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Fight Aging! Newsletter, March 8th 2021
Conclusion Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome. The Role of Reactive Oxygen Species in Aging is Complex https://www.fightaging.org/archives/2021/03/the-role-of-reactive-oxygen-species-in-ag...
Source: Fight Aging! - March 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The SREBP Pathway is a Mechanism by which Cancers Subvert Regulatory T Cells
Cancers subvert the immune system in a variety of ways, such as in order to aid growth, or suppress the immune response normally triggered by the presence of cancerous cells. Regulatory T cells are involved in halting the immune response after it is has done its job, and in preventing autoimmunity, in which the immune system attacks the body. This role is abused in cancerous tissue in order to protect the cancer from the immune system. Researchers here identify some of the controlling biochemistry that makes regulatory T cells behave differently in this scenario. The mechanism appears distinct enough, operating only in can...
Source: Fight Aging! - March 3, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Prostate cancer treatment: strategies for managing side effects
After skin cancer, prostate cancer is the most common cancer diagnosed in men in the U.S., with one in eight men at risk of being diagnosed with this cancer during his lifetime. If you or a man you care about is undergoing prostate cancer treatment, you may be living with treatment-related side effects. These can […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - January 29, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/miles-j-varn" rel="tag" > Miles J. Varn, MD < /a > < /span > Tags: Conditions Oncology/Hematology Urology Source Type: blogs

Stomach Cancer Stage 4 Treatment
Stomach cancer stage 4 is a complex diagnosis. It is the stage of cancer that requires specific treatment options. Is surgery an option for patients with stomach cancer stage 4? Stage 4 stomach cancer is characterized by rapid tumor growth, metastasizing to regional lymph nodes and distant organs (liver, bones, pancreas, less often lungs). With the development of metastases in other organs, characteristic symptoms occur such as jaundice and liver failure with liver damage, ascites with metastases in the peritoneum, bowel obstruction with metastases in the small intestine, etc. Therefore, at the advanced stages, ga...
Source: PickTheBrain | Motivation and Self Improvement - January 22, 2021 Category: Consumer Health News Authors: Booking Health Tags: health and fitness self-improvement cancer stomach cancer treatment Source Type: blogs

Do hair dyes increase cancer risk?
This study also had several limitations. First, participants were female nurses of mostly European descent, meaning the findings are not necessarily generalizable to men or to other racial or ethnic groups. Next, the study could not account for every single cancer risk factor (for example, exposure to pesticides and other environmental chemicals). Data were not collected on other hair grooming products beyond hair dyes, and subjects may have mistakenly reported use of permanent hair dyes when they were in fact using semi-permanent or natural dyes. Without data on actual color of hair dyes used, the authors assumed that hai...
Source: Harvard Health Blog - January 20, 2021 Category: Consumer Health News Authors: Shinjita Das, MD Tags: Cancer Skin and Hair Care Source Type: blogs

Fight Aging! Newsletter, January 11th 2021
This study demonstrates the potential of a natural (o-Vanillin) and a synthetic (RG-7112) senolytic compounds to remove senescent IVD cells, decrease SASP factors release, reduce the inflammatory environment and enhance the IVD matrix production. Removal of senescent cells, using senolytics drugs, could lead to improved therapeutic interventions and ultimately decrease pain and a provide a better quality of life of patients living with intervertebral disc degeneration and low back pain. From Ying Ann Chiao of Oklahoma Medical Research Foundation: Mitochondrial dysfunction plays a central role in aging and cardiovasc...
Source: Fight Aging! - January 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Targeted Delivery of a Short-Lived Radioactive Compound to Cancer Cells
The power of specific targeting of specific cell types is that any cell-killing mechanism can then be delivered. The more efficient the targeting, more more dangerous and effective the cell-killing mechanism can be. The reason why any given cancer therapy is less effective at killing cancer cells than it might be is because the targeting isn't perfect, and thus there is the need to limit the damage to other tissues in the body. A cancer-specific L-type amino acid transporter 1 (LAT1) is highly expressed in cancer tissues. Inhibiting the function of LAT1 has been known to have anti-tumor effects, but there has been...
Source: Fight Aging! - January 8, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Why are mRNA vaccines so exciting?
The very first vaccines for COVID-19 to complete Phase 3 testing are an entirely new type: mRNA vaccines. Vaccines of this type have never before been approved for use in any disease. How do they differ from traditional vaccines, and what makes them so exciting? How traditional vaccines work The main goal of a vaccine for a particular infectious agent, such as the virus that causes COVID-19, is to teach the immune system what that virus looks like. Once educated, the immune system will vigorously attack the actual virus, if it ever enters the body. Viruses contain a core of genes made of DNA or RNA wrapped in a coat of pro...
Source: Harvard Health Blog - December 10, 2020 Category: Consumer Health News Authors: Anthony Komaroff, MD Tags: Coronavirus and COVID-19 Health Vaccines Source Type: blogs

Drugstore skincare: Science-backed anti-aging ingredients that don ’t break the bank
With a sharp increase in working from home during the COVID-19 pandemic, more people are noticing age-related skin changes up close on their videoconference calls. The good news? You don’t need to rush to the dermatologist for your anti-aging needs. The best skincare regimens to combat the cardinal signs of aging, which include uneven skin tone, fine lines, roughness, and dryness, can start from the comfort of your own home. You don’t need a prescription, time to get to a dermatologist, or deep pockets to score quality products. Here are a few science-backed, dermatologist-favorite ingredients that can help to slow, or...
Source: Harvard Health Blog - November 11, 2020 Category: Consumer Health News Authors: Neera Nathan, MD, MSHS Tags: Skin and Hair Care Source Type: blogs

Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest. BMP6 as a Target for Pro-Angiogenic Therapies https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/ Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a po...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

OneSkin Launches a Topical Senolytic Treatment
Senescent cells are damaging to tissue function and health when they linger and grow in number, as becomes the case with age. They contribute to the chronic inflammation of aging via their signaling, the senescence-associated secretory phenotype. In skin, senescent cells are most likely responsible for a sizable fraction of the more problematic later life skin aging, in the 50s and on. It is less clear and less likely that they have much do to with the changes seen from the late 20s into the 40s. The primary advantage inherent in targeting the mechanisms of aging specifically in skin is that the regulatory path to m...
Source: Fight Aging! - October 22, 2020 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs

Can appealing to teenagers ’ vanity improve sun-protective behaviors?
As the summer warmth lures us outside, parents may be struggling to get their teenagers to follow sun protection guidelines. It can be challenging to catch the attention of younger people, for whom health concerns such as skin cancer feel like a lifetime away. One promising strategy for educating teens about sun-protective behavior is to appeal to their vanity and meet them where they are — on their smartphones. Mobile app reveals possible effects of UV exposure A recent study in JAMA Dermatology looked at the impact of using a face-aging mobile application on sun-protective behaviors in a group of Brazilian high school ...
Source: Harvard Health Blog - July 30, 2020 Category: Consumer Health News Authors: Shinjita Das, MD Tags: Cancer Skin and Hair Care Source Type: blogs

Tinted sunscreens: Benefits beyond an attractive glow
Tinted sunscreens are having a moment. These mineral-based sunscreen formulations have an added color base that can help even out skin tone while protecting your skin. And thanks to their ability to block visible light, they may help certain skin conditions. Could the days of unsightly sunscreen residue be in your past? What is visible light, and how can it affect your skin? Ultraviolet (UV) radiation and visible light are both part of the electromagnetic spectrum. UV radiation is composed of three different wavelengths: UVA, UVB, and UVC. UVC is mostly absorbed by the ozone layer, so UVA and UVB are the primary wavelength...
Source: Harvard Health Blog - July 13, 2020 Category: Consumer Health News Authors: Neera Nathan, MD, MSHS Tags: Cancer Skin and Hair Care Source Type: blogs

Your Smartphone As The Swiss Knife Of Digital Health
7:39 a.m. That’s the time that your smartphone’s sonar deems as optimal for you to wake up today. With its gentle vibration from your bedside table, you pick it up to turn off the smart alarm. As you do so, your phone asks for your permission to use the built-in sensors and camera to run your routine morning scan. It analyzes your voice; evaluates your stress level based on a facial scan; checks your vital signs; and notifies you to take a picture of that mole on your forearm in order to detect any anomalies.  Thereafter, it outputs a comprehensible report with recommendations which you can send over to your ph...
Source: The Medical Futurist - June 16, 2020 Category: Information Technology Authors: Prans Tags: Artificial Intelligence E-Patients Health Sensors & Trackers Telemedicine & Smartphones stress health trackers Huntington's Alzheimer's disease covid19 camera apple health google fit WHO hemoglobin SpO2 Samsung oximetry F Source Type: blogs

Parent's Decision Not To Be Treated for Cancer Upsets Daughter
Photo credit Aaron Andrew Dear Carol: There’s probably no right answer to what I’m asking but I felt the need to write just for comfort. My mother died when I was in my teens, so Dad has been the only parent that I’ve had for more than 20 years. I have no siblings. Dad’s now in his 70s and has been diagnosed with prostate cancer. He’s beaten both melanoma and lung cancer in the past, but he tells me that this cancer should be slow-growing and that he’ll probably die before it’s a problem so he doesn’t want to treat it. I want him to go full-on with every treatment possible. I watched both of my parents figh...
Source: Minding Our Elders - May 14, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs