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Will Increased Understanding of Cellular Senescence Lead to an End to Cancer?
Selective destruction of senescent cells in old tissues offers the promise of some degree of rejuvenation, coupled with effective therapies for a range of age-related diseases that currently cannot be controlled. In the past few years, a number of companies have raised venture funding for the development of senolytic therapies, those capable of removing some portion of senescent cells with an acceptable side-effect profile. The potential market is enormous, and thus despite the many potential competitors, any new mechanism by which senescent cells can be destroyed might be the pathway to success and revenue for the individ...
Source: Fight Aging! - August 6, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

If Nobody Remembers Us
Here's my latest story, which published inGatherDC:Ann stood alone on the other side of the dance floor, swaying offbeat. I approached my friend in her white gown. She looked as chic as my tailored tux and bow tie, which someone else knotted for me because I suck at “adulting”. The closer I got to her, the more I thought Ann looked inebriated and like she wasn’t there at all. I also thought we looked better than the rest of our C-squad royalty status at the Grand Finale Gala for the Leukemia& Lymphoma Society Man& Woman of the Year campaign. We were celebrating a fundraising campaign that raised $2.4 million ...
Source: cancerslayerblog - July 26, 2018 Category: Cancer & Oncology Tags: death Source Type: blogs

Fight Aging! Newsletter, July 16th 2018
We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur. Over the course of the ...
Source: Fight Aging! - July 15, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Chimeric Antigen Receptor Therapy, but Using Natural Killer Cells
Adding chimeric antigen receptors to T cells (CAR-T), causing them to aggressively target cancer cells, has proven to be a fruitful approach to the treatment of cancer. Like most immunotherapies, it can result in potentially severe side-effects related to excessive immune activation, but it is also quite effective. Treatment of forms of leukemia in particular has produced good results in a large fraction of patients who have trialed the therapy. In the research reported here, scientists extend the chimeric antigen receptor approach to natural killer cells rather than T cells, noting that this may prove to be both safer and...
Source: Fight Aging! - July 9, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Exercise as part of cancer treatment
In a first, a national cancer organization has issued formal guidelines recommending exercise as part of cancer treatment, for all cancer patients. The Clinical Oncology Society of Australia (COSA) is very clear on the directive. Its recommendations are: Exercise should be embedded as part of standard practice in cancer care and viewed as an adjunct therapy that helps counteract the adverse effects of cancer and its treatment. All members of the multi-disciplinary cancer team should promote physical activity and help their patients adhere to exercise guidelines. Best practice cancer care should include referral to an accr...
Source: Harvard Health Blog - June 13, 2018 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Cancer Exercise and Fitness Health Source Type: blogs

Advanced Cancer Diagnostics Reduce Frequency of Misdiagnoses: Interview with Precipio CEO Ilan Danieli
According to 2010-2012 data from the National Cancer Institute (NCI), 40% of men and women will be diagnosed with cancer in their lifetime. In all its forms, cancer is known to be a clinically and emotionally challenging disease to manage. Despite th...
Source: Medgadget - May 18, 2018 Category: Medical Devices Authors: Michael Batista Tags: Diagnostics Exclusive Oncology Pathology Source Type: blogs

A pediatric oncologist looks for progress in Alzheimer ’s disease
A baby acutely ill with leukemia seems like the polar opposite of a woman with Alzheimer’s disease (AD), with her slow, insidious deterioration. Yet each disease can be progressive and fatal. I’ve cared for both, in different ways.  Can a childhood cancer doctor like me have insights about that other end of medicine, older adults with dementia? As a husband and caregiver, confronting my wife’s Alzheimer’s disease, I am appalled by the lack of effective therapy for her. As a clinical investigator myself, I’m appalled by what I see as a lack of direction in clinical dementia research, a lack of structure, and a l...
Source: Kevin, M.D. - Medical Weblog - May 8, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/ron-louie" rel="tag" > Ron Louie, MD < /a > Tags: Conditions Neurology Source Type: blogs

Two Faces of Macrophages in Cancer Tissue
This popular science article looks at opposing views of the role of macrophages in the development of tumors. Some groups see macrophages as aiding the cancer, and want to suppress them, while others are engaged in turning macrophages into an effective weapon to destroy cancer cells. This two-faced nature echos a range of unrelated work on macrophage behavior. These cells can be classed by their activities into what are known as polarizations. The M1 polarization is aggressive and inflammatory, willing to attack cells and pathogens, while the M2 polarization aids tissue growth and regeneration. The balance between the two ...
Source: Fight Aging! - April 25, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Your Nursing Career ' s Differential Diagnosis
In medicine, nursing, and healthcare, a differential diagnosis refers to the process of differentiating between two or more conditions sharing similar signs and symptoms. In the context of your nursing career, this process can be equally elucidating. Is there a careful career examination in your future? If so, what would your differential diagnosis be?Photo by rawpixel.com on UnsplashIt All Begins With AssessmentWhether you ' re examining a patient or dissecting the state of your own nursing career, you always begin with an assessment. The gathering of data is the first step in the nursing process, of course...
Source: Digital Doorway - April 16, 2018 Category: Nursing Tags: career career development careers healthcare careers nurse nurse career nurse careers nurses nursing nursing careers Source Type: blogs

Notes from WIRED Health 2018 at Francis Crick Institute
Set in its new home of the Francis Crick Institute, WIRED Health 2018 brought together world leaders and change-makers in cancer, aging, artificial intelligence, government, medical devices, and pharmaceuticals, to name but a few. Alongside the main...
Source: Medgadget - March 16, 2018 Category: Medical Devices Authors: Tom Peach Tags: Exclusive Source Type: blogs

Andrographolide and parthenolide kill myeloma stem cells
This study shows that parthenolide AND andrographolide do just that: they go after the ruffians. The abstract calls them two “potent anti-MM-CSC agents.” Potent…I like that! Okay, I’m going to see if I can extract some gems from the full study. As we’ve seen, it’s not enough to target the circulating plasma cells. If we want to get rid of the myeloma weed, we must go after the stem cells, the “clone troopers” (Star Wars, anyone?  No, I’m not really a fan, but I do remember that expression…). The only way to prevent relapses is to kill the cloners! Parthenolide is the first extract t...
Source: Margaret's Corner - February 14, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll andrographolide CSC myeloma parthenolide Source Type: blogs

Join the Undoctored Revolution
Let’s take back control over personal health. Share this to expose healthcare for the corrupt enterprise it is. Imagine that you receive a letter in the mail stating “In order to retain your right to freedom of speech, you will be billed $10,000 per year every year for the rest of your life.” You would be—-understandably-—outraged. Freedom of speech in America is precious, something Americans have waged wars to defend, something we now view as a basic right, no financial price required to maintain it. It should be free and available to everyone regardless of religion, color, political leanings, or income. ...
Source: Wheat Belly Blog - February 9, 2018 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle diy health Dr. Davis grain-free healthcare Source Type: blogs

Precision Medicine and Public Health (from Precision Medicine and the Reinvention of Human Disease)
Excerpted fromPrecision Medicine and the Reinvention of Human DiseaseDespite having the most advanced healthcare technology on the planet, life expectancy in the United States is not particularly high. Citizens from most of the European countries and the highly industrialized Asian countries enjoy longer life expectancies than the United States. According to the World Health Organization, the United States ranks 31st among nations, trailing behind Greece, Chile, and Costa Rica, and barely edging out Cuba [42]. Similar rankings are reported by the US Central Intelligence Agency [43]. These findings lead us to infer that acc...
Source: Specified Life - February 6, 2018 Category: Information Technology Tags: cancer cancer vaccines precision medicine prevention public health Source Type: blogs

Does myeloma run in the family?
Ever since I began doing research on myeloma, one of my certainties–although with something like myeloma you can never be absolutely certain!!!–has been that myeloma is NOT a hereditary disease. Yes, of course, I’ve read about a few patients who had relatives with myeloma, but…only a few. If you do an online search, you will find that not much is known about the causes of myeloma. A few known ones are things such as pesticide exposure, past exposure to radiation, genetic changes that turn our plasma cells into MM cells…stuff like that. The family connection seems to be a minor one… Today...
Source: Margaret's Corner - February 2, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll inherited cancer myeloma Source Type: blogs