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Block an Enzyme, Save a Life
Vern Schramm, professor of biochemistry at Albert Einstein College of Medicine, Bronx, New York. Credit: Albert Einstein College of Medicine.
Enzymes drive life. Without them, we couldn’t properly digest food, make brain chemicals, move—or complete myriad other vital tasks. Unfortunately, in certain cases, enzymes also can trigger a host of health problems, including cancer, bacterial infections, and hypertension (high blood pressure).
Understanding how enzymes work has been the research focus of Vern Schramm for more than 4 decades.
“When we started our work, we were driven not by the desire to find...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 26, 2019 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cellular Processes Diseases Precision Medicine Source Type: blogs
Cool Images: A Colorful —and Halloween-Inspired—Collection
Transformations aren’t just for people or pets around Halloween. Scientific images also can look different than you might expect, depending on how they’re photographed. Check out these tricky-looking images and learn more about the science behind them.
Credit: Nilay Taneja, Vanderbilt University, and Dylan T. Burnette, Ph.D., Vanderbilt University School of Medicine.
Do you have a hunch about what this image is? Perhaps something to do with dry leaves? It’s a human fibroblast cell undergoing cell division, or cytokinesis, into two daughter cells. Cytokinesis is essential for the growth and development...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 31, 2019 Category: Research Authors: Chrissa Chverchko Tags: Cells Biofilms Cellular Imaging Cool Images Source Type: blogs
Fight Aging! Newsletter, September 16th 2019
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial.
People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - September 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Clonal Mutation in Immune Cells Correlates with Epigenetic Age Acceleration
The nuclear DNA encoding near all of the protein machinery necessary to cell function is constantly damaged and constantly repaired. The repair mechanisms are highly efficient, and are backed up by numerous other systems intended to destroy cells that suffer particularly critical DNA damage, mutations that can lead to cancer or severe dysfunction. Nonetheless, damage accumulates. Near all of this damage is irrelevant, as it occurs randomly in single somatic cells with a limited life span, in genes that the cell isn't using. Unfortunately, there are ways for DNA damage to become significant.
The first is obviously ca...
Source: Fight Aging! - September 10, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 9th 2019
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling.
Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity
https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/
Researchers her...
Source: Fight Aging! - September 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Work on Senolytic Rejuvenation Therapies Begins to Attract More Mainstream Notice
This popular science piece on the development of senolytic therapies capable of clearing harmful senescent cells from aging tissues is a cut above the average. It is important to see more publicity for this line of work. Not because it will aid the industry, but because the more attention that is given to the field, the faster that existing senolytic treatments such as the dasatinib and quercetin combination will become available through off-label prescription and physician networks. Tens of millions of patients with inflammatory age-related diseases caused in part by senescent cells, and the many cancer survivors with hig...
Source: Fight Aging! - September 4, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Podcast: Procrastination or Mental Health Issues?
Since time was invented, people have fallen into three main categories: Chronically early, on-time, or late. You don’t need mental illness to put things off until the last minute and it doesn’t take anxiety to get things done well ahead of schedule.
But, there’s also no denying that living with mental illness can – and does – impact our ability to be punctual and to accomplish goals. In this episode, Gabe and Michelle discuss the difference between putting things off because we are making bad choices and putting things off because of mental health issues. Listen now!
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“The world ...
Source: World of Psychology - July 22, 2019 Category: Psychiatry & Psychology Authors: A Bipolar, a Schizophrenic, and a Podcast Tags: A Bipolar, A Schizophrenic, and a Podcast Personal Schizophrenia Self-Help Source Type: blogs
Podcast: Religion and Mental Illness
From leisure activities to politics to relationships, people tend to be influenced by their religious beliefs. In this episode, Gabe and Michelle discuss the pros and cons of religious influence when it comes to treating mental illness and explore whether it is helpful when trying to reach recovery.
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“They are dead (by suicide) and we are still stigmatizing their behavior.”
– Gabe
Highlights from ‘Religion and Mental Illness’ Episode
[2:00] The intersection of religion and mental illness.
[4:30] How the Jewish faith views mental illness.
[10:00] How Christianity views mental illnes...
Source: World of Psychology - July 15, 2019 Category: Psychiatry & Psychology Authors: A Bipolar, a Schizophrenic, and a Podcast Tags: A Bipolar, A Schizophrenic, and a Podcast Depression Ethics & Morality Schizophrenia Spirituality & Health Source Type: blogs
Private Health Insurance Organizations Shouldn ’t Dictate Quality of Care
By LYNLY JEANLOUIS
Health insurance companies are standing
in the way of many patients receiving affordable, quality healthcare. Insurance
companies have been denying patient claims for medical care, all while increasing
monthly premiums for most Americans. Many of the nation’s largest healthcare payers
are private “for-profit” companies that are focused on generating profits
through the healthcare system. Through a rigorous approval/denial system, health
insurance companies can dictate the type care patients receive. In some cases,
this has resulted in patients foregoing life-saving treatments or procedures. &nbs...
Source: The Health Care Blog - May 7, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Health insurance Lynly Jeanlouis private health insurance Quality improvement Quality of care Source Type: blogs
How IBM Watson Overpromised and Underdelivered on AI Health Care
My friend Phil Shaffer, a fellow retired Nuclear Radiologist, is an avid poster on Aunt Minnie. His AM post today about AI in general and Watson in particular is worthy of a wider audience, and here you are. It is based on an Engineering article in the IEEE Spectrum:How IBM Watson Overpromised and Underdelivered on AI Health Care. This is a cautionary tale for all who have anything to do with AI...If IBM stumbled in this venue, if IBM could fall victim to hype and hubris... Well, we all knew that. Big hype, zero output.I wouldn ' t bother to post this non-news, if it were not for the other questions it brings up...
Source: Dalai's PACS Blog - April 3, 2019 Category: Radiology Source Type: blogs
Fight Aging! Newsletter, February 11th 2019
We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP.
Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced A...
Source: Fight Aging! - February 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Acute Myeloid Leukemia Produces Senescent Cells to Promote its Own Growth, and is Thus Vulnerable to Senolytics
We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP.
Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced A...
Source: Fight Aging! - February 5, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Lesson from Three Parents of Children with Cancer
I grabbed my cell phone to shut off the alarm even before I opened my eyes. As usual on a Sunday morning, I checked the news before my feet left the warmth of the covers so I wouldn't miss a disaster, a tragedy, a loss to remember in the prayers of the day. That day, the first Sunday of Advent, the news of President George H. W. Bush's death led the news. Tears came to my eyes as I read Marshall Ramsey's tribute to the 41st president in The Washington Post. (Dec. 1, 2018; https://wapo.st/2CqDJ8Q.) The cartoonist's tribute showed a TBM Avenger parked in the clouds with Barbara and Robin Bush waiting for his arrival.I...
Source: Lions and Tigers and Bears - February 1, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, January 28th 2019
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging.
Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia
...
Source: Fight Aging! - January 27, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Recent Update on the Use of Immune Ablation and HSCT to Treat Autoimmunity
For more than twenty years now, Richard Burt's research teams have been working on the treatment of autoimmunity through the destruction and recreation of the immune system. Autoimmunity is a malfunction in the self-tolerance of immune cells, leading them to attack patient tissues. The malfunction is entirely contained in the immune system, so if the immune system is destroyed and replaced, the autoimmunity stops. If the genesis of autoimmunity is happenstance, an unfortunate one-time accident, then this is a cure. But if autoimmunity has a trigger outside the immune system in a given patient, it will return after some per...
Source: Fight Aging! - January 22, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
