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Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies
Bioorg Med Chem. 2023 Sep 7;94:117467. doi: 10.1016/j.bmc.2023.117467. Online ahead of print.ABSTRACTSulfonamides constitute an important class of classical carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. Herein we have accomplished the conjugation of biotin with an ample number of sulfonamide motifs with the aim of testing them in vitro as inhibitors of the human carbonic anhydrase (hCA) isoforms I and II (cytosolic isozymes), as well as hCA IX and XII (transmembrane, tumor-associated enzymes). Most of these newly synthesized compounds exhibited interesting inhibition profiles, with activities in the nanomolar range. The ...
Source: Bioorganic and Medicinal Chemistry - September 18, 2023 Category: Chemistry Authors: Paloma Begines Alessandro Bonardi Alessio Nocentini Paola Gratteri Simone Giovannuzzi Roberto Ronca Camilla Tavani Maria Luisa Massardi Óscar López Claudiu T Supuran Source Type: research

Nrf3 promotes the proliferation and migration of triple ‑negative breast cancer by activating PI3K/AKT/mTOR and epithelial‑mesenchymal transition
In conclusion, Nrf3 enhances cellular proliferation and migration by activating PI3K/AKT/mTOR signaling pathways, highlighting a novel therapeutic target for TNBC.PMID:37720674 | PMC:PMC10502936 | DOI:10.3892/ol.2023.14030
Source: Oncology Letters - September 18, 2023 Category: Cancer & Oncology Authors: Wan-Meng Chen Qing-Yong Hu Wei Hou Meng-Wei Chen Ya-Hui Chen Jian-Cai Tang Source Type: research

Schweinfurthiamide, a new alkaloid isolated from the tuber roots of Asparagus flagellaris Baker (Liliaceae)
Nat Prod Res. 2023 Sep 18:1-7. doi: 10.1080/14786419.2023.2257358. Online ahead of print.ABSTRACTThe phytochemical investigations of the tuber roots of Asparagus flagellaris led to the isolation of a new alkaloid, schweinfurthiamide (1) and eight known compounds. The structures of the isolated compounds were elucidated using spectroscopic techniques 1D and 2D NMR (1H, 13C, COSY, HMBC, HMQC, HSQC-TOCSY). The absolute configuration of 1 was unambiguously determined using DP4+ calculations. Compound 1 showed significant cytotoxicity against MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer) cancer cell ...
Source: Natural Product Research - September 18, 2023 Category: Biochemistry Authors: Elodie Nguelami Kamdeu Ad èle Nicaise Menye Nomo Abdou Tchoukoua Orleans Ngomo Pascal Djimeli Douanla Marguerite Hortence Tchuendem Kenmogne Yoshihito Shiono Turibio Kuiate Tabopda Source Type: research

Real-world evidence of neoadjuvant chemotherapy for breast cancer treatment in a Brazilian multicenter cohort: Correlation of pathological complete response with overall survival
CONCLUSION: The pCR rate and its prognostic value varied across BC subtypes. In our study, pCR could be used as a surrogate of favorable clinical outcome, as it was associated with higher OS and DFS rates.PMID:37722319 | DOI:10.1016/j.breast.2023.103577
Source: Breast - September 18, 2023 Category: Cancer & Oncology Authors: Marcelo Antonini Andr é Mattar Fernanda Grace Bauk Richter Gabriel Duque Pannain Marina Di ógenes Teixeira Andressa Gon çalves Amorim Odair Ferraro Reginaldo Coelho Guedes Lopes Luiz Henrique Gebrim Juliana Monte Real Source Type: research

Artificial intelligence in breast imaging: potentials and challenges
Phys Med Biol. 2023 Sep 18. doi: 10.1088/1361-6560/acfade. Online ahead of print.ABSTRACTBreast cancer, which is the most common type of malignant tumor among humans, is a leading cause of death in females. Standard treatment strategies, including neoadjuvant chemotherapy, surgery, postoperative chemotherapy, targeted therapy, endocrine therapy, and radiotherapy, are tailored for individual patients. Such personalized therapies have tremendously reduced the threat of breast cancer in females. Furthermore, early imaging screening plays an important role in reducing the treatment cycle and improving breast cancer prognosis. ...
Source: Physics in Medicine and Biology - September 18, 2023 Category: Physics Authors: Jiawei Li Danli Sheng Jiangang Chen Chao You Shuai Liu Huixiong Xu Cai Chang Source Type: research

Erratum to: Comprehensive serum lipidomic analyses reveal potential biomarkers for malignant breast cancer: A case-control study
Cancer Biomark. 2023 Sep 14. doi: 10.3233/CBM-239003. Online ahead of print.NO ABSTRACTPMID:37718782 | DOI:10.3233/CBM-239003
Source: Cancer Biomarkers - September 18, 2023 Category: Cancer & Oncology Source Type: research

Diagnostic performance of two versions of an artificial intelligence system in interval breast cancer detection
CONCLUSION: The present study showed that Tranpara v1.7 has a higher specificity, sensitivity and diagnostic performance in IBC determination than v1.6. AI systems can be used in breast screening as a secondary or third reader in screening programs.PMID:37722761 | DOI:10.1177/02841851231200785
Source: Acta Radiologica - September 18, 2023 Category: Radiology Authors: Levent Çelik Davut Can G üner Ömer Özçağlayan Rahmi Çubuk Mustafa Erkin Ar ıbal Source Type: research

Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo
In conclusion, this study demonstrated the role of papaverine in enhancing the antitumor activity of NDV, suggesting a promising strategy for breast cancer therapy through nonchemotherapeutic drugs.PMID:37720338 | PMC:PMC10504052 | DOI:10.1155/2023/3324247
Source: International Journal of Microbiology - September 18, 2023 Category: Microbiology Authors: Sura Akram Ahmed Majeed Al-Shammari Hayder B Sahib Majid Sakhi Jabir Source Type: research

Efficient TNBC immunotherapy by dual reprogramming tumor-infiltrating dendritic cells and tumor-associated macrophages with stimulus-responsive miR155 nanocomplexes
In this study, pH/ROS-responsive microRNA-155 (miR155) nanocomplexes (MiR@PCPmP NPs) were developed to reprogram TIDCs and TAMs for efficient TNBC immunotherapy. This nanoplatform was based on a pH/ROS cleavable copolymer of poly(ethylene glycol)-carboxydimethyl maleate-poly(ethyleneimine)-peroxalate ester-poly(ε-caprolactone) grafted with mannose moieties (PEG-CDM-PEI[Man]-ox-PCL) which self-assembled with miRNA to form nanocomplexes. In the tumor microenvironment, the nanocomplexes showed selective cellular uptake by TIDCs and TAMs through PEG detachment and mannose exposure, followed by efficient endosomal escape, cyto...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Zhenghui Jing Yanfeng Li Jinxiao Song Xinlong Zang Source Type: research

A medication reconciliation failure: A case report and incident analysis
CONCLUSION: Anticoagulants are ranked first for the highest priority to receive a medication reconciliation. To achieve an optimal level of medication reconciliation, we ought to recognise and correct latent failures.PMID:37718852 | DOI:10.3233/JRS-230002
Source: International Journal of Risk and Safety in Medicine - September 18, 2023 Category: Drugs & Pharmacology Authors: R Ascen ção P Lopes Vaz C Pereira Gomes J Costa P Broeiro-Gon çalves Source Type: research

Erratum to: Comprehensive serum lipidomic analyses reveal potential biomarkers for malignant breast cancer: A case-control study
Cancer Biomark. 2023 Sep 14. doi: 10.3233/CBM-239003. Online ahead of print.NO ABSTRACTPMID:37718782 | DOI:10.3233/CBM-239003
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Source Type: research

 In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
Bioinformation. 2023 Jan 31;19(1):43-47. doi: 10.6026/97320630019043. eCollection 2023.ABSTRACTThe medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of R. tetraphylla extract demonstrated significant cytotoxic activity against MCF-7 breast can...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Abraham Sabu Selvaraj J Gayatridevi R Dilipan E Source Type: research

Breaking barriers: bilosomes gel potentials to pave the way for transdermal breast cancer treatment with Tamoxifen
CONCLUSION: Bilosomes gels could be a promising option for locally delivering tamoxifen to the breast through the skin, offering an encouraging transdermal solution.PMID:37722711 | DOI:10.1080/03639045.2023.2256404
Source: Drug Development and Industrial Pharmacy - September 18, 2023 Category: Drugs & Pharmacology Authors: Reem Abou Assi Ibrahim M Abdulbaqi Siew Mei Tan Habibah A Wahab Yusrida Darwis Siok-Yee Chan Source Type: research

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