD) is an important tool in external beam radiotherapy to detect major errors by assessing differences between expected and delivered dose and to record the received dose by individual patients. Also, in intraoperative radiation therapy (IORT), IVD is highly relevant to register the delivered dose. This is especially relevant in low-risk breast cancer patients since a high dose of IORT is delivered in a single fraction. In contrast to external beam radiotherapy, online treatment planning based on intraoperative imag...
Source: Physics in Medicine and Biology - August 22, 2023 Category: Physics Authors: Anna L Petoukhova Roland Snijder Thomas Vissers Heleen Ceha Henk Struikmans Source Type: research
Estimated Absolute Percentage of Biopsied Tissue Positive for Gleason Pattern 4 (eAPP4) in Low Dose Rate Prostate Brachytherapy: Evaluation of Prognostic Utility in a Large Cohort
CONCLUSIONS: eAPP4 was strongly predictive of recurrence and metastasis-free survival in a large cohort of patients receiving LDR-BT treatment for IR-PCa. Treatment of future patients with IR-PCa could include the use of eAPP4 prognostication.PMID:37604278 | DOI:10.1016/j.radonc.2023.109859
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 21, 2023 Category: Radiology Authors: Geoffrey Casey Harvey Quon Tyler Meyer Michael Sia Kundan Thind Subhadip Das Daniel Cho Philip McGeachy Siraj Husain Kevin Martell Source Type: research
Feasibility of quantitative diffusion-weighted imaging during intra-procedural MRI-guided brachytherapy of locally advanced cervical and vaginal cancers
To determine the feasibility of quantitative apparent diffusion coefficient (ADC) acquisition during magnetic resonance imaging-guided brachytherapy (MRgBT) using reduced field-of-view (rFOV) diffusion-weighted imaging (DWI).
Source: Brachytherapy - August 21, 2023 Category: Cancer & Oncology Authors: Megan C. Jacobsen, Bastien Rigaud, Samantha J. Simiele, Gaiane M. Rauch, Matthew S. Ning, Sastry Vedam, Ann H. Klopp, R. Jason Stafford, Kristy K. Brock, Aradhana M. Venkatesan Source Type: research
The prognosis of patients with prostate cancer receiving permanent seed implantation stratified by prostate volume: should we be reluctant to treat with brachytherapy because of a very small prostate ( & lt;15 cc)?
CONCLUSIONS: Our results obtained by analyzing a very large Japanese prospective database showed no difference in treatment outcomes according to PV (<15 cc, 15-20 cc, and ˃20 cc). Our study confirmed that PI in small prostates (even <15 cc) remains an effective treatment option.PMID:37597804 | DOI:10.1016/j.radonc.2023.109855
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 19, 2023 Category: Radiology Authors: Koji Masui Norihisa Katayama Atsunori Yorozu Takashi Kikuchi Satoshi Higashide Shinsuke Kojima Shiro Saito Source Type: research
