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The Meat of the Matter: Learning How Gut Microbiota Might Reduce Harm from Red Meat
Microbiota in the intestines. Credit: iStock. Research on how diet impacts the gut microbiota has rapidly expanded in the last several years. Studies show that diets rich in red meat are linked to diseases such as colon cancer and heart disease. In both mice and humans, researchers have recently discovered differences in the gut microbiota of those who eat diets rich in red meat compared with those who don’t. This is likely because of a sugar molecule in the red meat, called N-glycolylneuraminic acid (Neu5Gc), that our bodies can’t break down. Researchers believe the human immune system sees Neu5Gc as foreign. T...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 11, 2019 Category: Research Authors: Matt Mills Tags: Being a Scientist Cells Bacteria Biofilms Cellular Processes Microbes Source Type: blogs

Fight Aging! Newsletter, December 9th 2019
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - December 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

What Are the Risks of Drinking Alcohol?
Drinking alcohol causes damage to your health in both the short term and long term, even for moderate drinkers. For individuals who suffer from addiction to alcohol and frequently drink in excess, these risks become higher. Knowing the risks of drinking alcohol is important to help avoid drinking to excess and reduce the likelihood of these risks. Short-Term Risks of Drinking Alcohol There are many short-term risks that occur when drinking alcohol. These risks can happen to anyone, including individuals suffering from alcohol use disorder, or individuals who are drinking for the very first time. Injuries When you drink al...
Source: Cliffside Malibu - December 3, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility alcohol use risks Source Type: blogs

Fight Aging! Newsletter, December 2nd 2019
In conclusion, T2D impairs vascular function by dysregulated autophagy. Therefore, autophagy could be a potential target for overcoming diabetic microvascular complications. To What Degree Does Loss of Skeletal Muscle with Age Contribute to Immunosenescence? https://www.fightaging.org/archives/2019/11/to-what-degree-does-loss-of-skeletal-muscle-with-age-contribute-to-immunosenescence/ Sarcopenia, the progressive loss of muscle mass and strength, is characteristic of aging. A perhaps surprisingly large fraction of the losses can be averted by strength training, but there are nonetheless inexorable process...
Source: Fight Aging! - December 1, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fabulous Fats in Your Holiday Feast
Happy Thanksgiving! During this time of year, family and friends gather to enjoy rich foods and good company. Even if you typically follow a healthy diet, it can be hard to make wholesome food choices during occasions like these. Our previous post, Five Fabulous Fats, highlighted essential fats made in our bodies. Here we discuss five important fats our bodies can’t make on their own, the foods that contain them, and why you should include a healthy dose of each in your diet. Geranial Credit: iStock. Geranial, a fat some people may not know about, is present in the oils of several citrus plants such a...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 26, 2019 Category: Research Authors: Matt Mills Tags: Chemistry, Biochemistry and Pharmacology Cellular Processes Source Type: blogs

2 Supplements That Prevent Heart Disease And Cancer
The most recent trial confirms that two nutrients can reduce deaths from heart attacks and cancer. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - November 24, 2019 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Heart Disease Source Type: blogs

Kimberly ’ s Two-Month Wheat BellyTransformation
  Look at Kimberly’s dramatic transformation in appearance after just two months on the Wheat Belly lifestyle: the lateral dimensions of her face are reduced, her cheeks are no longer bloated, the around-the-eye swelling is gone and her eyes are bigger. She lost “only” 20 pounds but, judging by the “deflation” of her facial features, it looks more like 100 pounds—this is what happens when you reverse the body-wide inflammation caused by wheat/grain consumption. “I didn’t recognize myself! This side-by-side spoke volumes! I’ve lost about 20 pounds so far. I was 237, no...
Source: Wheat Belly Blog - November 21, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open Inflammation Weight Loss wheat belly Source Type: blogs

Fight Aging! Newsletter, November 4th 2019
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice. Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - November 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Bariatric surgery . . . . for kids?!
  That’s precisely what the American Academy of Pediatrics (AAP) is recommending: more weight loss surgery for overweight kids. This sort of perverted advice reflects the deep and widespread failure of the healthcare system to address nutrition and health, resorting instead to an awful surgical “solution” that, contrary to the AAP’s declaration that it is a proven safe option, is filled with complications, nutritional deficiencies, dysbiotic alterations in bowel flora, hormonal disruptions, and—not all that rarely—death. (Granted that it was over 10 years ago, but the first patient ...
Source: Wheat Belly Blog - October 31, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open bariatric surgery gastric bypass lap bad Weight Loss wheat belly Source Type: blogs

A Perspective on Longevity Biotech Investment from James Peyer of Kronos BioVentures
James Peyer, formerly of Apollo Ventures and now at the larger Kronos BioVentures, has a range of interesting views on the new and growing longevity biotechnology industry. Apollo Ventures was one of the earlier longevity-focused funds to emerge from the comparatively small community of scientists, patient advocates, and investors enthusiastic to accelerate progress towards the treatment of aging as a medical condition. The presentation here was given earlier this year at the Ending Age-Related Diseases conference organized by the Life Extension Advocacy Foundation. In the matter of creating new medical therapies, t...
Source: Fight Aging! - October 30, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

If you are happy and you know it … you may live longer
Plenty of research suggests optimistic people have a reduced risk of heart disease, stroke, and declines in lung capacity and function. Optimism is also associated with a lower risk of early death from cancer and infection. And now a new study links optimism to living a longer life. What does this new research on optimism tell us? The study in Proceedings of the National Academy of Sciences found that people who had higher levels of optimism had a longer life span. They also had a greater chance of living past age 85. The researchers analyzed data gleaned from two large population studies: about 70,000 women from the Nurse...
Source: Harvard Health Blog - October 16, 2019 Category: Consumer Health News Authors: David R. Topor, PhD, MS-HPEd Tags: Behavioral Health Healthy Aging Mental Health Source Type: blogs

The Top Health Wearables For A Healthy Lifestyle
Fitbit or Apple Watch for running? Garmin or Misfit for swimming? Sleep Cycle or Sleep as Android for sleep tracking? What about measuring heart rate, blood pressure, or tracking how to cut out stress from your life? Dozens of gadgets on the healthcare wearable market promise you a healthier lifestyle, but it’s easy to go astray in the jungle of digital health gadgets. Let me show you my top choices when it comes to health wearables and trackers. Guidance in the health wearable universe By now, I have tested and used more than a hundred devices and gadgets that measure health parameters or vital signs. Thus,...
Source: The Medical Futurist - October 5, 2019 Category: Information Technology Authors: nora Tags: Health Sensors & Trackers Portable Diagnostics activity fitness fitness trackers Health 2.0 Healthcare Innovation meditation mental health Personalized medicine sleep sleep optimization sleep tracking stress technology wear Source Type: blogs

Fight Aging! Newsletter, September 23rd 2019
Discussion of Developmental Effects on Aging Microtubule Function and Longevity in Nematodes Quantifying the Correlation Between Poverty and Faster Pace of Aging Matthew O'Connor Presenting on Underdog Pharmaceuticals at Undoing Aging 2019 https://www.fightaging.org/archives/2019/09/matthew-oconnor-presenting-on-underdog-pharmaceuticals-at-undoing-aging-2019/ Here Matthew O'Connor of the SENS Research Foundation talks about the research that led to founding of Underdog Pharmaceuticals, a biotech startup incubated by the foundation to commercialize a means of targeting 7-ketocholesterol in atheroscleros...
Source: Fight Aging! - September 22, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Senolytic Treatment with Dasatinib and Quercetin Confirmed to Reduce the Burden of Senescent Cells in Human Patients
Setting aside the mice genetically engineered to destroy senescent cells, the combination of dasatinib and quercetin is the oldest of the senolytic treatments used in animal studies. Senolytic therapies are those that selectively destroy senescent cells in old tissues in order to produce rejuvenation, turning back the progression of numerous age-related conditions. Unusually for early stage research, these initial senolytics are actually quite effective, considered in the grand scheme of things. Thus they have moved directly to human trials in some cases. The first data on their ability to produce the same outcomes in huma...
Source: Fight Aging! - September 18, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Chimeric Antigen Receptor T Cells as a Treatment for Fibrosis
Chimeric antigen receptor (CAR) T cell therapies are used to treat cancer, engineering T cells to be more aggressive towards cancer cells. The approach has proven quite effective in comparison to past treatments for a number of cancer types. In principle this CAR-T immunotherapy can be used to target any cell population that has distinct surface markers, not just cancer cells. Here, researchers demonstrate the ability to destroy the fibroblasts responsible for generating fibrosis in the aging heart. Fibrosis is a form of dysregulated tissue maintenance, in which cells build up scar-like deposits of collagen that degrade ti...
Source: Fight Aging! - September 18, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs