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Flipping the Stack: Can New Technology Drive Health Care ’s Future?
Conclusion & Implications   As with any analysis of technology promising “disruption”, the careful reader needs to ask themselves one primary question. Is this change real? Or is this just another PowerPoint from a futurist that will be brushed off by the “mother of all adaptive systems”? The technology trends we have described are already in motion. The question is, how big their impact will be in health care? And how long will it take? Here are a few suggestions for hospitals executives to help them understand the transition and assess the rate of change. Get familiar with the technologies...
Source: The Health Care Blog - April 11, 2020 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Matthew Holt Flipping the Stack Indu Subaiya Source Type: blogs

How Self-Development Protects You
We often think of self-development as a pursuit that builds positive capabilities such as courage, ambition, or a success mindset. And of course it can generate many positive results if we truly invest in it, such as loving relationships, a meaningful and lucrative career, and a rewarding lifestyle. But we can easily overlook just how beautifully self-development protects us from major problems in life, including serious but common problems that drag many people down for years, if not decades. Preventing Self-Destruction I originally got into self-development as a path away from self-destructive behavior when I wa...
Source: Steve Pavlina's Personal Development Blog - April 8, 2020 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Health Lifestyle Source Type: blogs

Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

COVID-19: If you ’re older and have chronic health problems, read this
By now, you’ve probably heard this warning about the new coronavirus pandemic: those who are older and have a chronic medical condition are at increased risk for severe disease and death. If you fall into this category, here’s important information about the coronavirus outbreak tailored to you. If you look at the data, older adults and those with chronic health problems who get COVID-19 are more likely to require hospitalization and admission to an intensive care unit. And so far in the US, 80% of the deaths from the new coronavirus virus have occurred in people who were older. But this raises a number of questions: ...
Source: Harvard Health Blog - April 1, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Healthy Aging Infectious diseases Men's Health Prevention Women's Health Source Type: blogs

Impaired Autophagy in the Aging of Stem Cell Populations
The cellular housekeeping mechanisms of autophagy act to recycle proteins and structures within the cell. Upregulation of autophagy appears to be a crucial part of the reason why the response to mild stresses - such as heat, cold, lack of nutrients, and toxins - can actually improve cell and tissue function. Certainly the practice of calorie restriction relies upon functional autophagy in order to extend healthy life span. Researchers here note that autophagy is important in the maintenance of the many stem cell populations throughout the body that are required for ongoing tissue maintenance. The characteristic impairment ...
Source: Fight Aging! - March 30, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, March 30th 2020
This study, for the first time, shows that transplantation of non-autologous mitochondria from healthy skeletal muscle cells into normal cardiomyocytes leads to short-term improvement of bioenergetics indicating "supercharged" state. However, over time these improved effects disappear, which suggests transplantation of mitochondria may have a potential application in settings where there is an acute stress. Outlining Some of the Science Behind Partial Reprogramming at Turn.bio https://www.fightaging.org/archives/2020/03/outlining-some-of-the-science-behind-partial-reprogramming-at-turn-bio/ Turn.bio is a...
Source: Fight Aging! - March 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Travis and Ashley rediscover health and slenderness on the Wheat Belly lifestyle
Ashley convinced her husband, Travis, to join her in following the Wheat Belly lifestyle that began with the Wheat Belly 10-Day Grain Detox. Ashley lost 70 pounds, while Travis experienced both weight loss and health/emotional benefits. Travis elaborates: “I feel like I have a new lease on life and I feel better than I have ever felt in my entire life (40 years old). “I started this WOE at 285 lbs on July 21, 2019, so it’s been 8 months and I’m down 65 lbs. It took me a couple months before I finally felt like I had completely detoxed and felt great everyday. It’s a bit overwhelming at first but it all be...
Source: Wheat Belly Blog - March 24, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open Gliadin gluten grain-free Inflammation Weight Loss wheat belly Source Type: blogs

Go figure: A healthy eating approach helps people be healthy
This study was not perfect. You could argue, as these authors do, that the fact that participants chose their preferred diet is a good thing, as it could theoretically improve adherence. However, it also resulted in very different-sized groups to start with. The varying adherence and exercise option choices were adjusted for as well as possible. And the study relied heavily on self-reporting, which is always iffy. Healthy eating patterns have benefits beyond weight loss But we can still learn a great deal here. The Mediterranean approach to eating (which can be easily modified to suit any country or cultural food preferenc...
Source: Harvard Health Blog - March 16, 2020 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Cooking and recipes Diet and Weight Loss Healthy Eating Source Type: blogs

Fight Aging! Newsletter, March 16th 2020
We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site. Age-Related Epigenetic Changes that Suppress Mitochondrial Function https://www.fightaging.org/archives/2020/03/age-related-epigenetic-changes-that-suppress-mitochondrial-function/ Today's open access research reports on two specific epigenetic changes observed in old individuals that act to reduce mitochondrial function. This joins an existing list of genes for which expression changes are known to impact mitochondrial function with age. A herd of hundreds of mitochondria are found ...
Source: Fight Aging! - March 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Wrong Inflection Point in Aging Research
While it is still a small field in comparison to much of biotechnology and medicine, research into slowing and reversing the aging process has achieved legitimacy and growth in the past decade. This newfound capacity for progress results from a great deal of work by patient advocates, visionary researchers, and other allies to overcome public disinterest and a hostile leadership in the field of gerontology. Sadly, most participants in the now energized research and development communities are pursuing varieties of a poor strategy, often called geroscience. They have taken the wrong realization regarding the plastici...
Source: Fight Aging! - March 13, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Insulin Resistance: the silent killer that you can completely reverse – even if your doctor doesn ’ t know how
You may have already heard the term “insulin resistance,” as it has been widely discussed by doctors and the media. But did you know that you can reduce or reverse it in the vast majority of people? Insulin resistance, i.e., the inability of the body’s cells, especially liver, muscle, and brain, to respond to insulin and allow blood sugar to enter cells, drives numerous abnormal health conditions including type 2 diabetes, hypertension, coronary heart disease, fatty liver, Alzheimer’s dementia, and cancer. It is therefore a driving force behind so many modern and common chronic health conditions. Yo...
Source: Wheat Belly Blog - March 12, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open can belly fat can insulin resistance be reversed lose weight reduce belly fat reverse inflammation visceral fat wheat belly Source Type: blogs

Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Can short bouts of running lengthen lives?
Working hard and feeling like you don’t have any time to exercise? Well, the reality is we all have time. If you’re feeling bad about not exercising enough or at all, some exciting data crunching from a recent British Journal of Sports Medicine (BJSM) analysis of research on running and mortality rates could supply the motivation you need. What amount of running is better than no running? An abundance of research supports the health benefits of exercise. In a blog post last year, I wrote about a study in JAMA that took the first look at the effect of various cardiorespiratory fitness levels on longevity. That study sho...
Source: Harvard Health Blog - March 4, 2020 Category: Consumer Health News Authors: Marwa A. Ahmed, MD, MS Tags: Exercise and Fitness Health Healthy Aging Heart Health Source Type: blogs

HDAC Inhibition Suppresses the Senescence-Associated Secretory Phenotype
The research materials here cover the recent work of one of many groups digging deeper in the mechanisms of cellular senescence, in search of novel ways to make senescent cells less harmful to surrounding tissues, or means to selectively destroy them outright. The accumulation of senescent cells with age is now well proven to contribute to aging, generating chronic inflammation and disrupting tissue function via a potent mix of signals known as the senescence-associated secretory phenotype, or SASP. The scientists involved here have discovered that HDAC inhibitors can to some degree suppress the SASP, and this intervention...
Source: Fight Aging! - March 3, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, March 2nd 2020
In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging. Wnt/β-Catenin Signaling as a Point of Intervention to Spur Greater Neural Regeneration https://www.fightaging.org/archives/2020/02/wnt-%ce%b2-catenin-signali...
Source: Fight Aging! - March 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs