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Point-Of-Care Biosensor to Detect Oral Cancer
Researchers at the University of Florida have created a point-of-care biosensor that can rapidly detect a biomarker for oral cancer. The device uses test strips, such as those used in blood glucose tests, to spot cell proliferation regulating inhibit...
Source: Medgadget - January 5, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics ENT Oncology oral cancer UF uflorida Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces en...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sweet bitter: a doctor ’ s cancer diagnosis
I screen patients for skin cancer on a regular basis, and one of my research interests is to find new biomarkers of cancer prognosis – to be able to separate out cancers that won’t actually do someone any harm versus cancers that could very well spread, grow unchecked and uncontrolled, and potentially end a life. I
Read more…
Sweet bitter: a doctor’s cancer diagnosis originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - December 14, 2022 Category: General Medicine Authors: Anonymous Tags: Physician Oncology/Hematology Source Type: blogs
T Cell Immunotherapy an Improvement Over Checkpoint Inhibition
Researchers here report on the results of a phase III trial of tumor infiltrating leukocyte (TIL) therapy for melanoma. A patient's T cells are multiplied outside the body and then injected, along with chemotherapy beforehand to clear existing T cell populations, and IL-2 delivery afterwards to promote replication of the delivered T cells. It has meaningful side-effects, as do other cancer immunotherapies, but the outcome is an improvement over the present standard approach of checkpoint inhibition for melanoma. Even as better approaches to cancer therapy are in development, such as those based on interference in telomere ...
Source: Fight Aging! - December 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
As Balwani and Holmes Head To Jail …Will Others in Health Tech Follow?
by MIKE MAGEE
This week’s headlines seemingly closed a chapter on the story of medical research criminality in America. Ramesh “Sunny” Balwani, former president and COO of Theranos was sentenced to 13 years in prison for fraud. That’s 2 years more than his former business and romantic partner, Elizabeth Holmes.
White crime criminal defense attorney for all things science tech, Michael Weinstein, took the opportunity to trumpet out a confident message that crime doesn’t pay in Medicine with these words, “It clearly sends a signal to Silicon Valley that puffery and fraud and misrepresentation will be pr...
Source: The Health Care Blog - December 9, 2022 Category: Consumer Health News Authors: matthew holt Tags: Medical Practice Ethics Henry K. Beecher Medical Ethics Mike Magee Theranos Source Type: blogs
Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells as a Cancer Vaccine
Researchers here note the discovery that vaccinating mice with senescent cancer cells ensures that the immune system will more aggressively attack a later introduction of cancerous cells. Since we know that most cancer therapies induce senescence in cancerous cells to a fair degree, one has to think that the effectiveness of this approach will diminish as a cancer progresses to form a solid tumor and co-opts the immune system in various ways. Still, it sounds as though it could be a potentially useful after, for example, surgical resection of a tumor, to help reduce the odds that the cancer will reoccur.
Scientis...
Source: Fight Aging! - November 9, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cancers Force T Cells into Senescence
We report that both mouse malignant tumor cells and regulatory T cells (Tregs) can induce responder T cell senescence, similar as shown in human Treg and tumor cells. Accumulated senescent T cells also exist in the TME in tumor models of lung cancer, breast cancer, and melanoma. Induction of ataxia-telangiectasia mutated protein (ATM)-associated DNA damage is the cause for T cell senescence induced by both mouse tumor cells and Treg cells, which is also regulated by mitogen-activated protein kinase (MAPK) signaling.
Furthermore, blockages of ATM-associated DNA damage and/or MAPK signaling pathways in T cells can pre...
Source: Fight Aging! - October 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How An A.I.-Based Skin Checking App Can Work With A National Healthcare System
You might be already familiar with skin checking apps, we too have discussed them quite extensively recently. Skin checking applications allow users to take pictures of their suspicious skin lesions, upload these pictures to a server, the images are first evaluated by an A.I. algorithm and the results will be later validated by a dermatologist.
However, this time there is something new under the sun: AIP Labs and Semmelweis University (Hungary’s leading medical university) developed a skin checking application that offers several features we have not seen before. It was launched to work integrated with the natio...
Source: The Medical Futurist - September 8, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine Digital Health Research E-Patients Future of Medicine Healthcare Design Healthcare Policy Telemedicine & Smartphones AI dermatology skin skin cancer skin checker skin checking app digital Source Type: blogs
Top 10 Research Topics To Pursue In Digital Health
The question we most frequently get at The Medical Futurist Institute is easily the one asking for guidance on potential research topics. In fact, we face it so often that we decided to write a summary of our thoughts to provide an overview and some insights to anyone who is willing to dive deep into digital health but is unsure about the best direction to take.
Whatever you choose, take a look at these four criteria first
Find a nicheAim for uncharted territoriesLook for ease of entrySeek answers to important questions
We compiled a list of ten research topics we believe are in line with the above principles and ...
Source: The Medical Futurist - September 1, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Artificial Intelligence in Medicine Digital Health Research E-Patients Future of Medicine Health Sensors & Trackers Healthcare Design Healthcare Policy Portable Medical Diagnostics Telemedicine & Smartphones AI EMR v Source Type: blogs
Fight Aging! Newsletter, August 29th 2022
This study demonstrates that adoptive astrocytic Mt transfer enhances neuronal Mn-SOD-mediated anti-oxidative defense and neuroplasticity in the brain, which potentiate functional recovery following ICH.
First Generation Stem Cell Therapies Remain Comparatively Poorly Understood
https://www.fightaging.org/archives/2022/08/first-generation-stem-cell-therapies-remain-comparatively-poorly-understood/
We are something like thirty years into the increasingly widespread use of first generation stem cell therapies. Cells are derived from a variety of sources, processed, and transplanted into patients. Near all ...
Source: Fight Aging! - August 28, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cancer Vaccines Using Lipid Nanoparticle Delivered mRNA Seem Promising
Cancer vaccines work by instructing the immune system to attack a particular cell surface feature characteristic of cancer cells. Cancers tend to subvert the immune system and suppress its activities in and around tumor tissue, however, so improvements in the effectiveness of a vaccine, the degree to which it will rouse the immune system to action, are helpful. Here, researchers present an example of the way in which the present generation of new vaccine technologies can be applied to this goal in the development of improved cancer vaccines.
Researchers had previously designed lipid nanoparticles (LNPs) that targe...
Source: Fight Aging! - August 23, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Amazing Technologies Changing The Future Of Dermatology
Smart algorithms will soon diagnose skin cancer, dermatologists consult patients online, and 3D printers will print out synthetic skin to fight tissue shortages. There is a lot going on in dermatology, and medical professionals should prepare in time for the technological changes before they start swiping through the specialty. Let’s start by familiarising ourselves with the most amazing technologies changing the future of dermatology!
Skin cancer is too common
According to statistics from the WHO, currently, some 1.5 million non-melanoma skin cancers and 325,000 melanoma skin cancers occur globally each year. Data...
Source: The Medical Futurist - August 4, 2022 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine Telemedicine & Smartphones 3d printing AI artificial intelligence digital Healthcare Innovation nanotechnology Personalized medicine robotics wearables GC1 dermatology Source Type: blogs
Surgical Dressing Helps Kill Melanoma, Regenerate Healthy Cells
Scientists at the University of Nottingham in the UK have created a surgical dressing that is specifically designed to facilitate and enhance photothermal therapy following melanoma resection. The dressing allows for near-infrared photothermal therap...
Source: Medgadget - July 19, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Dermatology Materials Medicine Oncology Rehab Surgery melanoma UniofNottingham Source Type: blogs
