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Health Care Needs Its Rosa Parks Moment
BY SHANNON BROWNLEE On Wednesday, October 25, 2017 I was at the inaugural Society for Participatory Medicine conference. It was a fantastic day and the ending keynote was the superb Shannon Brownlee. It was great to catch up with her and I’m grateful that she agreed to let THCB publish her speech. Settle back with a cup of coffee (or as it’s Thanksgiving, perhaps something stronger), and enjoy–Matthew Holt George Burns once said, the secret to a good sermon is to have a good beginning and a good ending—and to have the two as close together as possible. I think the same is true of final keynotes after a...
Source: The Health Care Blog - November 22, 2017 Category: Consumer Health News Authors: Matthew Holt Tags: OP-ED Patients Physicians Lown Institute Overtreatment Right Choice Alliance Shannon Brownlee Society for Participatory Medicine Source Type: blogs

One Last Story on How Life Sucks After Breast Cancer
Okay, maybe I have been in a rut because I have been stuck at home after knee surgery because I can ' t drive. Or maybe because I have a cold that I am obsessing on crappy lives after cancer. Or maybe the internet gods had their stars align and all these stories ended up on my laptop in the same time period. But I hope this will be the last one for a while.Here ' s the story of a young woman who lost both her husband and her sister because of her lengthy cancer treatment." “The reality is that probably four out of seven days I’m in bed,” explains the 39-year-old, who lives with her mother at Bundall.“I’ve had my ...
Source: Caroline's Breast Cancer Blog - November 6, 2017 Category: Cancer & Oncology Tags: being a patient breast cancer bonds breast cancer treatment stress Source Type: blogs

Fight Aging! Newsletter, October 16th 2017
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - October 15, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Small Molecule Drug that Selectively Induces Apoptosis in Cancer Cells
This cancer research is interesting for the strong resemblance it bears to current senolytic strategies to destroy senescent cells by forcing them into the programmed cell death process of apoptosis: these cells are primed for that fate, but fail to reach it on their own. The therapies used affect normal cells as well as the targeted senescent cells, but cause little impact in the healthy cells that should be spared. This same type of approach is here applied to cancerous cells, using a close relative of the pro-apoptosis targets employed for senescent cells. Considered at the high level, this makes an interesting counterp...
Source: Fight Aging! - October 10, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The $475,000 drug
The US Food and Drug Administration recently approved the first gene therapy, Kymriah, to treat B-cell acute lymphoblastic leukemia. It uses a lentivirus to modify the patient’s T cells to kill tumor cells. Acute lymphoblastic leukemia, or ALL, is caused by uncontrolled growth of B cells, which normally produce antibodies to fight off infections. It is the most common cancer in children. The uncontrolled production of these cells by the bone marrow causes a shortage of blood cell production, leading to fever, increased risk of infection, and anemia. These B cells have on their surfaces a protein called B19 – wh...
Source: virology blog - September 15, 2017 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information ALL B cell B-cell acute lymphoblastic leukemia B19 CAR chimeric antigen receptor gene therapy Kymriah lentivirus viral viruses Source Type: blogs

Funtabulously Frivolous Friday Five 204
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 204. Question 1 Richard Doll published an epidemiology paper in 1950. What had he discovered? + Reveal the Funtabulous Answer expand(document.getElementById('ddet1398470481'));expand(document.getElementById('ddetlink1398470481')) The link between smoking and lung can...
Source: Life in the Fast Lane - September 7, 2017 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five addison's disease bubo bubonic plague cancer endocarditis JF Kennedy Libman Sacks moritz roth richard doll roth spots SLE smoking Source Type: blogs

After 8 years, this doctor is finally treating his pancreatic tumors
I’ve known that I’ve had tumors in my pancreas since 2009. Until now I’ve done nothing about them. This might sound like a counter-intuitive, even foolhardy strategy, especially for an oncologist, who should surely know better than to let his disease gain an advantage through his own inaction. But I don’t have the “usual” type of pancreatic cancer, the kind that claimed the life of Patrick Swayze and has sentenced many other lesser-known patients to a hasty, painful, jaundiced death. Adenocarcinoma of the pancreas is, indeed, a fearsome foe; I certainly haven’t compiled a list of m...
Source: Kevin, M.D. - Medical Weblog - September 6, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mark-a-lewis" rel="tag" > Mark A. Lewis, MD < /a > Tags: Conditions Gastroenterology Oncology/Hematology Surgery Source Type: blogs

Another Piece of Bad (And Misunderstood) Advice
Who has heard that green tea is good for people with cancer and for preventing cancer? ' Raises hand 'Yes I have heard that. I don ' t really like green tea that much but I do drink it occasionally. I know people who purposely drink green tea because it is ' better ' for them. So here ' sthe bad news:" Green tea and green tea extracts are widely consumed by patients with cancer. Yet overall there is no clinical evidence that green tea or its chemical components slow tumor progression in humans — and importantly, there is some evidence that green tea compounds might interfere with anticancer treatment. "There is some earl...
Source: Caroline's Breast Cancer Blog - June 30, 2017 Category: Cancer & Oncology Tags: fake news medical information medical research Source Type: blogs

Chimeric Antigen Receptor Therapies Continue to Do Well Against Blood Cancers
Chimeric antigen receptor approaches to cancer treatment involve taking a patient's T cells and equipping them with a new receptor that allows the immune cells to target specific characteristics of cancer cells. Despite the usual complications and challenges that tend to occur in the development of immunotherapies, involving potentially dangerous disruption of the immune system, this type of therapy has proven to be highly effective against blood cancers. It remains to be deployed against solid cancers, although researchers are well on their way towards reaching that goal, but there is every reason to expect it to be just ...
Source: Fight Aging! - June 6, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 1st 2017
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation." In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create molec...
Source: Fight Aging! - April 30, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

An Approach to Deliver Chimeric Antigen Receptor T Cells to Solid Tumors
The approaches to cancer therapies that we should pay attention to are those capable of targeting many different types of cancer. The only practical way to meaningfully accelerate progress towards robust control of cancer as a whole is for the research community to prioritize treatments that have a much broader impact for a given investment in development. Chimeric antigen receptor (CAR) methods, in which T cells are engineered to direct their attention towards markers that identify cancer cells, can plausibly be adapted to many different cancers with minimal cost. Given that, they are a step in the right direction towards...
Source: Fight Aging! - April 25, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Is There a Way to Lower The Risk of Cancer for Children Undergoing CT Scan?
Children are morevulnerableto radiation than adults. According to research from the University of Melbourne, CT scans can exponentially increase a child ’s rate of developing cancer. In conjunction with the World Congress of Public Health, the university is revising 2013 data that found children who had undergone CT scans had a 24 percent higher risk of developing cancer than those who never went through the machine. The beams of ionizing radiatio n can trigger cellular damage.Study leader John Mathews and his team evaluated Medicare records of10.9 millionAustralians 19 years and younger. They found that most individuals...
Source: radRounds - April 15, 2017 Category: Radiology Authors: Julie Morse Source Type: blogs

Is Healthcare a Right? A Privilege? Something Entirely Different?
By BRIAN JOONDEPH, MD Election Day 2016 should have been Christmas morning for Republicans. Long awaited control of the White House and both houses of Congress. A chance to deliver on an every two-year election cycle promise to repeal and replace Obamacare. In 2010 Republicans needed the House. They got it. In 2014, it was the Senate. Delivered. But we still need the White House they said. Asked and answered with President Donald Trump. So, what happened a few weeks ago when the House bill fizzled like a North Korean missile launch? Disparate factions within the House couldn’t unify behind Speaker Paul Ryan’s plan, des...
Source: The Health Care Blog - April 8, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Brian Joondeph Source Type: blogs

Op-Ed in The Hill on Allowing Medicare to Directly Negotiate Drug Prices
Conclusion There is no denying that Medicare and other government-funded programs are facing a serious funding crisis and that changes to the programs are long overdue. However, it is important to review history and not make the same mistakes that have already been made in attempting to resolve the issue. Instead, Dr. Fonseca believes that “Medicare beneficiaries should have more freedom to choose the coverage and services that best meet their individual needs and preferences.”       Related StoriesCMS Releases Report on Drug RebatesMedPAC Considers Revised Approaches to Part B Drug P...
Source: Policy and Medicine - March 16, 2017 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs

Trials of Autophagy Enhancement to Treat Parkinson ' s Disease
Researchers are planning trials of a repurposed drug in order to test the effectiveness of enhanced autophagy to treat Parkinson's disease, a condition characterized by loss of the small population of dopaminergenic neurons in the brain. Autophagy is a cellular housekeeping method, and the various genes associated with Parkinson's suggest that the underlying disease mechanism is made worse by inadequate clearance of damaged mitochondria in neurons. Beyond Parkinson's disease, methods of producing increased autophagy are of general interest to those who would like to slow the aging process. Greater levels of autophagy are o...
Source: Fight Aging! - March 16, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs