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DALLAS BUYERS CLUB meets SCIENTIFIC INTEGRITY
DALLAS BUYERS CLUB  is a biopic about an unlikely hero, directed by Québécois Jean-Marc Valle and written by Craig Borten and Melisa Wallack. In case you get a call from your local AIDS-Walk coordinator, remember 50,000 cases of AIDS (Acquired Immune Deficiency Syndrome) still occur in the USA annually. Transmission is largely preventable with education, testing and early intervention. Ethnic peoples of color are disproportionately affected in new cases. Thirty-five years ago, I never imagined AIDS would be the defining disease of my career and then some.  After my AIDS-Walk call, I ...
Source: blog.bioethics.net - July 20, 2014 Category: Medical Ethics Authors: September Williams, MD Tags: Health Care syndicated Source Type: blogs

Rare Diseases Hiding Among Common Diseases
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. Here is an excerpt from Chapter 12:It is easy to find cases wherein a rare disease accounts for a somewhat uncommon clinical presentation of a common disease. 12.1.2 Rule—Uncommon presentations of common diseases are sometimes rare diseases, camouflaged by a common clinical phenotype. Brief Rationale—Common diseases tend to occur with a charac...
Source: Specified Life - July 18, 2014 Category: Pathologists Tags: common disease cryptic disease disease genetics genetics of common diseases genetics of complex disease orphan disease orphan drugs rare disease subsets of disease Source Type: blogs

Aneuploidy and Carcinogenesis
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. The book has an extensive glossary, that explains the meaning and relevance of medical terms appearing throughout the chapters. The glossary can be read as a stand-along document. Here is an example of one term, "aneuploidy", excerpted from the glossary.Aneuploidy - The presence of an abnormal number of chromosomes (for the species) in a cell. Mos...
Source: Specified Life - July 15, 2014 Category: Pathologists Tags: aneuploidy cancer types carcinogenesis common cancers common disease cytogenetics glossary orphan disease orphan drugs rare cancers rare disease tumor biology tumor types types of cancer Source Type: blogs

'Chasing Life' or Coping with a Cancer Diagnosis
I have been watching a new show on ABC Family called 'Chasing Life'. I was drawn to it for two reasons - its based in Boston and its about someone with cancer. I always like to check out the shows based locally - to see how good or bad a job they do. This one doesn't even attempt Boston accents which is good (because they never get them right) and is entire unrealistic in that a three generation family lives in a townhouse on Beacon Hill, which probably lists for a few million.Here is the 'official' show description:"Chasing Life follows twenty-something April (Italia Ricci), a smart and quick-witted aspiring journali...
Source: Caroline's Breast Cancer Blog - July 12, 2014 Category: Cancer Tags: cancer bonds coping television Source Type: blogs

Rare Cancer are Subsets of Common Cancers
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. One of the key ideas developed in the book is that each common diseases is actually an aggregate of cellular processes that are present, individually, in rare diseases. In the case of the common cancers, we can find specific rare diseases that are subsets of the common diseases. Here is an excerpt from Chapter 8: 8.3.3 Inherited syndromes that cau...
Source: Specified Life - July 9, 2014 Category: Pathologists Tags: cancer syndromes carcinogenesis common cancers common disease familial cancer syndromes genetic disease orphan disease orphan drugs rare cancers rare disease Source Type: blogs

Neuropsychology Abstract of the Day: Parenting Stress
CONCLUSIONS: Although children demonstrated both neurocognitive deficits and functional impairments, results favor psychosocial factors, such as parental stress, as a predictor of overall functional impairment. The implications of this study suggest that late effects aggregate to impact day-to-day functioning in pediatric cancer survivor populations and parental stress may serve as a marker for heightened risk. The results suggest that broader functional domains, especially school and self-care domains, should be evaluated and considered when identifying potential targets for psychosocial interventions. Copyright © 2014 J...
Source: BrainBlog - July 1, 2014 Category: Neurologists Source Type: blogs

Summer Scholars at the SENS Research Foundation
Every year a group of exceptional young scientists come to work on projects at the SENS Research Foundation in California and in allied laboratories around the country. Producing the rejuvenation therapies of tomorrow is a project that will last for decades: the researchers who will lead companies and academic laboratories into the final stretches to produce the first comprehensive rejuvenation toolkit are still undergraduates and postgraduates today, just starting their careers. It is a very exciting time to be in biotechnology. It is of great importance that today's leaders in the field of aging research do better than ...
Source: Fight Aging! - July 1, 2014 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

A Gala, a Trophy, and $50,000 for Cancer Research
Read this first: I Hope My Friends Forgive Me: What It’s Like to FundraiseIn less than 20 minutes at the rehearsal for candidates before the Man & Woman of the Year Grand Finale Gala, I broke protocol and walked onstage to meet myself.Candidates were instructed to arrive to rehearsal fully dressed. My custom-tailored super fly tuxedo direct from Vietnam was delayed in production for three weeks, forcing me to rent a slim-fit tux from Men’s Wearhouse. Two lessons for you aspiring economists: being slim costs extra (my tux rental cost $180 versus a much cheaper standard fit), and that $180 is called a sunk cost. Temp...
Source: I've Still Got Both My Nuts: A True Cancer Blog - June 24, 2014 Category: Cancer Tags: a day in my life man of the year Source Type: blogs

A Novel Form of Cancer Immunotherapy
The immune system is very complex and one of the least understood areas of our biology, which is reflected in the presently poor knowledge of the causes of autoimmune disorders and lack of effective treatment options. There is a lot of work taking place on manipulating the immune system to attack cancer, however, and this and other work on immunity will in the years ahead establish the understanding that is presently lacking. This research is an example of the type, and may ultimately turn out to be more valuable for what it reveals about the immune system rather than its use in cancer treatment: A class of drug currently...
Source: Fight Aging! - June 23, 2014 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

I Hope My Friends Forgive Me: What It’s Like to Fundraise
"I'm determined to get $50,000." (my email to JD, June 12, 3:55 p.m.)"What are you at now? $50k seems VERY improbable by Saturday. Believe me I'm rooting for it, but seems like a long shot." (JD email to me, June 12, 3:58 p.m.)"We are at $41,000." (my email to JD, June 12, 4:01 p.m.)"We are up to $43,600. We are going to get $50k. I am going to tell LLS that I promise to pay the remainder if we don't get there at the Grand Finale Gala. No f.ing way am I going to get that close and not close it out." (my email to JD, June 13, 10:12 p.m.)This is the story of how my fundraising team raised $50,000 including $8,000 in less tha...
Source: I've Still Got Both My Nuts: A True Cancer Blog - June 18, 2014 Category: Cancer Tags: fear and rage man of the year Source Type: blogs

Top stories in health and medicine, June 17, 2014
From MedPage Today: Victoza Lowers Glucose in Genetic Form of Diabetes. Liraglutide (Victoza) works roughly as well as standard sulfonylurea treatment for an inherited type of diabetes but with less hypoglycemia. Canola Oil Cuts Heart Risk in Diabetes. Adding canola oil to the diet improved glycemic control and reduced cardiovascular risk in type 2 diabetes in one study, while an overall healthier diet reduced risk of developing diabetes in another. Puberty Hormone Tied to Premature Ovarian Failure. Kisspeptin hormones may play a key role in premature ovarian failure and in the control of oocyte biology. Lower-Cost Gener...
Source: Kevin, M.D. - Medical Weblog - June 17, 2014 Category: Journals (General) Authors: Tags: News Cancer Diabetes Endocrinology Source Type: blogs

Top stories in health and medicine, June 16, 2014
From MedPage Today: The Hobby Lobby Case: The Stakes for Birth Control. One of the most watched issues before the Supreme Court this term may turn on the question of religious freedom. But it will also likely determine how women will be able to access a key provision of the Affordable Care Act — one seeking to guarantee no-cost prescription contraception in most health insurance plans. Risk Factors ID’d for Stroke Readmits. Among patients with stroke, those with a more severe event and those with more hospitalizations leading up to the stroke were most likely to be readmitted within 30 days. Combo Therapy Boo...
Source: Kevin, M.D. - Medical Weblog - June 16, 2014 Category: Journals (General) Authors: Tags: News Cancer Heart Rheumatology Source Type: blogs

Former Novartis Japan Employee Held for Data Manipulation
A former employee of Novartis AG (NOVN)’s Japanese unit was arrested in Tokyo on charges of manipulating data on a drug study, the latest setback for the pharmaceutical company in the country.Nobuo Shirahashi, who was a director of the unit’s scientific affairs department, violated pharmaceutical law by understating side effects in a study that evaluated hypertension drug Diovan’s efficacy in cutting stroke risk and getting researchers to publish it, the Tokyo prosecutors office said in a faxed statement today.Shirahashi couldn’t be reached and Novartis Japan declined to make contact information for him or his...
Source: PharmaGossip - June 11, 2014 Category: Pharma Commentators Authors: insider Source Type: blogs

Cancer Treatment Is Over!
I got to ring the brass bell in the lobby of the radiation center last Wednesday.  I rang three times as is the custom.  Except for that celebratory ritual, the day was a bit anti-climatic.  This whole cancer episode has … Continue reading →
Source: Being Cancer Network - June 10, 2014 Category: Cancer Authors: Dennis Pyritz Tags: Journal * Living with Cancer Biotherapy Head and neck cancer Leukemia Radiation Recurrence Side effects Survivorship Source Type: blogs