• Filter By:

Nuclear expression of Ku70/80 is associated with CHEK2 germline mutations in breast cancer
This study is the first reporting an association of Ku70/80 expression with CHEK2 germline mutations in breast cancer. The results suggest that evaluation of Ku70/80 expression in breast cancer may improve the selection of breast cancer patients for Ku70/80 inhibitor therapy, and point to CHEK2-associated breast cancer and a subset of ER-positive breast cancer as potential suitable targets for such therapy.PMID:37728466 | DOI:10.5114/pjp.2023.129518
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: Rosik Jakub Machaj Filip Bodnar Daniel Hybiak Jolanta Huzarski Tomasz Cybulski Cezary Lubi ński Jan Domaga ła Wenancjusz Pawe ł Domagała Source Type: research

Prognosis-related novel immunostaining pattern for programmed cell death ligand 1 and prognostic value of tumour-infiltrating lymphocytes in triple-negative breast cancer
This study aims to determine the prognostic significance of programmed cell death ligand 1 (PD-L1) expression and tumour-infiltrating lymphocytes (TILs) in triple- negative breast cancer (TNBC). PD-L1 expression and TIL percentage were determined in TNBCs that did not receive neoadjuvant therapy. The relationship between PD-L1 expression and the percentage of TILs with survival was investigated. The presence of intratumoural PD-L1-positive tumour-infiltrating immune cells (TIICs) in tumours with ≥ 1% PD-L1 expression was identified as a new PD-L1 evaluation parameter. The presence of intratumoural PD-L1-positive TIICs as...
Source: Polish Journal of Pathology - September 20, 2023 Category: Pathology Authors: P ınar Savaş G ürdeniz Serin P ınar Gürsoy Osman Zekio ğlu Necmettin Özdemir Source Type: research

DNA is Better at Math than You Are
By KIM BELLARD I was tempted to write about the work being done at Wharton that suggests that AI may already be better at being entrepreneurial than most of us, and of course I’m always interested to see how nanoparticles are starting to change health care (e.g., breast cancer or cancer more generally), but when I saw what researchers at China’s Shanghai Jiao Tong University have done with DNA-based computers, well, I couldn’t pass that up.  If PCs helped change the image of computers from the big mainframes, and mobile phones further redefined what a computer is, then DNA computers may cause us to one day...
Source: The Health Care Blog - September 20, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech DNA Future of Computing Kim Bellard Source Type: blogs

Genes, Vol. 14, Pages 1820: Identification of Breast Cancer Metastasis Markers from Gene Expression Profiles Using Machine Learning Approaches
Yoo Cancer metastasis accounts for approximately 90% of cancer deaths, and elucidating markers in metastasis is the first step in its prevention. To characterize metastasis marker genes (MGs) of breast cancer, XGBoost models that classify metastasis status were trained with gene expression profiles from TCGA. Then, a metastasis score (MS) was assigned to each gene by calculating the inner product between the feature importance and the AUC performance of the models. As a result, 54, 202, and 357 genes with the highest MS were characterized as MGs by empirical p-value cutoffs of 0.001, 0.005, and 0.01, respectively. The ...
Source: Genes - September 20, 2023 Category: Genetics & Stem Cells Authors: Jinmyung Jung Sunyong Yoo Tags: Article Source Type: research

Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study
The relationship between migraine and breast cancer risk has generated conflicting findings. We attempted to assess the association between migraine and breast cancer risk using Mendelian randomization (MR) an...
Source: BMC Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Tian Fang, Zhihao Zhang, Huijie Zhou, Wanchun Wu, Fuqing Ji and Liqun Zou Tags: Research Source Type: research

Heat-shock protein 90α protects NME1 against degradation and suppresses metastasis of breast cancer
British Journal of Cancer, Published online: 20 September 2023; doi:10.1038/s41416-023-02435-3Heat-shock protein 90α protects NME1 against degradation and suppresses metastasis of breast cancer
Source: British Journal of Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Yanchao Zhang Guomeng Zhao Liting Yu Xindong Wang Yao Meng Jinlei Mao Ziyi Fu Yongmei Yin Jinyao Li Xun Wang Changying Guo Source Type: research

Self-efficacy, motivation, and habits: psychological correlates of exercise among women with breast cancer
ConclusionResults suggest that incorporating strategies that support identified motivation, habits, and coping self-efficacy in future interventions could promote increased exercise behaviour among breast cancer populations. Future longitudinal research should examine associations with exercise in a more representative, population-based sample.
Source: Supportive Care in Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research

Cost-effectiveness of granulocyte colony-stimulating factors (G-CSFs) for the prevention of febrile neutropenia (FN) in patients with cancer
ConclusionsBiosimilar filgrastim and pegfilgrastim as primary prophylaxis are cost-effective approaches to avoid FN events in patients with BC, NSCLC, or NHL at intermediate risk for FN in Austria, France, and Germany.
Source: Supportive Care in Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research

The interaction of financial toxicity and social support on social functioning in post-chemotherapy breast cancer patients: a cross-sectional study
ConclusionThere was an additive interaction of financial toxicity and social support in the social functioning of post-chemotherapy breast cancer patients. Those patients with high financial toxicity and low social support are the most likely to benefit from relevant intervention measures compared to other breast cancer populations.
Source: Supportive Care in Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research

The effectiveness of exercise on the symptoms in breast cancer patients undergoing adjuvant treatment: an umbrella review of systematic reviews and meta-analyses
ConclusionsResearch is still needed to confirm the majority of studies’ recommendations for exercise during adjuvant treatment for breast cancer patients, as it is crucial for managing symptoms in the rehabilitation process. To increase the efficiency of exercise in symptom management, future studies may focus more on the application of bridge symptoms, symptom networks, and ecological instantaneous assessment.
Source: Frontiers in Oncology - September 20, 2023 Category: Cancer & Oncology Source Type: research

The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism
Obesity and type 2 diabetes are chronic metabolic diseases that impact tens to hundreds of millions of adults, especially in developed countries. Each condition is associated with an elevated risk of breast cancer and with a poor prognosis after treatment. The mechanisms connecting poor metabolic health to breast cancer are numerous and include hyperinsulinemia, inflammation, excess nutrient availability, and adipose tissue dysfunction. Here, we focus on adipose tissue, highlighting important roles for both adipocytes and fibroblasts in breast cancer progression. One potentially important mediator of adipose tissue effects...
Source: Frontiers in Endocrinology - September 20, 2023 Category: Endocrinology Source Type: research

Manipulating PTPRD function with ectodomain antibodies Research Papers
Protein tyrosine phosphatases (PTPs) are critical regulators of signal transduction but have yet to be exploited fully for drug development. Receptor protein tyrosine phosphatase (RPTP/PTPRD) has been shown to elicit tumor-promoting functions, including elevating SRC activity and promoting metastasis in certain cell contexts. Dimerization has been implicated in the inhibition of receptor protein tyrosine phosphatases (RPTPs). We have generated antibodies targeting PTPRD ectodomains with the goal of manipulating their dimerization status ectopically, thereby regulating intracellular signaling. We have validated antibody bin...
Source: Genes and Development - September 20, 2023 Category: Genetics & Stem Cells Authors: Qian, Z., Song, D., Ipsaro, J. J., Bautista, C., Joshua-Tor, L., Yeh, J. T.- H., Tonks, N. K. Tags: Research Papers Source Type: research

Lymph node metastases in breast cancer: Mechanisms and molecular imaging
Breast cancer is the most common malignant disease of women in the world. Breast cancer often metastasizes to axillary lymph nodes. Accurate assessment of the status of axillary lymph nodes is crucial to the staging and treatment of breast cancer. None of the methods used clinically for preoperative noninvasive examination of axillary lymph nodes can accurately identify cancer cells from a molecular level. In recent years, with the in-depth study of lymph node metastases, the mechanisms and molecular imaging of lymph node metastases in breast cancer have been reported.
Source: Clinical Imaging - September 20, 2023 Category: Radiology Authors: Jieyi Ping, Wei Liu, Zhihui Chen, Cuiying Li Tags: Breast Imaging Source Type: research

Cancers, Vol. 15, Pages 4646: Inhibition of EphA3 Expression in Tumour Stromal Cells Suppresses Tumour Growth and Progression
Scott Peter W. Janes Tumour progression relies on interactions with untransformed cells in the tumour microenvironment (TME), including cancer-associated fibroblasts (CAFs), which promote blood supply, tumour progression, and immune evasion. Eph receptor tyrosine kinases are cell guidance receptors that are most active during development but re-emerge in cancer and are recognised drug targets. EphA3 is overexpressed in a wide range of tumour types, and we previously found expression particularly in stromal and vascular tissues of the TME. To investigate its role in the TME, we generated transgenic mice with inducibl...
Source: Cancers - September 20, 2023 Category: Cancer & Oncology Authors: Mary E. Vail Rae H. Farnsworth Linda Hii Stacey Allen Sakshi Arora Robin L. Anderson Ross A. Dickins Akira Orimo Sunny Z. Wu Alexander Swarbrick Andrew M. Scott Peter W. Janes Tags: Article Source Type: research

Context-Specific Estimation of Future Unrelated Medical Costs and Their Impact on Cost-Effectiveness Analyses
ConclusionOur case study revealed that the inclusion of UFMC had modest effect on the ICERs, and thus did not alter the conclusion. Thus, we should estimate context-specific UFMC if they are expected to change the ICERs significantly, and transparently report the corresponding assumptions to uphold the integrity and reliability of the economic evaluation.
Source: PharmacoEconomics - September 19, 2023 Category: Health Management Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20