Filtered By:
Cancer: Leukemia

This page shows you your search results in order of date. This is page number 4.

Order by Relevance | Date

Total 341 results found since Jan 2013.

Reuse of a Small Molecule to Increase Autophagy in the Brain is Trialed for Alzheimer ' s Disease
Today I'll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is beneficial to tissue function, health, and longevity, and thus there is considerable interest in the research community in producing therapies that boost the operation of autophagy. This hasn't made a great deal of progress towards the clinic, but nonetheless in any of the sizable databases of...
Source: Fight Aging! - June 5, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Growing research shows how two of the major cancer treatments, radiation and chemotherapy, can lead to long-term cognitive impairment
Mind jumble: Understanding chemo brain (Stanford Medicine): Sarah Liu was treated for leukemia as a teenager. She attended her high school graduation on a four-hour pass from Lucile Packard Children’s Hospital Stanford and was bald under her white graduation cap, her arm bandaged where she’d been receiving chemotherapy drugs. Liu survived cancer and the ordeal of her treatment, and for many years she thrived. But today, at 53, she struggles to remember the names of all the Stanford oncologists who helped her, though she reveres them for saving her life. Many years later, her childhood cancer treatments — chemotherapy...
Source: SharpBrains - June 5, 2020 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness Technology astrocyte chemo-brain chemobrain chemotherapy chemotherapy-related cognitive impairment cognitive difficulties Cognitive-impairment microglia myelin oligodendrocyte OPC Source Type: blogs

Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Chimeric Antigen Receptor Macrophages Instead of T Cells
Chimeric antigen receptor T cell therapies have done well in the treatment of leukemias, and are being adapted for use with cancers that form solid tumors. A patient's own cells are engineered to bear a new synthetic receptor that matches a specific protein on the surface of cancerous cells, which encourages an effective immune response against the cancer. As researchers discuss here, an alternative to the continued use of T cells of the adaptive immune system is to apply chimeric antigen receptors to macrophages of the innate immune system instead. Chimeric antigen receptor (CAR) T cell therapy has been a game-c...
Source: Fight Aging! - March 30, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, March 23rd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - March 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Two Way Relationship Between Cellular Senescence and Cancer in Bone Marrow
Cells become senescent in response to a variety of circumstances. The vast majority are cases of replicative senescence, somatic cells reaching the Hayflick limit. Cell damage and toxic environments also produce senescence, and senescent cells are also created as a part of the wound healing process. A senescent cell ceases replication and begins to secrete inflammatory and pro-growth signals, altering the nearby extracellular matrix and behavior of surrounding cells - even encouraging them to become senescent as well. Near all senescent cells last a short time only, as they self-destruct or are removed by the immune...
Source: Fight Aging! - March 20, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Popular Science Overview of the Development of Senolytic Therapies
This popular science article is a decent introduction to the still young field of senolytic therapies to selectively destroy senescent cells in aged tissues. That said, the author fails to note any of the numerous senolytic programs other than those of the Mayo Clinic and Unity Biotechnology - which represent an increasingly small portion of the field as a whole. The accumulation of lingering senescent cells is one of the contributing causes of aging; these errant cells secrete a potent mix of signals that spur chronic inflammation, change cellular behavior for the worse, and destructively remodel tissue structure. Senolyt...
Source: Fight Aging! - March 3, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

The Growing Importance of Medical Intervention
For most of the years while I was coming up in the world of public health and social policy, it was accepted truth that medical intervention made only a small contribution to population health. Quantifying " population health " as a single entity is obviously highly problematic. There are many components that people will value differently. There is mean life expectancy at birth, which is a common measure that is not terribly difficult to calculate; although as I have explained here before and won ' t bother to do again right now it ' s a fictitious construct that does not predict how long you actually have to live. Rather ...
Source: Stayin' Alive - January 9, 2020 Category: American Health Source Type: blogs

Fight Aging! Newsletter, January 6th 2020
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - January 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Look Back at 2019: Progress Towards the Treatment of Aging as a Medical Condition
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - December 31, 2019 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

Fight Aging! Newsletter, December 23rd 2019
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons. Epige...
Source: Fight Aging! - December 22, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, December 16th 2019
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - December 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cancer Survivors have Double the Risk of Suffering a Later Stroke
We present a contemporary analysis of risk of fatal stroke among more than 7.5 million cancer patients and report that stroke risk varies as a function of disease site, age, gender, marital status, and time after diagnosis. The risk of stroke among cancer patients is two times that of the general population and rises with longer follow-up time. The relative risk of fatal stroke, versus the general population, is highest in those with cancers of the brain and gastrointestinal tract. The plurality of strokes occurs in patients older than 40 years of age with cancers of the prostate, breast, and colorectum. Patients of any ag...
Source: Fight Aging! - December 9, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

DNA Circuits to Identify Cancer Cells
Researchers from Duke University have developed a new DNA-based tool to identify cancer cells. Their system is a DNA circuit. DNA binding to specific cell markers produces a signal if and only if two specific proteins are present, helping to improve ...
Source: Medgadget - December 2, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Medicine Nanomedicine Oncology Source Type: blogs