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mRNA Vaccines: From Tackling Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.  What is mRNA? In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs

mRNA Vaccines: From Tackling A Pandemic To Treating Cancer
The story of the multi-decade uphill battle Katalin Karikó and her fellow researchers fought to prove messenger RNA can viably be used in medicine is widely known today. In just as little as two years, the world has learned about mRNA technology and how fast it can react when the need arises holding almost unlimited promises in future applications. As always is the case with “instant hits” in science, the ride was actually very long and bumpy, but more on that later.  What is mRNA? In very simple terms: messenger ribonucleic acids (or mRNAs in short) are the body’s natural way to transport messages from o...
Source: The Medical Futurist - July 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Biotechnology Future of Medicine Nanotechnology cancer cancer research covid19 vaccine research HIV mRNA messenger RNA cancer vaccine malaria malaria vaccine HIV vaccine pancreatic cancer pancreatic cancer va Source Type: blogs

6 changes that could lower the risk of developing prostate cancer
After skin cancer, prostate cancer is the most common type of cancer diagnosed in people with a prostate. Some risk factors associated with prostate cancer can’t be mitigated. Those factors include older age, a family history of prostate cancer, and race (Black men have double the risk of developing prostate cancer compared to white men).Read more …6 changes that could lower the risk of developing prostate cancer originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - July 7, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/miles-j-varn" rel="tag" data-wpel-link="internal" > Miles J. Varn, MD < /a > < /span > Tags: Conditions Oncology/Hematology Source Type: blogs

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
June 09, 2022 Edition-----The Russian war on Ukraine is now well over 100 days old. The destruction and deaths are just awful and the world is being seriously re-shaped. Where this ends is unknowable but unlikely to be good.In the US we are seeing almost daily mass shootings and no-one seems to know what to do. Just pathetic.In the UK the hangover is slowly lifting after the 4 day royal celebration.In OZ we are having an energy crisis which we hope we will find solutions for soon!-----Major Issues.------https://www.theaustralian.com.au/business/economics/australias-labor-government-faces-a-whole-new-economic-ball-game/news...
Source: Australian Health Information Technology - June 9, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, May 9th 2022
In conclusion, although several favorable effects are obtained in our heterochronic non-myeloablative transplantation model, additional optimization is needed for better rejuvenation effects. More on GPNMB as a Target for Senolytic Therapies to Clear Senescent Cells https://www.fightaging.org/archives/2022/05/more-on-gpnmb-as-a-target-for-senolytic-therapies-to-clear-senescent-cells/ You might recall that researchers recently demonstrated that vaccination against GPNMB is a senolytic strategy, reducing the harmful burden of senescent cells in aged tissues by directing the immune system to destroy these c...
Source: Fight Aging! - May 8, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

More on GPNMB as a Target for Senolytic Therapies to Clear Senescent Cells
In conclusion, our results taken together with the above considerations demonstrated that GPNMB was upregulated by lysosomal stress associated with cellular senescence and acted as a protective factor for senescent cells, and suggest that targeting cell/tissue-specific seno-antigens like GPNMB could be a reasonable strategy for next-generation senolytic therapy with higher selectivity and fewer off-target effects. Link: https://doi.org/10.1038/s41598-022-10522-3
Source: Fight Aging! - May 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens. Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Many Mediocre Cancer Therapies Become Much Better When More Targeted to Cancerous Tissues
One of the important areas of cancer research and development that appears to receive a great deal of attention and funding, but in practice seems slow to make it from the laboratory to the clinic, is the targeting of therapeutics to cancerous cells. Reductio ad absurdum, near any of dozens of existing chemotherapeutics would do the job of completely clearing tumors, with minimal to no side-effects, if one could only find a way to delivery tiny amounts of the therapeutic to every cancer cell while avoiding every healthy cell. The inability to target treatments this effectively is exactly why cancer remains such a problem. ...
Source: Fight Aging! - March 9, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

What Has A.I. In Medicine Ever Done For Us? At Least 50 Things!
Remember Monty Python’s brilliant Life of Brian movie scene where the Judean Jewish insurgent commando, planning the abduction of Pilate’s wife in return for all the horrors they had to endure from the Roman Empire, asks the rhetorical question: what have the Romans ever done for us? With the hype and overmarketing, not to speak about the fears around A.I, we asked the same question. What has A.I. in medicine ever done for us? Well, we found at least 50 things. I have 50 responses to the pressing question on everyone’s mind who is interested in healthcare but tired of the hype or the doomsday scenarios around A.I....
Source: The Medical Futurist - March 1, 2022 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Future of Medicine AI cancer diagnostics digital health Healthcare Innovation medical Radiology technology medical imaging treatment administration digital health technology Source Type: blogs

Addressing racial and ethnic inequities in data-driven health technologies
This report highlights the opportunities and barriers for artificial intelligence to improve the health of the UK ’s minority ethnic groups. Data-driven technologies like artificial intelligence (AI) are powerful tools demonstrating potential in the diagnosis and treatment of diseases such as skin cancer. Yet these could inadvertently worsen the health inequalities experienced by minority ethnic groups if cur rent challenges such as biased algorithms, poor data collection and a lack of diversity in research and development are not urgently addressed. The report calls for further research and transparent discussion on the...
Source: Health Management Specialist Library - March 1, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: Digital health and data Source Type: blogs

Fight Aging! Newsletter, February 7th 2022
In this study, we used accelerometer measurements (1) to examine the association of physical activity and mortality in a population-based sample of US adults and (2) to estimate the number of deaths prevented annually with modest increases in moderate-to-vigorous physical activity (MVPA) intensity. This analysis included 4,840 participants. Increasing MVPA by 10, 20, or 30 minutes per day was associated with a 6.9%, 13.0%, and 16.9% decrease in the number of deaths per year, respectively. We estimated that approximately 110,000 deaths per year could be prevented if US adults aged 40 to 85 years or older increased th...
Source: Fight Aging! - February 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, December 20th 2021
In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development. CYTOR Upregulation as a Path to Improved Muscle Function in Later Life https://www.fightaging.org/archives/2021/12/cytor-u...
Source: Fight Aging! - December 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Fasting Mimicking Diet Improves Anti-Cancer Immune Function
The fasting mimicking diet is, in essence, a clever strategy to pull in significant funding for the rigorous study of the use of forms of calorie restriction as a therapy. A fasting mimicking diet involves taking in just few enough calories to trigger most of the benefits of fasting. There must exist a dividing line in calorie intake at which nutrient sensor mechanisms determine that the body is in a state of fasting. Early research into fasting mimicking found that dividing line to be somewhere in the vicinity of 500 to 750 calories daily, but later studies use lower calorie levels. Another important point of calibration ...
Source: Fight Aging! - December 3, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, October 4th 2021
In conclusion, premature thymic involution and chronic inflammation greatly contribute to increased morbidity and mortality in CKD patients. Mechanisms are likely to be multiple and interlinked. Even when the quest to fountain of youth is a pipe dream, there are many scientific opportunities to prevent or to, at least in part, reverse CKD-related immune senescence. Further studies should precisely define most important pathways driving premature immune ageing in CKD patients and best therapeutic options to control them. Extending Life Without Extending Health: Vast Effort Directed to the Wrong Goals https://www...
Source: Fight Aging! - October 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs