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Towards Better Cancer Vaccines via Identification of Important Neoantigens and T Cell Populations
Tumor cells have identifying surface markers that the immune system can in principle attack, but vaccination against those surface markers in order to encourage an anti-tumor immune response has been hit and miss. Researchers here dig deeper into the mechanisms that may explain this variability in response, and thus allow a more viable approach to patient-specific cancer vaccines that will more effectively rouse the immune system to target cancerous cells.
When cells begin to turn cancerous, they start producing mutated proteins not seen in healthy cells. These cancerous proteins, also called neoantigens, can aler...
Source: Fight Aging! - September 28, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Handheld Photoacoustic Device for Lymph Node Assessment
Researchers at Pohang University of Science & Technology in South Korea have developed a handheld photoacoustic device that can locate sentinel lymph nodes near the armpit. The technology could help clinicians to locate the correct lymph node fro...
Source: Medgadget - September 23, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Surgery Source Type: blogs
Big Tech In Medicine: How Amazon, Apple, Microsoft, Google, IBM & NVIDIA Disrupt Healthcare
We’ve spent a good part of our summer writing about Big Tech and how these companies, Amazon, Google/Alphabet, Microsoft, Apple, IBM and NVIDIA have approached medicine and its trillion-dollar market possibilities. These six companies have the most projects in healthcare, and their presence is not negligible at all: they all have the power and the incentive to transform and help digitise this market.
Moreover, all of these companies have something peculiar and very unique to give. Amazon’s distribution network can change the way we think of pharmacies in the future. Microsoft can bring steadiness, reason and predict...
Source: The Medical Futurist - August 24, 2021 Category: Information Technology Authors: Judit Kuszkó Tags: TMF Forecast Artificial Intelligence in Medicine Digital Health Research Future of Medicine Future of Pharma Genomics Health Insurance Health Sensors & Trackers Portable Medical Diagnostics Security & Privacy Telemedicine & Smartphon Source Type: blogs
Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Strength Training and Aerobic Exercise Reduce Cancer Mortality
Researchers here note that undertaking strength training and aerobic exercise acts to reduce mortality due to cancer, to a similar degree as these activities are known to reduce all cause mortality in later life. The mechanisms involved are likely diverse, but it is worth noting that (a) muscle tissue is metabolically active in beneficial ways, such that more muscle is better than less muscle, (b) better immune function is linked to exercise, and immune surveillance is critical to cancer prevention, and (c) exercise helps to reduce chronic inflammation, where chronic inflammation helps to drive the establishment and develo...
Source: Fight Aging! - August 17, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
BAFT Upregulation Makes T Cells Resistant to Exhaustion
When faced with long-lasting challenges, such as cancer or persistent infections that the immune system struggles to clear, T cells of the adaptive immune system can become exhausted. The exhausted cells lose function, diminishing both the immediate immune response and the ability to form immune memory that will enable a robust future response to the same threat. Researchers see this in the engineered T cells used in chimeric antigen receptor (CAR) T cell therapies, and there is thus a strong incentive to find ways to address the issue by identifying important causes or regulators of T cell exhaustion, and interfering to p...
Source: Fight Aging! - July 28, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
3D Printing in Medicine And Healthcare – The Ultimate List In 2021
3D printing has demonstrated huge potential for the future of medicine in the previous years, and its development is unstoppable. Just look at the impressive list of 3D printed healthcare materials and medical equipment below!
How does 3D printing in medicine work?
3D printing in medicine is part of the innovative process called additive manufacturing, which means producing three-dimensional solid objects from a digital file. How the technology works, we explained the technology in our article on bioprinting here.
As technology evolves, researchers work on various solutions. For example, engineers from the University of B...
Source: The Medical Futurist - July 13, 2021 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Biotechnology Future of Medicine Healthcare Design Medical Education Personalized Medicine bioprinting Innovation Video GC1 3d printed biomaterial tissue engineering Source Type: blogs
Emerging Trend Alert – Skin Checking Algorithms
In our new series, Emerging Trends, we are looking at those technologies in digital health that are on a certain ‘hype cycle’ – technologies and solutions that currently stand out from the rest because of their novelty, timeliness, or greatness. These are solutions everyone’s talking about or the ones they should. We are beginning with skin checking algorithms, which is definitely a course currently rising. Let’s have a deeper look.
Everyone should have a skin check done from time to time. Skin cancer is one of the most common cancer types worldwide: one in five people in the U.S. is expected to receive a ...
Source: The Medical Futurist - June 17, 2021 Category: Information Technology Authors: Judit Kuszkó Tags: Covid-19 Artificial Intelligence in Medicine Digital Health Research E-Patients Future of Medicine Healthcare Policy Personalized Medicine Portable Medical Diagnostics google nature dermatology A.I. Semmelweis skin SkinVision Source Type: blogs
Emerging Trends: Skin Checking Algorithms
In our new series, Emerging Trends, we are looking at those technologies in digital health that are on a certain ‘hype cycle’ – technologies and solutions that currently stand out from the rest because of their novelty, timeliness, or greatness. These are solutions everyone’s talking about or the ones they should. We are beginning with skin checking algorithms, which is definitely a course currently rising. Let’s have a deeper look.
Everyone should have a skin check done from time to time. Skin cancer is one of the most common cancer types worldwide: one in five people in the U.S. is expected to receive a ...
Source: The Medical Futurist - June 17, 2021 Category: Information Technology Authors: Judit Kuszkó Tags: Covid-19 Artificial Intelligence in Medicine Digital Health Research E-Patients Future of Medicine Healthcare Policy Personalized Medicine Portable Medical Diagnostics google nature dermatology A.I. Semmelweis skin SkinVision Source Type: blogs
Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated.
Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth
https://www.fightaging.org/archiv...
Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
New Bioprinting Technique to Make Artificial Cartilage Implants
Researchers at the University of Alberta have developed a method to 3D print cartilage-like materials consisting of a collagen hydrogel containing human chondrocytes. The printed structures mimic human nasal cartilage in terms of its mechanical, mole...
Source: Medgadget - May 10, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Orthopedic Surgery Plastic Surgery Source Type: blogs
Arming T Cells with IL-24 Improves the Ability to Destroy Cancerous Cells
Altering T cells of the adaptive immune system to enable recognition of cancerous cells is a mainstream area of research these days. The approach of adding chimeric antigen receptors to T cells, tailored to a cancer, is well established for blood cancers, but still challenging for solid tumors, characterized a wide variety of cancerous cells and signatures. Researchers here show that genetic modification of T cells to produce IL-24 allows these immune cells to effectively destroy cancerous cells that lack recognizable surface features, so long as they are close to cancerous cells that can be recognized. Further, the proces...
Source: Fight Aging! - May 10, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Software Spots Suspicious Skin Lesions on Smartphone Photos
Melanoma, which accounts for over 70 percent of all skin cancers, occurs when pigment producing cells called melanocytes multiply uncontrollably. This cancer is typically diagnosed through visual inspection of Suspicious Pigmented Lesions (SPLs), and...
Source: Medgadget - April 20, 2021 Category: Medical Devices Authors: Rukmani Sridharan Tags: Dermatology Informatics Oncology Source Type: blogs
Can AI Reinvent Radiation Therapy for Cancer Patients?
John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.Of all the advances in health care artificial intelligence (AI), medical imaging is probably the most remarkable success story. Two prominent examples come to mind: Machine learning has helped improve the screening and diagnosis of retinal disease and is making inroads in skin cancer detection. Given these developments, it ’s not surprising to find researchers and clinicians developing the digital tools to improve radiotherapy, which combines imaging techno...
Source: Life as a Healthcare CIO - April 19, 2021 Category: Information Technology Source Type: blogs
