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Assessment of proprioception, muscle strength and endurance during dynamic isokinetic test in patients with breast cancer-related lymphedema
The difference in proprioception, muscle strength, and endurance between the extremity with lymphedema and the extremity without lymphedema in women with breast cancer-related lymphedema will provide valuable information in terms of prioritizing these parameters in treatment.
Source: Clinical Biomechanics - September 21, 2023 Category: Orthopaedics Authors: Ferdiye Zabit, Gozde Iyigun, Mehtap Malkoc Source Type: research

Celebrity Identification and Reasoned Action: An Integrative Model of the Relationship Between Media Use and Breast Cancer Screening Intention
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Source: Health Communication - September 21, 2023 Category: Health Management Authors: Suahn Jang ChoYan TianDepartment of Communication & Media, University of Missouri-St. Louis Source Type: research

Early breast cancer risk detection: a novel framework leveraging polygenic risk scores and machine learning
Conclusion BRECARDA can enhance disease risk prediction, identify high-risk individuals for BC screening, facilitate disease diagnosis and improve population-level screening efficiency. It can serve as a valuable and supplemental platform to assist doctors in BC diagnosis and evaluation.
Source: Journal of Medical Genetics - September 21, 2023 Category: Genetics & Stem Cells Authors: Tao, L. R., Ye, Y., Zhao, H. Tags: Genotype-phenotype correlations Source Type: research

Detection of pathogenic variants in breast cancer susceptibility genes in bilateral breast cancer
Conclusion We have shown a high rate of detection of BRCA1 and BRCA2 PVs in triple negative and grade 3 ER+HER2– first primary diagnoses, respectively. High rates of HER2+ were associated with CHEK2 PVs, and women ≤30 years were associated with TP53 PVs. First primary ER status in BRCA1/2 strongly predicts the second tumour will be the same ER status even if unusual for PVs in that gene.
Source: Journal of Medical Genetics - September 21, 2023 Category: Genetics & Stem Cells Authors: Evans, D. G., Burghel, G. J., Schlecht, H., Harkness, E. F., Gandhi, A., Howell, S. J., Howell, A., Forde, C., Lalloo, F., Newman, W. G., Smith, M. J., Woodward, E. R. Tags: Cancer genetics Source Type: research

A Versatile PDA(DOX) Nanoplatform for Chemo-Photothermal Synergistic Therapy against Breast Cancer and Attenuated Doxorubicin-Induced Cardiotoxicity
Photothermal therapy (PTT) is a highly clinical application promising cancer treatment strategy with safe, convenient surgical procedures and excellent therapeutic efficacy on superficial tumors. However, a si...
Source: Journal of Nanobiotechnology - September 21, 2023 Category: Nanotechnology Authors: Siqi Geng, Qiang Feng, Chujie Wang, Ying Li, Jiaying Qin, Mingsheng Hou, Jiedong Zhou, Xiaoyu Pan, Fei Xu, Baoru Fang, Ke Wang and Zhangsen Yu Tags: Methodology Source Type: research

Prevalence of psychological distress and associated factors among Omani women diagnosed with breast cancer: a single-centre, cross-sectional study
Conclusions More than half of the women surveyed had been diagnosed at an advanced stage, with up to 21.6% presenting with symptoms of anxiety and depression. Healthcare professionals in Oman should consider additional screening for anxiety and depressive symptoms in this group and encourage patients with BC to disclose emotional information during consultations, particularly for those aged ≥60 years.
Source: BMJ Open - September 21, 2023 Category: General Medicine Authors: Al-Fahdi, A., Chan, M. F., Al-Siyabi, W., Al-Yafai, E., Al-Khatri, M., Al-Azri, M. Tags: Open access, Oncology Source Type: research

Optimization of small molecule degraders and antagonists for targeting estrogen receptor based on breast cancer: current status and future
The estrogen receptor (ER) is a classical receptor protein that plays a crucial role in mediating multiple signaling pathways in various target organs. It has been shown that ER-targeting therapies inhibit breast cancer cell proliferation, enhance neuronal protection, and promote osteoclast formation. Several drugs have been designed to specifically target ER in ER-positive (ER+) breast cancer, including selective estrogen receptor modulators (SERM) such as Tamoxifen. However, the emergence of drug resistance in ER+ breast cancer and the potential side effects on the endometrium which has high ER expression has posed signi...
Source: Frontiers in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Source Type: research

Evaluation of anti-cancer effects of carnosine and melittin-loaded niosomes in MCF-7 and MDA-MB-231 breast cancer cells
Conclusion: Our study successfully declared that Mel-NIO had more anti-cancer effects than Car-NIO in both MCF-7 and MDA-MB-231 breast cancer cells.
Source: Frontiers in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Source Type: research

Effects of Pilates method on quality of life, fatigue and sleep quality among breast cancer women receiving hormone therapy – Two-arm randomized clinical trial
To analyze the effect of the Pilates method on the quality of life, fatigue, and sleep quality of patients undergoing adjuvant clinical treatment with hormone therapy for breast cancer.
Source: Journal of Bodywork and Movement Therapies - September 21, 2023 Category: Physiotherapy Authors: Bruna Leite, Luiza Andreatta Denig, Leonessa Boing, Tatiana de Bem Fretta, Adriana Coutinho de Azevedo Guimar ães Source Type: research

Use of Circulating Tumor DNA (ctDNA) for Early Molecular Detection of Breast Cancer Relapse in Patients with Triple-Negative Breast Cancer (TNBC)
AbstractPurpose of ReviewThe intent of this review is to discuss the clinical utility of circulating tumor DNA (ctDNA) analysis for molecular residual disease (MRD) detection in patients with early-stage TNBC.Recent FindingsBaseline ctDNA concentration correlates with tumor clinical features. ctDNA dynamics during neoadjuvant chemotherapy (NAC) predicts pathologic complete response (pCR), residual cancer burden (RCB), and relapse. Use of ctDNA plus imaging modalities during NAC may improve accuracy of pCR prediction. A lead-time exists from MRD detection and relapse. Tumor-informed assays tracking multiple ctDNA variants s...
Source: Current Breast Cancer Reports - September 21, 2023 Category: Cancer & Oncology Source Type: research

Effect of artificial intelligence –based computer-aided diagnosis on the screening outcomes of digital mammography: a matched cohort study
ConclusionsAI-CAD increases the specificity for radiologists without decreasing sensitivity as a supportive tool in the single reading of DM for breast cancer screening.Clinical relevance statementThis study shows that AI-CAD could improve the specificity of radiologists ’ DM interpretation in the single reading system without decreasing sensitivity, suggesting that it can benefit patients by reducing false positive and recall rates.Key Points• In this retrospective-matched cohort study (DM without AI-CAD vs DM with AI-CAD), radiologists showed higher specificity and lower AIR when AI-CAD was used to support decision-m...
Source: European Radiology - September 20, 2023 Category: Radiology Source Type: research

Preventing Breast Cancer Overtreatment Preventing Breast Cancer Overtreatment
The risk of developing breast cancer in individuals with pathogenic cancer syndrome variants may be less elevated in those without a first-degree family history.MDedge News
Source: Medscape Hematology-Oncology Headlines - September 20, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Molecular Biology Mechanisms and Emerging Therapeutics of Triple-Negative Breast Cancer
Source: Biologics: Targets and Therapy - September 20, 2023 Category: Biochemistry Tags: Biologics: Targets and Therapy Source Type: research

Namibia: Breast Cancer, the Second-Most Common Cancer in Namibia
[Namibian] Breast cancer has affected the lives of countless Namibian women and their families, but Namibians are determined to improve breast cancer awareness, early detection, and treatment.
Source: AllAfrica News: Health and Medicine - September 20, 2023 Category: African Health Tags: Health and Medicine Namibia Noncommunicable Diseases Southern Africa Source Type: news

IceCure Medical Receives FDA Response to De Novo Classification Request for Breast Cancer
CAESAREA, Israel, Sept. 20, 2023 -- (Healthcare Sales & Marketing Network) -- IceCure Medical Ltd. (Nasdaq: ICCM), developer of the ProSense® System, a minimally-invasive cryoablation technology that destroys tumors by freezing as an alternative to su... Devices, FDA IceCure Medical, ProSense System, cryoablation
Source: HSMN NewsFeed - September 20, 2023 Category: Pharmaceuticals Source Type: news

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