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Hormonal therapies for advanced prostate cancer linked to a higher risk of falls and fractures
Falls rank among the top causes of death and injuries among the elderly, and the risk increases significantly in older people being treated for cancer. Now, investigators are reporting that a newer class of drugs for advanced prostate cancer is associated with a significant increase in fall risk. Called androgen receptor inhibitors, or ARIs, these drugs target testosterone, a hormone that accelerates the growth of prostate tumors. Unlike traditional hormonal treatments that interfere with the body’s ability to make testosterone (known as androgen deprivation therapy, or ADT), ARIs work by preventing testosterone from...
Source: Harvard Health Blog - January 7, 2021 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Living With Prostate Cancer Prostate Knowledge Treatments HPK Source Type: blogs

Ageless: The New Science of Getting Older Without Getting Old
is a forthcoming book discussing the aging research community and its newfound interest in treating aging as a medical condition. Aging is the cause of age-related disease and mortality, and far longer, far healthier lives lie ahead in the era in which the mechanisms of aging are targeted, rather than only their consequences. In this popular press article, the author and the book are discussed. The views are sensible and forward-looking, suggesting that it may be worth picking up when it is published in a few months. The author began professional life as a physicist. As a child, he was fascinated by space, the wa...
Source: Fight Aging! - January 7, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Supporting Promising Medtech Firms: Interview with Paul Grand, CEO of MedTech Innovator
MedTech Innovator is a medical technology accelerator program that supports medtech companies in translating their technologies into beneficial products. Much of this support takes the form of competitions. At present, MedTech Innovator holds competi...
Source: Medgadget - January 4, 2021 Category: Medical Devices Authors: Conn Hastings Tags: etc. Exclusive Source Type: blogs

3 easy ways to eat a healthier diet
While many people might be taking a pass on formal New Year’s resolutions this year, others may mark a fresh start this month by resolving to make up for poor eating habits of the past. But this motivation is often focused on a diet that’s too ambitious, or too restrictive. Without a solid plan, you may fail quickly. So consider a compromise: start with these three easy ways to eat a healthier diet. Aim for real food only Look at your plate and note what’s processed and what isn’t. Maybe it’s the whole thing (like a frozen dinner), or maybe it’s just part of your meal (like the bottled dressing on your salad). ...
Source: Harvard Health Blog - January 4, 2021 Category: Consumer Health News Authors: Heidi Godman Tags: Diet and Weight Loss Health Healthy Eating Source Type: blogs

Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

6 Ways to Stop Stressing about Disease
Many people are genetically predisposed to developing certain diseases, among them diabetes, cancer, heart disease and Alzheimer’s. It’s natural to worry if you’ve watched family members endure the illnesses. However, the cortisol released in your body by chronic stress, which can be caused by worry, could increase your susceptibility. The fix? Be proactive. Limiting stress may not completely protect you from the disease that you dread, but it can help your overall health and, for some diseases, this could help you avoid a trigger. Where do you start? View this slideshow on HealthCentral to learn about how you can st...
Source: Minding Our Elders - December 28, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism. Mouse Age Matters: How Age Affects the Murine Plasma Metabolome A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Data for COVID-19 Mortality in Older People in the US
The general consensus on mortality due to COVID-19 is that it falls most heavily on people who are more impacted by aging: poor immune function when it comes to defense against pathogens; high levels of chronic inflammation that create a greater susceptibility to the way in which SARS-CoV-2 kills people; existing chronic disease; and a mortality rate that is already high even setting aside the pandemic. When younger people die due to the virus, in much smaller numbers, it is where they share these characteristics of inflammation, deficient immune systems, and chronic disease. This level of morbidity is unusual in younger i...
Source: Fight Aging! - December 23, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Nutritional lessons from the coronavirus pandemic
You’ve heard the headlines: Upon contracting COVID-19, people with various co-morbidities are at increased risk for becoming critically ill, such as developing acute respiratory distress syndrome necessitating mechanical ventilation. They are several-fold more likely to die of the disease, also. Among the most common health conditions that put people at high risk for becoming severely ill include: Obesity Type 2 diabetes Hypertension Coronary disease and heart failure Cerebrovascular disease There are other conditions that also confer increased risk such as smoking, lung disease, and lung cancer. But the four condi...
Source: Wheat Belly Blog - December 14, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open coronavirus covid Inflammation insulin pandemic undoctored wheat belly Source Type: blogs

Your Relationship With Unreasonable Standards
Here’s a simple rule of thumb that I learned at the start of the pandemic: If you think you’re being reasonably cautious, you’re probably taking on too much risk. If you think you’re being unreasonably cautious, you’re probably doing it right. This made sense to me, so I aimed to keep my COVID-prevention standards higher than I thought was reasonable. I sought to keep them at a level that made me wonder if I was overdoing it. Since the start of the pandemic, Rachelle and I haven’t had friends or family over, we stopped doing in-person meetups, and we stopped all travel. We have ...
Source: Steve Pavlina's Personal Development Blog - December 13, 2020 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Health Lifestyle Relationships Source Type: blogs

Fight Aging! Newsletter, December 14th 2020
In conclusion, aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels. These alterations may impair BBB integrity and potentially reduce cerebrovascular health with aging. Senescent Cells Fail to Maintain Proteostasis https://www.fightaging.org/archives/2020/12/senescent-cells-fail-to-maintain-proteostasis/ Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking pla...
Source: Fight Aging! - December 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, December 7th 2020
In this study, except for the reduction in body weight, the aging characteristics related to epidermal and muscle tissue in mice were significantly ameliorated in the CR group compared with the control group. Additional studies have indicated that not stem cells themselves but the stem cell microenvironment is the key factor mediating stem cell activation, proliferation and differentiation. Mitochondrial dysfunction is an important factor leading to age-related muscular atrophy. Considering the dependence of skeletal muscle on ATP, loss of mitochondrial function, which can lead to a decrease in strength and enduranc...
Source: Fight Aging! - December 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Teaching Old Cells New Tricks: Insights Into Molecular-Level Aging
When someone mentions aging, you may think of visible changes, like graying hair. Scientists can see signs of aging in cells, too. Understanding how basic cell processes are involved in aging is a first step to help people lead longer, healthier lives. NIGMS-funded researchers are discovering how aging cells change and applying this knowledge to health care. Discovering the Wisdom of Worms C. elegans with a ribosomal protein glowing red and muscle fibers glowing green. Credit: Hannah Somers, Mount Desert Island Biological Laboratory. Aric Rogers, Ph.D., and Jarod Rollins, Ph.D., assistant professors of regenerati...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 2, 2020 Category: Research Authors: Chrissa Chverchko Tags: Injury and Illness Cellular Processes Research Roundup Source Type: blogs

Fight Aging! Newsletter, November 30th 2020
We examined specific aspects of metabolism in male PolG+/mut mice at 6 and 12 months of age under three dietary conditions: normal chow (NC) feeding, high-fat feeding (HFD), and 24-hr starvation. We performed mitochondrial proteomics and assessed dynamics and quality control signaling in muscle and liver to determine whether mitochondria respond to mtDNA point mutations by altering morphology and turnover. In the current study, we observed that the accumulation of mtDNA point mutations failed to disrupt metabolic homeostasis and insulin action in male mice, but with aging, metabolic health was likely preserved by counterme...
Source: Fight Aging! - November 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs