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ASO Visual Abstract: Association of Moderate-Risk Breast Cancer Genes with Contralateral Prophylactic Mastectomy and Bilateral Disease
Ann Surg Oncol. 2023 Sep 20. doi: 10.1245/s10434-023-14280-y. Online ahead of print.NO ABSTRACTPMID:37728824 | DOI:10.1245/s10434-023-14280-y
Source: Ann Oncol - September 20, 2023 Category: Cancer & Oncology Authors: Jennifer Q Zhang Carlos Henrique Dos Anjos Varadan Sevilimedu Angelena Crown Kimberly A Amoroso Melissa L Pilewskie Mark E Robson Mary L Gemignani Source Type: research

Potential impact of HercepTest ™ mAb PharmDx (Dako Omnis) (ge001) in breast cancer diagnosis
Pol J Pathol. 2023;74(2):82-88. doi: 10.5114/pjp.2023.129352.ABSTRACTThe HER2 gene is a biomarker for breast cancer prognosis and treatment. Overexpression of HER2 protein determined by immunohistochemistry (IHC) or amplification of the HER2 gene determined by fluorescence in situ hybridization (FISH) is a condition for qualifying patients for anti-HER2 therapy. Due to the high toxicity of anti-HER2 treatment, proper patient selection is essential. In our study we compared 40 cases with IHC staining of HER2 antibody determined by Ventana PATHWAY anti-HER2/neu antibody (4B5) as HER2 2+ with the new antibody (HercepTest™ m...
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: Andrzej Marsza łek Agata Kubicka Inga Jagie łło Anna Malicka-Durczak Source Type: research

Nuclear expression of Ku70/80 is associated with CHEK2 germline mutations in breast cancer
This study is the first reporting an association of Ku70/80 expression with CHEK2 germline mutations in breast cancer. The results suggest that evaluation of Ku70/80 expression in breast cancer may improve the selection of breast cancer patients for Ku70/80 inhibitor therapy, and point to CHEK2-associated breast cancer and a subset of ER-positive breast cancer as potential suitable targets for such therapy.PMID:37728466 | DOI:10.5114/pjp.2023.129518
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: Rosik Jakub Machaj Filip Bodnar Daniel Hybiak Jolanta Huzarski Tomasz Cybulski Cezary Lubi ński Jan Domaga ła Wenancjusz Pawe ł Domagała Source Type: research

Prognosis-related novel immunostaining pattern for programmed cell death ligand 1 and prognostic value of tumour-infiltrating lymphocytes in triple-negative breast cancer
This study aims to determine the prognostic significance of programmed cell death ligand 1 (PD-L1) expression and tumour-infiltrating lymphocytes (TILs) in triple- negative breast cancer (TNBC). PD-L1 expression and TIL percentage were determined in TNBCs that did not receive neoadjuvant therapy. The relationship between PD-L1 expression and the percentage of TILs with survival was investigated. The presence of intratumoural PD-L1-positive tumour-infiltrating immune cells (TIICs) in tumours with ≥ 1% PD-L1 expression was identified as a new PD-L1 evaluation parameter. The presence of intratumoural PD-L1-positive TIICs as...
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: P ınar Savaş G ürdeniz Serin P ınar Gürsoy Osman Zekio ğlu Necmettin Özdemir Source Type: research

Cancer Health Literacy in Black Women With Breast Cancer: A Comprehensive Literature Review
Clin J Oncol Nurs. 2023 Sep 15;27(5):507-513. doi: 10.1188/23.CJON.507-513.ABSTRACTBACKGROUND: Patients with cancer have unique health literacy needs that affect health outcomes. In regard to breast cancer, Black women are more commonly diagnosed with high-grade breast tumors and have increased mortality rates.OBJECTIVES: This review examines the role of health literacy and discusses health disparities that affect cancer health literacy and health behaviors in Black women with breast cancer.METHODS: A literature search was conducted using CINAHL®, PubMed®, Ovid®, and Google Scholar™. A total of 12 studies were identif...
Source: Clinical Journal of Oncology Nursing - September 20, 2023 Category: Nursing Authors: LaTarvia Moore Alexis Elizabeth Hayes Source Type: research

ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway
In conclusion, this study uncovers the role of ZNF746 in promoting M2 macrophage polarisation and suggests that ZNF746 may be a promising therapeutic target for limiting BC progression.PMID:37730102 | DOI:10.1016/j.cellsig.2023.110892
Source: Cellular Signalling - September 20, 2023 Category: Cytology Authors: Lu Liu Wen-Yue Zhao Xin-Yu Zheng Source Type: research

Exosomal miRNAs as Next-generation Therapy Vehicles in Breast Cancer
Curr Gene Ther. 2023;23(5):330-342. doi: 10.2174/1566523223666230215103524.ABSTRACTThe second most pervasive cancer affecting the survival of women across the world is breast cancer. One of the biggest challenges in breast cancer treatment is the chemoresistance of cancer cells to various medications after some time. Therefore, highly specific blood-based biomarkers are required for early breast cancer diagnosis to overcome chemoresistance and improve patient survival. These days, exosomal miRNAs have attracted much attention as early diagnostic blood-based biomarkers because of their high stability, secretion from maligna...
Source: Current Gene Therapy - September 20, 2023 Category: Genetics & Stem Cells Authors: Priyanka Thakur Harshita Dahiya Ankur Kaushal Vijai Kumar Gupta Adesh K Saini Reena V Saini Source Type: research

Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: < em > in vitro < /em > and < em > in vivo < /em > studies
Xenobiotica. 2023 Sep 20:1-32. doi: 10.1080/00498254.2023.2260886. Online ahead of print.ABSTRACT1. Two curcumin analogs, (1E,6E)-1,7-bis(3,5-diethyl-4-hydroxyphenyl)hepta-1,6-diene-3,5- dione (N17) and its prodrug ((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(2,6-diethyl-4,1- phenylene)bis(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate) (N17'), were evaluated as breast cancer resistance protein (BCRP) inhibitors.2. MDCKII-BCRP and MDCKII-WT were used to evaluate the modulation effects of N17 and N17' on BCRP and to explore the relevant mechanism. Sprague-Dawley rats were orally administered rosuvastatin (ROS), a probe su...
Source: Xenobiotica - September 20, 2023 Category: Research Authors: Chung-Ping Yu Yi-Ru Wang Yu-Chi Hou Min-Tsang Hsieh Pei-Ying Li Sheng-Chu Kuo Shiuan-Pey Lin Source Type: research

Synthesis and antitumor activity of bagasse xylan derivatives modified by graft-esterification and cross-linking
Int J Biol Macromol. 2023 Sep 18:126867. doi: 10.1016/j.ijbiomac.2023.126867. Online ahead of print.ABSTRACTA crucial aspect in achieving sustainable development of biomass materials is the modification of renewable polysaccharides to create various high-value functional materials. In this paper, bagasse xylan (BX) was used as a raw material to introduce benzyl methacrylate (BMA) through graft copolymerization reaction to generate the intermediate product BX-g-BMA. Subsequently, the target product (CA-BX-g-BMA) was synthesized by catalytic esterification of BX-g-BMA with citric acid (CA) in AmimCl ionic liquid. Meanwhile, ...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Bin Zhao Heping Li Kexin Tian Yue Su Zhiming Zou Source Type: research

Analysis of Prognoses according to Breast MRI Results in Patients with Axillary Lymph Node Metastases from an Unknown Primary Origin
CONCLUSION: The prognoses of MR-negative patients with ACUPax who received ALND and WBRT followed by chemotherapy were as good as those of patients with MRI-detected primary breast cancers.PMID:37727923 | DOI:10.3349/ymj.2023.0181
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: E-Ryung Choi Ok Hee Woo Eun Young Ko Boo-Kyung Han Ji Soo Choi Eun Sook Ko Haejung Kim Myoung Kyoung Kim Jeong Eon Lee Source Type: research

PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey
CONCLUSION: Our results raise some important issues concerning the evaluation of PD-L1 in the "real-life" setting, providing strategies for its implementation.PMID:37726962 | DOI:10.1177/03008916231196781
Source: Tumori - September 20, 2023 Category: Cancer & Oncology Authors: Bruna Cerbelli Alessio Cirillo Giulia Pomati Angelina Pernazza Andrea Ascione Simona Pisegna Annalinda Pisano Martina Leopizzi Maria Gemma Pignataro Leopoldo Costarelli Antonino Mul è Andrea Vecchione Piera Catalano Luigi Coppola Giuseppe Perrone Letizia Source Type: research

Prevalence of women with breast implants in Sweden: a study based on the population-based mammography screening programme
CONCLUSION: The prevalence of breast implants in Swedish women is estimated to be around 4%. The population-based mammography screening programme in countries with a publicly funded welfare-type healthcare system and a clear documentation of mammography screening attendance, seems to be a feasible way to establish the prevalence of breast implants in the population. The large number of women with breast implants warrants further studies regarding the best diagnostic and treatment alternatives for this group. Pre-registration: ClinicalTrials.Gov identifier NCT05222100.PMID:37728392 | DOI:10.2340/jphs.v58.15298
Source: Journal of Plastic Surgery and Hand Surgery - September 20, 2023 Category: Surgery Authors: Emma Hansson Sarah Zaya Susanne Meyer Alexa Freiin von Wrangel Fredrik W ärnberg Sophia Zackrisson Source Type: research

Prevalence of women with breast implants in Sweden: a study based on the population-based mammography screening programme
CONCLUSION: The prevalence of breast implants in Swedish women is estimated to be around 4%. The population-based mammography screening programme in countries with a publicly funded welfare-type healthcare system and a clear documentation of mammography screening attendance, seems to be a feasible way to establish the prevalence of breast implants in the population. The large number of women with breast implants warrants further studies regarding the best diagnostic and treatment alternatives for this group. Pre-registration: ClinicalTrials.Gov identifier NCT05222100.PMID:37728392 | DOI:10.2340/jphs.v58.15298
Source: Hand Surgery - September 20, 2023 Category: Surgery Authors: Emma Hansson Sarah Zaya Susanne Meyer Alexa Freiin von Wrangel Fredrik W ärnberg Sophia Zackrisson Source Type: research

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